GB1043639A - Lubricants for compression tabletting - Google Patents

Abstract

Tablets are manufactured by conventional compression tabletting methods, wherein the tabletting lubricant is a polyfluorocarbon or a mixture of two or more polyfluorocarbons. The tablets are suitable for oral injection, and particularly contain a physiologically active ingredient (see Divs. A5-A6). Preferred polymers include polytetrafluoroethylene, and its copolymer with hexafluoropropylene; polyvinylidene fluoride and its hexafluoropropylene copolymer; and polytrifluorochloroethylene, and its vinylidene fluoride copolymer; or mixtures of these. The polymer may comprise from 1 to 15% by weight of the tablet, and is preferably used as a powder with a particle size of 1 to 150 microns, preferably 1 to 25 microns. Other ingredients in the tabletting composition may be physiologically active agents; bulking materials such as sugars or calcium salts; disintegrants such as starch, alginates, and microcrystalline cellulose; and water-repellants. A compression coat may be applied which may employ, as a lubricant, the polymers of the invention.ALSO:Tablets are prepared by conventional tabletting procedures, using as a tabletting lubricant, one or more fluorocarbon polymers. Suitable polymers include polytetrafluoroethylene, the copolymer of tetrafluoroethylene and hexafluoropropylene, polyvinylidene fluoride, the copolymer of vinylidene fluoride and hexafluoropropylene, polytrifluorochloroethylene, or the copolymer of vinylidene fluoride and trifluorochloroethylene or a mixture of two or more of these polymers. The polymer preferably has a particle size of 1 to 150 microns, and comprises from 1 to 15% by weight of the tablet. Other components which may be present in the tablets include bulking materials such as sugars and inorganic salts, disintegrants such as starches, alginates, or microcrystalline cellulose, water repellants, and colouring agents, and the tablets may be coated with enteric films (e.g. cellulose acetate phthalate, or polyvinyl acetate) or non-enteric films (e.g. sugar, methyl cellulose, or sodium carboxymethyl cellulose). If such coats are applied by compression coating techniques, the fluorocarbon polymers may be used as lubricants in this procedure also, suitably in proportions of 1 to 15% by weight of the coating granulate. Examples are given for the preparation according to the invention of tablets containing the following active ingredients 1) 2-[N-benzyl-N-(2-N,N-dimethyl aminoethyl)-amino]-pyridine hydrochloride; 2) Methyl-a -phenyl-a -(2-piperidyl)-acetate hydrochloride; 3) 6-chloro-7-sulphamyl-2H-3, 4-dihydro-1, 2, 4-benzothiadiazine-1, 1-dioxide; and of tablets containing 1-hydrazino-phthalazine hydrochloride in a core, compression coated, also using lubricants according to the invention, with a methyl-cellulose-containing coat.