FR2941954B1 - N- (6-AZA-BICYCLO ° 3.2.1! OCT-1-YL) -ARYL-METHYL DERIVATIVES BENZAMIDE, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION - Google Patents

N- (6-AZA-BICYCLO ° 3.2.1! OCT-1-YL) -ARYL-METHYL DERIVATIVES BENZAMIDE, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION

Info

Publication number
FR2941954B1
FR2941954B1 FR0900579A FR0900579A FR2941954B1 FR 2941954 B1 FR2941954 B1 FR 2941954B1 FR 0900579 A FR0900579 A FR 0900579A FR 0900579 A FR0900579 A FR 0900579A FR 2941954 B1 FR2941954 B1 FR 2941954B1
Authority
FR
France
Prior art keywords
aza
benzamide
bicyclo
oct
aryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0900579A
Other languages
French (fr)
Other versions
FR2941954A1 (en
Inventor
Gihad Dargazanli
Bouhtou Genevieve Estenne
Florence Medaisko
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Sanofi Aventis France
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR0900579A priority Critical patent/FR2941954B1/en
Application filed by Sanofi Aventis France filed Critical Sanofi Aventis France
Priority to MX2011008459A priority patent/MX2011008459A/en
Priority to TW099104006A priority patent/TW201034667A/en
Priority to EP10708304A priority patent/EP2396335A1/en
Priority to BRPI1008544A priority patent/BRPI1008544A2/en
Priority to KR1020117021204A priority patent/KR20110118813A/en
Priority to PCT/FR2010/050204 priority patent/WO2010092287A1/en
Priority to ARP100100345A priority patent/AR075380A1/en
Priority to JP2011548759A priority patent/JP2012517412A/en
Priority to AU2010212703A priority patent/AU2010212703A1/en
Priority to CN2010800156289A priority patent/CN102388050A/en
Priority to CA2751866A priority patent/CA2751866A1/en
Priority to SG2011057213A priority patent/SG173607A1/en
Priority to UY0001032429A priority patent/UY32429A/en
Publication of FR2941954A1 publication Critical patent/FR2941954A1/en
Application granted granted Critical
Publication of FR2941954B1 publication Critical patent/FR2941954B1/en
Priority to IL214487A priority patent/IL214487A0/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Anesthesiology (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
FR0900579A 2009-02-10 2009-02-10 N- (6-AZA-BICYCLO ° 3.2.1! OCT-1-YL) -ARYL-METHYL DERIVATIVES BENZAMIDE, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION Expired - Fee Related FR2941954B1 (en)

Priority Applications (15)

Application Number Priority Date Filing Date Title
FR0900579A FR2941954B1 (en) 2009-02-10 2009-02-10 N- (6-AZA-BICYCLO ° 3.2.1! OCT-1-YL) -ARYL-METHYL DERIVATIVES BENZAMIDE, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
CN2010800156289A CN102388050A (en) 2009-02-10 2010-02-09 N-[(6-azabicyclo[3.2.1]oct-1-yl)-aryl-methyl]-benzamide derivatives, preparation thereof, and therapeutic use thereof
EP10708304A EP2396335A1 (en) 2009-02-10 2010-02-09 N-[(6-azabicyclo[3.2.1]oct-1-yl)-aryl-methyl]-benzamide derivatives, preparation thereof, and therapeutic use thereof
BRPI1008544A BRPI1008544A2 (en) 2009-02-10 2010-02-09 n - [(6-aza-bicyclo [3.2.1] oct-1-yl) -arylmethyl] -benzamide derivatives, their preparation and their therapeutic application
KR1020117021204A KR20110118813A (en) 2009-02-10 2010-02-09 N-[(6-azabicyclo[3.2.1]oct-1-yl)aryl-methyl]-benzamide derivatives, preparation thereof, and therapeutic use thereof
PCT/FR2010/050204 WO2010092287A1 (en) 2009-02-10 2010-02-09 N-[(6-azabicyclo[3.2.1]oct-1-yl)-aryl-methyl]-benzamide derivatives, preparation thereof, and therapeutic use thereof
ARP100100345A AR075380A1 (en) 2009-02-10 2010-02-09 DERIVATIVES OF N (6-AZA-BICICLO (3.2.1) OCT-1-IL) -ARIL-METIL) -BENZAMIDA, ITS PREPARATION AND ITS APPLICATION IN THERAPEUTICS.
JP2011548759A JP2012517412A (en) 2009-02-10 2010-02-09 N-[(6-Azabicyclo [3.2.1] oct-1-yl) -aryl-methyl] -benzamide derivatives, their preparation and their therapeutic use
MX2011008459A MX2011008459A (en) 2009-02-10 2010-02-09 N-[(6-azabicyclo[3.2.1]oct-1-yl)-aryl-methyl]-benzamide derivatives, preparation thereof, and therapeutic use thereof.
TW099104006A TW201034667A (en) 2009-02-10 2010-02-09 N-[(6-azabicyclo[3.2.1]oct-1-yl)arylmethyl]benzamide derivatives, preparation and therapeutic use thereof
CA2751866A CA2751866A1 (en) 2009-02-10 2010-02-09 N-[(6-azabicyclo[3.2.1]oct-1-yl)-aryl-methyl]-benzamide derivatives, preparation thereof, and therapeutic use thereof
SG2011057213A SG173607A1 (en) 2009-02-10 2010-02-09 N-[(6-azabicyclo[3.2.1]oct-1-yl)-aryl-methyl]-benzamide derivatives, preparation thereof, and therapeutic use thereof
AU2010212703A AU2010212703A1 (en) 2009-02-10 2010-02-09 N-[(6-azabicyclo[3.2.1]oct-1-yl)-aryl-methyl]-benzamide derivatives, preparation thereof, and therapeutic use thereof
UY0001032429A UY32429A (en) 2009-02-10 2010-02-10 DERIVATIVES OF N - [(6-AZA-BICICLO [3.2.1] OCT-1-IL) -ARIL-METIL] -BENZAMIDA, ITS PREPARATION AND ITS APPLICATION IN THERAPEUTICS
IL214487A IL214487A0 (en) 2009-02-10 2011-08-07 N-[(6-azabicyclo[3.2.1]oct-1-yl)-aryl-methyl]-benzamide derivatives, preparation thereof, and therapeutic use thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0900579A FR2941954B1 (en) 2009-02-10 2009-02-10 N- (6-AZA-BICYCLO ° 3.2.1! OCT-1-YL) -ARYL-METHYL DERIVATIVES BENZAMIDE, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION

Publications (2)

Publication Number Publication Date
FR2941954A1 FR2941954A1 (en) 2010-08-13
FR2941954B1 true FR2941954B1 (en) 2011-04-08

Family

ID=40935769

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0900579A Expired - Fee Related FR2941954B1 (en) 2009-02-10 2009-02-10 N- (6-AZA-BICYCLO ° 3.2.1! OCT-1-YL) -ARYL-METHYL DERIVATIVES BENZAMIDE, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION

Country Status (15)

Country Link
EP (1) EP2396335A1 (en)
JP (1) JP2012517412A (en)
KR (1) KR20110118813A (en)
CN (1) CN102388050A (en)
AR (1) AR075380A1 (en)
AU (1) AU2010212703A1 (en)
BR (1) BRPI1008544A2 (en)
CA (1) CA2751866A1 (en)
FR (1) FR2941954B1 (en)
IL (1) IL214487A0 (en)
MX (1) MX2011008459A (en)
SG (1) SG173607A1 (en)
TW (1) TW201034667A (en)
UY (1) UY32429A (en)
WO (1) WO2010092287A1 (en)

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2861076B1 (en) * 2003-10-17 2006-01-06 Sanofi Synthelabo N-HETEROCYCLYMETHYLBENZAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USE
FR2861070B1 (en) * 2003-10-17 2006-01-06 Sanofi Synthelabo DERIVATIVES OF N- [PHENYL (PYRROLIDIN-2-YL) METHYL] BENZAMIDE AND N - [(AZEPAN-2-YL) PHENYLMETHYL] BENZAMIDE, THEIR PREPARATION AND THEIR THERAPEUTIC USE
WO2005058317A1 (en) * 2003-12-18 2005-06-30 Glaxo Group Limited Glycine transporter-1 inhibirors
CA2627177A1 (en) * 2005-10-28 2007-05-10 Merck & Co., Inc. Piperidine glycine transporter inhibitors
MX2009005676A (en) * 2006-11-30 2010-03-22 Cenerx Biopharma Inc Dialkylamino alkyl esters of pivagabine as medicaments for the treatment of central nervous system disorders.
TW200911808A (en) * 2007-07-23 2009-03-16 Astrazeneca Ab Novel compounds

Also Published As

Publication number Publication date
CN102388050A (en) 2012-03-21
CA2751866A1 (en) 2010-08-19
KR20110118813A (en) 2011-11-01
SG173607A1 (en) 2011-09-29
WO2010092287A1 (en) 2010-08-19
EP2396335A1 (en) 2011-12-21
JP2012517412A (en) 2012-08-02
MX2011008459A (en) 2011-12-16
IL214487A0 (en) 2011-09-27
AU2010212703A1 (en) 2011-09-01
TW201034667A (en) 2010-10-01
AR075380A1 (en) 2011-03-30
UY32429A (en) 2010-09-30
FR2941954A1 (en) 2010-08-13
BRPI1008544A2 (en) 2016-03-15

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Effective date: 20121031