FR2986071A1 - METHOD FOR PROGNOSING, IN VITRO, IN A BLOOD SAMPLE, THE PROBABILITY FOR A PATIENT TO EVOLVE TO A SEVERE DENGUE - Google Patents
METHOD FOR PROGNOSING, IN VITRO, IN A BLOOD SAMPLE, THE PROBABILITY FOR A PATIENT TO EVOLVE TO A SEVERE DENGUE Download PDFInfo
- Publication number
- FR2986071A1 FR2986071A1 FR1250646A FR1250646A FR2986071A1 FR 2986071 A1 FR2986071 A1 FR 2986071A1 FR 1250646 A FR1250646 A FR 1250646A FR 1250646 A FR1250646 A FR 1250646A FR 2986071 A1 FR2986071 A1 FR 2986071A1
- Authority
- FR
- France
- Prior art keywords
- severe dengue
- patient
- prognosing
- vitro
- probability
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 208000009714 Severe Dengue Diseases 0.000 title abstract 5
- 239000008280 blood Substances 0.000 title abstract 2
- 210000004369 blood Anatomy 0.000 title abstract 2
- 238000000338 in vitro Methods 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 239000003550 marker Substances 0.000 abstract 2
- 206010037660 Pyrexia Diseases 0.000 abstract 1
- 238000004393 prognosis Methods 0.000 abstract 1
- 230000002250 progressing effect Effects 0.000 abstract 1
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56983—Viruses
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/82—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving vitamins or their receptors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
- G01N2333/08—RNA viruses
- G01N2333/18—Togaviridae; Flaviviridae
- G01N2333/183—Flaviviridae, e.g. pestivirus, mucosal disease virus, bovine viral diarrhoea virus, classical swine fever virus (hog cholera virus) or border disease virus
- G01N2333/185—Flaviviruses or Group B arboviruses, e.g. yellow fever virus, japanese encephalitis, tick-borne encephalitis, dengue
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
- G01N2333/4701—Details
- G01N2333/4728—Details alpha-Glycoproteins
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/50—Determining the risk of developing a disease
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/56—Staging of a disease; Further complications associated with the disease
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Pathology (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Microbiology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
La présente invention a pour objet un procédé pour pronostiquer, in vitro, dans un échantillon sanguin, la probabilité pour un patient d'évoluer vers une dengue sévère, dans lequel : a) on détermine la quantité d'au moins un marqueur et b) on la compare avec une quantité de référence obtenue à partir d'un groupe d'individus qui ont été diagnostiqués comme étant atteints d'une dengue non sévère, et si la quantité déterminée dans l'étape a) est supérieure à la quantité de référence établie dans l'étape b), on pronostique que le patient va évoluer vers une dengue sévère, ainsi que l'utilisation de marqueur (s) de pronostic et un kit de pronostic de l'évolution vers une dengue sévère.The present invention relates to a method for prognosing, in vitro, in a blood sample, the probability of a patient progressing to a severe dengue, wherein: a) the quantity of at least one marker is determined and b) it is compared with a reference amount obtained from a group of individuals who have been diagnosed with non-severe dengue, and if the quantity determined in step a) is greater than the reference amount established in step b), it is predicted that the patient will progress to severe dengue, as well as the use of prognostic marker (s) and a prognosis kit of progression to severe dengue fever.
Priority Applications (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR1250646A FR2986071B1 (en) | 2012-01-24 | 2012-01-24 | METHOD FOR PROGNOSING, IN VITRO, IN A BLOOD SAMPLE, THE PROBABILITY FOR A PATIENT TO EVOLVE TO A SEVERE DENGUE |
PCT/FR2013/050143 WO2013110894A1 (en) | 2012-01-24 | 2013-01-23 | Method for the in vitro prediction of the probability of a patient developing severe dengue, based on a blood sample |
BR112014017952-2A BR112014017952B1 (en) | 2012-01-24 | 2013-01-23 | PROCESS FOR PROOGNIZING IN VITRO IN A BLOOD SAMPLE THE PROBABILITY FOR A PATIENT TO EVOLVE INTO SEVERE DENGUE |
PT137041950T PT2807486T (en) | 2012-01-24 | 2013-01-23 | Method for the in vitro prediction of the probability of a patient developing severe dengue, based on blood sample |
US14/364,456 US9863948B2 (en) | 2012-01-24 | 2013-01-23 | Method for the in vitro prediction of the probability of a patient developing severe dengue, based on a blood sample |
ES13704195.0T ES2627940T3 (en) | 2012-01-24 | 2013-01-23 | Procedure to predict, in vitro, in a blood sample the probability for a patient to evolve into severe dengue |
EP13704195.0A EP2807486B1 (en) | 2012-01-24 | 2013-01-23 | Method for the in vitro prediction of the probability of a patient developing severe dengue, based on blood sample |
US15/852,528 US10823732B2 (en) | 2012-01-24 | 2017-12-22 | Method for the in vitro prediction of the probability of a patient developing severe dengue, based on a blood sample |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR1250646A FR2986071B1 (en) | 2012-01-24 | 2012-01-24 | METHOD FOR PROGNOSING, IN VITRO, IN A BLOOD SAMPLE, THE PROBABILITY FOR A PATIENT TO EVOLVE TO A SEVERE DENGUE |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2986071A1 true FR2986071A1 (en) | 2013-07-26 |
FR2986071B1 FR2986071B1 (en) | 2014-02-28 |
Family
ID=46826603
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR1250646A Active FR2986071B1 (en) | 2012-01-24 | 2012-01-24 | METHOD FOR PROGNOSING, IN VITRO, IN A BLOOD SAMPLE, THE PROBABILITY FOR A PATIENT TO EVOLVE TO A SEVERE DENGUE |
Country Status (7)
Country | Link |
---|---|
US (2) | US9863948B2 (en) |
EP (1) | EP2807486B1 (en) |
BR (1) | BR112014017952B1 (en) |
ES (1) | ES2627940T3 (en) |
FR (1) | FR2986071B1 (en) |
PT (1) | PT2807486T (en) |
WO (1) | WO2013110894A1 (en) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR3017713B1 (en) * | 2014-02-18 | 2018-01-12 | Biomerieux | METHOD AND KIT FOR DETERMINING THE PROBABILITY FOR A PATIENT TO EVOLVE TO A SEVERE DENGUE |
FR3017714A1 (en) | 2014-02-18 | 2015-08-21 | Biomerieux Sa | METHOD AND KIT FOR DETERMINING THE PROBABILITY FOR A PATIENT TO EVOLVE TO A SEVERE DENGUE |
MY168633A (en) * | 2014-06-13 | 2018-11-14 | Univ Malaya | Biomarker for severe dengue |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009145810A2 (en) * | 2008-01-08 | 2009-12-03 | University Of Massachusetts Medical School | St2-based dengue fever diagnostic |
WO2011092219A1 (en) * | 2010-01-26 | 2011-08-04 | University College Dublin, National University Of Ireland | Biomarkers of cardiovascular disease including lrg |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8715654B2 (en) * | 2008-10-02 | 2014-05-06 | Celtaxsys, Inc. | Methods of modulating the negative chemotaxis of immune cells |
BR112012025593A2 (en) * | 2010-04-06 | 2019-06-25 | Caris Life Sciences Luxembourg Holdings | circulating biomarkers for disease |
WO2012178196A2 (en) * | 2011-06-24 | 2012-12-27 | La Jolla Institute For Allergy And Immunology | Protection against dengue virus and prevention of severe dengue disease |
-
2012
- 2012-01-24 FR FR1250646A patent/FR2986071B1/en active Active
-
2013
- 2013-01-23 BR BR112014017952-2A patent/BR112014017952B1/en active IP Right Grant
- 2013-01-23 EP EP13704195.0A patent/EP2807486B1/en active Active
- 2013-01-23 PT PT137041950T patent/PT2807486T/en unknown
- 2013-01-23 US US14/364,456 patent/US9863948B2/en active Active
- 2013-01-23 ES ES13704195.0T patent/ES2627940T3/en active Active
- 2013-01-23 WO PCT/FR2013/050143 patent/WO2013110894A1/en active Application Filing
-
2017
- 2017-12-22 US US15/852,528 patent/US10823732B2/en active Active
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009145810A2 (en) * | 2008-01-08 | 2009-12-03 | University Of Massachusetts Medical School | St2-based dengue fever diagnostic |
WO2011092219A1 (en) * | 2010-01-26 | 2011-08-04 | University College Dublin, National University Of Ireland | Biomarkers of cardiovascular disease including lrg |
Non-Patent Citations (5)
Title |
---|
CHAIYARATANA WATHANEE ET AL: "Serum ferritin levels in children with dengue infection", SOUTHEAST ASIAN JOURNAL OF TROPICAL MEDICINE AND PUBLIC HEALTH, PROJECT OD SEAMEO, BANGKOK, vol. 39, no. 5, 1 September 2008 (2008-09-01), pages 832 - 836, XP009165364, ISSN: 0125-1562 * |
LIDIANE M ALBUQUERQUE ET AL: "Two-Dimensional Difference Gel Electrophoresis (DiGE) Analysis of Plasmas from Dengue Fever Patients", JOURNAL OF PROTEOME RESEARCH, AMERICAN CHEMICAL SOCIETY, WASHINGTON, DC, US, vol. 8, no. 12, 4 December 2009 (2009-12-04), pages 5431 - 5439, XP008146903, ISSN: 1535-3907, [retrieved on 20091021], DOI: 10.1021/PR900236F * |
PAWITAN JEANNE A: "Dengue virus infection: predictors for severe dengue.", ACTA MEDICA INDONESIANA APR 2011, vol. 43, no. 2, April 2011 (2011-04-01), pages 129 - 135, XP002688549, ISSN: 0125-9326 * |
SRIKIATKHACHORN ANON ET AL: "Markers of dengue disease severity.", CURRENT TOPICS IN MICROBIOLOGY AND IMMUNOLOGY 2010, vol. 338, 2010, pages 67 - 82, XP009165400, ISSN: 0070-217X * |
WEIVODA S ET AL: "ELISA for human serum leucine-rich alpha-2-glycoprotein-1 employing cytochrome c as the capturing ligand", JOURNAL OF IMMUNOLOGICAL METHODS, ELSEVIER SCIENCE PUBLISHERS B.V.,AMSTERDAM, NL, vol. 336, no. 1, 20 July 2008 (2008-07-20), pages 22 - 29, XP022682287, ISSN: 0022-1759, [retrieved on 20080404], DOI: 10.1016/J.JIM.2008.03.004 * |
Also Published As
Publication number | Publication date |
---|---|
US10823732B2 (en) | 2020-11-03 |
US20150126386A1 (en) | 2015-05-07 |
BR112014017952A8 (en) | 2017-07-11 |
US20180120316A1 (en) | 2018-05-03 |
FR2986071B1 (en) | 2014-02-28 |
BR112014017952B1 (en) | 2022-05-24 |
WO2013110894A1 (en) | 2013-08-01 |
EP2807486A1 (en) | 2014-12-03 |
EP2807486B1 (en) | 2017-03-15 |
US9863948B2 (en) | 2018-01-09 |
BR112014017952A2 (en) | 2017-06-20 |
PT2807486T (en) | 2017-06-22 |
ES2627940T3 (en) | 2017-08-01 |
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