FR3046936A1 - MULTILAYER DERMAL ADHESIVE DEVICE, FAR INFRARED RADIATION RECEIVER OR TRANSCEIVER, IN PARTICULAR FOR MEDICAL PURPOSES, ADHESIVE PATCH OR ARTICLES COMPRISING THE ADHESIVE MULTILAYER - Google Patents

Abstract

The aim of the invention is to provide medical or sanitary articles or devices made from a self-adhesive composite multilayer film, which increase the efficiency and extend the spectrum of far-infrared (IRL) activity. in the prevention and treatment of sanitary and physiological disorders, in the improvement of the physical and mental performances of an individual, or in cosmetic treatments. For this purpose, the invention relates to a multilayer film consisting on the one hand of a non-tacky outer layer that is dry to the touch on the basis of a polymer and, on the other hand, of a surface adhesive layer on the surface with an adhesive power based on a polymer matrix in which are dispersed ceramic particles capable of emitting and / or returning at least one far-infrared radiation; at least a portion of these particles being preferably MnO2-based particles, and Co2O3-based particles; this multilayer composite film on the other hand with elongation capacity preferably in all directions to increase the wearing comfort. The invention also relates to a patch and other articles comprising this composite multilayer film, as well as their manufacturing processes and their medical or cosmetic applications.

Description

MULTILAYER DERMAL ADHESIVE DEVICE, TRANSMITTER OR REFLECTOR OF FAR INFRARED RADIATION, IN PARTICULAR FOR MEDICAL PURPOSES, ADHESIVE PATCH OR ARTICLE COMPRISING THE ADHESIVE MULTILAYER

Field of the invention The invention belongs to the field of medical devices emitters or reflectors of far infrared radiation IRL, and intended to be affixed or applied, directly on the body of a living individual, to provide the latter with health effects and / or or beneficial cosmetics. It can be among others the prevention or the treatment of certain pathologies e.g. those related to muscular or articular pain-discomfort, of the improvement of cicatrization. These devices may be multilayer films of self-adhesive ceramic polymers and polymers loaded with IRL properties, body-fixable adhesive patches comprising this multilayer film of polymers. These devices provide improved comfort compared to other systems on the market by these multidirectional elongations and its cutaneous tolerance. The invention also relates to the manufacture of these devices and the processing methods implementing them.

Technological background and technical problem

Infrared is generally considered to have a wavelength of between 0.76 μm and 1000 μm. They are classified between near infrared, average infrared and far infrared (IRL), the latter corresponding to the range of wavelengths from 3 pm to 1000 pm inclusive.

When irradiated with infrared, water and organic and / or high molecular weight materials may partially absorb them. IRLs whose wavelength is between 4 pm and 14 pm are particularly interesting. Indeed, this range of wavelengths promotes the resonance and activation of water molecules. This is the case with water of animal or vegetable organisms. The induced effects include the following: - increase the temperature of the skin and cause a sensation of heat, being absorbed at the level of the skin (epidermis and / or dermis), where the energy of the far infrared radiation is converted into heat - increase blood flow to the skin through the dilation of the capillaries, which promotes blood circulation, - activate the metabolism, - reduce the pain sensations.

The IRL presides over all growth and all development of life in nature. The IRLs are those emitted mainly by the human or animal body in the form of heat. The body responds to this phenomenon by dilating the blood vessels to improve circulation at all levels, which revitalizes the tissues and contributes to their repair and regeneration. Most materials emit IRLs. Certain ceramics (for example those chosen from metal oxides) may emit infrared radiation when they receive energy. In particular, metal oxide ceramics have the property of returning the IRLs, in particular those emitted by the human body when these ceramics are placed on the latter. The state of the art thus includes patent applications which describe articles loaded with ceramics sensitive to IRLs and used for sanitary purposes.

European Patent Application EP1504824A1 discloses a film of polyethylene terephthalate (PET) coated with a material based on a resin and ceramic, useful as a packaging film or food protection. This material is prepared from a paste containing the resin and a solvent, in which is mixed a far infrared emitting ceramic. After coating the PET film with the paste, on a given thickness, it is dried and then the whole undergoes calendering. The thickness of ceramic material is lower than that of the PET film. It is also indicated in this document that it is possible to replace the PET film with a thin fabric. In addition, this document indicates that the films obtained are useful for improving the keeping warm, the warming and the health of living beings.

Patent Application EP1199400A2 describes aqueous polyurethane dispersions for textile coating. These dispersions contain 5 to 150 parts by weight of ceramic powder (preferably silicon carbide) per 100 parts by weight of polymer. The coating layers made from this composition are presented as improving the protection against ultraviolet and thermal insulation. This latter property results, according to this patent application, from the combination of the effects of the ceramic powder with those of microbubbles.

The products according to these patent applications are perfectible in terms of the efficiency of the IRL (emission levels), the protection and comfort of users of articles such as clothing, coated with IRL coating EP1816254B1 discloses in particular a film of composite material comprising 30% by weight of ceramic dispersed in 70% by weight of polyurethane (polymer matrix). The ceramic used has the average composition indicated below in% by mass TiO 2: 30 to 40%; SiO2: 10 to 20%; MnO2: 10 to 20% Al2O: 10 to 20%; Fe 2 O 3: 5 to 10%; MgO: 3 to 7%; Co203: 3 to 7%; ZrO2 <5%. This film is then fixed by gluing or by direct coating on a polyamide fabric treated with a hydrophobic / oleophobic compound (e.g. Teflon®) by padding.

The films of polymer / ceramic composite material according to EP1816254B1, are fixed on woven fabrics, nonwoven fabrics, knitted fabrics, so as to form a textile material for the manufacture, for example, of interior and exterior garments, of various accessories. clothing, or household linen or mattresses. EP1816254B1 does not disclose other articles or devices made from these films of polymer / ceramic composite material. The EP1816254B1 therefore leaves room for the optimization of articles or devices made from these films of polymer / ceramic composite material, which make it possible to improve the efficiency and extend the spectrum of activity of the IRLs for prevention and treatment of health and physiological disorders.

Patent Application PCT No. FR / 2013/05 1906 based on FR No. 12 57656 discloses in particular a composite multifilette, intended to be applied to the body of a living individual to emit and / or send back to this body at least one far-infrared radiation, for preventive and / or therapeutic and / or cosmetic purposes and / or to improve one or more of its physiological functions, this multifilette comprising at least two superposed sheets each formed by a composite material consisting of a polymer-based matrix in which ceramic particles are dispersed capable of emitting and / or returning at least one far-infrared radiation, at least a portion of these particles being preferably particles based on MnC> 2 and particles based on C02O3

PCT Application No. FR / 2013/05 1906 based on FR No. 12 57656 does not disclose a composite multilayer film construction comprising at least one tack-free, non-sticky polymer layer and at least one self-adhesive polymer / ceramic layer which no longer requires adhesive textile support intended to be applied or applied, directly on the body of a living individual and constituted by a polymer-based matrix in which ceramic particles are dispersed which may emitting and / or returning at least one far-infrared radiation, at least a portion of these particles being preferably MnC 2 -based particles and C02O3-based particles and other by multidirectional elongation and tolerance thus avoiding the formation of a small pimple on the skin and an abrasion of it.

Objectives of the invention

In this context, the invention aims to satisfy at least one of the following objectives: i) to provide medical, sanitary or cosmetic articles or devices made from a non-sticky polymer composite multilayer film material which is dry to the touch and self-adhesive polymer / ceramic with multi-directional elongations and skin tolerance, said articles or devices for increasing efficiency and extending the spectrum of IRL activity in the prevention and treatment of health and physiological disorders of an individual, in improving the physical and / or mental performance of an individual or in cosmetic treatments; (ii) provide medical, sanitary or cosmetic articles or devices made from non-tacky, self-adhering, polymeric / ceramic self-adhesive polymeric / multilayer composite film material with multi-directional elongation and skin tolerance to be applied to the body of an individual for transmitting and / or returning to this body at least one IRL radiation, for preventive and / or therapeutic and / or cosmetic purposes and / or for the purpose of improving one or more of its physiological functions; (iii) providing medical, sanitary or cosmetic articles or devices made from non-tacky, self-adhering polymeric / ceramic polymer composite multilayer film material with multidirectional elongation and skin tolerance satisfactory to at least l one of the objectives (i) to (iii) above, while offering the individual satisfactory comfort; (iv) providing medical, sanitary or cosmetic articles or devices made from non-tacky, self-adhesive polymeric / ceramic composite multilayer film composite material with multi-directional elongations and a skin tolerance satisfactory to at least l one of the objectives (i) to (iv) above and possessing one or more of the following characteristics: impermeability to water in liquid form, permeability to water vapor, possibility of being permeable or impervious to air; (v) providing medical, sanitary or cosmetic articles or devices made from non-tacky, self-adhering polymeric / ceramic polymer composite multilayer film material with multidirectional elongation and skin tolerance satisfactory to at least l one of the objectives (i) to (v) above and potentially allowing the improvement of at least one of the following functions: - increased comfort especially against periarticular and muscular pain / stiffness; healing; - reduction of stress and muscle fatigue; relief of muscle spasms; - regulation of the peripheral circulation; - increase of the feeling of well-being; (vi) providing medical, sanitary or cosmetic articles or devices made from non-tack-free, self-adhesive polymeric / ceramic polymeric composite film material with multidirectional elongations and skin tolerance satisfactory to at least one of one of the objectives (i) to (vi) above and constituted by at least two polymer layers of which at least one of the two faces is self-adhesive, a patch comprising at least two layers of composite polymers of which at least one one of the two faces is self-adhesive, a bandage comprising at least two layers of composite polymers of which at least one of the two faces is self-adhesive; (vii) provide an industrial, economical and efficient process for the manufacture of medical, sanitary or cosmetic articles or devices made from non-tacky, self-adhering polymer and adhesive polymer / ceramic composite material satisfactory to at least one of one of the objectives (i) to (viii) above; viii) provide a method of prevention and treatment of the health and physiological disorders of an individual; of using medical, sanitary or cosmetic articles or devices made from non-tacky, self-adhesive polymer / adhesive polymer composite film material to increase efficiency and extend spectrum of IRL activity; (ix) provide a method of improving the physical and / or mental performance of an individual by the use of medical, sanitary or cosmetic articles or devices made from non-tacky, polymeric, polymeric composite film material and polymer / ceramic self-adhesive, and in order to increase the efficiency and extend the spectrum of activity of the IRL.

Brief description of the invention

The above objectives, among others, are satisfied by the invention which relates first of all to a device in the form of a multilayer film of non-tacky polymer composite material dry to the touch and polymer / ceramic self-adhesive, here so-called "multilayer film of non-tacky, self-adhering polymer / ceramic self-adhesive polymer composite material", intended to be applied to the body of a living individual to emit and / or return to that body at least one far-infrared ray, for preventive and / or therapeutic and / or cosmetic purposes and / or in order to improve one or more of its physiological functions, this multilayer film of non-tacky polymer and non-tacky polymer / ceramic self-adhesive composite material comprising at least two superimposed layers whose non-sticky outer layer dries to the touch, for example a protection of the inner layer, is constituted by a matrix of b polymer and whose inner layer intended to be in contact with the skin of the individual is constituted by a matrix based on self-adhesive polymer in which are dispersed ceramic particles capable of emitting and / or returning to the less far-infrared radiation, at least a portion of these particles being preferably MnC 2 -based particles and CO 2 O 3 -based particles.

According to an advantageous embodiment of the invention this multilayer film on the one hand with elongation capacity (AL) in the longitudinal and transverse direction and preferably in all directions, according to the standard ISO 527-3, AL expressed as a percentage (%) being in ascending order preferably between 5 to 5000, 50 to 3000, 200 to 1000.

According to a remarkable characteristic of the invention, this multilayer film of non-tacky polymer composite material which is dry to the touch and polymer / ceramic self-adhesive is provided with a tacking power expressed by a peeling force (F) expressed in Newton per cm 5 cm. according to an internal standard which consists in firstly applying the self-adhesive part of the multilayer film of non-tacky polymer composite material dry to the touch and polymer / self-adhesive ceramic with a width of 5 cm on the forearm of a shaved individual, on healthy, dry, cream-free skin for a minimum of 10 minutes and in a second step to measure the peel force at a 90 degree angle between the forearm and the direction of traction using a dynamometer, F expressed in Newton by 5 centimeters being in ascending order preferably between 0.05 and 100, 1.0 and 50, 1.5 and 25, 2 and 10.

Advantageously this multilayer film of non-tacky polymeric composite material dry to the touch and polymer / ceramic self-adhesive having a permeability to water vapor (P), according to ASTM E96 BW at 20 ° C with 35% of relative humidity, P expressed in g / m2 / 24h being in a growing order preferably between 500 to 50,000, 1000 to 30,000; 5000 to 12,000.

According to a remarkable characteristic of the invention, this film of tack-free polymer-adhesive / self-adhesive ceramic composite material has thicknesses of between 30 and 5000 in μm and preferably in increasing order. 100 and 2000; 200 and 600. - According to a preferred embodiment of the invention, at least one of the layers of the multilayer film of tack-free polymer and non-tacky polymeric / self-adhesive ceramic composite material comprises ceramic particles and particles. based on natural carbon black. According to an advantageous particle size characteristic of the invention, the ceramic-based particles have a mean diameter D 50i, measured according to the sedimentometric method such that (in μm and in a preferably increasing order): 1 <D 50 <500; 1 <D50i <400; 1 <D50i <300; - 1 <D50i <100; 1 <D50i <50; 2 <D50i <20; - 3 <D50, <10; D50i = 5; The particles based on natural carbon black have a mean diameter D 502, measured as indicated above, such that (in μm and in increasing order of preference): 1 <D 502 <500; 1 <D502 <400; 1 <D502 <300; - 1 <D502 <100; 1 <D502 <50; 2 <D502 <20; - 3 <D502 <10; D502 "5;

In particular, it has been found interesting in accordance with a preferred feature of the invention to substantially increase the emissivity of the multilayer composite polymer and polymer / ceramic self-adhesive material, to ensure that the self-adhesive polymer / ceramic layer comprises at least 10% by weight of MnO2-based particles and at least 1% (or even at least 5%) by weight of Co2C-based particles> 3% (by weight relative to the total mass of the particles).

Preferably, the non-tacky polymer and / or self-adhesive polymer composite multilayer film according to the invention comprises ceramic particles based on at least one of the following oxides: Al 2 O 3, Fe 2 O 3, TiO 2, Cr 2 O 3, S102, MgO, ZrO2, Y2O3. The mixtures of several of these oxides are conceivable.

According to an advantageous arrangement of the invention, the self-adhesive polymer / ceramic layer comprises at least 5%, preferably from 5 to 40%, of particles based on SiO 2 (% by weight relative to the total mass of the particles ).

According to a remarkable characteristic of the invention, the ceramic-based particles of the self-adhesive polymer / ceramic layer have: either the following composition (in% by weight relative to the total mass of the particles): TiO 2 at 40% - SiO 2 10 to 20% - MnO 2 10 to 20% - Al 2 O 3 10 to 20% - Fe 2 O 3 5 to 10% - MgO 1 to 5% - CO 2 O 3 1 to 5% - ZrO 2, Cr 2 O 3, Y 2 O 3 <5% each, the sum of the percentages being equal to 100%. The emissivity can be substantially increased by incorporating into the self-adhesive polymer / ceramic layer particles based on natural carbon black. The invention relates to a dermal adhesive self-adhesive patch device.

According to an advantageous characteristic of the invention, this patch comprises at least one protective film on the self-adhesive polymer / ceramic layer. The invention relates, secondly, to the use of the non-tacky, self-adhesive polymer / ceramic self-adhesive polymer composite multilayer film, patch and article referred to above, for cosmetic purposes or for cosmetic purposes. preventive and / or therapeutic medical and / or cosmetic and / or to improve one or more of its physiological functions, and in particular for at least one of the following purposes: - increased comfort especially against periarticular pain / stiffness and muscular healing; - reduction of stress and muscle fatigue; - relief of muscle spasms; regulation of the peripheral circulation; increased feeling of well-being;

The non-tacky polymer and / or self-adhesive polymer composite multilayer film, patches and articles according to the invention, are used in such a way that the self-adhesive polymer / ceramic layer is applied to one or more zones. (s) precise (s) and determined (s) of the body of a living individual to emit and / or return to this body at least a far infrared radiation, to produce on this individual beneficial effects abovementioned. Definitions

Throughout this presentation, any singular denotes indifferently a singular or a plural.

The definitions given hereinafter by way of example may be used for the interpretation of this disclosure: • "X-based particles" means that the particles concerned each comprise at least 50% and up to 100% of the species X. • "far infrared radiation, or IRL", is an infrared radiation whose wavelength is for example in pm and in increasing order preferably between 3 and 100; between 3 and 20; between 4 and 15; between 4 and 14.

Detailed description of the invention

The following description of details of the invention and preferred embodiments will better understand the latter and bring out all its advantages and its variants.

FIG. 1 is a diagrammatic representation of a patch (dressing) according to the invention comprising a dry non-tacky polymer film at touchdown 1 bonded by one of these faces to a self-adhesive polymer / ceramic film 2 according to the invention; self-adhesive side of the polymer / ceramic film not bonded to the non-sticky polymer film dry to the touch 1 is covered with a protective film 3,4, intended to be removed for use just before gluing the patch on the skin of the skin. to treat. Each protective film 3,4 has in its inner end-end zone flaps 3a and 4a.

FIGS. 2 and 3 are emissivity diagrams of the self-adhesive polymer / ceramic composite material according to the invention and manufactured according to Example 2 without natural carbon black (FIG. 2) and according to the invention and manufactured according to example 1 with natural carbon black (Figure 3).

FIG. 4 represents the elongation values in% of a patch (dressing) of dimension 10 cm by 5 cm and the tensile force necessary for breaking in the longitudinal and transverse direction according to example 1.

The photograph of FIG. 5 represents a view of the micro-capillaries made at the posterographic portion of the left annular.

The photograph of FIG. 6 represents an image of the measurement of the temperature on a patch according to the invention

The photograph of Figure 7 shows an image of the measurement of temperature on a placebo patch.

The photographs of Figures 8 &amp; 9 show the very positive effect of the patch according to the invention on the speed of healing of the cut in the heel.

The self-adhesive dry polymer and non-tack polymer multilayer composite film 1 shown in FIG. 1 consists of several layers formed on the one hand by a material based on a polymer matrix for the dry non-adhesive layer. to the touch and formed on the other hand for the self-adhesive layer by a composite material consisting of a matrix based on self-adhesive polymer in which are dispersed ceramic particles capable of emitting and / or returning at least one radiation IRL. The number n of layer is e.g. between 2 and 10.

The tack-free, non-sticky layer 1 is formed by a non-tacky polymer matrix that is dry to the touch by the very nature of the polymer.

This non-sticky non-adhesive layer 1 at a thickness of between 3 and 60 microns.

This non-tacky dry layer at touchdown 1 has a water vapor permeability equal to or greater than 500 g / m2 / 24h.

The matrix polymer of the non-tacky dry layer at touch 1 is preferably chosen from thermoplastic or thermosetting polymers, and even more preferably from the group comprising and ideally consisting of the following polymers: polyurethanes, acrylics, polyesters, polyether amide blocks, polyamides, optionally halogenated polyolefins, for example fluorinated (poly tetra-fluoroethylene PTFE).

The self-adhesive polymer / ceramic layer 2 is formed by a self-adhesive polymer matrix of the nature of the polymers and loaded with ceramic particles.

This self-adhesive polymer / ceramic layer 2 at a thickness of between 5 and 350 microns

This self-adhesive polymer / ceramic layer 2 is provided with a water vapor permeability equal to or greater than 1500 g / m 2 / 24h, for example.

The polymer / s of the self-adhesive matrix 2 is preferably chosen from adhesive thermoplastic or thermosetting polymers, and even more preferably from the group comprising and ideally consisting of the following polymers: polyurethanes, acrylics, copolymers polystyrene / butadiene (SBS), natural or artificial latices (polyisoprene), hydrogels such as carboxymethylcelluloses, poly N-isopropylacrylamide, PEG (polyethylene glycol), silicone elastomer gels, silicone elastomers, butyl rubber, vinyl acetate, natural rubber, nitrile rubber, styrene block copolymer, styrene.

The ceramic-based particles dispersed in the self-adhesive polymer matrix represent, in increasing order preferably from 1 to 60, from 5 to 50, from 10 to 40, from 20 to 35% by weight of the composite material. In this example, the particle concentration is 30% by weight of the composite material.

In this example, the ceramic-based particles of the self-adhesive layer 2 have the following composition (in% by weight relative to the total mass of the particles). - TiO 2 30 to 40% - -SiO 2 10 to 20% - -MnO 2 10 to 20% - -A1203 10 to 20% - * -Fe203 5 to 10% - -MgO 1 to 5% - Co203 1 to 5% - ZrO 2 , Cr203, Y203 <5% each, the sum of the percentages being equal to 100%.

These ceramic-based particles have a mean diameter D50i, measured according to the sedimentometric method of 5 microns.

In addition to the ceramic-based particles, particles of natural carbon black are also dispersed in the matrix of the self-adhesive polymer / ceramic layer 2, in a concentration, expressed in mass% of the composite material and given in increasing order. preferably, (from 1 to 60, from 5 to 50, from 10 to 40, from 20 to 35%). In this example, the concentration of natural carbon black is 30% by weight of the composite material.

These particles based on natural carbon black have a mean diameter D50i, measured according to the sedimentometric method of 5 microns.

According to one variant, the self-adhesive polymer / ceramic particle matrix (possibly natural carbon black) of the layer 2 is in the form of a foam.

Manufacture of patch (pamement) composed of non-tacky polymer composite film dry touch 1 and self-adhesive polymer / ceramics 2.

In a first embodiment of the method of manufacturing the non sticky polymer composite patch (dressing) dry touch 1 and polymer / ceramic self-adhesive 2.

In this embodiment of the manufacturing process, the first step consists in producing the dry non-tacky polymer layer at touchdown 1, the mother composition of the polymer of the non-adhesive dry matrix at touchdown 1 is in liquid form: Dispersion of polymer or a precursor thereof in an aqueous or organic liquid, total or partial solution of polymer or a precursor thereof in an organic liquid. A thin layer of this total or partial solution of polymer is then deposited, for example on a first silicone transfer paper, according to a technique known elsewhere. To achieve this step, it is known to use a line-type coating apparatus with a squeegee fixed on a cylinder. The first silicone transfer paper flows between the doctor blade and the cylinder. The total or partial solution of polymer is deposited in front of the squeegee, the spacing between the squeegee and the first silicone transfer paper allows the deposition of the parent composition dispersion and the control of the thickness of the dispersion layer. After applying a total or partial solution of polymer to the first silicone transfer paper, the carrier liquid is removed, for example by evaporation. In the case of removal of the carrier liquid by evaporation, the solution is heated, for example using an infrared bench, to a suitable temperature which depends on the nature of the carrier liquid. The evaporation temperature is, for example, about 60 ° C in the case of an organic phase, or about 100 ° C when the carrier liquid is an aqueous phase. Then, the polymer or its precursor is crosslinked so as to form the dry non-tacky polymer matrix at touchdown 1, increasing the temperature to about 160 ° C, preferably progressively. To ensure crosslinking of the polymer or its precursor, a crosslinking agent is provided in the solution. • The thickness of the non-sticky polymer film dry touch 1 depends on the amount of total or partial solution of polymer deposited on the first silicone transfer paper. To obtain a film with a thickness varying from about 3 μm to about 60 μm dry, about 9 g / m 2 is deposited at 180 g / m 2 of total or partial solution of polymer, for a film of 20 μm, between 60 g / m2 and 70 g / m2 of total or partial solution is used. Tests within the reach of the skilled person to determine this amount. The dry tack-free polymer film assembly 1 attached to the first silicone transfer paper is then rolled on itself to form a coil. • This coil composed of the non-sticky polymer film assembly dry touch 1 attached to the first siliconized transfer paper undergoes the same process for example using a line-type coating device to deposit the self-adhesive polymer / ceramic composite layer 2 on the face of the non-tacky, non-tacky, non-tacky polymer layer 1 on the first silicone transfer paper. In this embodiment of the process for manufacturing the self-adhesive polymer / ceramic layer 2, the mother composition of the polymer of the matrix is in liquid form: polymer dispersion or a precursor thereof in an aqueous or organic liquid, • total or partial solution of polymer or a precursor thereof in an organic liquid.

The ceramic particles and possibly natural carbon black are dispersed in this liquid master composition.

A thin layer of this mother-compound / particle dispersion is then deposited, for example on the first non-tacky, non-tacky polymer assembly at the touch pad 1 fixed on the first silicone transfer paper, according to a technique that is otherwise known. To achieve this step, it is known to use a line-type coating apparatus with a squeegee fixed on a cylinder. The dry non-tacky polymer assembly touched 1 fixed on the first silicone transfer paper circulates between the doctor blade and the cylinder. The mother-compound / particle dispersion is deposited in front of the squeegee, the gap between the squeegee and the dry non-tacky polymer assembly touched 1 fixed on the first silicone transfer paper allows the deposition of the parent / particle dispersion and the control of the thickness of the dispersion layer.

After having applied a layer of mother-compound dispersion / particles on the non-tacky polymer assembly touch dry 1 fixed on the first silicone transfer paper, the carrier liquid is removed, for example by evaporation. In the case of removal of the carrier liquid by evaporation, the composition is heated, for example using an infrared bench, to a suitable temperature that depends on the nature of the carrier liquid. The evaporation temperature is, for example, about 60 ° C in the case of an organic phase, or about 100 ° C when the carrier liquid is an aqueous phase. Then, the polymer or its precursor is crosslinked in order to form the matrix of the composite material, increasing the temperature to about 160 ° C., preferably progressively. In doing so, the particles of ceramic and natural carbon black are trapped in the self-adhesive matrix homogeneously. To ensure crosslinking of the polymer or its precursor, a crosslinking agent is provided in the composition. The thickness of the self-adhesive polymer / ceramic composite material film 2 depends on the amount of mother-compound / particle dispersion deposited on the non-tacky, dry-touch polymer film assembly 1 attached to the first silicone transfer paper. In order to obtain a self-adhesive polymer / ceramic film 2 with a thickness ranging from about 5 μιη to about 350 μm dry, about 10 g / m 2 is deposited at 700 g / m 2 of the mother-compound / particle dispersion. For example, for a 150 μm film, use is made between 280 g / m 2 and 320 g / m 2 of composition. The exact amount of parent / particle dispersion required for a desired film thickness varies, depending on the polymer, or its precursor, the matrix, the amount of ceramic-based particles and, optionally, black particles. natural carbon in the composition. Tests within the reach of the skilled person to determine this amount. At the exit of the device type coating line is deposited for example a second silicone transfer paper on the outer face of the polymer / ceramic self-adhesive film 2 to prevent it from adhering to the first siliconized transfer paper at the same time. winding of the coil. Then the first siliconized transfer paper is separated on the outside of the non-tacky polymer film at touchdown 1 of this coil.

The multilayer film of non-tacky polymer composite material dry touch 1 and polymer / ceramic self-adhesive 2 always attached to the second silicone transfer paper is then cut into strips. The second transfer paper is then separated from these strips, which is replaced by two protective films 3 and 4 that overlap at the center 3a and 4a before the final cut of the patch-shaped layer (dressing).

In a second embodiment of the method of manufacturing the patch (dressing) composite non-adhesive polymer 1 and polymer / ceramic self-adhesive 2.

In this embodiment of the manufacturing process, the first step is the manufacture of the dry non-tacky polymer layer at touchdown 1 is obtained by extrusion techniques.

The thermoplastic polymer can be in the form of granules or powder for extrusion. These products are commercial products.

This mixture is passed through an extrusion head. The thermoplastic polymer is heated to the point of softening and melting of the thermoplastic polymer, due to the rise in temperature in the extrusion head. The mixture is advanced through the heating compartments and the extrusion head, for example by means of the worm. At the outlet of the extrusion head, the film of composite material can be obtained by calendering, blowing or stretching, according to techniques known to those skilled in the art. In both cases, the mixture is cooled until solidification, in order to obtain a non-adhesive polymer film dry to the touch. The tack-free, non-sticky polymer film 1 is then rolled on itself to form a coil.

In this mode of implementation of the manufacturing method, the second step consists in manufacturing the self-adhesive composite polymer film 2 and assembling it with the non-tacky thermoplastic polymer film dry at touchdown 1. In this embodiment of the method for manufacturing the self-adhesive polymer / ceramic layer 2, the mother composition of the polymer of the matrix is in liquid form: polymer dispersion or a precursor thereof in a aqueous or organic liquid, • total or partial solution of polymer or a precursor thereof in an organic liquid.

The ceramic particles and possibly natural carbon black are dispersed in this liquid master composition.

A thin layer of this mother-compound / particle dispersion is then deposited, for example on a silicone transfer paper, according to a technique known elsewhere. To achieve this step, it is known to use a line-type coating apparatus with a squeegee fixed on a cylinder. The silicone transfer paper flows between the doctor blade and the cylinder. The parent / particle dispersion is deposited in front of the squeegee, the gap between the squeegee and the first silicone transfer paper allows the deposition of the parent composition / particle dispersion and the control of the thickness of the dispersion layer.

After having applied a layer of mother-compound / particle dispersion on the silicone transfer paper, the carrier liquid is removed, for example by evaporation. In the case of removal of the carrier liquid by evaporation, the composition is heated, for example using an infrared bench, to a suitable temperature that depends on the nature of the carrier liquid. The evaporation temperature is, for example, about 60 ° C in the case of an organic phase, or about 100 ° C when the carrier liquid is an aqueous phase. Then, the polymer or its precursor is crosslinked in order to form the matrix of the composite material, increasing the temperature to about 160 ° C., preferably progressively. In doing so, the particles of ceramic and natural carbon black are trapped in the self-adhesive matrix homogeneously. To ensure crosslinking of the polymer or its precursor, a crosslinking agent is provided in the composition. The thickness of the self-adhesive polymer / ceramic composite material film 2 depends on the amount of mother-compound / particle dispersion deposited on the silicone transfer paper. In order to obtain a self-adhesive polymer / ceramic film 2 with a thickness varying from about 5 μm to about 350 μm dry, about 10 g / m 2 is deposited at 700 g / m 2 of the masterbatch / particle dispersion. For example, for a 50 μm film, use is made between 280 g / m 2 and 320 g / m 2 of composition. The exact amount of parent / particle dispersion required for a desired film thickness varies, depending on the polymer, or its precursor, the matrix, the amount of ceramic-based particles and, optionally, black particles. natural carbon in the composition. Tests within the reach of the skilled person to determine this amount. At the exit of the device type coating line is deposited for example the non-tacky polymer film dry touch 1 on the outer surface of the polymer / ceramic self-adhesive film by pressing / calendering between two rollers to optimize the adhesion between the dry tack-free polymer film 1 and the self-adhesive polymer / ceramic film 2. The non-tack-tight, non-tacky polymer composite / multilayer film 2 and self-adhesive polymer / ceramic 2 attached to the transfer paper and then rolled on itself to form a reel.

The multilayer film of non-tacky polymer composite material dry touch 1 and self-adhesive polymer / ceramic 2 still fixed on the silicone transfer paper is then cut into strips. The transfer paper is then separated from these sheets, which is replaced by 2 protective films 3 and 4 overlapping at the center 3a and 4a before the final cut of the web in the form of a patch (dressing).

According to a third method of manufacture patch (dressing) polymer composite non tacky touch 1 and polymer / ceramic self-adhesive 2.

In this embodiment of the manufacturing process, the first step consists of the manufacture of the dry non-tacky polymer layer at touchdown 1, the mother composition of the polymer of the non-sticky matrix drying at touchdown 1 is in liquid form: Dispersion of polymer or a precursor thereof in an aqueous or organic liquid, total or partial solution of polymer or a precursor thereof in an organic liquid. A thin layer of this total or partial solution of polymer is then deposited, for example on a first silicone transfer paper, according to a technique known elsewhere. To achieve this step, it is known to use a line-type coating apparatus with a squeegee fixed on a cylinder. The first silicone transfer paper flows between the doctor blade and the cylinder. The total or partial solution of polymer is deposited in front of the squeegee, the spacing between the squeegee and the first silicone transfer paper allows the deposition of the composition-mother / particle dispersion and the control of the thickness of the dispersion layer. After applying a total or partial solution of polymer to the first silicone transfer paper, the carrier liquid is removed, for example by evaporation. In the case of removal of the carrier liquid by evaporation, the solution is heated, for example using an infrared bench, to a suitable temperature which depends on the nature of the carrier liquid. The evaporation temperature is, for example, about 60 ° C in the case of an organic phase, or about 100 ° C when the carrier liquid is an aqueous phase. Then, the polymer or its precursor is crosslinked so as to form the dry non-tacky polymer film at touchdown 1, increasing the temperature to about 160 ° C, preferably progressively. To ensure crosslinking of the polymer or its precursor, a crosslinking agent is provided in the solution. The thickness of the non-adhesive polymer layer 1 depends on the amount of total or partial solution of polymer deposited on the first silicone transfer paper. In order to obtain a dry tack-free polymer layer 1 with a thickness ranging from about 3 μm to about 60 μm dry, about 9 g / m 2 is deposited at 180 g / m 2 of total or partial solution of polymer. for a film of 20 μm, use is made between 60 g / m2 and 70 g / m2 of total or partial solution. Tests within the reach of the skilled person to determine this amount. This dry non-tacky polymer film 1 is then separated from the silicone transfer paper and then rolled on itself to form a coil.

In this embodiment of the manufacturing method, the second step consists of manufacturing the self-adhesive composite polymer / ceramic layer 2 and assembling it with the dry non-tacky polymer film at touchdown 1 In this embodiment of the process for manufacturing the self-adhesive polymer / ceramic layer 2, the mother composition of the polymer of the matrix is in liquid form: polymer dispersion or a precursor thereof in an aqueous or organic liquid, • total or partial solution of polymer or a precursor thereof in an organic liquid.

The ceramic particles and possibly natural carbon black are dispersed in this liquid master composition.

A thin layer of this mother-compound / particle dispersion is then deposited, for example on a silicone transfer paper, according to a technique known elsewhere. To achieve this step, it is known to use a line-type coating apparatus with a squeegee fixed on a cylinder. The silicone transfer paper flows between the doctor blade and the cylinder. The parent / particle dispersion is deposited in front of the squeegee, the gap between the squeegee and the first silicone transfer paper allows the deposition of the parent composition / particle dispersion and the control of the thickness of the dispersion layer.

After having applied a layer of mother-compound / particle dispersion on the silicone transfer paper, the carrier liquid is removed, for example by evaporation. In the case of removal of the carrier liquid by evaporation, the composition is heated, for example using an infrared bench, to a suitable temperature that depends on the nature of the carrier liquid. The evaporation temperature is, for example, about 60 ° C in the case of an organic phase, or about 100 ° C when the carrier liquid is an aqueous phase. Then, the polymer or its precursor is crosslinked in order to form the matrix of the composite material, increasing the temperature to about 160 ° C., preferably progressively. In doing so, the particles of ceramic and natural carbon black are trapped in the matrix homogeneously. To ensure crosslinking of the polymer or its precursor, a crosslinking agent is provided in the composition. The thickness of the self-adhesive polymer composite material film 2 depends on the amount of mother-compound / particle dispersion deposited on the silicone transfer paper. In order to obtain a self-adhesive polymer / ceramic film 2 having a thickness ranging from about 5 μm to about 350 μm dry, about 10 g / m 2 is deposited at 700 g / m 2 of mother-compound / particle dispersion. For example, for a 50 μm film, use is made between 280 g / m 2 and 320 g / m 2 of composition. The exact amount of parent / particle dispersion required for a desired film thickness varies, depending on the polymer, or its precursor, the matrix, the amount of ceramic-based particles and, optionally, black particles. natural carbon in the composition. Tests within the reach of the skilled person to determine this amount. At the exit of the device type coating line is deposited for example the non-tacky polymer film dry touch 1 on the outer surface of the polymer / ceramic self-adhesive film by pressing / calendering between two rollers to optimize the adhesion between the non-sticky dry polymer film at touchdown 1 and the self-adhesive polymer / ceramic film 2. The non-tacky polymer composite multilayer film dry to touch 1 and self-adhesive polymer / ceramic 2 fixed on the silicone transfer paper and then rolled on itself to form a coil.

The multilayer film of composite material dry polymer touch 1 and polymer / ceramic self-adhesive 2 always fixed on the silicone transfer paper is then cut into strips. The silicone transfer paper is then separated from these strips, which is replaced by two protective films 3 and 4 overlapping at the center 3a and 4a before final cutting of the web in the form of a patch (dressing).

According to a first possibility, the non-stick polymer composite multilayer film dry touch 1 and polymer / ceramic self-adhesive 2 is not porous. According to a second possibility, the non-sticky polymer composite film dry touch 1 and polymer / ceramic self-adhesive 2 is in the form of a foam, preferably open porosity. The invention also relates to the use of the self-adhesive dry polymer and non-tack polymer composite film, patch and articles, for cosmetic purposes or for preventive and / or therapeutic medical purposes and / or for to improve one or more of its physiological functions.

For each need (muscular or articular discomfort, sport, balance, healing, well-being), it is important to determine particular positions on the patient's body, from the non-sticky polymeric composite multilayer film to the self-adhesive polymer / ceramic touch. adhesive 2 and therefore patches and articles that carry them. There are therefore accurate maps that determine the effectiveness of medical or cosmetic devices according to the invention, for each need. These positioning can be for example: - Peripheral vascular-peripheral junctions; - Particular points of the muscle to increase the effect of contraction or relaxation; - Particular points of the tendon to increase relaxation, plyometrics, proprioception

Particular points of the nervous system (spinal cord brain, nerve plexus of the belly) in order to have effects on the global relaxation, the ortho and parasympathetic systems, the psyche.

Some patches positioning maps allow the regulation of energy reserves. Other maps can have a global effect of regulation and harmonization. The invention also relates to a medical or cosmetic device comprising a non-tacky polymeric composite multilayer film dry to the touch and polymer / self-adhesive ceramic, in particular according to the invention, and / or at least one patch according to the invention, and a instructions for use indicating at least one mapping of positioning of the patches on the body, corresponding to at least one medical or cosmetic treatment. The invention will now be illustrated by the following examples.

EXAMPLES

Example 1 - Manufacture of a patch (dressing) based on a non-tacky polymer composite multilayer film dry to the touch and polymer / self-adhesive ceramic with particles of natural carbon black.

A tack-free, non-tacky polymer film is prepared from the parent composition dispersion of the following polymer (% by weight): 100 parts by weight of hydrophilic aliphatic ether-ester polyurethane dissolved in the organic liquid phase; organic liquid phase: 10 parts of toluol and 10 parts of isopropyl alcohol - 2.5 parts by weight of crosslinking agent: polyisocyanate.

It is also possible to add pigments and / or dyes in the composition.

The polyurethane-based composition is deposited on a silicone transfer paper on a coating line. Then, it is dried in an oven at a temperature of about 60 ° C before being cured (or polymerized) at a temperature of about 160 ° C.

A non-tacky dry-touch polyurethane film 155 cm wide is obtained on a 160 cm wide silicone transfer paper which is wound on a cardboard tube to form a coil.

The following polymer / ceramic self adhesive composition / mass dispersion (% by weight) is prepared: 70 parts by weight of a hydrophilic polyurethane dispersion in water (50:50 by weight of the dispersion). Water is the carrier liquid. 30 parts by weight of an acrylic dispersion in water (50:50 by weight of the dispersion). Water is the carrier liquid. 17 parts by weight of ceramic-black mixture of natural carbon - TiO 2 15-20% - SiO 2 5-10% - MnO 2 5-10% - A1203 5-10% - Fe203 2.5-5% - MgO 0.5 2.5% - Co203 0.5 to 2.5% - Zr02, Cr203, Y203 <2.5% each, - Natural carbon black 40 to 60%

The sum of the percentages being equal to 100%. , dispersed in the dough.

It is also possible to add pigments and / or dyes in the composition.

The self-adhesive natural polymer / ceramic-black carbon-polymer composition dispersion is coated on the coil composed of the non-tacky polyurethane film to the touch of a width of 155 cm on a silicone transfer paper 160 cm wide, at the using a coating head. The assembly is then dried at about 100 ° C. and then subjected to a temperature of about 160 ° C. for self-crosslinking of the polymer matrix, in a drying oven. The self-adhesive natural polymer / ceramic-black carbon part of the self-adhesive non-tacky polymer-1 and polymer / ceramic-black natural carbon composite film 2 thus obtained contains 30% by weight of ceramic and 70% by weight of polymer matrix. At the exit of the coating line type device is deposited a second silicone transfer paper on the outer surface of the polymer film / ceramic-black self-adhesive natural carbon 2 to prevent it from adhering to the first silicone transfer paper when winding the spool.

Then, the first siliconized transfer paper on the outside of the dry non-tacky polymer film is removed at touchdown 1 of this coil.

This roll of multilayer film of non-tacky polymer composite material dry touch 1 and polymer / ceramic-black self-adhesive natural carbon 2 always attached to the second silicone transfer paper is then cut into thirty-four sections of roll each having a width equal to 4.5 cm.

The realization of patches or dressings is done on a machine well known to those skilled in the art. On one side is a rolled roll of multilayer film of non-tacky polymer composite material dry touch 1 and polymer / ceramic-black self-adhesive natural carbon 2 on silicone transfer paper, during unwinding the silicone paper is removed. transfer and unwinding / laying on the self-adhesive natural carbon / ceramic-black side 2 two rolls of protective film 3 and 4 in polyethylene removable before use laid across the entire width and edge to edge with the multilayer film roll of polymer composite material 1 and self-adhesive polymer 2. One of the two protective films 3 removable before use overlaps the other removable protective film 4 before use in order to be able to remove the removable protective films before use before sticking the patch or dressing on the skin.

The dressing roll consisting of a first part of the multilayer film of non-tacky polymer composite material dry touch 1 and polymer / ceramic-black of self-adhesive natural carbon 2 of a second part of the two protective films 3 and 4 removable before use is then calendered between two cylinders to make adhesive the multilayer film of non-tacky polymer composite material dry touch 1 and polymer / ceramic-black natural carbon self-adhesive 2 and the two removable protective films 3 and 4.

The last step is to cut the dressing roll continuously using a punch formed of cutting blades fixed on a rotating cylinder. The dressings thus cut are packaged in boxes.

Example 2 - Manufacture of a patch (dressing) based on a non-tacky polymer composite multilayer film dry to the touch and self-adhesive polymer / ceramic without particles of natural carbon black.

A non-tacky polymer film is prepared from the parent composition dispersion of the following polymer (% by weight): 100 parts by weight of aliphatic ether-hydrophilic ester polyurethane, in solution in the organic liquid phase, phase organic liquid: 10 parts of toluol and 10 parts of isopropyl alcohol - 2.5 parts by weight of crosslinking agent: polyisocyanate.

It is also possible to add pigments and / or dyes in the composition.

The polyurethane-based composition is deposited on a silicone transfer paper on a coating line. Then, it is dried in an oven at a temperature of about 60 ° C before being cured (or polymerized) at a temperature of about 160 ° C.

A non-tacky dry-touch polyurethane film 155 cm wide is obtained on a 160 cm wide silicone transfer paper which is wound on a cardboard tube to form a coil.

The following polymer / ceramic self adhesive composition / mass dispersion (% by weight) is prepared: 70 parts by weight of a hydrophilic polyurethane dispersion in water (50:50 by weight of the dispersion). Water is the carrier liquid. 30 parts by weight of an acrylic dispersion in water (50:50 by weight of the dispersion). Water is the carrier liquid. 17 parts by weight of ceramic-black mixture of natural carbon - TiO 2 20 to 40% - SiO 2 10 to 20% - MnO 2 10 to 20% - Al 2 O 3 10 to 20% - Fe 2 O 3 5 to 10% - MgO 1 to 5% - Co 2 O 3 1 to 5% - ZrO 2, Cr 2 O 3, Y 2 O 3 <5% each,

The sum of the percentages being equal to 100%. , dispersed in the dough.

It is also possible to add pigments and / or dyes in the composition.

The self-adhesive polymer / ceramic composition dispersion is coated on the coil composed of the 155 cm wide non-sticky polyurethane dry film on a 160 cm wide silicone transfer paper, using a coating head. The assembly is then dried at about 100 ° C. and then subjected to a temperature of about 160 ° C. for self-crosslinking of the polymer matrix, in a drying oven.

The polymer / ceramic-self-adhesive part 2 of the self-adhesive dry polymer and non-tacky polymer composite film 1 thus obtained contains 30% by weight of ceramic and 70% by weight of polymer matrix. At the output of the coating line type device is deposited a second silicone transfer paper on the outer face of the self-adhesive polymer / ceramic film 2 to prevent it from adhering to the first silicone transfer paper during winding of the coil.

Then, the first siliconized transfer paper on the outside of the dry non-tacky polymer film is removed at touchdown 1 of this coil.

This roll of multilayer film of non-tacky polymer composite material dry touch 1 and self-adhesive polymer / ceramic 2 still fixed on the second silicone transfer paper is then cut into thirty-four sections of roll each having a width equal to 4.5 cm.

The realization of patches or dressings is done on a machine well known to those skilled in the art. On one side a rolled roll of multilayer film of non-tacky polymer composite material dry touch 1 and polymer / ceramic self-adhesive 2 on silicone transfer paper, during unwinding, the silicone transfer paper is removed and we unwind / laying on the self-adhesive polymer / ceramic face 2 two rolls of protective film 3 and 4 of polyethylene removable before use laid across the width and edge to edge with the roll of multilayer film of non-tacky polymer composite dry material at touchdown 1 and self-adhesive polymer / ceramic 2.

One of the two protective films 3 removable before use overlaps the other protective film 4 removable before use to remove the removable protective films before use before sticking the patch or dressing on the skin.

The dressing roll composed of a first part of the multilayer film of non-tacky polymer composite material dry touch 1 and polymer / ceramic self-adhesive 2, a second part of the two removable protective films 3 and 4 before use is then calendered between two cylinders to adhere the multilayer film of non-tacky polymer composite material dry touch 1 and polymer / ceramic self-adhesive 2 and the two removable protective films 3 and 4.

The last step is to cut the dressing roll continuously using a punch formed of cutting blades fixed on a rotating cylinder. The dressings thus cut are packaged in boxes

Example 3 - Manufacture of a patch (dressing) based on a non-tacky polymer composite multilayer film and self-adhesive polymer / ceramic in the form of a foam with particles of natural carbon black.

In this example, a non-sticky polymer composite multilayer film is produced at touch 1 and polymer / ceramic-black self-adhesive natural carbon 2 in which the self-adhesive polymer / ceramic is in foam form.

A tack-free, non-tacky polymer film is prepared from the parent composition dispersion of the following polymer (% by weight): 100 parts by weight of hydrophilic aliphatic ether-ester polyurethane dissolved in the organic liquid phase; organic liquid phase: 10 parts of toluol and 10 parts of isopropyl alcohol - 2.5 parts by weight of crosslinking agent: polyisocyanate.

It is also possible to add pigments and / or dyes in the composition.

The polyurethane-based composition is deposited on a silicone transfer paper with a coating line. Then, it is dried in an oven at a temperature of about 60 ° C before being cured (or polymerized) at a temperature of about 160 ° C.

A non-tacky polyurethane film is obtained on the 155 cm wide dry touched surface 1 on a 160 cm wide silicone transfer paper which is wound on a cardboard tube to form a coil.

The self-adhesive polymer / ceramic foam is prepared from a precursor composition containing 70% by weight of a hydrophilic polyurethane dispersion in water (50:50 by weight), - 30% by weight of a dispersion of acrylic in water (50:50 by mass), 15% by mass of ceramic - TiO 2 15 to 20% - SiO 2 5 to 10% - MnO 2 5 to 10% - A1203 5 to 10% - Fe 2 O 3 2.5 to 5 % - MgO 0.5 to 2.5% - Co203 0.5 to 2.5% - ZrO 2, Cr 2 O 3, Y 2 O 3 <2.5% each, - Natural carbon black 40 to 60% the sum of the percentages being equal to 100, 5% by mass of polyisocyanate as agent crosslinker, a foaming agent (sodium sulfosuccinate, 1% by weight), liquid ammonia to regulate the pH and a foam stabilizer (ammonium stearate).

It is also possible to add pigments and / or dyes in the composition. Before being coated on the face of the dry polymer film touched 1 on silicone transfer paper, the composition is transferred to a frothing apparatus, in order to prepare a mechanical foam, that is to say a foam obtained at the end of a mechanical process. The foam is coated on the face of the non-tacky polymer film dry to touch 1 not fixed on silicone transfer paper, then the whole is dried and polymerized as described above. The polymerization makes it possible to stabilize the foam. At the exit of the coating line type device is deposited a second silicone transfer paper on the outer surface of the polymer film / ceramic-black self-adhesive natural carbon 2 to prevent it from adhering to the first silicone transfer paper when winding the spool.

Then the first siliconized transfer paper is separated on the outside of the non-tacky polymer film at touchdown 1 of this coil.

The multilayer film composite non-sticky polymer material dry touch 1 and polymer / ceramic-black self-adhesive natural carbon 2 always attached to the second silicone transfer paper is then cut into strips.

This roll of multilayer film of non-tacky polymer composite material dry touch 1 and polymer / ceramic-black self-adhesive natural carbon 2 always attached to the second silicone transfer paper is then cut into thirty-four sections of roll each having a width equal to 4.5 cm.

The realization of patches or dressings is done on a machine well known to those skilled in the art. One side is a rolled roll of multilayer film of non-tacky polymer composite material dry touch 1 and polymer / ceramic-black self-adhesive natural carbon 2 on silicone transfer paper, during unwinding, the silicone transfer paper is removed and unwinding / laying on the self-adhesive natural carbon / ceramic-black carbon side 2 two rolls of removable polyethylene protective film 3 and 4 before use laid across the width and edge to edge with the multilayer film roll of non-tacky polymer composite material dry to touch 1 and polymer / ceramics-natural carbon black self-adhesive 2.

One of the two removable protective films 3 before use overlaps the other removable protective film 4 before use in order to be able to remove the removable protective films before use before sticking the patch or dressing on the skin.

The dressing roll consisting of a first part of the multilayer film of non-tacky polymer composite material dry touch 1 and polymer / ceramic-black self-adhesive natural carbon 2, a second part of the two removable protective films 3 and 4 before use is then calendered between two cylinders to make adhesive the multilayer film of non-tacky polymer composite material dry touch 1 and polymer / ceramic-black natural carbon self-adhesive 2 and the two removable protective films 3 and 4.

The last step is to cut the dressing roll continuously using a punch formed of cutting blades fixed on a rotating cylinder. The dressings thus cut are packaged in boxes.

Example 4 Infrared Emissivity Measurement of the Patches (Dressings) Manufactured in Example 1

For the quality of the patch (dressing) in terms of emission of far infrared radiation, emissivity diagrams are produced as shown in FIG. 2 for the patches (dressings) of example 2 and FIG. 3 for the patches (dressings). of Example 1.

This measurement is carried out using a spectrometer in accordance with a conventional methodology such as that implemented by the "Dipartimento di Fisica - Universita 'di Pisa, Largo B. Pontecorvo, 3 1-56127 PISA - ITALY"

FIG. 2 shows the curve of the% emissivity (E) as a function of the wavelength in microns obtained for the patch (dressing) of example 2 in which the composite film contains only the ceramic. This material has an emissivity which increases by 83% for a wavelength of 4 μm to reach a maximum of about 90-93% from 10 to 20 μm.

FIG. 3 shows the curve of the% emissivity (E) as a function of the wavelength in microns, obtained for the patch (dressing) of example 1 in which the composite film contains the ceramic and the natural carbon black. This material has an emissivity which increases by 85% for a wavelength of 4 μm to reach a maximum of about 96-98% from 10 to 20 μm. The beneficial effect of natural carbon black in terms of increased IRL emissivity is clear from the comparison of Figures 2 and 3.

Example 5 - Medical uses of the patches (dressings) manufactured in Example 1 Clinical tests 1. Internal method for measuring the speed of circulation of red blood cells in the micro-capillary end of the fingers by capillaroscopy. The protocol used is the following:

This internal method consists of observing the skin of the edge of the nail. Thus, it allows to study the appearance of capillaries (small microscopic arteries) around the nail.

The test subject sits down. One of the nails is cleaned with an antiseptic solution. Then drop a drop of oil on the nail and place it under a light plate. The nail is examined under a microscope called capillaroscope. We performed the measurement according to this internal method on the left ring finger.

Protocol of the internal method

The capillaroscope used for this test is brand DIGILENS and referenced DMX 960. It is connected to a computer to record, visualized the circulation of blood cells. Software can calculate the speed of circulation of blood cells.

Subject: 2 women aged 25 to 30 and in good health. 2 men aged 25 to 30 and in good health.

Observations were made at the posteroinngeal portion of the left annulus.

The subject remained at rest 5 minutes before the start of taking pictures.

The first series of images is made initially without patching on the posterior part of the left annulus.

The patch according to the invention is then applied at the level of the posterior part of the left annular. The subject remains at rest for 5 minutes before the second image series.

The second series of images is performed in a second step with the laying of a patch according to the invention on the posterior part of the left annular.

The findings are as follows:

The first series of image without patch gives the speed of reference.

The second series of images with the patch according to the invention demonstrates that the blood cells circulate better and faster.

According to this internal method, the blood cell circulation rate in the micro-capillaries increases on average by 36% on subjects with a patch according to the invention located on the posterior part of the left annular.

The photograph of FIG. 5 represents an image of the micro-capillaries made at the level of the posterographic portion of the left annular. 2. Internal method for measuring cutaneous temperature with a patch according to the invention versus a placebo patch.

The protocol used is the following:

Patching the outer part of the forearm and measuring the temperature using a FLIR brand infra-red camera.

The placebo patch is composed of the same polymers as the patch according to the invention but does not contain ceramic and natural carbon black according to the invention.

The natural carbon black and the ceramic according to the invention have been replaced by a black pigment of organic origin.

The surface of the placebo patch and the patch according to the invention as well as the weight are identical.

The thermal measurement is performed after a contact time of 60 minutes.

The results obtained are as follows: The temperature according to the internal method measured on the patch according to the invention is 33.6 ° C. whereas the temperature on the placebo patch conforms to the cutaneous temperature of 34.3 ° C.

The patch according to the invention reduces the energy loss of the measurement zone by 0.8 ° C. whereas the placebo patch takes the cutaneous temperature.

The photograph of FIG. 6 represents an image of the measurement of the temperature on a patch according to the invention.

The photograph of Figure 7 shows an image of the measurement of temperature on a placebo patch. 3. Healing study The protocol used is as follows: 17 people injured due to accidents with life and having an open wound were either given sutures for their wound or treated with bandages and adhesives healing healing . In all cases, once the wounds are protected by conventional dressings, a patch completely covering the conventional dressing is applied throughout the healing period.

Ex: Heel notched 3 mm deep. Wound covered with a compeed® healing wound dressing, so that the athlete can continue running, himself covered by a patch according to Example 1 for 12 days.

In all cases, there was no observed worsening (pus, granulocytes, degeneration of the wound). All wounds healed faster than the average is between 12 and 19 days depending on the case. All wounds were properly closed and none had adhesions two months later.

The photograph of Figure 8 shows the notched heel.

The photograph of Figure 9 the same heel after 19 days.

The photographs of Figures 8 &amp; 9 show the very positive effect of the patch according to the invention on the speed of healing of the cut in the heel. 4. Study muscle and joint discomfort.

The protocol used is the following:

This test was conducted on the dressings according to Example 1 versus placebo.

Evaluations were made after 12 hours and 3 days.

Indeed, in this study, there are 4 discomforts articular train carrier including: - 23 ankles - 14 knees - 7 hips - 31 lumbar and 10 muscular diseases covering the entire body.

During the wearing of the patches, the perceived benefits in the painful areas were characterized by: - an improvement of the difficulty to the movements in 90% of the cases; - an improvement in rest hardness in 86% of cases; - a feeling of release in 73% of cases; - improved fluidity and joint flexibility in 88% of cases.

The joints found an indolence and therefore an operation within 12 hours in 27% of subjects and overall the effect is felt in 96% of cases within 3 days after patching. 5. Study of acute cutaneous tolerance The protocol used is as follows:

Test in open 72 hours.

Objective of the study: To determine the primary irritant potential of the patch according to the invention after single application in open for 72 hours in the adult volunteer.

Subjects: 10 volunteers with normal skin corresponding to inclusion and noninclusion criteria determined by LISKIN. STUDY PERIOD: 11/12/15 - 15/12/15 EXPERIMENTAL PLAN: Monocentric single blind study.

Evaluation Criteria: - Irritation Index Medium I.I.M. = total score of reactions total number of volunteers Methods of analysis Classification of the product according to its I.I.M. : Value of I.LM. Product classification I.I.M. <0.08 Non-irritating (NI) 0.08 □ I.I.M. <0.16 Very slightly irritating (TLI) 0.16 □ I.I.M. <0.56 Slightly irritating (LI) 0.56 □ I.I.M. <1 Moderately irritating (MI) 1.00 □ I.I.M. <1.60 Irritant (I) 1.60 □ I.I.M. Very Irritating (I) Results: Product Name I.I.M. at 30 'I.I.M. at 24h

Conclusion: Under the experimental conditions selected, the patch according to the invention was found to be NON-IRRITATING at 30 minutes and 24 hours readings, according to the quotation of ΓΙ.Ι.Μ.

Claims (10)

1. Composite multilayer film consisting on the one hand of a non-tacky outer layer dry touched, and secondly of an inner adhesive layer on the surface with an adhesive power intended to be adhered to the body of a living individual to emit and / or return to this body at least one far-infrared radiation, for preventive and / or therapeutic and / or cosmetic purposes and / or to improve one or more of its physiological functions, this multilayer film is composed of one part of a non-tacky outer layer which is dry to the touch on the basis of a polymer and, on the other hand, of a surface adhesive layer on the surface with an adhesive power based on a polymer matrix in which particles of ceramic capable of emitting and / or returning at least one far infrared radiation; at least a portion of these particles being preferably MnO2-based particles, and Co203-based particles; this composite multilayer film on the one hand with elongation capacity (AL) in the longitudinal and transverse direction and preferably in all directions, according to the standard ISO 527-3, AL expressed in percentage (%) being in a sequence crescent preferably between 5 to 5000, 50 to 3000, 200 to 1000 and on the other hand with a tackiness expressed by a peel force (F) expressed in Newton per 5 centimeters according to an internal standard which consists in applying firstly the surface tacky side with an adhesive power of the inner layer of the composite multilayer film consisting of a non-sticky outer layer dries to the touch and a surface adhesive inner layer with an adhesive power cut on a width of 5 cm and applied on the forearm of a shaved individual, on healthy, dry, cream-free skin for a minimum of 10 minutes and in a second step to measure the peel strength with an angle of 90 degrees between the forearm and the direction of traction using a dynamometer, F expressed in Newton by 5 centimeters being in a rising order preferably between 0.05 and 100, 1.0 and 50, 1.5 and 25, 2 and 10 and on the other hand having a water vapor permeability (P), according to ASTM E96 BW at 20 ° C with 35% relative humidity, P expressed in g / m2 / 24h being in ascending order preferably between 500 to 50,000, 1000 to 30,000; 5000 to 12,000. A composite multilayer film according to claim 1, wherein the non-tacky outer layer dries to the touch consisting of a polymer-based matrix and the inner adhesive layer based on a sticky polymer matrix in which particles of ceramics capable of emitting and / or returning at least one far-infrared radiation have thicknesses ranging between, in pm and in a preferably increasing order, between 30 and 5000; 100 and 2000; 200 and 600 A composite multilayer film according to any one of the preceding claims wherein the polymer-touch-dry, non-tacky outer layer is a film or a foam. A composite multilayer film according to claim 1 or 2, wherein, in the case of greater than 1, at least one of the layers of the polymer-touch-dry, non-tacky outer layer is a foam and at least one of the layers of the polymer-touch-dry, non-tacky outer layer is a film, or the layers are a foam or the layers are a film. A composite multilayer film according to any one of claims 1 to 4, wherein the adhesive-based inner polymer layer with adhesive properties in which ceramic particles are dispersed is a film or a foam. A composite multilayer film according to any one of claims 1 to 4, wherein, in the case of -n- greater than 1, at least one of the layers of the adhesive-based inner layer of polymer with adhesive properties in which ceramic particles are dispersed is a film and at least one of the layers and the adhesive-based inner layer of polymer with adhesive properties in which ceramic particles are dispersed is a foam, or the layers are a foam or the layers are a film. 7. Patch resulting multilayer composite film according to any one of the preceding claims, said patch being provided with a protective film on at least one of the two faces and preferably on the inner face provided with the adhesive-based inner layer. of polymer with adhesive properties in which are dispersed ceramic particles and natural carbon black. 8. The resulting patch of the multilayer composite film according to any one of the preceding claims, characterized in that it has a surface between, in cm2 and in increasing order preferably: 1 and 5000; 5 and 50; 8 and 30; 10 and 20; 20 and 15. 9. Article comprising at least one patch according to claim 4, said article being selected from the group comprising, or more preferably constituted by bandages, dressings. 10. A medical or cosmetic device comprising at least one composite multilayer film according to any one of claims 1 to 3, patch according to claims 4 and 5, article according to claim 6 and a user guide indicating at least one positioning map adhesive multilayers on the body, corresponding to at least one medical or cosmetic treatment.