GB1081796A - Improvements in or relating to oily adjuvants for water-in-oil emulsions of antigenic materials - Google Patents

Improvements in or relating to oily adjuvants for water-in-oil emulsions of antigenic materials

Info

Publication number
GB1081796A
GB1081796A GB34730/65A GB3473065A GB1081796A GB 1081796 A GB1081796 A GB 1081796A GB 34730/65 A GB34730/65 A GB 34730/65A GB 3473065 A GB3473065 A GB 3473065A GB 1081796 A GB1081796 A GB 1081796A
Authority
GB
United Kingdom
Prior art keywords
vaccine
water
relating
mixture
pertussis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB34730/65A
Inventor
Lewis Burnell Holt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
WRIGHT FLEMING INST OF MICROBI
Original Assignee
WRIGHT FLEMING INST OF MICROBI
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by WRIGHT FLEMING INST OF MICROBI filed Critical WRIGHT FLEMING INST OF MICROBI
Priority to GB34730/65A priority Critical patent/GB1081796A/en
Publication of GB1081796A publication Critical patent/GB1081796A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0016—Combination vaccines based on diphtheria-tetanus-pertussis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/70—Multivalent vaccine
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

A single shot trivalent injectable vaccine comprises a water-in-oil emulsion of diphtheria toxoid, tetanus toxoid and pertussis vaccine adsorbed on a mineral carrier in aqueous suspension, emulsified with an equal volume of a mixture of squalane, as an oily adjuvant and mannide mono-oleate as emulsifier. The mineral carrier may be aluminium phosphate or aluminium hydroxide. Also disclosed is a quadruple vaccine of the above vaccine further mixed with a polio virus emulsion, and for comparative purposes, similar trivalent vaccine compositions wherein the oily adjuvant is 1) almond oil, 2) a paraffin hydrocarbon; and also a simple nonemulsified mixture of aqueous toxoids of diphtheria, tetanus, and pertussis.
GB34730/65A 1965-08-13 1965-08-13 Improvements in or relating to oily adjuvants for water-in-oil emulsions of antigenic materials Expired GB1081796A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB34730/65A GB1081796A (en) 1965-08-13 1965-08-13 Improvements in or relating to oily adjuvants for water-in-oil emulsions of antigenic materials

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB34730/65A GB1081796A (en) 1965-08-13 1965-08-13 Improvements in or relating to oily adjuvants for water-in-oil emulsions of antigenic materials

Publications (1)

Publication Number Publication Date
GB1081796A true GB1081796A (en) 1967-08-31

Family

ID=10369262

Family Applications (1)

Application Number Title Priority Date Filing Date
GB34730/65A Expired GB1081796A (en) 1965-08-13 1965-08-13 Improvements in or relating to oily adjuvants for water-in-oil emulsions of antigenic materials

Country Status (1)

Country Link
GB (1) GB1081796A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2135190A (en) * 1983-02-22 1984-08-30 Human Oltoanyagtermelo Lyophilized adsorbed polyvalent vaccines
EP0187286A1 (en) * 1984-12-20 1986-07-16 BEHRINGWERKE Aktiengesellschaft Oil-adjuvated vaccine and its manufacturing process
USRE32393E (en) * 1967-09-01 1987-04-07 Kabivitrum Ab Composition for enhancing the administration of pharmacologically active agents

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE32393E (en) * 1967-09-01 1987-04-07 Kabivitrum Ab Composition for enhancing the administration of pharmacologically active agents
GB2135190A (en) * 1983-02-22 1984-08-30 Human Oltoanyagtermelo Lyophilized adsorbed polyvalent vaccines
EP0187286A1 (en) * 1984-12-20 1986-07-16 BEHRINGWERKE Aktiengesellschaft Oil-adjuvated vaccine and its manufacturing process

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