FR2969613B1 - NOVEL 1,2,3,4-TETRAHYDRO-PYRIMIDO {1,2-A} PYRIMIDIN-6-ONE DERIVATIVES, THEIR PREPARATION AND THEIR PHARMACEUTICAL USE - Google Patents

NOVEL 1,2,3,4-TETRAHYDRO-PYRIMIDO {1,2-A} PYRIMIDIN-6-ONE DERIVATIVES, THEIR PREPARATION AND THEIR PHARMACEUTICAL USE

Info

Publication number
FR2969613B1
FR2969613B1 FR1061197A FR1061197A FR2969613B1 FR 2969613 B1 FR2969613 B1 FR 2969613B1 FR 1061197 A FR1061197 A FR 1061197A FR 1061197 A FR1061197 A FR 1061197A FR 2969613 B1 FR2969613 B1 FR 2969613B1
Authority
FR
France
Prior art keywords
pyrimido
pyrimidin
tetrahydro
derivatives
novel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR1061197A
Other languages
French (fr)
Other versions
FR2969613A1 (en
Inventor
Jerome Arigon
Maurice Brollo
Romain Combet
Florence Durand
Ahmad Youssef El
Jean Robert Labrosse
Jean Philippe Letallec
Baptiste Ronan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Sanofi Aventis France
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR1061197A priority Critical patent/FR2969613B1/en
Application filed by Sanofi Aventis France filed Critical Sanofi Aventis France
Priority to PL11799724T priority patent/PL2655375T3/en
Priority to US13/996,866 priority patent/US8815853B2/en
Priority to SI201130400T priority patent/SI2655375T1/en
Priority to DK11799724.7T priority patent/DK2655375T3/en
Priority to HUE11799724A priority patent/HUE024504T2/en
Priority to PT11799724T priority patent/PT2655375E/en
Priority to PCT/EP2011/073874 priority patent/WO2012085244A1/en
Priority to ES11799724.7T priority patent/ES2531465T3/en
Priority to EP11799724.7A priority patent/EP2655375B1/en
Publication of FR2969613A1 publication Critical patent/FR2969613A1/en
Application granted granted Critical
Publication of FR2969613B1 publication Critical patent/FR2969613B1/en
Priority to HRP20150235TT priority patent/HRP20150235T1/en
Priority to CY20151100220T priority patent/CY1116100T1/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FR1061197A 2010-12-23 2010-12-23 NOVEL 1,2,3,4-TETRAHYDRO-PYRIMIDO {1,2-A} PYRIMIDIN-6-ONE DERIVATIVES, THEIR PREPARATION AND THEIR PHARMACEUTICAL USE Expired - Fee Related FR2969613B1 (en)

Priority Applications (12)

Application Number Priority Date Filing Date Title
FR1061197A FR2969613B1 (en) 2010-12-23 2010-12-23 NOVEL 1,2,3,4-TETRAHYDRO-PYRIMIDO {1,2-A} PYRIMIDIN-6-ONE DERIVATIVES, THEIR PREPARATION AND THEIR PHARMACEUTICAL USE
ES11799724.7T ES2531465T3 (en) 2010-12-23 2011-12-22 Pyrimidinone derivatives, their preparation and pharmaceutical use
SI201130400T SI2655375T1 (en) 2010-12-23 2011-12-22 Pyrimidinone derivatives, preparation thereof and pharmaceutical use thereof
DK11799724.7T DK2655375T3 (en) 2010-12-23 2011-12-22 PYRIMIDINON DERIVATIVES, PREPARATION AND PHARMACEUTICAL USE THEREOF
HUE11799724A HUE024504T2 (en) 2010-12-23 2011-12-22 Pyrimidinone derivatives, preparation thereof and pharmaceutical use thereof
PT11799724T PT2655375E (en) 2010-12-23 2011-12-22 Pyrimidinone derivatives, preparation thereof and pharmaceutical use thereof
PL11799724T PL2655375T3 (en) 2010-12-23 2011-12-22 Pyrimidinone derivatives, preparation thereof and pharmaceutical use thereof
US13/996,866 US8815853B2 (en) 2010-12-23 2011-12-22 Pyrimidinone derivatives, preparation thereof and pharmaceutical use thereof
EP11799724.7A EP2655375B1 (en) 2010-12-23 2011-12-22 Pyrimidinone derivatives, preparation thereof and pharmaceutical use thereof
PCT/EP2011/073874 WO2012085244A1 (en) 2010-12-23 2011-12-22 Pyrimidinone derivatives, preparation thereof and pharmaceutical use thereof
HRP20150235TT HRP20150235T1 (en) 2010-12-23 2015-03-02 Pyrimidinone derivatives, preparation thereof and pharmaceutical use thereof
CY20151100220T CY1116100T1 (en) 2010-12-23 2015-03-03 PYRIMIDINONE PRODUCTS, THEIR PREPARATION AND THE PHARMACEUTICAL USE

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR1061197A FR2969613B1 (en) 2010-12-23 2010-12-23 NOVEL 1,2,3,4-TETRAHYDRO-PYRIMIDO {1,2-A} PYRIMIDIN-6-ONE DERIVATIVES, THEIR PREPARATION AND THEIR PHARMACEUTICAL USE

Publications (2)

Publication Number Publication Date
FR2969613A1 FR2969613A1 (en) 2012-06-29
FR2969613B1 true FR2969613B1 (en) 2013-02-08

Family

ID=44174648

Family Applications (1)

Application Number Title Priority Date Filing Date
FR1061197A Expired - Fee Related FR2969613B1 (en) 2010-12-23 2010-12-23 NOVEL 1,2,3,4-TETRAHYDRO-PYRIMIDO {1,2-A} PYRIMIDIN-6-ONE DERIVATIVES, THEIR PREPARATION AND THEIR PHARMACEUTICAL USE

Country Status (1)

Country Link
FR (1) FR2969613B1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201321127D0 (en) * 2013-11-29 2014-01-15 Velgene Biotechnology Compound with Anti-cancer properties

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ520300A (en) * 2000-01-24 2004-05-28 Kinacia Pty Ltd Morpholino-substituted pyridopyrimidine, quinolone and benzopyranone derivatives that inhibit the enzyme phosphoinositide (PI) 3-kinase
US7598377B2 (en) * 2002-08-16 2009-10-06 Astrazeneca Ab Inhibition of phosphoinositide 3-kinase β
WO2008148074A2 (en) * 2007-05-24 2008-12-04 Research Foundation Of State University Of New York Inhibitors of mtor and methods of treatment using same
AU2009206804A1 (en) * 2008-01-25 2009-07-30 Astrazeneca Ab Enantiomerically pure (-) 2-[1-(7-methyl-2-(morpholin-4-yl)-4-oxo-4H-pyrido[1,2-a]pyrimidin-9-yl)ethylamino]benzoic acid, its use in medical therapy, and a pharmaceutical composition comprising it - 026
AU2010267815B2 (en) * 2009-07-02 2015-07-16 Sanofi Novel 1,2,3,4-tetrahydro-pyrimido(1,2-a)pyrimidin-6-one derivatives, preparation thereof, and pharmaceutical use thereof

Also Published As

Publication number Publication date
FR2969613A1 (en) 2012-06-29

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