GB1010491A - Improvements relating to the production of aryl alkyl sulphones - Google Patents
Improvements relating to the production of aryl alkyl sulphonesInfo
- Publication number
- GB1010491A GB1010491A GB3372862A GB3372862A GB1010491A GB 1010491 A GB1010491 A GB 1010491A GB 3372862 A GB3372862 A GB 3372862A GB 3372862 A GB3372862 A GB 3372862A GB 1010491 A GB1010491 A GB 1010491A
- Authority
- GB
- United Kingdom
- Prior art keywords
- sulphone
- aryl alkyl
- excess
- aromatic
- production
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
Abstract
Pure aryl alkyl sulphones are made by subjecting substantially equimolar amounts of aluminium chloride and alkane sulphonyl chloride and an excess of an aromatic hydrocarbon or halogenated aromatic hydrocarbons to a Friedel-Crafts, reaction at a temperature substantially in the range 70-80 DEG C., for 7 to 12 hours, recovering the excess of the aromatic reactant and separating the aryl alkyl sulphone. The excess aromatic reactant may be recovered by distillation under reduced pressure and the sulphone isolated by cooling the reaction mixture, pouring the mixture on to ice and hydrochloric acid, extracting the sulphone with ether and distilling the solution, preferably at a pressure at or below 0.1 mm. mercury. Examples describe the preparation of p-fluorophenyl ethyl sulphone, p-fluorophenyl methyl sulphone and p-chlorophenyl ethyl sulphone.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR872194 | 1961-09-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1010491A true GB1010491A (en) | 1965-11-17 |
Family
ID=8762150
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3372862A Expired GB1010491A (en) | 1961-09-14 | 1962-09-03 | Improvements relating to the production of aryl alkyl sulphones |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB1010491A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1993018000A1 (en) * | 1992-03-03 | 1993-09-16 | Zeneca Limited | Regioselective sulphonylation of substituted aromatic compounds |
-
1962
- 1962-09-03 GB GB3372862A patent/GB1010491A/en not_active Expired
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1993018000A1 (en) * | 1992-03-03 | 1993-09-16 | Zeneca Limited | Regioselective sulphonylation of substituted aromatic compounds |
| US5468903A (en) * | 1992-03-03 | 1995-11-21 | Zeneca Limited | Regioselective sulfonylation reaction of substituted aromatic compounds |
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