GB1062337A - Basic ethers and process for their manufacture - Google Patents

Basic ethers and process for their manufacture

Info

Publication number
GB1062337A
GB1062337A GB45282/63A GB4528263A GB1062337A GB 1062337 A GB1062337 A GB 1062337A GB 45282/63 A GB45282/63 A GB 45282/63A GB 4528263 A GB4528263 A GB 4528263A GB 1062337 A GB1062337 A GB 1062337A
Authority
GB
United Kingdom
Prior art keywords
acid addition
addition salt
resulting
general formula
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB45282/63A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BASF Schweiz AG
Original Assignee
Ciba AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba AG filed Critical Ciba AG
Publication of GB1062337A publication Critical patent/GB1062337A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines

Abstract

The invention comprises piperazine derivatives of the general formula <FORM:1062337/C2/1> (wherein R represents a C1- 7 alkyl group) and acid addition salts thereof, and the preparation thereof by reacting 1-(3-methylphenyl)-piperazine or a metal salt thereof with a reactive ester of a 3-C1- 7 alkoxy-3-phenylpropanol, and, if desired, converting a resulting acid addition salt into the free compound or into another acid addition salt, or a resulting free compound into an acid addition salt, or, if desired, separating a resulting mixture of isomers into the single isomers. Pharmaceutical preparations comprise a compound of the general formula above or a physiologically tolerable acid addition salt thereof and a pharmaceutically suitable carrier for enteral, parenteral or topical administration. They have antihypertensive and diuretic activity.
GB45282/63A 1962-11-15 1963-11-15 Basic ethers and process for their manufacture Expired GB1062337A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US23802762A 1962-11-15 1962-11-15
US25324663A 1963-01-23 1963-01-23

Publications (1)

Publication Number Publication Date
GB1062337A true GB1062337A (en) 1967-03-22

Family

ID=26931273

Family Applications (1)

Application Number Title Priority Date Filing Date
GB45282/63A Expired GB1062337A (en) 1962-11-15 1963-11-15 Basic ethers and process for their manufacture

Country Status (2)

Country Link
CH (3) CH435294A (en)
GB (1) GB1062337A (en)

Also Published As

Publication number Publication date
CH435294A (en) 1967-05-15
CH433335A (en) 1967-04-15
CH433334A (en) 1967-04-15

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