GB1080599A - Improvements in and relating to l-ornithine l-aspartate - Google Patents
Improvements in and relating to l-ornithine l-aspartateInfo
- Publication number
- GB1080599A GB1080599A GB50695/63A GB5069563A GB1080599A GB 1080599 A GB1080599 A GB 1080599A GB 50695/63 A GB50695/63 A GB 50695/63A GB 5069563 A GB5069563 A GB 5069563A GB 1080599 A GB1080599 A GB 1080599A
- Authority
- GB
- United Kingdom
- Prior art keywords
- ornithine
- aspartate
- salt
- type
- relating
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- IXUZXIMQZIMPSQ-ZBRNBAAYSA-N [(4s)-4-amino-4-carboxybutyl]azanium;(2s)-2-amino-4-hydroxy-4-oxobutanoate Chemical compound OC(=O)[C@@H](N)CCC[NH3+].[O-]C(=O)[C@@H](N)CC(O)=O IXUZXIMQZIMPSQ-ZBRNBAAYSA-N 0.000 title abstract 2
- 108010049063 ornithylaspartate Proteins 0.000 title abstract 2
- 150000003839 salts Chemical class 0.000 abstract 5
- AHLPHDHHMVZTML-BYPYZUCNSA-N L-Ornithine Chemical compound NCCC[C@H](N)C(O)=O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 abstract 4
- CKLJMWTZIZZHCS-UHFFFAOYSA-N D-OH-Asp Natural products OC(=O)C(N)CC(O)=O CKLJMWTZIZZHCS-UHFFFAOYSA-N 0.000 abstract 2
- CKLJMWTZIZZHCS-UWTATZPHSA-N L-Aspartic acid Natural products OC(=O)[C@H](N)CC(O)=O CKLJMWTZIZZHCS-UWTATZPHSA-N 0.000 abstract 2
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 abstract 2
- AHLPHDHHMVZTML-UHFFFAOYSA-N Orn-delta-NH2 Natural products NCCCC(N)C(O)=O AHLPHDHHMVZTML-UHFFFAOYSA-N 0.000 abstract 2
- 229960005261 aspartic acid Drugs 0.000 abstract 2
- 229960003104 ornithine Drugs 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 239000002184 metal Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP5790262 | 1962-12-27 | ||
| JP5741963 | 1963-10-29 | ||
| JP6427663 | 1963-10-29 | ||
| JP6250163 | 1963-11-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1080599A true GB1080599A (en) | 1967-08-23 |
Family
ID=27463499
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB50695/63A Expired GB1080599A (en) | 1962-12-27 | 1963-12-23 | Improvements in and relating to l-ornithine l-aspartate |
Country Status (5)
| Country | Link |
|---|---|
| BE (1) | BE641880A (enrdf_load_stackoverflow) |
| FR (1) | FR3150M (enrdf_load_stackoverflow) |
| GB (1) | GB1080599A (enrdf_load_stackoverflow) |
| LU (1) | LU45106A1 (enrdf_load_stackoverflow) |
| NL (1) | NL302572A (enrdf_load_stackoverflow) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4447366A (en) * | 1980-12-04 | 1984-05-08 | Morelle Jean V | Derivatives of lysine and aspartic acid |
| US8173706B2 (en) | 2009-04-03 | 2012-05-08 | Ocera Therapeutics, Inc. | L-ornithine phenyl acetate and methods of making thereof |
| US8389576B2 (en) | 2004-11-26 | 2013-03-05 | Ucl Business Plc | Compositions comprising ornithine and phenylacetate or phenylbutyrate for treating hepatic encephalopathy |
| US8946473B2 (en) | 2010-10-06 | 2015-02-03 | Ocera Therapeutics, Inc. | Methods of making L-ornithine phenyl acetate |
| US10039735B2 (en) | 2014-11-24 | 2018-08-07 | Ucl Business Plc | Treatment of diseases associated with hepatic stellate cell activation using ammonia-lowering therapies |
| US10835506B2 (en) | 2015-08-18 | 2020-11-17 | Ocera Therapeutics, Inc. | Treatment and prevention of muscle loss using L-ornithine in combination with at least one of phenylacetate and phenylbutyrate |
| US11066352B2 (en) | 2017-05-11 | 2021-07-20 | Ocera Therapeutics, Inc. | Processes of making L-ornithine phenylacetate |
| US11266620B2 (en) | 2009-06-08 | 2022-03-08 | Ucl Business Ltd | Treatment of portal hypertension and restoration of liver function using L-ornithine phenylacetate |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107540413A (zh) * | 2017-09-14 | 2018-01-05 | 精晶药业股份有限公司 | 一种从门冬氨酸鸟氨酸结晶母液中提取尿素的方法 |
-
0
- NL NL302572D patent/NL302572A/xx unknown
-
1963
- 1963-12-23 GB GB50695/63A patent/GB1080599A/en not_active Expired
- 1963-12-23 LU LU45106D patent/LU45106A1/xx unknown
- 1963-12-26 FR FR958559A patent/FR3150M/fr active Active
- 1963-12-27 BE BE641880A patent/BE641880A/xx unknown
Cited By (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4447366A (en) * | 1980-12-04 | 1984-05-08 | Morelle Jean V | Derivatives of lysine and aspartic acid |
| US9566257B2 (en) | 2004-11-26 | 2017-02-14 | Ucl Business Plc | Compositions comprising ornithine and phenylacetate or phenylbutyrate for treating hepatic encephalopathy |
| US10610506B2 (en) | 2004-11-26 | 2020-04-07 | Ucl Business Ltd | Compositions comprising ornithine and phenylacetate or phenylbutyrate for treating hepatic encephalopathy |
| US8389576B2 (en) | 2004-11-26 | 2013-03-05 | Ucl Business Plc | Compositions comprising ornithine and phenylacetate or phenylbutyrate for treating hepatic encephalopathy |
| US9034925B2 (en) | 2009-04-03 | 2015-05-19 | Ocera Therapeutics, Inc. | L-ornithine phenyl acetate and methods of making thereof |
| US11161802B2 (en) | 2009-04-03 | 2021-11-02 | Ocera Therapeutics, Inc. | L-ornithine phenyl acetate and methods of making thereof |
| US8785498B2 (en) | 2009-04-03 | 2014-07-22 | Ocera Therapeutics, Inc. | L-ornithine phenyl acetate and methods of making thereof |
| US9604909B2 (en) | 2009-04-03 | 2017-03-28 | Ocera Therapeutics, Inc. | L-ornithine phenyl acetate and methods of making thereof |
| US8492439B2 (en) | 2009-04-03 | 2013-07-23 | Ocera Therapeutics, Inc. | L-ornithine phenyl acetate and methods of making thereof |
| US10173964B2 (en) | 2009-04-03 | 2019-01-08 | Ocera Therapeutics, Inc. | L-ornithine phenyl acetate and methods of making thereof |
| US10550069B2 (en) | 2009-04-03 | 2020-02-04 | Ocera Therapeutics, Inc. | L-ornithine phenyl acetate and methods of making thereof |
| US8173706B2 (en) | 2009-04-03 | 2012-05-08 | Ocera Therapeutics, Inc. | L-ornithine phenyl acetate and methods of making thereof |
| US11266620B2 (en) | 2009-06-08 | 2022-03-08 | Ucl Business Ltd | Treatment of portal hypertension and restoration of liver function using L-ornithine phenylacetate |
| US8946473B2 (en) | 2010-10-06 | 2015-02-03 | Ocera Therapeutics, Inc. | Methods of making L-ornithine phenyl acetate |
| US9260379B2 (en) | 2010-10-06 | 2016-02-16 | Ocera Therapeutics, Inc. | Methods of making L-ornithine phenyl acetate |
| US10039735B2 (en) | 2014-11-24 | 2018-08-07 | Ucl Business Plc | Treatment of diseases associated with hepatic stellate cell activation using ammonia-lowering therapies |
| US11040021B2 (en) | 2014-11-24 | 2021-06-22 | Ucl Business Ltd | Treatment of diseases associated with hepatic stellate cell activation using ammonia-lowering therapies |
| US10525029B2 (en) | 2014-11-24 | 2020-01-07 | Ucl Business Ltd | Treatment of diseases associated with hepatic stellate cell activation using ammonia-lowering therapies |
| US10835506B2 (en) | 2015-08-18 | 2020-11-17 | Ocera Therapeutics, Inc. | Treatment and prevention of muscle loss using L-ornithine in combination with at least one of phenylacetate and phenylbutyrate |
| US11066352B2 (en) | 2017-05-11 | 2021-07-20 | Ocera Therapeutics, Inc. | Processes of making L-ornithine phenylacetate |
Also Published As
| Publication number | Publication date |
|---|---|
| LU45106A1 (enrdf_load_stackoverflow) | 1964-02-24 |
| BE641880A (enrdf_load_stackoverflow) | 1964-04-16 |
| NL302572A (enrdf_load_stackoverflow) | |
| FR3150M (fr) | 1965-02-22 |
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