FR3012953B1 - METHOD AND SYSTEM FOR DETERMINING ENDOPHENOTYPES CHARACTERISTIC OF A DISEASE, SUCH AS SCHIZOPHRENIA - Google Patents

METHOD AND SYSTEM FOR DETERMINING ENDOPHENOTYPES CHARACTERISTIC OF A DISEASE, SUCH AS SCHIZOPHRENIA

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Publication number
FR3012953B1
FR3012953B1 FR1361152A FR1361152A FR3012953B1 FR 3012953 B1 FR3012953 B1 FR 3012953B1 FR 1361152 A FR1361152 A FR 1361152A FR 1361152 A FR1361152 A FR 1361152A FR 3012953 B1 FR3012953 B1 FR 3012953B1
Authority
FR
France
Prior art keywords
parameters
subjects
endophenotypes
schizophrenia
disease
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
FR1361152A
Other languages
French (fr)
Other versions
FR3012953A1 (en
Inventor
Magali Seassau
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Suricog Fr
Institut National de la Sante et de la Recherche Medicale INSERM
Original Assignee
Institut National de la Sante et de la Recherche Medicale INSERM
EYe Brain
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Institut National de la Sante et de la Recherche Medicale INSERM, EYe Brain filed Critical Institut National de la Sante et de la Recherche Medicale INSERM
Priority to FR1361152A priority Critical patent/FR3012953B1/en
Priority to EP14809479.0A priority patent/EP3068282A1/en
Priority to PCT/FR2014/052867 priority patent/WO2015071583A1/en
Publication of FR3012953A1 publication Critical patent/FR3012953A1/en
Application granted granted Critical
Publication of FR3012953B1 publication Critical patent/FR3012953B1/en
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/16—Devices for psychotechnics; Testing reaction times ; Devices for evaluating the psychological state
    • A61B5/163—Devices for psychotechnics; Testing reaction times ; Devices for evaluating the psychological state by tracking eye movement, gaze, or pupil change
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
    • A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
    • A61B3/113—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for determining or recording eye movement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/16—Devices for psychotechnics; Testing reaction times ; Devices for evaluating the psychological state
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/16—Devices for psychotechnics; Testing reaction times ; Devices for evaluating the psychological state
    • A61B5/162—Testing reaction times
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/16—Devices for psychotechnics; Testing reaction times ; Devices for evaluating the psychological state
    • A61B5/165—Evaluating the state of mind, e.g. depression, anxiety

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Surgery (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Medical Informatics (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pathology (AREA)
  • Social Psychology (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Educational Technology (AREA)
  • Developmental Disabilities (AREA)
  • Child & Adolescent Psychology (AREA)
  • Human Computer Interaction (AREA)
  • Ophthalmology & Optometry (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

La présente invention concerne le domaine des biomarqueurs pour des maladies à composante héritable, telle que la schizophrénie. Un procédé selon l'invention comprend les étapes suivantes : soumettre (400) des sujets malades (G1) et des sujets apparentés (G2) à un test visuel (10); pendant ledit test, enregistrer les mouvements des yeux à l'aide d'un dispositif de suivi de mouvements oculaires (15); déterminer (402), dans les enregistrements obtenus (16), une pluralité de paramètres oculomoteurs pour chaque sujet; comparer (404) les paramètres déterminés de chaque sujet à des paramètres respectifs de référence (VS) afin de déterminer des paramètres déficitaires ; et sélectionner (406), en tant qu'endophénotypes, les paramètres déterminés comme déficitaires pour au moins une proportion prédéfinie des sujets malades ou une proportion prédéfinie des sujets apparentés, de sorte à constituer un profil endophénotypique (408) de patient pour ladite maladie.The present invention relates to the field of biomarkers for diseases with a heritable component, such as schizophrenia. A method according to the invention comprises the following steps: subjecting (400) sick subjects (G1) and related subjects (G2) to a visual test (10); during said test, recording eye movements using an eye movement tracker (15); determining (402), in the obtained recordings (16), a plurality of oculomotor parameters for each subject; comparing (404) the determined parameters of each subject to respective reference parameters (VS) in order to determine deficit parameters; and selecting (406), as endophenotypes, those parameters determined to be deficient for at least a predefined proportion of diseased subjects or a predefined proportion of related subjects, so as to constitute an endophenotypic patient profile (408) for said disease.

FR1361152A 2013-11-14 2013-11-14 METHOD AND SYSTEM FOR DETERMINING ENDOPHENOTYPES CHARACTERISTIC OF A DISEASE, SUCH AS SCHIZOPHRENIA Active FR3012953B1 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
FR1361152A FR3012953B1 (en) 2013-11-14 2013-11-14 METHOD AND SYSTEM FOR DETERMINING ENDOPHENOTYPES CHARACTERISTIC OF A DISEASE, SUCH AS SCHIZOPHRENIA
EP14809479.0A EP3068282A1 (en) 2013-11-14 2014-11-10 Method and system for determining endophenotypes characteristic of an illness, such as schizophrenia
PCT/FR2014/052867 WO2015071583A1 (en) 2013-11-14 2014-11-10 Method and system for determining endophenotypes characteristic of an illness, such as schizophrenia

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR1361152A FR3012953B1 (en) 2013-11-14 2013-11-14 METHOD AND SYSTEM FOR DETERMINING ENDOPHENOTYPES CHARACTERISTIC OF A DISEASE, SUCH AS SCHIZOPHRENIA

Publications (2)

Publication Number Publication Date
FR3012953A1 FR3012953A1 (en) 2015-05-15
FR3012953B1 true FR3012953B1 (en) 2015-12-18

Family

ID=50424390

Family Applications (1)

Application Number Title Priority Date Filing Date
FR1361152A Active FR3012953B1 (en) 2013-11-14 2013-11-14 METHOD AND SYSTEM FOR DETERMINING ENDOPHENOTYPES CHARACTERISTIC OF A DISEASE, SUCH AS SCHIZOPHRENIA

Country Status (3)

Country Link
EP (1) EP3068282A1 (en)
FR (1) FR3012953B1 (en)
WO (1) WO2015071583A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR3066097A1 (en) * 2017-05-10 2018-11-16 Universite Claude Bernard Lyon 1 DEVICE AND METHOD FOR NEUROPSYCHOLOGICAL EVALUATION
CN111863256B (en) * 2020-07-20 2024-01-09 中国科学院生物物理研究所 Mental disease detection device based on visual cognitive impairment

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2978910B1 (en) * 2011-08-11 2015-07-17 E Ye Brain METHOD FOR DETECTING AN OCULOMOTORAL ABNORMALITY IN A SUBJECT BY VISUAL SEARCH TEST, AND A SYSTEM FOR ASSISTING SUCH A DETECTION
GB201200122D0 (en) * 2012-01-05 2012-02-15 Univ Aberdeen An apparatus and a method for psychiatric evaluation

Also Published As

Publication number Publication date
FR3012953A1 (en) 2015-05-15
EP3068282A1 (en) 2016-09-21
WO2015071583A1 (en) 2015-05-21

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