FR3084837B1 - MUCOADHESIVE FILM-GENERATING COMPOSITION AND ITS USE FOR THE TREATMENT OF PAIN RELATED TO TOOTHING - Google Patents

MUCOADHESIVE FILM-GENERATING COMPOSITION AND ITS USE FOR THE TREATMENT OF PAIN RELATED TO TOOTHING Download PDF

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Publication number
FR3084837B1
FR3084837B1 FR1870919A FR1870919A FR3084837B1 FR 3084837 B1 FR3084837 B1 FR 3084837B1 FR 1870919 A FR1870919 A FR 1870919A FR 1870919 A FR1870919 A FR 1870919A FR 3084837 B1 FR3084837 B1 FR 3084837B1
Authority
FR
France
Prior art keywords
weight
composition
toothing
treatment
generating composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
FR1870919A
Other languages
French (fr)
Other versions
FR3084837A1 (en
Inventor
Claire Bouvier
Elodie Mathey
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Urgo Recherche Innovation et Developpement
Original Assignee
Urgo Recherche Innovation et Developpement
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Urgo Recherche Innovation et Developpement filed Critical Urgo Recherche Innovation et Developpement
Priority to FR1870919A priority Critical patent/FR3084837B1/en
Priority to EP19748829.9A priority patent/EP3833326A1/en
Priority to PCT/EP2019/070976 priority patent/WO2020030569A1/en
Publication of FR3084837A1 publication Critical patent/FR3084837A1/en
Application granted granted Critical
Publication of FR3084837B1 publication Critical patent/FR3084837B1/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38Cellulose; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0063Periodont
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/70Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7007Drug-containing films, membranes or sheets

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention a donc pour objet une composition topique filmogène comprenant au moins deux hydrocolloïdes de nature différente, au moins un polymère filmogène gélifiant, au moins un plastifiant, au moins un actif et au moins un solvant inorganique, caractérisée en ce que (a) Au moins un des hydrocolloïdes est de la carboxymethylcellulose et représente 0,5 à 5% en poids du poids total de la composition, (b) Au moins un des hydrocolloïdes est de la croscarmellose et représente 0,5 à 5% en poids du poids total de la composition, (c) le polymère filmogène gélifiant représente 0,5 à 5% en poids du poids total de la composition (d) le plastifiant représente de 5 à 20% en poids du poids total de la composition, (e) L'actif représente de 0,5 à 6% en poids du poids total de la composition (f) le solvant inorganique représente 60 à 80% en poids du poids total de la composition.The subject of the present invention is therefore a film-forming topical composition comprising at least two hydrocolloids of different natures, at least one gelling film-forming polymer, at least one plasticizer, at least one active ingredient and at least one inorganic solvent, characterized in that (a) At least one of the hydrocolloids is carboxymethylcellulose and represents 0.5 to 5% by weight of the total weight of the composition, (b) At least one of the hydrocolloids is croscarmellose and represents 0.5 to 5% by weight of the weight total of the composition, (c) the gelling film-forming polymer represents 0.5 to 5% by weight of the total weight of the composition (d) the plasticizer represents from 5 to 20% by weight of the total weight of the composition, (e) The active agent represents from 0.5 to 6% by weight of the total weight of the composition (f) the inorganic solvent represents 60 to 80% by weight of the total weight of the composition.

FR1870919A 2018-08-10 2018-08-10 MUCOADHESIVE FILM-GENERATING COMPOSITION AND ITS USE FOR THE TREATMENT OF PAIN RELATED TO TOOTHING Active FR3084837B1 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
FR1870919A FR3084837B1 (en) 2018-08-10 2018-08-10 MUCOADHESIVE FILM-GENERATING COMPOSITION AND ITS USE FOR THE TREATMENT OF PAIN RELATED TO TOOTHING
EP19748829.9A EP3833326A1 (en) 2018-08-10 2019-08-05 Mucoadhesive film-forming composition and use thereof for the treatment of pain linked to teething
PCT/EP2019/070976 WO2020030569A1 (en) 2018-08-10 2019-08-05 Mucoadhesive film-forming composition and use thereof for the treatment of pain linked to teething

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR1870919A FR3084837B1 (en) 2018-08-10 2018-08-10 MUCOADHESIVE FILM-GENERATING COMPOSITION AND ITS USE FOR THE TREATMENT OF PAIN RELATED TO TOOTHING

Publications (2)

Publication Number Publication Date
FR3084837A1 FR3084837A1 (en) 2020-02-14
FR3084837B1 true FR3084837B1 (en) 2021-10-29

Family

ID=65244348

Family Applications (1)

Application Number Title Priority Date Filing Date
FR1870919A Active FR3084837B1 (en) 2018-08-10 2018-08-10 MUCOADHESIVE FILM-GENERATING COMPOSITION AND ITS USE FOR THE TREATMENT OF PAIN RELATED TO TOOTHING

Country Status (3)

Country Link
EP (1) EP3833326A1 (en)
FR (1) FR3084837B1 (en)
WO (1) WO2020030569A1 (en)

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6483996A (en) 1995-07-10 1997-02-10 E.I. Du Pont De Nemours And Company Herbicidal sulfonamides
FR2781666B1 (en) * 1998-07-30 2000-09-08 Oreal SOLID COSMETIC COMPOSITION AND USES THEREOF
US20030206942A1 (en) * 1998-09-25 2003-11-06 Neema Kulkarni Fast dissolving orally consumable films containing an antitussive and a mucosa coating agent
NZ530439A (en) * 2001-04-20 2004-11-26 Lavipharm Lab Inc Intraoral delivery of nicotine for smoking cessation
DE10226494A1 (en) 2002-06-14 2004-01-08 Lts Lohmann Therapie-Systeme Ag Film-shaped mucoadhesive dosage forms for administration of cannabis active ingredients
EP1660056A4 (en) * 2003-08-15 2008-12-17 Arius Two Inc Adhesive bioerodible transmucosal drug delivery system
US9687445B2 (en) * 2012-04-12 2017-06-27 Lts Lohmann Therapie-Systeme Ag Oral film containing opiate enteric-release beads
WO2014020155A1 (en) * 2012-08-02 2014-02-06 Clinpharm Reform Gmbh Oral transmucosal adminstration forms of s-ketamine

Also Published As

Publication number Publication date
EP3833326A1 (en) 2021-06-16
WO2020030569A1 (en) 2020-02-13
FR3084837A1 (en) 2020-02-14

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