GB1024907A - Quinazolines - Google Patents

Abstract

The invention comprises 2-guanidinoquinazolines of the formula <FORM:1024907/C2/1> wherein R1, R2, R3 and R4 each represent hydrogen, chlorine, bromine, alkyl, alkoxy, alkenyloxy or aralkoxy, provided that not more than three of R1 to R4 are hydrogen atoms, provided that where one of R1 to R4 is chlorine at least one other of R1 to R4 is selected from the specified groups other than hydrogen, and provided that where one of R1 to R4 is an alkyl or alkoxy group at least one other of R1 to R4 is selected from the specified atoms or groups other than hydrogen, alkyl and alkoxy; R5 represents hydrogen or alkyl; and R6 represents hydrogen, alkyl, aralkyl or an aromatic group (e.g. phenyl or chlorophenyl); and acid addition and quaternary salts of such compounds. The above guanidinoquinazolines are prepared by reacting 1,2-dihydroquinoline of the formula <FORM:1024907/C2/2> (wherein each R represents an alkyl group and X- is the anion of the acid HX) with a dicyandiamide of the formula <FORM:1024907/C2/3> in the presence of an acid capable of forming an acid addition salt with the 1,2-dihydroquinoline.ALSO:A bacteriostatic composition comprises a 2-guanidino-quinazoline of the formula:- <FORM:1024907/A5-A6/1> wherein R1, R2, R3 and R4 each represent hydrogen, chlorine, bromine, alkyl, alkoxy, alkenyloxy or aralkoxy, provided that not more than three of R1 to R4 are hydrogen atoms, provided that where one or R1 to R4 is chlorine at least one other of R1 to R4 is selected from the specified groups other than hydrogen, and provided that where one of R1 to R4 is an alkyl or alkoxy group at least one other of R1 to R4 is selected from the specified atoms or groups other than hydrogen, alkyl and alkoxy; R5 represents hydrogen or alkyl; and R6 represents hydrogen, alkyl, aralkyl or an aromatic group (e.g. phenyl or chlorophenyl); or an acid addition or quaternary salt thereof in admixture with a diluent such as water, soap, a sodium salt of a long-chain alkylated aromatic sulphonic acid, toluene, cyclohexane, petroleum ether, chloroform, chlorobenzene, castor oil, sperm oil, cottonseed oil, rape oil, mineral oil or talc, and formulated into solutions, suspensions, emulsions, dispersions, lotions, pastes, creams, ointments or powders. The above compositions or the active ingredients thereof per se may be used to protect cloth, leather, plants, vegetables and fruit against bacteria and fungi.