GB1052223A - - Google Patents
Info
- Publication number
- GB1052223A GB1052223A GB1052223DA GB1052223A GB 1052223 A GB1052223 A GB 1052223A GB 1052223D A GB1052223D A GB 1052223DA GB 1052223 A GB1052223 A GB 1052223A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alkali metal
- keto
- steroid
- bis
- acetylide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
Abstract
1,052,223. Steroids. SCHERICO Ltd. Dec. 20, 1963 [Jan. 16, 1963 (2) ; Sept. 30, 1963], No. 50365/63. Heading C2U. The invention comprises a steroid of the androstane series containing double bonds in positions 1(2) and 5(6) of the ring system and containing a keto group in position 3, a methyl group in position 17α, and a free or esterified group in position 17#, and a process for preparing a 3-keto-1,5-bis-dehydro-steroid, which comprises reacting a 3-keto-1,4-bis-dehydrosteroid having a free hydrogen atom at position 6, with a basic isomerization agent in a solvent which does not give up a proton, with the proviso that when the isomerization agent is an alkali metal alkoxide, the solvent is dialkyl sulphoxide or an N,N-dialkyl alkanoic acid amide. As isomerization agents there may be used an alkali metal acetylide, an alkali metal alkyl substituted acetylide, an alkali metal or an alkaline-earth metal hydride, an alkali metal amide, an alkali metal triphenylmethyl or an alkali metal alkoxide. Pharmaceutical compositions having anabolic activity and containing the above compounds are administered orally.
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1052223A true GB1052223A (en) |
Family
ID=1756869
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1052223D Active GB1052223A (en) |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB1052223A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4340538A (en) * | 1980-07-21 | 1982-07-20 | The Upjohn Company | Process for producing 6α-fluoro-Δ1,4 -3-keto steroids |
-
0
- GB GB1052223D patent/GB1052223A/en active Active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4340538A (en) * | 1980-07-21 | 1982-07-20 | The Upjohn Company | Process for producing 6α-fluoro-Δ1,4 -3-keto steroids |
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