FR2947550B1 - NOVEL 2,3-DIHYDRO-1H-IMIDAZO {1,2-A} PYRIMIDIN-5-ONE DERIVATIVES, THEIR PREPARATION AND THEIR PHARMACEUTICAL USE AS AKT PHOSPHORYLATION INHIBITORS (PKB) - Google Patents

NOVEL 2,3-DIHYDRO-1H-IMIDAZO {1,2-A} PYRIMIDIN-5-ONE DERIVATIVES, THEIR PREPARATION AND THEIR PHARMACEUTICAL USE AS AKT PHOSPHORYLATION INHIBITORS (PKB)

Info

Publication number
FR2947550B1
FR2947550B1 FR0903236A FR0903236A FR2947550B1 FR 2947550 B1 FR2947550 B1 FR 2947550B1 FR 0903236 A FR0903236 A FR 0903236A FR 0903236 A FR0903236 A FR 0903236A FR 2947550 B1 FR2947550 B1 FR 2947550B1
Authority
FR
France
Prior art keywords
pkb
imidazo
pyrimidin
dihydro
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0903236A
Other languages
French (fr)
Other versions
FR2947550A1 (en
Inventor
Maurice Brollo
Ahmad Youssef El
Romme Bruno Filoche
Frank Halley
Andreas Karlsson
Laurent Schio
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Sanofi Aventis France
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR0903236A priority Critical patent/FR2947550B1/en
Application filed by Sanofi Aventis France filed Critical Sanofi Aventis France
Priority to LTEP10742012.7T priority patent/LT2448939T/en
Priority to PCT/FR2010/051373 priority patent/WO2011001112A1/en
Priority to AU2010267814A priority patent/AU2010267814B2/en
Priority to MX2012000097A priority patent/MX2012000097A/en
Priority to SG10201403138WA priority patent/SG10201403138WA/en
Priority to DK10742012.7T priority patent/DK2448939T3/en
Priority to CN201080039104.3A priority patent/CN102482285B/en
Priority to EP10742012.7A priority patent/EP2448939B1/en
Priority to CA2767051A priority patent/CA2767051C/en
Priority to BRPI1015949A priority patent/BRPI1015949A2/en
Priority to JP2012518118A priority patent/JP5663571B2/en
Priority to ARP100102346A priority patent/AR077446A1/en
Priority to PL10742012T priority patent/PL2448939T3/en
Priority to US13/381,571 priority patent/US8828997B2/en
Priority to RU2012103460/04A priority patent/RU2554868C2/en
Priority to PT107420127T priority patent/PT2448939T/en
Priority to SI201031451A priority patent/SI2448939T1/en
Priority to SG2011097227A priority patent/SG177421A1/en
Priority to ES10742012.7T priority patent/ES2627428T3/en
Priority to HUE10742012A priority patent/HUE034503T2/en
Priority to KR1020127002797A priority patent/KR101745028B1/en
Priority to UY0001032753A priority patent/UY32753A/en
Priority to TW099121898A priority patent/TWI458730B/en
Publication of FR2947550A1 publication Critical patent/FR2947550A1/en
Priority to IL217294A priority patent/IL217294A/en
Publication of FR2947550B1 publication Critical patent/FR2947550B1/en
Application granted granted Critical
Priority to HRP20170827TT priority patent/HRP20170827T1/en
Priority to CY20171100567T priority patent/CY1119442T1/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
FR0903236A 2009-07-02 2009-07-02 NOVEL 2,3-DIHYDRO-1H-IMIDAZO {1,2-A} PYRIMIDIN-5-ONE DERIVATIVES, THEIR PREPARATION AND THEIR PHARMACEUTICAL USE AS AKT PHOSPHORYLATION INHIBITORS (PKB) Expired - Fee Related FR2947550B1 (en)

Priority Applications (27)

Application Number Priority Date Filing Date Title
FR0903236A FR2947550B1 (en) 2009-07-02 2009-07-02 NOVEL 2,3-DIHYDRO-1H-IMIDAZO {1,2-A} PYRIMIDIN-5-ONE DERIVATIVES, THEIR PREPARATION AND THEIR PHARMACEUTICAL USE AS AKT PHOSPHORYLATION INHIBITORS (PKB)
SI201031451A SI2448939T1 (en) 2009-07-02 2010-07-01 2,3-dihydro-1h-imidazo (1,2-a) pyrimidin-5-one derivatives, the preparation and pharmaceutical use thereof
RU2012103460/04A RU2554868C2 (en) 2009-07-02 2010-07-01 NOVEL DERIVATIVES OF 2,3-DIHYDRO-1H-IMIDAZO[1,2-a]PYRIMIDIN-5-ONE, METHOD OF OBTAINING THEREOF AND APPLICATION IN PHARMACY
MX2012000097A MX2012000097A (en) 2009-07-02 2010-07-01 Novel 2,3-dihydro-1h-imidazo(1,2-a)pyrimidin-5-one derivatives, preparation thereof, and pharmaceutical use thereof.
SG10201403138WA SG10201403138WA (en) 2009-07-02 2010-07-01 Novel 2,3-dihydro-1h-imidazo(1,2-a)pyrimidin-5-one derivatives, preparation thereof and pharmaceutical use thereof
DK10742012.7T DK2448939T3 (en) 2009-07-02 2010-07-01 DERIVATIVES OF 2,3-DIHYDRO-1H-IMIDAZO {1,2-A} PYRIMIDIN-5-ON, PREPARATION AND PHARMACEUTICAL USE thereof
CN201080039104.3A CN102482285B (en) 2009-07-02 2010-07-01 Novel 2,3-dihydro-1h-imidazo(1,2-a)pyrimidin-5-one derivatives, preparation thereof, and pharmaceutical use thereof
EP10742012.7A EP2448939B1 (en) 2009-07-02 2010-07-01 2,3-dihydro-1h-imidazo {1,2-a} pyrimidin-5-one derivatives, the preparation and pharmaceutical use thereof
CA2767051A CA2767051C (en) 2009-07-02 2010-07-01 Novel 2,3-dihydro-1h-imidazo(1,2-a)pyrimidin-5-one derivatives, preparation thereof, and pharmaceutical use thereof
BRPI1015949A BRPI1015949A2 (en) 2009-07-02 2010-07-01 2,3-dihydro-1h-imidazo [1,2-a] pyrimidin-5-one derivatives, their preparation and their pharmaceutical use
JP2012518118A JP5663571B2 (en) 2009-07-02 2010-07-01 Novel 2,3-dihydro-1H-imidazo {1,2-a} pyrimidin-5-one derivatives, their preparation and their pharmaceutical use
PCT/FR2010/051373 WO2011001112A1 (en) 2009-07-02 2010-07-01 Novel 2,3-dihydro-1h-imidazo(1,2-a)pyrimidin-5-one derivatives, preparation thereof, and pharmaceutical use thereof
PL10742012T PL2448939T3 (en) 2009-07-02 2010-07-01 2,3-dihydro-1h-imidazo {1,2-a} pyrimidin-5-one derivatives, the preparation and pharmaceutical use thereof
US13/381,571 US8828997B2 (en) 2009-07-02 2010-07-01 2,3-dihydro-1H-imidazo(1,2-a)pyrimidin-5-one derivatives, preparation thereof, and pharmaceutical use thereof
LTEP10742012.7T LT2448939T (en) 2009-07-02 2010-07-01 2,3-dihydro-1h-imidazo {1,2-a} pyrimidin-5-one derivatives, the preparation and pharmaceutical use thereof
AU2010267814A AU2010267814B2 (en) 2009-07-02 2010-07-01 Novel 2,3-dihydro-1H-imidazo(1,2-a)pyrimidin-5-one derivatives, preparation thereof, and pharmaceutical use thereof
PT107420127T PT2448939T (en) 2009-07-02 2010-07-01 2,3-dihydro-1h-imidazo {1,2-a} pyrimidin-5-one derivatives, the preparation and pharmaceutical use thereof
SG2011097227A SG177421A1 (en) 2009-07-02 2010-07-01 Novel 2,3-dihydro-1h-imidazo(1,2-a)pyrimidin-5-one derivatives, preparation thereof, and pharmaceutical use thereof
ES10742012.7T ES2627428T3 (en) 2009-07-02 2010-07-01 New 2,3-dihydro-1H-imidazo {1,2-a} pyrimidin-5-one derivatives, their preparation and pharmaceutical use
HUE10742012A HUE034503T2 (en) 2009-07-02 2010-07-01 2,3-dihydro-1h-imidazo {1,2-a} pyrimidin-5-one derivatives, the preparation and pharmaceutical use thereof
KR1020127002797A KR101745028B1 (en) 2009-07-02 2010-07-01 Novel 2,3-dihydro-1h-imidazo(1,2-a)pyrimidin-5-one derivatives, preparation thereof, and pharmaceutical use thereof
ARP100102346A AR077446A1 (en) 2009-07-02 2010-07-01 DERIVATIVES OF 2,3-DIHIDRO-1H-IMIDAZO (1,2-A) PIRIMIDIN-5-ONA. YOUR PREPARATION AND YOUR PHARMACEUTICAL USE
UY0001032753A UY32753A (en) 2009-07-02 2010-07-02 NEW DERIVATIVES OF 2,3-DIHIDRO-1H-IMIDAZO {1,2-a} PIRIMIDIN-5-ONA, ITS PREPARATION AND ITS USE IN PHARMACEUTICAL
TW099121898A TWI458730B (en) 2009-07-02 2010-07-02 Novel 2,3-dihydro-1h-imidazo{1,2-a}pyrimidin-5-one derivatives, preparation thereof and pharmaceutical use thereof
IL217294A IL217294A (en) 2009-07-02 2011-12-29 2,3- dihydro-1h-imidazo (1,2-a)pyrimidin-5-one derivatives, process for their preparation, pharmaceutical compositions comprising them and use thereof for the preparation of medicaments
HRP20170827TT HRP20170827T1 (en) 2009-07-02 2017-05-30 2,3-dihydro-1h-imidazo {1,2-a} pyrimidin-5-one derivatives, the preparation and pharmaceutical use thereof
CY20171100567T CY1119442T1 (en) 2009-07-02 2017-05-31 2,3-Dihydro-1H-imidazo {1,2-A} PYRIMIDIN-5-ONE PRODUCTION, PREPARATION OF THESE AND PHARMACEUTICAL USE

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0903236A FR2947550B1 (en) 2009-07-02 2009-07-02 NOVEL 2,3-DIHYDRO-1H-IMIDAZO {1,2-A} PYRIMIDIN-5-ONE DERIVATIVES, THEIR PREPARATION AND THEIR PHARMACEUTICAL USE AS AKT PHOSPHORYLATION INHIBITORS (PKB)

Publications (2)

Publication Number Publication Date
FR2947550A1 FR2947550A1 (en) 2011-01-07
FR2947550B1 true FR2947550B1 (en) 2012-05-18

Family

ID=41820323

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0903236A Expired - Fee Related FR2947550B1 (en) 2009-07-02 2009-07-02 NOVEL 2,3-DIHYDRO-1H-IMIDAZO {1,2-A} PYRIMIDIN-5-ONE DERIVATIVES, THEIR PREPARATION AND THEIR PHARMACEUTICAL USE AS AKT PHOSPHORYLATION INHIBITORS (PKB)

Country Status (1)

Country Link
FR (1) FR2947550B1 (en)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100339379C (en) * 2000-09-01 2007-09-26 圣诺菲-合成实验室公司 2-pyridinyl-6,7,8,9-tetrahydropyrimido{1,2-a}pyrimidin-4-one and 7-pyridinyl-1,3-dihydoimidazo{1,2-a}pyrimidin-5(1h)one derivatives
CA2457965C (en) * 2001-09-21 2010-06-01 Sanofi-Synthelabo Substituted 2-pyridinyl-6,7,8,9-tetrahydropyrimido[1,2-a]pyrimidin-4-one and 7-pyridinyl-2,3-dihydroimidazo[1,2-a]pyrimidin-5(1h)one derivatives
EP1480983B1 (en) * 2002-02-28 2005-11-09 Sanofi-Aventis Heteroaryl substituted 2-pyridinyl and 2-pyrimidinyl-6,7,8,9-tetrahydropydimido[1,2-a]pyrimidin-4-one derivatives
AR053358A1 (en) * 2005-04-15 2007-05-02 Cancer Rec Tech Ltd DNA INHIBITORS - PK
WO2008148074A2 (en) * 2007-05-24 2008-12-04 Research Foundation Of State University Of New York Inhibitors of mtor and methods of treatment using same

Also Published As

Publication number Publication date
FR2947550A1 (en) 2011-01-07

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