GB1079083A - New methylene steroids - Google Patents
New methylene steroidsInfo
- Publication number
- GB1079083A GB1079083A GB33571/64A GB3357164A GB1079083A GB 1079083 A GB1079083 A GB 1079083A GB 33571/64 A GB33571/64 A GB 33571/64A GB 3357164 A GB3357164 A GB 3357164A GB 1079083 A GB1079083 A GB 1079083A
- Authority
- GB
- United Kingdom
- Prior art keywords
- oxo
- methylene
- methyl
- estrene
- prepared
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- -1 methylene steroids Chemical class 0.000 title abstract 3
- 238000006243 chemical reaction Methods 0.000 abstract 3
- HSFWRNGVRCDJHI-UHFFFAOYSA-N alpha-acetylene Natural products C#C HSFWRNGVRCDJHI-UHFFFAOYSA-N 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- CVCLKUWHLCRAES-FXNLYBPTSA-N (8R,9R,10S,13R)-13-methyl-16-methylidene-2,3,4,5,6,7,8,9,10,11,12,17-dodecahydro-1H-cyclopenta[a]phenanthrene Chemical class C=C1C[C@]2(C)C(=C1)[C@@H]1CCC3CCCC[C@@H]3[C@H]1CC2 CVCLKUWHLCRAES-FXNLYBPTSA-N 0.000 abstract 1
- HUHXLHLWASNVDB-UHFFFAOYSA-N 2-(oxan-2-yloxy)oxane Chemical compound O1CCCCC1OC1OCCCC1 HUHXLHLWASNVDB-UHFFFAOYSA-N 0.000 abstract 1
- 239000002841 Lewis acid Substances 0.000 abstract 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- 239000003263 anabolic agent Substances 0.000 abstract 1
- 229940124325 anabolic agent Drugs 0.000 abstract 1
- 239000000969 carrier Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003433 contraceptive agent Substances 0.000 abstract 1
- 238000006114 decarboxylation reaction Methods 0.000 abstract 1
- 150000002084 enol ethers Chemical class 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- CCGKOQOJPYTBIH-UHFFFAOYSA-N ethenone Chemical compound C=C=O CCGKOQOJPYTBIH-UHFFFAOYSA-N 0.000 abstract 1
- 150000002170 ethers Chemical class 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 150000007517 lewis acids Chemical class 0.000 abstract 1
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- XYFCBTPGUUZFHI-UHFFFAOYSA-O phosphonium Chemical compound [PH4+] XYFCBTPGUUZFHI-UHFFFAOYSA-O 0.000 abstract 1
- 239000000583 progesterone congener Substances 0.000 abstract 1
- LXMSZDCAJNLERA-ZHYRCANASA-N spironolactone Chemical compound C([C@@H]1[C@]2(C)CC[C@@H]3[C@@]4(C)CCC(=O)C=C4C[C@H]([C@@H]13)SC(=O)C)C[C@@]21CCC(=O)O1 LXMSZDCAJNLERA-ZHYRCANASA-N 0.000 abstract 1
- 229960002256 spironolactone Drugs 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
- 150000003431 steroids Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/567—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH1122363 | 1963-09-11 | ||
| CH752864 | 1964-06-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1079083A true GB1079083A (en) | 1967-08-09 |
Family
ID=25701518
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB33571/64A Expired GB1079083A (en) | 1963-09-11 | 1964-08-17 | New methylene steroids |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US3300521A (enExample) |
| BE (1) | BE652906A (enExample) |
| GB (1) | GB1079083A (enExample) |
| NL (1) | NL6410545A (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4416821A (en) * | 1982-02-17 | 1983-11-22 | The Upjohn Company | Process for preparing 16-methylene steroids |
| HUE027821T2 (en) | 2011-12-23 | 2016-11-28 | Crystal Pharma Sau | A method for alkinylation of 16-substituted-17-ketosteroid derivatives |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3117060A (en) * | 1961-07-14 | 1964-01-07 | Merck Ag Fa E | 16-methylene-testosterone derivatives |
-
0
- BE BE652906D patent/BE652906A/xx unknown
-
1964
- 1964-08-17 GB GB33571/64A patent/GB1079083A/en not_active Expired
- 1964-09-01 US US393753A patent/US3300521A/en not_active Expired - Lifetime
- 1964-09-10 NL NL6410545A patent/NL6410545A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US3300521A (en) | 1967-01-24 |
| BE652906A (enExample) | |
| NL6410545A (enExample) | 1965-03-12 |
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