GB1090115A - Mannich bases of rifamycin sv - Google Patents
Mannich bases of rifamycin svInfo
- Publication number
- GB1090115A GB1090115A GB13653/64A GB1365364A GB1090115A GB 1090115 A GB1090115 A GB 1090115A GB 13653/64 A GB13653/64 A GB 13653/64A GB 1365364 A GB1365364 A GB 1365364A GB 1090115 A GB1090115 A GB 1090115A
- Authority
- GB
- United Kingdom
- Prior art keywords
- rifamycin
- alkyl
- oxides
- derivative
- carboxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 229940109171 rifamycin sv Drugs 0.000 title abstract 4
- HJYYPODYNSCCOU-ODRIEIDWSA-N rifamycin SV Chemical compound OC1=C(C(O)=C2C)C3=C(O)C=C1NC(=O)\C(C)=C/C=C/[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@H](C)[C@@H](OC)\C=C\O[C@@]1(C)OC2=C3C1=O HJYYPODYNSCCOU-ODRIEIDWSA-N 0.000 title abstract 2
- RREANTFLPGEWEN-MBLPBCRHSA-N 7-[4-[[(3z)-3-[4-amino-5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidin-2-yl]imino-5-fluoro-2-oxoindol-1-yl]methyl]piperazin-1-yl]-1-cyclopropyl-6-fluoro-4-oxoquinoline-3-carboxylic acid Chemical compound COC1=C(OC)C(OC)=CC(CC=2C(=NC(\N=C/3C4=CC(F)=CC=C4N(CN4CCN(CC4)C=4C(=CC=5C(=O)C(C(O)=O)=CN(C=5C=4)C4CC4)F)C\3=O)=NC=2)N)=C1 RREANTFLPGEWEN-MBLPBCRHSA-N 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 abstract 3
- 150000001204 N-oxides Chemical class 0.000 abstract 3
- HJYYPODYNSCCOU-ZDHWWVNNSA-N Rifamycin SV Natural products COC1C=COC2(C)Oc3c(C)c(O)c4c(O)c(NC(=O)C(=C/C=C/C(C)C(O)C(C)C(O)C(C)C(OC(=O)C)C1C)C)cc(O)c4c3C2=O HJYYPODYNSCCOU-ZDHWWVNNSA-N 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- AZQWKYJCGOJGHM-UHFFFAOYSA-N 1,4-benzoquinone Chemical compound O=C1C=CC(=O)C=C1 AZQWKYJCGOJGHM-UHFFFAOYSA-N 0.000 abstract 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 abstract 2
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 abstract 2
- QIGBRXMKCJKVMJ-UHFFFAOYSA-N Hydroquinone Chemical compound OC1=CC=C(O)C=C1 QIGBRXMKCJKVMJ-UHFFFAOYSA-N 0.000 abstract 2
- BTVYFIMKUHNOBZ-ZDHWWVNNSA-N Rifamycin S Natural products COC1C=COC2(C)Oc3c(C)c(O)c4C(=O)C(=CC(=O)c4c3C2=O)NC(=O)C(=C/C=C/C(C)C(O)C(C)C(O)C(C)C(OC(=O)C)C1C)C BTVYFIMKUHNOBZ-ZDHWWVNNSA-N 0.000 abstract 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
- BTVYFIMKUHNOBZ-ODRIEIDWSA-N Rifamycin S Chemical compound O=C1C(C(O)=C2C)=C3C(=O)C=C1NC(=O)\C(C)=C/C=C/[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@H](C)[C@@H](OC)\C=C\O[C@@]1(C)OC2=C3C1=O BTVYFIMKUHNOBZ-ODRIEIDWSA-N 0.000 abstract 1
- IYABWNGZIDDRAK-UHFFFAOYSA-N allene Chemical group C=C=C IYABWNGZIDDRAK-UHFFFAOYSA-N 0.000 abstract 1
- 125000004202 aminomethyl group Chemical group [H]N([H])C([H])([H])* 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 229960005070 ascorbic acid Drugs 0.000 abstract 1
- 235000010323 ascorbic acid Nutrition 0.000 abstract 1
- 239000011668 ascorbic acid Substances 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/08—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (15)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB13653/64A GB1090115A (en) | 1964-04-02 | 1964-04-02 | Mannich bases of rifamycin sv |
| IL6523157A IL23157A (en) | 1964-04-02 | 1965-03-15 | Mannich bases of rifamycin sv |
| US442166A US3349082A (en) | 1964-04-02 | 1965-03-23 | Mannich bases of rifamycin sv |
| FI0715/65A FI44399B (en:Method) | 1964-04-02 | 1965-03-24 | |
| DE19651595876 DE1595876A1 (de) | 1964-04-02 | 1965-03-25 | Verfahren zur Herstellung von Aminomethylderivaten von Rifamycin SV |
| DK156965AA DK115992B (da) | 1964-04-02 | 1965-03-26 | Fremgangsmåde til fremstilling af aminometylderivater af rifamycin SV eller N-oxyder deraf. |
| AT283565A AT259136B (de) | 1964-04-02 | 1965-03-29 | Verfahren zur Herstellung von neuen Aminomethylderivaten von Rifamycin SV und deres N-Oxyden |
| ES0311202A ES311202A1 (es) | 1964-04-02 | 1965-03-30 | Procedimiento para preparar un derivado de rifamicina sv. |
| NL6504053A NL6504053A (en:Method) | 1964-04-02 | 1965-03-31 | |
| BR168430/65A BR6568430D0 (pt) | 1964-04-02 | 1965-03-31 | Bases mannich da rifocina sv |
| CH456365A CH476010A (de) | 1964-04-02 | 1965-04-01 | Verfahren zur Herstellung von Aminomethylderivaten von Rifamycin SV |
| SE8164/67A SE313309B (en:Method) | 1964-04-02 | 1965-04-01 | |
| SE4216/65A SE316479B (en:Method) | 1964-04-02 | 1965-04-01 | |
| BE661982D BE661982A (en:Method) | 1964-04-02 | 1965-04-02 | |
| FR11684A FR1434532A (fr) | 1964-04-02 | 1965-04-02 | Procédé de préparation de bases de mannich de la rifamycine et de leurs nu-oxydes |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB13653/64A GB1090115A (en) | 1964-04-02 | 1964-04-02 | Mannich bases of rifamycin sv |
| GB4418064 | 1964-10-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1090115A true GB1090115A (en) | 1967-11-08 |
Family
ID=26249901
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB13653/64A Expired GB1090115A (en) | 1964-04-02 | 1964-04-02 | Mannich bases of rifamycin sv |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US3349082A (en:Method) |
| AT (1) | AT259136B (en:Method) |
| BE (1) | BE661982A (en:Method) |
| BR (1) | BR6568430D0 (en:Method) |
| CH (1) | CH476010A (en:Method) |
| DE (1) | DE1595876A1 (en:Method) |
| DK (1) | DK115992B (en:Method) |
| ES (1) | ES311202A1 (en:Method) |
| FI (1) | FI44399B (en:Method) |
| GB (1) | GB1090115A (en:Method) |
| IL (1) | IL23157A (en:Method) |
| NL (1) | NL6504053A (en:Method) |
| SE (2) | SE313309B (en:Method) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3524845A (en) * | 1967-05-29 | 1970-08-18 | Ciba Geigy Corp | Process for the manufacture of 3-formylrifamycin-sv |
| US3542762A (en) * | 1967-06-07 | 1970-11-24 | Lepetit Spa | Process for rifamycins |
| WO2010068383A1 (en) * | 2008-12-11 | 2010-06-17 | Janssen Pharmaceutica Nv | Novel rifamycin 3, 4- (3' -substituted aminomethyl) fused pyrrolo derivatives |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1165179A (en) * | 1966-10-25 | 1969-09-24 | Lepetit Spa | Derivatives of Rifamycin SV |
| CH536851A (de) * | 1966-10-25 | 1973-05-15 | Ciba Geigy Ag | Verfahren zur Herstellung neuer antibiotisch wirksamer Verbindungen der Rifamycinreihen |
| GB1159267A (en) * | 1966-11-03 | 1969-07-23 | Lepetit Spa | Rifamycin Derivatives |
| GB1172155A (en) * | 1967-03-01 | 1969-11-26 | Lepetit Spa | New Rifamycins |
| FR2059967A1 (en:Method) * | 1969-08-06 | 1971-06-11 | Lepetit Spa | |
| AR207762A1 (es) * | 1973-07-25 | 1976-10-29 | Archifar Ind Chim Trentino | Procedimiento para la preparacion de 3-((4-metil-1-piperazin-1-il)-imino)-metil-rifamicina sv o rifampicina |
| IT1090771B (it) * | 1977-12-20 | 1985-06-26 | Alfa Farmaceutici Spa | Derivati delle 3 carbossirifamicines ed sv e procedimento per la loro preparazione |
| IT1090772B (it) * | 1977-12-20 | 1985-06-26 | Alfa Farmaceutici Spa | Derivati della rifamicina e procedimento per la loro preparazione |
| EP2136626A4 (en) * | 2007-03-19 | 2011-02-23 | Oregon State | Mannich base n-oxide drugs |
-
1964
- 1964-04-02 GB GB13653/64A patent/GB1090115A/en not_active Expired
-
1965
- 1965-03-15 IL IL6523157A patent/IL23157A/xx unknown
- 1965-03-23 US US442166A patent/US3349082A/en not_active Expired - Lifetime
- 1965-03-24 FI FI0715/65A patent/FI44399B/fi active
- 1965-03-25 DE DE19651595876 patent/DE1595876A1/de active Pending
- 1965-03-26 DK DK156965AA patent/DK115992B/da unknown
- 1965-03-29 AT AT283565A patent/AT259136B/de active
- 1965-03-30 ES ES0311202A patent/ES311202A1/es not_active Expired
- 1965-03-31 BR BR168430/65A patent/BR6568430D0/pt unknown
- 1965-03-31 NL NL6504053A patent/NL6504053A/xx unknown
- 1965-04-01 SE SE8164/67A patent/SE313309B/xx unknown
- 1965-04-01 SE SE4216/65A patent/SE316479B/xx unknown
- 1965-04-01 CH CH456365A patent/CH476010A/de not_active IP Right Cessation
- 1965-04-02 BE BE661982D patent/BE661982A/xx unknown
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3524845A (en) * | 1967-05-29 | 1970-08-18 | Ciba Geigy Corp | Process for the manufacture of 3-formylrifamycin-sv |
| US3542762A (en) * | 1967-06-07 | 1970-11-24 | Lepetit Spa | Process for rifamycins |
| WO2010068383A1 (en) * | 2008-12-11 | 2010-06-17 | Janssen Pharmaceutica Nv | Novel rifamycin 3, 4- (3' -substituted aminomethyl) fused pyrrolo derivatives |
Also Published As
| Publication number | Publication date |
|---|---|
| BE661982A (en:Method) | 1965-08-02 |
| US3349082A (en) | 1967-10-24 |
| IL23157A (en) | 1969-01-29 |
| DE1595876A1 (de) | 1970-03-26 |
| DK115992B (da) | 1969-12-01 |
| ES311202A1 (es) | 1965-07-01 |
| FI44399B (en:Method) | 1971-08-02 |
| SE316479B (en:Method) | 1969-10-27 |
| BR6568430D0 (pt) | 1973-08-07 |
| NL6504053A (en:Method) | 1965-10-04 |
| AT259136B (de) | 1967-12-27 |
| SE313309B (en:Method) | 1969-08-11 |
| CH476010A (de) | 1969-07-31 |
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