GB1008649A - New 4,5-dihydro-imidazole derivatives and process for their preparation - Google Patents

New 4,5-dihydro-imidazole derivatives and process for their preparation

Info

Publication number
GB1008649A
GB1008649A GB1931764A GB1931764A GB1008649A GB 1008649 A GB1008649 A GB 1008649A GB 1931764 A GB1931764 A GB 1931764A GB 1931764 A GB1931764 A GB 1931764A GB 1008649 A GB1008649 A GB 1008649A
Authority
GB
United Kingdom
Prior art keywords
general formula
nitrile
acid addition
stands
prepared
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1931764A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chinoin Private Co Ltd
Original Assignee
Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt filed Critical Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt
Publication of GB1008649A publication Critical patent/GB1008649A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/06—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention comprises compounds of the general formula <FORM:1008649/C2/1> in which A stands for a valency bond or a methylene or ethylene group, X stands for a halogen atom or an alkyl or hydroxyl radical and Y stands for hydrogen atom or ahydroxyl group, and acid addition salts thereof, and the preparation thereof by reacting a nitrile of the general formula <FORM:1008649/C2/2> wherein A, X and Y have the above meanings with a 1:1 mole mixture of ethylene diamine and the di-acid addition salt of ethylene diamine or with a mono-acid addition salt of ethylene diamine, and converting the products thus obtained into their acid addition salts if desired or setting the bases free from their above salts. The nitriles of the second general formula above, wherein X represents an alkyl group are prepared by reacting cinnamic acid nitrile with the appropriate substituted benzene derivative in the presence of aluminium chloride, and those wherein X and Y are hydroxy are prepared by diazotizing the corresponding amino compound and warning the solution of the diazo compound thus obtained. b -Phenyl-b (p-chloro-phenyl)-propio-nitrile is prepared by reacting cinnamic acid nitrile and chlorobenzene in the presence of an anhydrous aluminium chloride. Pharmaceutical compositions, having a sedative effect inhibiting spontaneous motility and also the excitemnt caused by phenmetrazine, and which also potentiate narcosis when administered orally, parenterally or rectally, contain a compound of the first general formula above or an acid additional salt thereof in admixture with appropriate pharmaceutical carriers. Salts specified include ascortates. The compositions may take the form of tablets, coated pills, suspensions, solutions, powders or granules, capsules, emulsions or suppositories.
GB1931764A 1963-05-13 1964-05-08 New 4,5-dihydro-imidazole derivatives and process for their preparation Expired GB1008649A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HUCI000444 1963-05-13

Publications (1)

Publication Number Publication Date
GB1008649A true GB1008649A (en) 1965-11-03

Family

ID=10994308

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1931764A Expired GB1008649A (en) 1963-05-13 1964-05-08 New 4,5-dihydro-imidazole derivatives and process for their preparation

Country Status (2)

Country Link
GB (1) GB1008649A (en)
NL (1) NL6405247A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0624638A1 (en) * 1993-05-13 1994-11-17 The Lubrizol Corporation Compositions useful as additives for lubricants and liquid fuels

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0624638A1 (en) * 1993-05-13 1994-11-17 The Lubrizol Corporation Compositions useful as additives for lubricants and liquid fuels
US5458793A (en) * 1993-05-13 1995-10-17 The Lubrizol Corporation Compositions useful as additives for lubricants and liquid fuels
US5560755A (en) * 1993-05-13 1996-10-01 The Lubrizol Corporation Compositions useful as additives for lubricants and liquid fuels

Also Published As

Publication number Publication date
NL6405247A (en) 1964-11-16

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