GB1072795A - Solid composition containing fat-soluble vitamins and processes for making it - Google Patents
Solid composition containing fat-soluble vitamins and processes for making itInfo
- Publication number
- GB1072795A GB1072795A GB3458264A GB3458264A GB1072795A GB 1072795 A GB1072795 A GB 1072795A GB 3458264 A GB3458264 A GB 3458264A GB 3458264 A GB3458264 A GB 3458264A GB 1072795 A GB1072795 A GB 1072795A
- Authority
- GB
- United Kingdom
- Prior art keywords
- amylose
- vitamin
- retrograded
- water
- solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Fodder In General (AREA)
Abstract
Vitamin compositions in the form of a dry finely-divided free-flowing solid, insoluble in water at temperatures up to 100 DEG C., comprise a fat-soluble vitamin-active composition dispersed in a carrier of retrograded amylose. The fat-soluble vitamins are A, D, E and K, and compounds having the activity of these, including precursors thereof. Particularly mentioned are vitamin A-alcohol, -aldehyde and its phenolic complexes such as retinol quinolate, -esters such as the acetate and palmitate, and the vitamin A precursor b -carotene; the E vitamins a -tocopherol and a -tocopheryl acetate, and the oil-soluble antioxidants butylated hydroxy anisole, butylated hydroxy toluene and ethoxyquin; and natural or synthetic products having vitamin D or K activity. Retrograded amylose is described as a water-insoluble microcrystalline substance, formed by aggregation of colloidal amylose particles in aqueous solution on ageing the solution or by other treatments; it may be colloidally dissolved in water at superatmospheric pressure and temperatures of at least 150 DEG to 160 DEG C. The carrier may include edible plasticisers such as sugars, gums, methyl cellulose, or gelatin. The compositions are prepared by: (1) Preparing an aqueous colloidal solution of amylose; (2) dispersing therein the vitamin-active composition; and (3) converting the dispersion, under conditions at which the amylose retrogrades, into dry solid particles. The amylose solution is prepared suitably from pure retrograded amylose, by either solution in water at elevated temperature and pressure, or by agitation with aqueous alkali metal hydroxide; the vitamin active composition may be dispersed therein by simple stirring or agitation. The third step may be effected by methods wherein the dispersion is agitated with, or extruded or sprayed into, a retrogradation medium, the latter being water or a non-polar hydrocarbon, e.g. hexane when the amylose has been dissolved in superheated water, or an aqueous solution of a neutralising agent, such as an ammonium salt of a strong acid, when the amylose is dissolved in alkali. The retrograded particles are then removed from the medium, dehydrated (e.g. by air drying) and, if required, comminuted. Alternatively, the dispersion may be simultaneously retrograded and dried, by spray drying, or drying on a heated continuous belt, or retrograded on a chilled belt and subsequently dehydrated, and then comminuted. The product is useful as a vitamin concentrate for addition to animal or poultry feed.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US30522263A | 1963-08-28 | 1963-08-28 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1072795A true GB1072795A (en) | 1967-06-21 |
Family
ID=23179868
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB3458264A Expired GB1072795A (en) | 1963-08-28 | 1964-08-24 | Solid composition containing fat-soluble vitamins and processes for making it |
Country Status (1)
Country | Link |
---|---|
GB (1) | GB1072795A (en) |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4755397A (en) * | 1986-12-24 | 1988-07-05 | National Starch And Chemical Corporation | Starch based particulate encapsulation process |
US4812445A (en) * | 1987-02-06 | 1989-03-14 | National Starch And Chemical Corporation | Starch based encapsulation process |
US4853168A (en) * | 1987-12-23 | 1989-08-01 | National Starch And Chemical Corporation | Process for spinning starch fibers |
EP0343993A1 (en) * | 1988-05-26 | 1989-11-29 | Btg International Limited | Delayed release formulations |
GB2257358A (en) * | 1991-06-12 | 1993-01-13 | Wheli Inter Ag | Protected vital substances |
EP0525333A1 (en) * | 1991-06-25 | 1993-02-03 | BASF Aktiengesellschaft | High amylose-content starches for preparing powdery compositions |
WO1994001092A1 (en) * | 1992-07-03 | 1994-01-20 | Nederlandse Organisatie Voor Toegepast-Natuurwetenschappelijk Onderzoek Tno | Composition for controlled release of an active substance and method for the preparation of such a composition |
-
1964
- 1964-08-24 GB GB3458264A patent/GB1072795A/en not_active Expired
Cited By (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4755397A (en) * | 1986-12-24 | 1988-07-05 | National Starch And Chemical Corporation | Starch based particulate encapsulation process |
US4812445A (en) * | 1987-02-06 | 1989-03-14 | National Starch And Chemical Corporation | Starch based encapsulation process |
US4853168A (en) * | 1987-12-23 | 1989-08-01 | National Starch And Chemical Corporation | Process for spinning starch fibers |
US5108758A (en) * | 1988-05-26 | 1992-04-28 | National Research Development Corporation | Delayed release formulations |
WO1989011269A1 (en) * | 1988-05-26 | 1989-11-30 | Agricultural & Food Research Council | Delayed release formulations |
GB2220350B (en) * | 1988-05-26 | 1991-09-04 | Agricultural & Food Res | Delayed release formulations |
EP0343993A1 (en) * | 1988-05-26 | 1989-11-29 | Btg International Limited | Delayed release formulations |
GB2257358A (en) * | 1991-06-12 | 1993-01-13 | Wheli Inter Ag | Protected vital substances |
GB2257358B (en) * | 1991-06-12 | 1996-01-03 | Wheli Inter Ag | Protected vital substances |
EP0525333A1 (en) * | 1991-06-25 | 1993-02-03 | BASF Aktiengesellschaft | High amylose-content starches for preparing powdery compositions |
US5290567A (en) * | 1991-06-25 | 1994-03-01 | Basf Aktiengesellschaft | Pulverulent products composed of a water-insoluble core substance and of a protective covering |
WO1994001092A1 (en) * | 1992-07-03 | 1994-01-20 | Nederlandse Organisatie Voor Toegepast-Natuurwetenschappelijk Onderzoek Tno | Composition for controlled release of an active substance and method for the preparation of such a composition |
US5585114A (en) * | 1992-07-03 | 1996-12-17 | Nederlandse Organisatie Voor Toegepast-Natuurwetenschappelijk Onderzoek Tno | Composition for controlled release of an active substance and method for the preparation of such a composition |
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