FR3137839B1 - Procédé et installation de traitement d’un tissu d'origine humaine ou animale, utilisant une circulation dynamique de fluide supercritique additivé - Google Patents

Procédé et installation de traitement d’un tissu d'origine humaine ou animale, utilisant une circulation dynamique de fluide supercritique additivé

Info

Publication number
FR3137839B1
FR3137839B1 FR2207325A FR2207325A FR3137839B1 FR 3137839 B1 FR3137839 B1 FR 3137839B1 FR 2207325 A FR2207325 A FR 2207325A FR 2207325 A FR2207325 A FR 2207325A FR 3137839 B1 FR3137839 B1 FR 3137839B1
Authority
FR
France
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
FR2207325A
Other versions
FR3137839A1 (fr
Inventor
Raphaël Bardonnet
Solène Rota
Emmanuel Pauthe
Michel Boissiere
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CY Cergy Paris Universite
Biobank Co Ltd
Original Assignee
CY Cergy Paris Universite
Biobank Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CY Cergy Paris Universite, Biobank Co Ltd filed Critical CY Cergy Paris Universite
Priority to FR2207325A priority Critical patent/FR3137839B1/fr
Priority to PCT/FR2023/051010 priority patent/WO2024018136A1/fr
Priority to US18/994,100 priority patent/US20260014286A1/en
Priority to EP23751327.0A priority patent/EP4558187A1/fr
Publication of FR3137839A1 publication Critical patent/FR3137839A1/fr
Application granted granted Critical
Publication of FR3137839B1 publication Critical patent/FR3137839B1/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Disinfection or sterilisation of materials or objects, in general; Accessories therefor
    • A61L2/16—Disinfection or sterilisation of materials or objects, in general; Accessories therefor using chemical substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
    • A61L27/3687—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by the use of chemical agents in the treatment, e.g. specific enzymes, detergents, capping agents, crosslinkers, anticalcification agents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B08—CLEANING
    • B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
    • B08B7/00—Cleaning by methods not provided for in a single other subclass or a single group in this subclass
    • B08B7/0021—Cleaning by methods not provided for in a single other subclass or a single group in this subclass by liquid gases or supercritical fluids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2103/00—Materials or objects being the target of disinfection or sterilisation
    • A61L2103/05—Living organisms or biological materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2202/00—Aspects relating to methods or apparatus for disinfecting or sterilising materials or objects
    • A61L2202/10—Apparatus features
    • A61L2202/11—Apparatus for generating biocidal substances, e.g. vaporisers, UV lamps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2202/00—Aspects relating to methods or apparatus for disinfecting or sterilising materials or objects
    • A61L2202/10—Apparatus features
    • A61L2202/12—Apparatus for isolating biocidal substances from the environment
    • A61L2202/121—Sealings, e.g. doors, covers, valves, sluices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2202/00—Aspects relating to methods or apparatus for disinfecting or sterilising materials or objects
    • A61L2202/10—Apparatus features
    • A61L2202/12—Apparatus for isolating biocidal substances from the environment
    • A61L2202/122—Chambers for sterilisation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2202/00—Aspects relating to methods or apparatus for disinfecting or sterilising materials or objects
    • A61L2202/10—Apparatus features
    • A61L2202/12—Apparatus for isolating biocidal substances from the environment
    • A61L2202/123—Connecting means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2202/00—Aspects relating to methods or apparatus for disinfecting or sterilising materials or objects
    • A61L2202/10—Apparatus features
    • A61L2202/15—Biocide distribution means, e.g. nozzles, pumps, manifolds, fans, baffles, sprayers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2202/00—Aspects relating to methods or apparatus for disinfecting or sterilising materials or objects
    • A61L2202/10—Apparatus features
    • A61L2202/17—Combination with washing or cleaning means

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Dermatology (AREA)
  • Botany (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Extraction Or Liquid Replacement (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Des matrices tissulaires (2) à base de collagène sont traitées dans un réacteur (1) par un flux de dioxyde de carbone supercritique, en incluant au moins un additif chimique inséré par un dispositif d’introduction (P2, V12) en communication avec une boucle (20). L’additif est injecté dans le dioxyde de carbone liquide ou supercritique alors que le réacteur est déjà pressurisé. Le procédé associe, dans un flux de traitement dynamique qui circule dans la boucle (20) associée au réacteur, le CO2 supercritique comme solvant et un additif chimique comme co-solvant afin d'augmenter l'action sur le tissu traité. La circulation d’additif, injecté progressivement puis recirculé avec le CO2, fait partie d’un premier cycle de traitement. Plusieurs cycles, chacun avec un additif, peuvent se succéder, séparés par une étape de séparation de l’additif et du CO2 réalisée avec ou sans maintien de la pressurisation et de la circulation du CO2. Figure de l’abrégé : Figure 1
FR2207325A 2022-07-18 2022-07-18 Procédé et installation de traitement d’un tissu d'origine humaine ou animale, utilisant une circulation dynamique de fluide supercritique additivé Active FR3137839B1 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
FR2207325A FR3137839B1 (fr) 2022-07-18 2022-07-18 Procédé et installation de traitement d’un tissu d'origine humaine ou animale, utilisant une circulation dynamique de fluide supercritique additivé
PCT/FR2023/051010 WO2024018136A1 (fr) 2022-07-18 2023-07-03 Procédé et installation de traitement d'un tissu d'origine humaine ou animale, utilisant une circulation dynamique de fluide supercritique additivé
US18/994,100 US20260014286A1 (en) 2022-07-18 2023-07-03 Method and facility for treating human or animal tissue by dynamically circulating an additive-containing supercritical fluid
EP23751327.0A EP4558187A1 (fr) 2022-07-18 2023-07-03 Procédé et installation de traitement d'un tissu d'origine humaine ou animale, utilisant une circulation dynamique de fluide supercritique additivé

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR2207325A FR3137839B1 (fr) 2022-07-18 2022-07-18 Procédé et installation de traitement d’un tissu d'origine humaine ou animale, utilisant une circulation dynamique de fluide supercritique additivé
FR2207325 2022-07-18

Publications (2)

Publication Number Publication Date
FR3137839A1 FR3137839A1 (fr) 2024-01-19
FR3137839B1 true FR3137839B1 (fr) 2026-04-24

Family

ID=83355272

Family Applications (1)

Application Number Title Priority Date Filing Date
FR2207325A Active FR3137839B1 (fr) 2022-07-18 2022-07-18 Procédé et installation de traitement d’un tissu d'origine humaine ou animale, utilisant une circulation dynamique de fluide supercritique additivé

Country Status (4)

Country Link
US (1) US20260014286A1 (fr)
EP (1) EP4558187A1 (fr)
FR (1) FR3137839B1 (fr)
WO (1) WO2024018136A1 (fr)

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2699408B1 (fr) * 1992-12-21 1995-03-24 Bioland Procédé de traitement de tissus osseux et biomatériaux implantables correspondants.
US5723012A (en) 1993-12-09 1998-03-03 Bioland Uses for a current of supercritical carbon dioxide as an antiviral agent
FR2735372B1 (fr) * 1995-06-13 1997-09-05 Bioland Nouvelles utilisations d'un courant de dioxyde de carbone supercritique a titre d'agent antiviral
WO1999056892A1 (fr) * 1998-05-06 1999-11-11 Steris Corporation Nettoyage d'un fluide dans l'intervalle sous-critique et systeme et procede de decontamination antimicrobienne
US7008591B2 (en) * 2001-10-17 2006-03-07 Edwards Lifesciences Corporation Supercritical fluid extraction process for tissue preparation
US6848458B1 (en) * 2002-02-05 2005-02-01 Novellus Systems, Inc. Apparatus and methods for processing semiconductor substrates using supercritical fluids
EA012049B1 (ru) * 2003-11-19 2009-08-28 Скф Технолоджис А/С Способ и процесс контроля профилей температуры, давления и плотности в процессах с плотными текучими средами

Also Published As

Publication number Publication date
FR3137839A1 (fr) 2024-01-19
US20260014286A1 (en) 2026-01-15
EP4558187A1 (fr) 2025-05-28
WO2024018136A1 (fr) 2024-01-25

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