FR3042202B1 - Procede de criblage de composes a effet anti-inflammatoire base sur la proteine dact3 et nouvelles strategies therapeutiques - Google Patents

Procede de criblage de composes a effet anti-inflammatoire base sur la proteine dact3 et nouvelles strategies therapeutiques Download PDF

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Publication number
FR3042202B1
FR3042202B1 FR1559742A FR1559742A FR3042202B1 FR 3042202 B1 FR3042202 B1 FR 3042202B1 FR 1559742 A FR1559742 A FR 1559742A FR 1559742 A FR1559742 A FR 1559742A FR 3042202 B1 FR3042202 B1 FR 3042202B1
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FR
France
Prior art keywords
dact3
protein
new therapeutic
therapeutic strategies
screening compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR1559742A
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English (en)
Other versions
FR3042202A1 (fr
Inventor
Luis G. BERMUDEZ-HUMARAN
Philippe Langella
Florian CHAIN
Marion Lenoir
Rebeca Martin Rosique
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Institut National de Recherche pour lAgriculture lAlimentation et lEnvironnement
Original Assignee
Institut National de la Recherche Agronomique INRA
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Publication date
Application filed by Institut National de la Recherche Agronomique INRA filed Critical Institut National de la Recherche Agronomique INRA
Priority to FR1559742A priority Critical patent/FR3042202B1/fr
Priority to PCT/FR2016/052638 priority patent/WO2017064421A1/fr
Publication of FR3042202A1 publication Critical patent/FR3042202A1/fr
Application granted granted Critical
Publication of FR3042202B1 publication Critical patent/FR3042202B1/fr
Expired - Fee Related legal-status Critical Current
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A61K38/57—Protease inhibitors from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/06—Gastro-intestinal diseases
    • G01N2800/065—Bowel diseases, e.g. Crohn, ulcerative colitis, IBS
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/70—Mechanisms involved in disease identification
    • G01N2800/7095—Inflammation

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Physics & Mathematics (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pain & Pain Management (AREA)
  • Biophysics (AREA)
  • Rheumatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

La présente invention est relative à un procédé de criblage de composés à effet anti-inflammatoire sur la base de la protéine DACT3. En particulier, le procédé consiste à sélectionner des composés ayant un effet activateur sur la protéine DACT3 ou capable d'augmenter l'expression de celle-ci. La présente invention est également relative à de nouvelles stratégies thérapeutiques des maladies inflammatoires chroniques de l'intestin.
FR1559742A 2015-10-13 2015-10-13 Procede de criblage de composes a effet anti-inflammatoire base sur la proteine dact3 et nouvelles strategies therapeutiques Expired - Fee Related FR3042202B1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
FR1559742A FR3042202B1 (fr) 2015-10-13 2015-10-13 Procede de criblage de composes a effet anti-inflammatoire base sur la proteine dact3 et nouvelles strategies therapeutiques
PCT/FR2016/052638 WO2017064421A1 (fr) 2015-10-13 2016-10-13 Procédé de criblage de composés à effet anti-inflammatoire basé sur la protéine dact3 et nouvelles stratégies thérapeutiques

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR1559742A FR3042202B1 (fr) 2015-10-13 2015-10-13 Procede de criblage de composes a effet anti-inflammatoire base sur la proteine dact3 et nouvelles strategies therapeutiques
FR1559742 2015-10-13

Publications (2)

Publication Number Publication Date
FR3042202A1 FR3042202A1 (fr) 2017-04-14
FR3042202B1 true FR3042202B1 (fr) 2020-02-07

Family

ID=55345935

Family Applications (1)

Application Number Title Priority Date Filing Date
FR1559742A Expired - Fee Related FR3042202B1 (fr) 2015-10-13 2015-10-13 Procede de criblage de composes a effet anti-inflammatoire base sur la proteine dact3 et nouvelles strategies therapeutiques

Country Status (2)

Country Link
FR (1) FR3042202B1 (fr)
WO (1) WO2017064421A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11926849B2 (en) 2019-03-29 2024-03-12 The General Hospital Corporation Biosensors in human gut organoids

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011504462A (ja) * 2007-11-02 2011-02-10 エージェンシー フォー サイエンス，テクノロジー アンド リサーチ 腫瘍の予防および治療のための方法および化合物
KR101104105B1 (ko) * 2007-12-14 2012-01-12 한국생명공학연구원 대장암 진단용 조성물 및 그 용도
ES2791627T3 (es) * 2012-11-12 2020-11-05 Inst Catalana Recerca Estudis Avancats Métodos y kits para el pronóstico del cáncer colorrectal
EP2749289A1 (fr) * 2012-12-26 2014-07-02 Institut National De La Recherche Agronomique (INRA) Peptides anti-inflammatoires

Also Published As

Publication number Publication date
FR3042202A1 (fr) 2017-04-14
WO2017064421A1 (fr) 2017-04-20

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