FR2947547B1 - NOVEL (6-OXO-1,6-DIHYDRO-PYRIMIDIN-2-YL) -AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR PHARMACEUTICAL USE AS AKT PHOSPHORYLATION INHIBITORS (PKB) - Google Patents
NOVEL (6-OXO-1,6-DIHYDRO-PYRIMIDIN-2-YL) -AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR PHARMACEUTICAL USE AS AKT PHOSPHORYLATION INHIBITORS (PKB)Info
- Publication number
- FR2947547B1 FR2947547B1 FR0903239A FR0903239A FR2947547B1 FR 2947547 B1 FR2947547 B1 FR 2947547B1 FR 0903239 A FR0903239 A FR 0903239A FR 0903239 A FR0903239 A FR 0903239A FR 2947547 B1 FR2947547 B1 FR 2947547B1
- Authority
- FR
- France
- Prior art keywords
- pkb
- pyrimidin
- dihydro
- oxo
- novel
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (46)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0903239A FR2947547B1 (en) | 2009-07-02 | 2009-07-02 | NOVEL (6-OXO-1,6-DIHYDRO-PYRIMIDIN-2-YL) -AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR PHARMACEUTICAL USE AS AKT PHOSPHORYLATION INHIBITORS (PKB) |
CA2767064A CA2767064C (en) | 2009-07-02 | 2010-07-01 | Novel (6-oxo-1, 6-dihydro-pyrimidin-2-yl)-amide derivatives, preparation thereof, and pharmaceutical use thereof as akt(pkb) phosphorylation inhibitors |
EA201270111A EA021088B1 (en) | 2009-07-02 | 2010-07-01 | (6-oxo-1, 6-dihydropyrimidin-2-yl)amide derivatives, preparation thereof, and pharmaceutical use thereof as akt(pkb) phosphorylation inhibitors |
NZ597579A NZ597579A (en) | 2009-07-02 | 2010-07-01 | Novel (6-oxo-1, 6-dihydro-pyrimidin-2-yl)-amide derivatives, preparation thereof, and pharmaceutical use thereof as akt(pkb) phosphorylation inhibitors |
PL10742014T PL2448927T3 (en) | 2009-07-02 | 2010-07-01 | Novel (6-oxo-1, 6-dihydro-pyrimidin-2-yl)-amide derivatives, preparation thereof, and pharmaceutical use thereof as akt phosphorylation inhibitors |
PT107420143T PT2448927E (en) | 2009-07-02 | 2010-07-01 | Novel (6-oxo-1, 6-dihydro-pyrimidin-2-yl)-amide derivatives, preparation thereof, and pharmaceutical use thereof as akt phosphorylation inhibitors |
PE2012000004A PE20120640A1 (en) | 2009-07-02 | 2010-07-01 | NEW DERIVATIVES OF (6-OXO-1,6-DIHIDRO-PIRIMIDIN-2-IL) -AMIDE, ITS PREPARATION AND ITS PHARMACEUTICAL USE AS PHOSPHORILATION INHIBITORS OF AKT (PKB) |
JP2012518120A JP5680638B2 (en) | 2009-07-02 | 2010-07-01 | Novel (6-oxo-1,6-dihydropyrimidin-2-yl) amide derivatives, their preparation and their pharmaceutical use as AKT (PKB) phosphorylation inhibitors |
KR1020127002839A KR20120106714A (en) | 2009-07-02 | 2010-07-01 | Novel (6-oxo-1,6-dihydro-pyrimidin-2-yl)amide derivatives, preparation thereof, and pharmaceutical use thereof as akt(pkb) phosphorylation inhibitors |
EP10742014.3A EP2448927B1 (en) | 2009-07-02 | 2010-07-01 | Novel (6-oxo-1, 6-dihydro-pyrimidin-2-yl)-amide derivatives, preparation thereof, and pharmaceutical use thereof as akt phosphorylation inhibitors |
PCT/FR2010/051375 WO2011001114A1 (en) | 2009-07-02 | 2010-07-01 | Novel (6-oxo-1, 6-dihydro-pyrimidin-2-yl)-amide derivatives, preparation thereof, and pharmaceutical use thereof as akt(pkb) phosphorylation inhibitors |
MYPI2011006377 MY153042A (en) | 2009-07-02 | 2010-07-01 | Novel (6-oxo-1, 6-dihydro-pyrimidin-2-yl)-amide derivatives, preparation thereof, and pharmaceutical use thereof as akt(pkb) phosphorylation inhibitors |
ARP100102350A AR077364A1 (en) | 2009-07-02 | 2010-07-01 | DERIVATIVES OF 6-OXO-1,6- DIHIDRO -PIRIMIDIN-2-IL-) AMIDA, ITS PREPARATION AND ITS PHARMACEUTICAL USE AS AKT PHOSPHORILATION INHIBITORS (PKB) |
MA34593A MA33501B1 (en) | 2009-07-02 | 2010-07-01 | New derivatives (6-oxo-1,6-dihydro-pyridine-2 -yl) - amide, their preparation and pharmaceutical use as akt phosphorylation inhibitors (pkb) |
DK10742014.3T DK2448927T3 (en) | 2009-07-02 | 2010-07-01 | HIS UNKNOWN (6-OXO-1,6-DIHYDRO-PYRIMIDIN-2-YL) -AMIDE DERIVATIVES, PREPARING THEREOF AND PHARMACEUTICAL USE THEREOF AS ACTIVE PHOSPHOROUSATION INHIBITORS |
SI201030607T SI2448927T1 (en) | 2009-07-02 | 2010-07-01 | Novel (6-oxo-1, 6-dihydro-pyrimidin-2-yl)-amide derivatives, preparation thereof, and pharmaceutical use thereof as akt phosphorylation inhibitors |
SG10201402867TA SG10201402867TA (en) | 2009-07-02 | 2010-07-01 | Novel (6-oxo-1, 6-dihydro-pyrimidin-2-yl)-amide derivatives, preparation thereof, and pharmaceutical use thereof as akt(pkb) phosphorylation inhibitors |
RS20140306A RS53317B (en) | 2009-07-02 | 2010-07-01 | Novel (6-oxo-1,6-dihydro-pyrimidin-2-yl)amide derivatives, prepration thereof, and pharmaceutical use thereof as akt phosphorylation inhibitors |
BRPI1015913-4A BRPI1015913A2 (en) | 2009-07-02 | 2010-07-01 | (6-oxo-1,6-dihydro-pyrimidin-2-yl) -amide derivatives, their preparation and their pharmaceutical use as inhibitors of akt phosphorylation (pkb) |
AU2010267816A AU2010267816B2 (en) | 2009-07-02 | 2010-07-01 | Novel (6-oxo-1, 6-dihydro-pyrimidin-2-yl)-amide derivatives, preparation thereof, and pharmaceutical use thereof as AKT(PKB) phosphorylation inhibitors |
SG2011097938A SG177469A1 (en) | 2009-07-02 | 2010-07-01 | Novel (6-oxo-1, 6-dihydro-pyrimidin-2-yl)-amide derivatives, preparation thereof, and pharmaceutical use thereof as akt(pkb) phosphorylation inhibitors |
UAA201201036A UA107357C2 (en) | 2009-07-02 | 2010-07-01 | (6-oxo-1,6-dihydropyrimidine-2-il)amide derivatives, their preparation and their pharmaceutical use as inhibitors of phosphorylation akt (pkb) |
MEP-2014-62A ME01885B (en) | 2009-07-02 | 2010-07-01 | Novel (6-oxo-1, 6-dihydro-pyrimidin-2-yl)-amide derivatives, preparation thereof, and pharmaceutical use thereof as akt phosphorylation inhibitors |
MX2012000094A MX2012000094A (en) | 2009-07-02 | 2010-07-01 | Novel (6-oxo-1, 6-dihydro-pyrimidin-2-yl)-amide derivatives, preparation thereof, and pharmaceutical use thereof as akt(pkb) phosphorylation inhibitors. |
ES10742014.3T ES2464125T3 (en) | 2009-07-02 | 2010-07-01 | New derivatives of (6-oxo-1,6-dihydro-pyrimidin-2-yl) -amide, its preparation and its pharmaceutical use as phosphorylation inhibitors of AKT |
CN201080039214.XA CN102548970B (en) | 2009-07-02 | 2010-07-01 | Novel (6-oxo-1,6-dihydro-pyrimidin-2-base) amide derivatives, its preparation method and its medicinal use as AKT (PKB) phosphorylation inhibitor |
TW99121906A TWI466883B (en) | 2009-07-02 | 2010-07-02 | Novel(6-oxo-1,6-dihydropyrimidin-2-yl)amide derivatives, preparation thereof and pharmaceutical use thereof as inhibitors of akt (pkb) phosphorylation |
UY0001032755A UY32755A (en) | 2009-07-02 | 2010-07-02 | NEW DERIVATIVES OF (6-OXO-1,6-DIHIDRO-PIRIMIDIN-2-IL) -AMIDA, ITS PREPARATION AND ITS PHARMACEUTICAL USE AS AKT PHOSPHORILATION INHIBITORS (PKB). |
CR20110703A CR20110703A (en) | 2009-07-02 | 2011-12-21 | NEW DERIVATIVES OF (6-OXO-1,6-DIHIDRO-PIRIMIDIN-2-IL) -AMIDA, ITS PREPARATION AND ITS PHARMACEUTICAL USE AS AKT PHOSPHORILATION INHIBITORS (PKB) |
TNP2011000657A TN2011000657A1 (en) | 2009-07-02 | 2011-12-22 | NOVEL (6-OXO-1,6-DIHYDRO-PYRIMIDIN-2-YL) -AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR PHARMACEUTICAL USE AS AKT PHOSPHORYLATION INHIBITORS (PKB) |
DO2011000407A DOP2011000407A (en) | 2009-07-02 | 2011-12-26 | NEW DERIVATIVES OF (6-OXO-1,6-DIHIDRO-PIRIMIDIN-2-IL) -AMIDA, ITS PREPARATION AND ITS PHARMACEUTICAL USE AS AKT PHOSPHORILATION INHIBITORS (PKB) |
US13/338,011 US8791255B2 (en) | 2009-07-02 | 2011-12-27 | (6-oxo-1,6-dihydropyrimidin-2-yl)amide derivatives, preparation thereof and pharmaceutical use thereof as AKT(PKB) phosphorylation inhibitors |
IL217295A IL217295A (en) | 2009-07-02 | 2011-12-29 | (6-oxo-1,6 - dihydropyrimidin -2 - yl) amide derivatives, preparation thereof and pharmaceutical use thereof for the treatment of cancer |
CO11180700A CO6480974A2 (en) | 2009-07-02 | 2011-12-29 | NEW DERIVATIVES OF (6-OXO-1,6-DIHIDRO-PIRIMIDIN-2-IL) -AMIDA, ITS PREPARATION AND ITS PHARMACEUTICAL USE AS AKT PHOSPHORILATION INHIBITORS (PKB) |
HN2011003482A HN2011003482A (en) | 2009-07-02 | 2011-12-30 | NEW DERIVATIVES OF (6-OXO-1,6-DIHIDRO-PIRIMIDIN-2-IL) AMIDA, ITS PREPARATION AND ITS PHARMACEUTICAL USE AS AKT PHOSPHORILATION INHIBITORS (PKB) |
IL217321A IL217321A0 (en) | 2009-07-02 | 2012-01-01 | Novel (6-oxo-1,6 - dihydro - pyrimidin - 2 - yl) - amide derivatives, prepartion thereof, and pharamaceutical use thereof as akt (pkb) phosphorylation inhibitors |
CL2012000003A CL2012000003A1 (en) | 2009-07-02 | 2012-01-02 | Compounds derived from substituted (6-oxo-1,6-dihydro-pyrimidin-2-yl) -amide; preparation procedure; pharmaceutical composition comprising them; intermediate compounds; and use of said compounds as akt (pkb) phosphorylation inhibitors for the treatment of cancer. |
EC2012011570A ECSP12011570A (en) | 2009-07-02 | 2012-01-03 | NEW DERIVATIVES OF (6-OXO-1,6-DIHIDRO-PIRIMIDIN-2-IL) -AMIDA, ITS PREPARATION AND ITS PHARMACEUTICAL USE AS AKT PHOSPHORILATION INHIBITORS (PKB) |
ZA2012/00026A ZA201200026B (en) | 2009-07-02 | 2012-01-03 | Novel (6-oxo-1,6-dihydro-pyrimidin-2-yl)-amide derivatives,preparation thereof,and pharmaceutical use thereof as akt(pkb) phosphorylation inhibotors |
NI201200002A NI201200002A (en) | 2009-07-02 | 2012-01-05 | NEW DERIVATIVES OF (6-OXO-1,6-DIHIDRO-PIRIMIDIN-2-IL) -AMIDE, ITS PREPARATION AND ITS PHARMACEUTICAL USE AS PHOSPHORILATION INHIBITORS OF AKT (PKB). |
CR20120071A CR20120071A (en) | 2009-07-02 | 2012-02-10 | OCTASACÁRIDOS N-ACILOS ACTIVADORES OF THE FGF RECEPTORS, THEIR PREPARATION AND THEIR APPLICATION IN THERAPEUTICS |
HK12109790.9A HK1169110A1 (en) | 2009-07-02 | 2012-10-05 | Novel (6-oxo-1, 6-dihydro-pyrimidin-2-yl)-amide derivatives, preparation thereof, and pharmaceutical use thereof as akt phosphorylation inhibitors (6--16--2-) akt |
HRP20140478AT HRP20140478T1 (en) | 2009-07-02 | 2014-05-28 | Novel (6-oxo-1, 6-dihydro-pyrimidin-2-yl)-amide derivatives, preparation thereof, and pharmaceutical use thereof as akt(pkb) phosphorylation inhibitors |
CY20141100419T CY1115626T1 (en) | 2009-07-02 | 2014-06-11 | NEW PRODUCTS (6-oxo-1,6-dihydro-pyrimidin-2-yl) -amide, their preparation and pharmaceutical use as unrestricted phosphorus |
US14/312,124 US8993565B2 (en) | 2009-07-02 | 2014-06-23 | (6-oxo-1,6-dihydropyrimidin-2-yl)amide derivatives, preparation thereof and pharmaceutical use thereof as AKT(PKB) phosphorylation inhibitors |
SM201400084T SMT201400084B (en) | 2009-07-02 | 2014-06-26 | New derivatives of 6- (osso-1,6diiro-pyrimidin-2-yl) -amide, their preparation and their pharmaceutical use as akt phosphorylation inhibitors |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0903239A FR2947547B1 (en) | 2009-07-02 | 2009-07-02 | NOVEL (6-OXO-1,6-DIHYDRO-PYRIMIDIN-2-YL) -AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR PHARMACEUTICAL USE AS AKT PHOSPHORYLATION INHIBITORS (PKB) |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2947547A1 FR2947547A1 (en) | 2011-01-07 |
FR2947547B1 true FR2947547B1 (en) | 2012-05-18 |
Family
ID=41611847
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR0903239A Expired - Fee Related FR2947547B1 (en) | 2009-07-02 | 2009-07-02 | NOVEL (6-OXO-1,6-DIHYDRO-PYRIMIDIN-2-YL) -AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR PHARMACEUTICAL USE AS AKT PHOSPHORYLATION INHIBITORS (PKB) |
Country Status (5)
Country | Link |
---|---|
BR (1) | BRPI1015913A2 (en) |
CR (1) | CR20120071A (en) |
FR (1) | FR2947547B1 (en) |
TN (1) | TN2011000657A1 (en) |
UA (1) | UA107357C2 (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111393374A (en) * | 2020-05-08 | 2020-07-10 | 张建蒙 | Oxo-dihydropyridazine derivative and application thereof in antitumor drugs |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009007749A2 (en) * | 2007-07-09 | 2009-01-15 | Astrazeneca Ab | Trisubstituted pyrimidine derivatives for the treatment of proliferative diseases |
-
2009
- 2009-07-02 FR FR0903239A patent/FR2947547B1/en not_active Expired - Fee Related
-
2010
- 2010-07-01 UA UAA201201036A patent/UA107357C2/en unknown
- 2010-07-01 BR BRPI1015913-4A patent/BRPI1015913A2/en not_active IP Right Cessation
-
2011
- 2011-12-22 TN TNP2011000657A patent/TN2011000657A1/en unknown
-
2012
- 2012-02-10 CR CR20120071A patent/CR20120071A/en unknown
Also Published As
Publication number | Publication date |
---|---|
CR20120071A (en) | 2012-11-01 |
BRPI1015913A2 (en) | 2020-08-18 |
UA107357C2 (en) | 2014-12-25 |
FR2947547A1 (en) | 2011-01-07 |
TN2011000657A1 (en) | 2013-05-24 |
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Legal Events
Date | Code | Title | Description |
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PLFP | Fee payment |
Year of fee payment: 8 |
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ST | Notification of lapse |
Effective date: 20180330 |