FR2967673B1 - SYNTHESIS OF N-HETEROCYCLES BY REDUCTIVE ALKYLATION OF CYAN DERIVATIVES - Google Patents

SYNTHESIS OF N-HETEROCYCLES BY REDUCTIVE ALKYLATION OF CYAN DERIVATIVES

Info

Publication number
FR2967673B1
FR2967673B1 FR1059672A FR1059672A FR2967673B1 FR 2967673 B1 FR2967673 B1 FR 2967673B1 FR 1059672 A FR1059672 A FR 1059672A FR 1059672 A FR1059672 A FR 1059672A FR 2967673 B1 FR2967673 B1 FR 2967673B1
Authority
FR
France
Prior art keywords
heterocycles
synthesis
reductive alkylation
cyan
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR1059672A
Other languages
French (fr)
Other versions
FR2967673A1 (en
Inventor
Stephane Laval
Wissam Jean Dayoub
Marc Lemaire
Dominique Delbrayelle
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universite Claude Bernard Lyon 1 UCBL
Minakem SAS
Original Assignee
Universite Claude Bernard Lyon 1 UCBL
Minakem SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universite Claude Bernard Lyon 1 UCBL, Minakem SAS filed Critical Universite Claude Bernard Lyon 1 UCBL
Priority to FR1059672A priority Critical patent/FR2967673B1/en
Priority to PCT/EP2011/070893 priority patent/WO2012069566A1/en
Priority to EP11793713.6A priority patent/EP2643309A1/en
Publication of FR2967673A1 publication Critical patent/FR2967673A1/en
Application granted granted Critical
Publication of FR2967673B1 publication Critical patent/FR2967673B1/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
    • C07D295/023—Preparation; Separation; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/02—Preparation by ring-closure or hydrogenation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
    • C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
FR1059672A 2010-11-24 2010-11-24 SYNTHESIS OF N-HETEROCYCLES BY REDUCTIVE ALKYLATION OF CYAN DERIVATIVES Expired - Fee Related FR2967673B1 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
FR1059672A FR2967673B1 (en) 2010-11-24 2010-11-24 SYNTHESIS OF N-HETEROCYCLES BY REDUCTIVE ALKYLATION OF CYAN DERIVATIVES
PCT/EP2011/070893 WO2012069566A1 (en) 2010-11-24 2011-11-24 Synthesis of n-heterocycles by reductive alkylation of cyan derivatives
EP11793713.6A EP2643309A1 (en) 2010-11-24 2011-11-24 Synthesis of n-heterocycles by reductive alkylation of cyan derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR1059672A FR2967673B1 (en) 2010-11-24 2010-11-24 SYNTHESIS OF N-HETEROCYCLES BY REDUCTIVE ALKYLATION OF CYAN DERIVATIVES

Publications (2)

Publication Number Publication Date
FR2967673A1 FR2967673A1 (en) 2012-05-25
FR2967673B1 true FR2967673B1 (en) 2012-12-28

Family

ID=43856140

Family Applications (1)

Application Number Title Priority Date Filing Date
FR1059672A Expired - Fee Related FR2967673B1 (en) 2010-11-24 2010-11-24 SYNTHESIS OF N-HETEROCYCLES BY REDUCTIVE ALKYLATION OF CYAN DERIVATIVES

Country Status (3)

Country Link
EP (1) EP2643309A1 (en)
FR (1) FR2967673B1 (en)
WO (1) WO2012069566A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103641769B (en) * 2013-12-06 2015-11-04 爱斯特（成都）生物制药有限公司 The preparation method of isoindoline hydrochloride
CN107365257B (en) * 2017-08-02 2019-04-02 厦门大学 A kind of 2- methyl cellosolve acetate glutaronitrile adds the method that hydrogen prepares 2 methyl pentamethylenediamine and 3- methyl piperidine

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2790804A (en) * 1955-06-04 1957-04-30 Ici Ltd Catalytic hydrogenation
FR2805535B1 (en) * 2000-02-25 2002-04-12 Adir NEW PROCESS FOR THE PREPARATION OF ISOINDOLINE
EP1717234A1 (en) * 2005-04-29 2006-11-02 Bioprojet Phenoxypropylpiperidines and -pyrrolidines and their use as histamine H3-receptor ligands
WO2007137738A1 (en) 2006-06-01 2007-12-06 Sanofi-Aventis Spirocyclic nitriles as protease inhibitors
US20080287479A1 (en) 2006-12-20 2008-11-20 Pfizer Inc Inhibitors of serine palmitoyltransferase

Also Published As

Publication number Publication date
FR2967673A1 (en) 2012-05-25
WO2012069566A1 (en) 2012-05-31
EP2643309A1 (en) 2013-10-02

Similar Documents

Publication Publication Date Title
FR17C1040I2 (en) ANTIVIRAL DERIVATIVE OF 2,5-DIBENZIMIDAZOL-5-YL-1-PHENYL-PYRROLIDINE
FR2957079B1 (en) PROCESS FOR THE SYNTHESIS OF CETOBENZOFURAN DERIVATIVES
IL252345B (en) Intermediate compounds for synthesis of antiviral compounds
IL262055B (en) Synthesis of lactams
SMT201600198B (en) DERIVATIVES OF 1,2,4-TRIAZINE-4-AMINE
BR112012006686A2 (en) substituted amide compound
BR112014003878A2 (en) synthesis of r-biphenylalaninol
BR112013023064A2 (en) synthesis process of ketobenzofuran derivatives
IT1401129B1 (en) PROCESS FOR THE SYNTHESIS OF BENZOTIADIAZOLIC COMPOUNDS
FR2958289B1 (en) PROCESS FOR THE PREPARATION OF 3-KETO-BENZOFURAN DERIVATIVES
FR2963006B1 (en) PROCESS FOR THE PREPARATION OF NITRO-BENZOFURAN DERIVATIVES
FR2958290B1 (en) PROCESS FOR THE PREPARATION OF SULFONAMIDO-BENZOFURAN DERIVATIVES
BRPI1007404A2 (en) method for synthesis of (1s, 2r) -milnacipran
CO6811866A2 (en) Substituted benzamide derivatives
FR3001964B1 (en) SYNTHESIS OF UNATURATED COMPACT BRANCHED BY CROSS METATHESIS
IT1393112B1 (en) PROCEDURE FOR THE PREPARATION OF PROSTAGLANDINE DERIVATIVES
EA201101675A1 (en) SPYROEPOXIDES AS INTERMEDIATE PRODUCTS OF SYNTHESIS
ZA201503913B (en) Synthesis of zsm-5
ECSP13012914A (en) SYNTHESIS OF DERIVATIVES OF 2-CARBOXAMIDA-CICLOAMINO-UREA
DK2606042T3 (en) DISUBSTITUTED TETRAHYDROFURANIAL COMPOUNDS AS ANTAGONISTS OF BRADYKININ-B1 RECEPTOR
EP2618662A4 (en) Synthesis of substituted salicylaldehyde derivatives
FR2961209B1 (en) PROCESS FOR THE SYNTHESIS OF FERROQUIN BY CONVERGENT REDUCING AMINATION
SMT201500035B (en) Synthesis of aliskiren
EP2726458A4 (en) Synthesis of cleistanthin a an derivatives thereof
EP2948437A4 (en) Novel approach for synthesis of catechins

Legal Events

Date Code Title Description
PLFP Fee payment

Year of fee payment: 6

PLFP Fee payment

Year of fee payment: 7

PLFP Fee payment

Year of fee payment: 8

PLFP Fee payment

Year of fee payment: 9

PLFP Fee payment

Year of fee payment: 10

PLFP Fee payment

Year of fee payment: 11

ST Notification of lapse

Effective date: 20220705