GB1017149A - A process for preparing 3'-phosphoadenosine-5'-phosphosulphate and adenosine-5'-phosphosulphate - Google Patents

A process for preparing 3'-phosphoadenosine-5'-phosphosulphate and adenosine-5'-phosphosulphate

Info

Publication number
GB1017149A
GB1017149A GB26778/64A GB2677864A GB1017149A GB 1017149 A GB1017149 A GB 1017149A GB 26778/64 A GB26778/64 A GB 26778/64A GB 2677864 A GB2677864 A GB 2677864A GB 1017149 A GB1017149 A GB 1017149A
Authority
GB
United Kingdom
Prior art keywords
adenosine
phosphosulphate
phosphate
examples
sources
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB26778/64A
Inventor
Seizi Igarashi
Yuichi Takeuchi
Akira Imada
Ikvo Nogami
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Priority to GB26778/64A priority Critical patent/GB1017149A/en
Priority to FR980664A priority patent/FR1426919A/en
Priority to DET26519A priority patent/DE1254105B/en
Priority to US380633A priority patent/US3268416A/en
Publication of GB1017149A publication Critical patent/GB1017149A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/30—Nucleotides
    • C12P19/32—Nucleotides having a condensed ring system containing a six-membered ring having two N-atoms in the same ring, e.g. purine nucleotides, nicotineamide-adenine dinucleotide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465—Streptomyces

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

31 - Phosphoadenosine - 51 - phosphosulphate and/or adenosine-51-phosphosulphate, or salts thereof, are prepared by inoculating micro-organisms belonging to the genus Streptomyces in an aqueous nutrient medium containing sources of assimilable carbon, nitrogen, phosphate and sulphate, incubating the inoculated medium and recovering the desired substances from the culture broth. Examples of carbon sources are starch, dextrin, glucose, sucrose, lactose, maltose and glycerol, examples of nitrogen sources are peptone, yeast extract, yeast, soya bean meal, cornsteep liquor, amino acids, ammonium salts and nitrates, examples of phosphate sources are dipotassium hydrogen phosphate and potassium dihydrogen phosphate and magnesium sulphate is specified as the sulphate source. The pH of the medium is preferably 7 and the incubation is suitably carried out at 20 DEG C. to 37 DEG C. After incubation the desired substances may be separated from the culture broth by acidifying and filtering the broth, treating the filtrate with activated charcoal, and eluting from the charcoal with ammoniacal aqueous ethanol. The eluate obtained may then be treated with a basic anion-exchange resin and adenosine-51-phosphosulphate and 31-phospho-adenosine-51-phosphosulphate are successively eluted with an aqueous solution of formic acid and ammonium formate. The eluates obtained are then freeze-dried. Numerous examples are given of suitable Streptomyces micro-organisms. 31 - phosphoadenosine - 51 -phosphate, adenosine - 51 - monophosphate, adenosine diphosphate, and adenosine triphosphate may also be isolated in minor amounts from the culture broth.
GB26778/64A 1964-06-29 1964-06-29 A process for preparing 3'-phosphoadenosine-5'-phosphosulphate and adenosine-5'-phosphosulphate Expired GB1017149A (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
GB26778/64A GB1017149A (en) 1964-06-29 1964-06-29 A process for preparing 3'-phosphoadenosine-5'-phosphosulphate and adenosine-5'-phosphosulphate
FR980664A FR1426919A (en) 1964-06-29 1964-07-03 Process for preparing 3'-phosphoadenosine-5'-phosphosulphate and adenosine-5'-phosphosulphate
DET26519A DE1254105B (en) 1964-06-29 1964-07-04 Process for the microbiological production of 3'-phosphoadenosine-5'-phosphosulfate
US380633A US3268416A (en) 1964-06-29 1964-07-06 Process for the preparation of 3'-phosphoadenosine-5'-phosphosulfate and adenosine-5'-phosphosulfate

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB26778/64A GB1017149A (en) 1964-06-29 1964-06-29 A process for preparing 3'-phosphoadenosine-5'-phosphosulphate and adenosine-5'-phosphosulphate

Publications (1)

Publication Number Publication Date
GB1017149A true GB1017149A (en) 1966-01-19

Family

ID=10249049

Family Applications (1)

Application Number Title Priority Date Filing Date
GB26778/64A Expired GB1017149A (en) 1964-06-29 1964-06-29 A process for preparing 3'-phosphoadenosine-5'-phosphosulphate and adenosine-5'-phosphosulphate

Country Status (1)

Country Link
GB (1) GB1017149A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007058278A1 (en) * 2005-11-17 2007-05-24 Yamasa Corporation Stable salt of 3'-phosphoadenosine 5'-phosphosulfate

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007058278A1 (en) * 2005-11-17 2007-05-24 Yamasa Corporation Stable salt of 3'-phosphoadenosine 5'-phosphosulfate
US7863438B2 (en) 2005-11-17 2011-01-04 Yamasa Corporation Stable salt of 3′-phosphoadenosine 5′-phosphosulfate
CN101356183B (en) * 2005-11-17 2011-07-13 Yamasa酱油株式会社 Stable salt of 3'-phosphoadenosine 5'-phosphosulfate
JP5072601B2 (en) * 2005-11-17 2012-11-14 ヤマサ醤油株式会社 Stable salt of 3'-phosphoadenosine-5'-phosphosulfate
KR101272112B1 (en) 2005-11-17 2013-06-07 야마사 쇼유 가부시키가이샤 Stable salt of 3'-phosphoadenosine 5'-phosphosulfate

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