GB1076037A - A process of producing purine derivatives - Google Patents

A process of producing purine derivatives

Info

Publication number
GB1076037A
GB1076037A GB46767/64A GB4676764A GB1076037A GB 1076037 A GB1076037 A GB 1076037A GB 46767/64 A GB46767/64 A GB 46767/64A GB 4676764 A GB4676764 A GB 4676764A GB 1076037 A GB1076037 A GB 1076037A
Authority
GB
United Kingdom
Prior art keywords
alkyl
amino
lower alkyl
adenine
mercapto
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB46767/64A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KH Neochem Co Ltd
Original Assignee
Kyowa Hakko Kogyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kogyo Co Ltd filed Critical Kyowa Hakko Kogyo Co Ltd
Publication of GB1076037A publication Critical patent/GB1076037A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • C—CHEMISTRY; METALLURGY
    • C25—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES; APPARATUS THEREFOR
    • C25B—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES FOR THE PRODUCTION OF COMPOUNDS OR NON-METALS; APPARATUS THEREFOR
    • C25B3/00—Electrolytic production of organic compounds
    • C25B3/20—Processes
    • C25B3/25—Reduction
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/28—Oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/28—Oxygen atom
    • C07D473/30—Oxygen atom attached in position 6, e.g. hypoxanthine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/36—Sulfur atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
  • Materials Engineering (AREA)
  • Metallurgy (AREA)
  • Electrolytic Production Of Non-Metals, Compounds, Apparatuses Therefor (AREA)

Abstract

Purine compounds e.g. guanine, hypoxanthine, are formed by electrolytic reduction of 4-amino-5-arylazo-pyrimidine or a derivative thereof in the presence of formic acid which closes the imidazole ring (i.e. forming a purine ring), from the intermediate reduction product. The starting material is of the general formula <FORM:1076037/C6-C7/1> where X1, Y1 are H, lower alkyl, OH, NH2, alkyl-amino, alkyl-mercapto, or SH; R1, which may be up to three in number, are H, alkyl, alkoxy, hydroxy, halogen, nitro-, sulpho- and carboxy-radicals (only one of X1 and Y1 being OH at any one time). Lower alkyl groups may also appear attached to one or both of the N atoms of the nucleus. The reaction is effected at above 90 DEG C. using a solvent e.g. formamide. A range of metals is specified for use as electrodes, including mercury as cathode. Products specified include adenine and derivatives thereof, e.g. 2-methyl mercapto adenine.
GB46767/64A 1963-11-26 1964-11-17 A process of producing purine derivatives Expired GB1076037A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP38063011A JPS4826037B1 (en) 1963-11-26 1963-11-26

Publications (1)

Publication Number Publication Date
GB1076037A true GB1076037A (en) 1967-07-19

Family

ID=13216935

Family Applications (1)

Application Number Title Priority Date Filing Date
GB46767/64A Expired GB1076037A (en) 1963-11-26 1964-11-17 A process of producing purine derivatives

Country Status (4)

Country Link
US (1) US3397129A (en)
JP (1) JPS4826037B1 (en)
DE (5) DE1695343A1 (en)
GB (1) GB1076037A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4014863A (en) * 1973-10-12 1977-03-29 Bayer Aktiengesellschaft Water-insoluble azo-pyrimidine pigments
US4113720A (en) * 1972-11-13 1978-09-12 Basf Aktiengesellschaft Disperse azo dye with diaminopyrimidine coupling component
EP0045503A1 (en) * 1980-08-05 1982-02-10 Kohjin Co., Ltd. Process for preparing adenine

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1252670B (en) * 1963-07-25 1967-10-26 Mobil Oil Corporation, New York NY (V St A) Process for the production of cyclo-tiropane and propene or methylcyclopropane and butenes
US3252876A (en) * 1963-12-12 1966-05-24 Socony Mobil Oil Co Inc Electrochemical preparation of acyloxy derivatives of alkyl-substituted condensed ring aromatic compounds
US3252877A (en) * 1963-12-12 1966-05-24 Socony Mobil Oil Co Inc Electrochemical preparation of acyloxy derivatives of condensed ring aromatic compounds

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4113720A (en) * 1972-11-13 1978-09-12 Basf Aktiengesellschaft Disperse azo dye with diaminopyrimidine coupling component
US4014863A (en) * 1973-10-12 1977-03-29 Bayer Aktiengesellschaft Water-insoluble azo-pyrimidine pigments
EP0045503A1 (en) * 1980-08-05 1982-02-10 Kohjin Co., Ltd. Process for preparing adenine
EP0118597A2 (en) * 1980-08-05 1984-09-19 Kohjin Co., Ltd. Process for preparing adenine
EP0118597A3 (en) * 1980-08-05 1985-05-15 Kohjin Co., Ltd. Process for preparing adenine

Also Published As

Publication number Publication date
DE1445986A1 (en) 1969-03-27
DE1695344A1 (en) 1972-05-04
DE1695341A1 (en) 1972-04-27
DE1695343A1 (en) 1972-05-04
US3397129A (en) 1968-08-13
JPS4826037B1 (en) 1973-08-03
DE1695342A1 (en) 1972-04-27

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