FR2938732A1 - Nutritive composition, useful for sportsman, preferably for practitioners of physical activity greater than an hour, comprises caffeine, amino acids e.g. leucine, isoleucine and valine, and carbohydrates - Google Patents
Nutritive composition, useful for sportsman, preferably for practitioners of physical activity greater than an hour, comprises caffeine, amino acids e.g. leucine, isoleucine and valine, and carbohydrates Download PDFInfo
- Publication number
- FR2938732A1 FR2938732A1 FR0806567A FR0806567A FR2938732A1 FR 2938732 A1 FR2938732 A1 FR 2938732A1 FR 0806567 A FR0806567 A FR 0806567A FR 0806567 A FR0806567 A FR 0806567A FR 2938732 A1 FR2938732 A1 FR 2938732A1
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- France
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- composition
- carbohydrates
- amino acids
- physical activity
- curcumin
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- 239000000203 mixture Substances 0.000 title claims abstract description 63
- 150000001720 carbohydrates Chemical class 0.000 title claims abstract description 37
- 235000014633 carbohydrates Nutrition 0.000 title claims abstract description 37
- 229940024606 amino acid Drugs 0.000 title claims abstract description 22
- 150000001413 amino acids Chemical class 0.000 title claims abstract description 22
- RYYVLZVUVIJVGH-UHFFFAOYSA-N caffeine Chemical compound CN1C(=O)N(C)C(=O)C2=C1N=CN2C RYYVLZVUVIJVGH-UHFFFAOYSA-N 0.000 title claims abstract description 20
- LPHGQDQBBGAPDZ-UHFFFAOYSA-N Isocaffeine Natural products CN1C(=O)N(C)C(=O)C2=C1N(C)C=N2 LPHGQDQBBGAPDZ-UHFFFAOYSA-N 0.000 title claims abstract description 10
- 229960001948 caffeine Drugs 0.000 title claims abstract description 10
- VJEONQKOZGKCAK-UHFFFAOYSA-N caffeine Natural products CN1C(=O)N(C)C(=O)C2=C1C=CN2C VJEONQKOZGKCAK-UHFFFAOYSA-N 0.000 title claims abstract description 10
- OCUSNPIJIZCRSZ-ZTZWCFDHSA-N (2s)-2-amino-3-methylbutanoic acid;(2s)-2-amino-4-methylpentanoic acid;(2s,3s)-2-amino-3-methylpentanoic acid Chemical compound CC(C)[C@H](N)C(O)=O.CC[C@H](C)[C@H](N)C(O)=O.CC(C)C[C@H](N)C(O)=O OCUSNPIJIZCRSZ-ZTZWCFDHSA-N 0.000 title claims abstract description 6
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- 230000000050 nutritive effect Effects 0.000 title abstract description 3
- 230000000694 effects Effects 0.000 claims abstract description 5
- VFLDPWHFBUODDF-FCXRPNKRSA-N curcumin Chemical compound C1=C(O)C(OC)=CC(\C=C\C(=O)CC(=O)\C=C\C=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-FCXRPNKRSA-N 0.000 claims description 26
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- WVWHRXVVAYXKDE-UHFFFAOYSA-N piperine Natural products O=C(C=CC=Cc1ccc2OCOc2c1)C3CCCCN3 WVWHRXVVAYXKDE-UHFFFAOYSA-N 0.000 claims description 9
- MXXWOMGUGJBKIW-YPCIICBESA-N piperine Chemical compound C=1C=C2OCOC2=CC=1/C=C/C=C/C(=O)N1CCCCC1 MXXWOMGUGJBKIW-YPCIICBESA-N 0.000 claims description 9
- 229940075559 piperine Drugs 0.000 claims description 9
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- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 claims description 4
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims description 4
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- 238000010521 absorption reaction Methods 0.000 claims 1
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- 239000003204 tranquilizing agent Substances 0.000 abstract 1
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- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 6
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- 239000000243 solution Substances 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- WQZGKKKJIJFFOK-PHYPRBDBSA-N alpha-D-galactose Chemical compound OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-PHYPRBDBSA-N 0.000 description 2
- 235000006708 antioxidants Nutrition 0.000 description 2
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- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 2
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- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 1
- 244000163122 Curcuma domestica Species 0.000 description 1
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- 208000013016 Hypoglycemia Diseases 0.000 description 1
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 description 1
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- 201000002481 Myositis Diseases 0.000 description 1
- 244000203593 Piper nigrum Species 0.000 description 1
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- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 description 1
- CANRESZKMUPMAE-UHFFFAOYSA-L Zinc lactate Chemical compound [Zn+2].CC(O)C([O-])=O.CC(O)C([O-])=O CANRESZKMUPMAE-UHFFFAOYSA-L 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
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- GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 description 1
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- 239000011777 magnesium Substances 0.000 description 1
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- 230000003923 mental ability Effects 0.000 description 1
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- 231100000957 no side effect Toxicity 0.000 description 1
- 239000002417 nutraceutical Substances 0.000 description 1
- 235000021436 nutraceutical agent Nutrition 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
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- 230000036314 physical performance Effects 0.000 description 1
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- 239000000843 powder Substances 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000000979 retarding effect Effects 0.000 description 1
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- 230000037078 sports performance Effects 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 230000009469 supplementation Effects 0.000 description 1
- PLSARIKBYIPYPF-UHFFFAOYSA-H trimagnesium dicitrate Chemical compound [Mg+2].[Mg+2].[Mg+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O PLSARIKBYIPYPF-UHFFFAOYSA-H 0.000 description 1
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- 235000019165 vitamin E Nutrition 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 229940050168 zinc lactate Drugs 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/385—Concentrates of non-alcoholic beverages
- A23L2/39—Dry compositions
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/38—Other non-alcoholic beverages
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/52—Adding ingredients
- A23L2/60—Sweeteners
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/175—Amino acids
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/30—Dietetic or nutritional methods, e.g. for losing weight
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
Description
La présente invention concerne une composition nutritive pour sportifs, en particulier pour pratiquants d'une activité physique supérieure à une heure. The present invention relates to a nutritional composition for athletes, particularly for practicing a physical activity greater than one hour.
Elle concerne plus particulièrement une composition, apte à être absorbée avant et/ou pendant l'activité physique, se présentant sous forme d'une boisson ou d'une préparation à reconstituer, buvable après reconstitution par dilution dans un solvant aqueux, ladite composition contenant majoritairement des glucides. It relates more particularly to a composition, capable of being absorbed before and / or during the physical activity, in the form of a drink or a preparation to be reconstituted, drinkable after reconstitution by dilution in an aqueous solvent, said composition containing mostly carbohydrates.
On est aujourd'hui à la recherche de solutions permettant d'améliorer la performance sportive lors de la réalisation d'un exercice physique de longue durée. On est en particulier à la recherche de solutions permettant de retarder l'apparition de la fatigue musculaire et nerveuse et d'améliorer les capacités attentionnelles pendant l'effort. We are now looking for solutions to improve athletic performance when performing a long-term physical exercise. In particular, we are looking for solutions to delay the onset of muscle and nerve fatigue and improve attentional abilities during exercise.
II est connu que la consommation d'hydrates de carbone permet d'optimiser l'oxydation des hydrates de carbone exogènes, de réduire l'oxydation des acides gras, d'économiser les réserves de glycogène hépatique et de diminuer la sensation de difficulté pendant un exercice physique. Parallèlement, il est bien admis que l'oxydation des acides aminés branchés est augmentée lors de la réalisation d'un exercice physique. L'ingestion d'acides aminés branchés semble bénéfique lors de la réalisation d'un exercice de type aérobie. En effet, lorsque les acides aminés branchés sont ingérés pendant un exercice de ce type, on observe une diminution du taux net de dégradation des protéines. De plus, l'administration d'acides aminés branchés avant, et pendant, un exercice de type aérobie à des personnes dont les stocks de glycogène sont réduits retarde la déplétion des stocks de glycogène musculaire. Toutefois, il a été observé que la prise d'acides aminés branchés avait un effet délétère sur la performance physique de personnes déficientes en glycogène phosphorylase et que cet effet était lié à une augmentation de la production d'ammoniaque. Il a été suggéré que cela pouvait être la même chose chez des sujets sains ayant des stocks bas de glycogène. Quand les acides aminés branchés sont ingérés avant ou pendant l'exercice par des sujets sains, on observe parfois une élévation de l'ammoniaque plasmatique. It is known that the consumption of carbohydrates optimizes the oxidation of exogenous carbohydrates, reduces the oxidation of fatty acids, saves the liver glycogen stores and reduces the sensation of difficulty during a period of time. physical exercise. At the same time, it is well accepted that the oxidation of branched amino acids is increased during the performance of a physical exercise. Ingesting branched amino acids seems beneficial when performing aerobic exercise. Indeed, when the branched amino acids are ingested during an exercise of this type, a decrease in the net rate of degradation of the proteins is observed. In addition, the administration of branched amino acids before, and during, aerobic exercise to people with reduced glycogen stores delays the depletion of muscle glycogen stores. However, it has been observed that the use of branched amino acids has a deleterious effect on the physical performance of glycogen phosphorylase deficient persons and that this effect is related to an increase in ammonia production. It has been suggested that this could be the same in healthy subjects with low glycogen stores. When branched amino acids are ingested before or during exercise by healthy subjects, elevation of plasma ammonia is sometimes observed.
Un but de la présente invention est donc de proposer la mise au point d'une composition qui combine les avantages de l'ingestion d'acides aminés branchés et d'hydrates de carbone pour un exercice de longue durée en vue de retarder l'impression de fatigue et d'augmenter les capacités mentales et par suite la performance du sportif sans observer d'effet délétère tel qu'une augmentation de la production d'ammoniaque. An object of the present invention is therefore to propose the development of a composition which combines the advantages of ingestion of branched amino acids and carbohydrates for a long-term exercise in order to delay printing. fatigue and increase the mental abilities and consequently the performance of the athlete without observing deleterious effect such as an increase in ammonia production.
Un autre but de la présente invention est de proposer une composition qui combine les avantages d'une ingestion d'acides aminés branchés et d'hydrates de carbone, acides aminés branchés et hydrates de carbone étant présents dans des quantités et des proportions appropriées pour augmenter la concentration d'acides aminés branchés dans le plasma et limiter l'augmentation du tryptophane libre donc son entrée dans le cerveau et par voie de conséquence, une fatigue d'origine centrale. Another object of the present invention is to provide a composition which combines the advantages of ingestion of branched amino acids and carbohydrates, branched amino acids and carbohydrates being present in amounts and proportions suitable for increasing the concentration of branched amino acids in the plasma and limit the increase of free tryptophan so its entry into the brain and consequently a central fatigue.
A cet effet, l'invention a pour objet une composition nutritive pour sportifs, en particulier pour pratiquants d'une activité physique supérieure à une heure, ladite composition, apte à être absorbée avant et/ou pendant l'activité physique, se présentant sous forme d'une boisson ou d'une préparation à reconstituer, buvable après reconstitution par dilution dans un solvant aqueux, ladite composition contenant majoritairement des glucides, caractérisée en ce que, outre les glucides en quantité majoritaire, ladite composition comprend de la caféine et des acides aminés branchés, à savoir de la leucine, de l'isoleucine et de la valine, glucides et acides aminés étant présents dans un rapport pondéral exprimé par rapport au poids sec total de ladite composition compris entre 30/1 et 15/1, de préférence voisin de 20/1. L'ingestion d'acides aminés et d'hydrates de carbone pendant la réalisation 25 d'un exercice physique de longue durée permet donc de retarder la fatigue centrale, d'améliorer les capacités mentales et par suite la performance du sportif. For this purpose, the subject of the invention is a nutritive composition for athletes, in particular for practicing a physical activity greater than one hour, said composition, capable of being absorbed before and / or during the physical activity, being presented under form of a drink or a preparation to be reconstituted, drinkable after reconstitution by dilution in an aqueous solvent, said composition containing predominantly carbohydrates, characterized in that, in addition to the carbohydrates in a majority amount, said composition comprises caffeine and branched amino acids, namely leucine, isoleucine and valine, carbohydrates and amino acids being present in a weight ratio expressed relative to the total dry weight of said composition of between 30/1 and 15/1, preferably close to 20/1. The ingestion of amino acids and carbohydrates during the carrying out of a long-term physical exercise thus makes it possible to delay the central fatigue, to improve the mental capacities and consequently the athlete's performance.
s Il doit être noté que dans tout ce qui précède, comme dans tout ce qui suit, on entend par quantité majoritaire des glucides, des glucides représentant au moins 60 %, de préférence au moins 75 % en poids par rapport au poids sec total de ladite composition. It should be noted that in all of the foregoing, as in all of the following, the term "majority amount of carbohydrates" means carbohydrates accounting for at least 60%, preferably at least 75% by weight based on the total dry weight of the carbohydrate. said composition.
Io La complémentation en caféine pendant la réalisation de cet exercice favorise l'oxydation des hydrates de carbone exogènes et peut améliorer la performance sportive. Io Caffeine supplementation during this exercise promotes oxidation of exogenous carbohydrates and can improve athletic performance.
Il est bien connu que l'exercice intense peut induire des dommages 15 musculaires et une inflammation, d'autant plus si la sensation de fatigue musculaire disparaît. Pour pallier un tel problème, la composition peut comprendre en outre de la curcumine, en tant qu'agent antioxydant et anti-inflammatoire, et de la pipérine, en tant qu'agent potentialisant l'activité de la curcumine. 20 L'avantage de la curcumine est qu'elle n'a pas d'effet secondaire au niveau gastro-intestinal et ne provoque pas de complication cardio-vasculaire. L'ajout de pipérine, un alcaloïde naturel de poivre noir, à la curcumine permet une augmentation de l'assimilation de 2 000 %. De préférence, la leucine, l'isoleucine et la valine sont dans un rapport pondéral 2/1/1 exprimé par rapport au poids sec total de ladite composition. It is well known that intense exercise can induce muscle damage and inflammation, especially if the feeling of muscle fatigue disappears. To overcome such a problem, the composition may further comprise curcumin, as an antioxidant and anti-inflammatory agent, and piperine, as an agent potentiating the activity of curcumin. The advantage of curcumin is that it has no side effect at the gastrointestinal level and does not cause cardiovascular complications. The addition of piperine, a natural alkaloid of black pepper, to curcumin allows an increase in assimilation of 2,000%. Preferably, leucine, isoleucine and valine are in a weight ratio of 2/1/1 expressed relative to the total dry weight of said composition.
De préférence encore, les glucides sont présents dans ladite composition 30 sous forme d'un mélange d'au moins deux glucides simples dont l'un est le fructose. Il doit être noté que par glucide simple, on entend les sucres simples ou hydrates de carbone, du type ose (monosaccharide) ou diholoside (disaccharide). A titre de glucide simple autre que le fructose, on peut citer le glucose, le galactose. Leur molécule, un hexose, n'est pas hydrolysable. En effet, l'association de différents hydrates de carbone simples (fructose, sucrose, glucose, maltose, galactose) permet une meilleure oxydation du glucose exogène par rapport à des solutions de glucose isocalorique. Cela est dû en partie à la multiplication des transporteurs. On évite ainsi leur saturation. More preferably, the carbohydrates are present in said composition as a mixture of at least two simple carbohydrates, one of which is fructose. It should be noted that simple carbohydrate is understood to mean simple sugars or carbohydrates, of the ose (monosaccharide) or diholoside (disaccharide) type. As a simple carbohydrate other than fructose, mention may be made of glucose and galactose. Their molecule, a hexose, is not hydrolyzable. Indeed, the combination of different simple carbohydrates (fructose, sucrose, glucose, maltose, galactose) allows a better oxidation of exogenous glucose compared with isocaloric glucose solutions. This is partly due to the multiplication of carriers. This avoids their saturation.
~o Les glucides présents dans la composition incluent en outre des maltodextrines. The carbohydrates present in the composition further include maltodextrins.
La composition peut en outre comprendre des sels minéraux, ces sels minéraux incluant au moins du sodium, du potassium et du zinc. '5 Comparée à l'ingestion d'eau seule, la consommation adéquate de sel avec de l'eau pendant la réalisation d'un exercice permet de soutenir la pression osmotique pour boire, de promouvoir la prise de boisson, de mieux maintenir les volumes plasmatiques et extracellulaires, de diminuer les sorties 20 urinaires et de limiter la baisse de la concentration plasmatique en sodium. De même, le zinc, en concentration physiologique, permet le contrôle des régulateurs de la fonction immunitaire et peut donc jouer un rôle important dans les situations requérant l'activation des monocytes, situation retrouvée au cours de l'exercice physique surtout s'il a été inducteur de lésions 25 musculaires. Or, il est largement admis que l'exercice, notamment s'il est inhabituel ou s'il comporte une grande proportion de contractions excentriques, est à l'origine de lésions musculaires. Ces lésions stimulent l'activité des monocytes et macrophages. The composition may further comprise inorganic salts, these mineral salts including at least sodium, potassium and zinc. '5 Compared with ingestion of water alone, the adequate consumption of salt with water during the exercise makes it possible to support the osmotic pressure to drink, to promote the taking of drink, to better maintain the volumes plasma and extracellular, decrease urine output and limit the decrease in plasma sodium concentration. Similarly, zinc, in physiological concentration, allows the control of the regulators of the immune function and can thus play an important role in the situations requiring the activation of the monocytes, situation found during the physical exercise especially if it has was inducing muscle lesions. However, it is widely accepted that exercise, especially if it is unusual or if it has a large proportion of eccentric contractions, is at the origin of muscular lesions. These lesions stimulate the activity of monocytes and macrophages.
30 La composition peut renfermer également des vitamines, de préférence des vitamines anti-oxydantes, telles que les vitamines C et E. Les vitamines B1, B2, B3 peuvent également être présentes. The composition may also contain vitamins, preferably antioxidant vitamins, such as vitamins C and E. Vitamins B1, B2, B3 may also be present.
La composition nutritive est formulée pour être administrée par voie orale. Avantageusement, selon la présente invention, cette composition peut comprendre tout véhicule ou excipient approprié acceptable du point de vue nutraceutique ainsi que des additifs conventionnels, tels que des arômes, s connus de l'homme du métier. Cette composition se présente soit sous forme de boisson prête à l'emploi, soit sous forme d'une préparation à reconstituer, par dilution de ladite préparation dans une solution aqueuse. Indépendamment de sa présentation initiale sous forme sèche ou humide, ladite composition présente de préférence une formulation exprimée en ~o pourcentage en poids par rapport au poids sec total de la composition telle que suit : glucides de 80 à 95 % acides aminés branchés de 3 à 7 (Yo curcumine de 0,2 à 0,4 % 15 pipérine de 0,0010 à 0,0041 °la caféine de 0,07 à 0,10 vitamines + sels minéraux + excipients + arômes qs (quantité suffisante) The nutritional composition is formulated to be administered orally. Advantageously, according to the present invention, this composition may comprise any suitable vehicle or excipient acceptable from a nutraceutical point of view as well as conventional additives, such as flavorings, known to those skilled in the art. This composition is either in the form of ready-to-use beverage, or in the form of a preparation to be reconstituted, by dilution of said preparation in an aqueous solution. Regardless of its initial presentation in dry or wet form, said composition preferably has a formulation expressed in ~ o percentage by weight relative to the total dry weight of the composition as follows: carbohydrates of 80 to 95% amino acids branched from 3 to 7 (Yo curcumin 0.2 to 0.4% piperine 0.0010 to 0.0041 ° caffeine 0.07 to 0.10 vitamins + minerals + excipients + flavors qs (sufficient amount)
La composition, telle que décrite ci-dessus, est plus particulièrement 20 appliquée à la prévention et/ou à la réduction des effets physiologiques négatifs d'une activité physique, en particulier d'une durée au moins égale à une heure. The composition, as described above, is more particularly applied to the prevention and / or reduction of the negative physiological effects of a physical activity, in particular of a duration of at least one hour.
L'invention a donc également pour objet l'utilisation de la composition 25 précitée comme composition isotonique apte à favoriser une bonne hydratation au cours de l'effort, limiter les pertes en minéraux, retarder la déplétion des stocks de glycogène et l'hypoglycémie, retarder l'apparition de la fatigue musculaire et nerveuse, améliorer les capacités attentionnelles pendant l'effort, diminuer les dommages musculaires, en particulier lors 30 d'exercice à forte composante excentrique. The invention therefore also relates to the use of the above-mentioned composition as an isotonic composition capable of promoting good hydration during exercise, limiting mineral losses, retarding the depletion of glycogen stores and hypoglycemia, delay the onset of muscular and nervous fatigue, improve attentional abilities during exercise, and reduce muscle damage, especially during exercise with a high eccentric component.
La composition, appliquée à l'amélioration des capacités attentionnelles et à la diminution des dommages musculaires pendant l'effort, permet donc d'améliorer la performance sportive lors de la réalisation d'un exercice physique de longue durée. Cette composition est une boisson isotonique, recommandée lors de la pratique de toutes activités physiques et sportives d'une durée supérieure à 1 heure réalisées en ambiance neutre à froide (température environnementale inférieure à 25°C). Cette composition convient aussi bien aux pratiquants de sport individuel que collectif. La quantité de boisson ingérée devra être comprise entre 0,5 et 1,5 L/heure. Cette quantité dépend de la durée et de l'intensité de l'exercice mais aussi des conditions environnementales. Il est recommandé de consommer entre io 200 et 250 mL de cette composition juste avant l'épreuve. En effet, si l'on ne boit pas la boisson de l'effort à l'échauffement mais plus tard, il est démontré une altération de l'efficacité des glucides ingérés ainsi qu'une diminution de la performance sur un exercice de longue durée. The composition, applied to the improvement of attentional abilities and to the reduction of muscular damage during the effort, thus makes it possible to improve the sports performance when performing a long-term physical exercise. This composition is an isotonic drink, recommended during the practice of all physical activities and sports lasting more than 1 hour performed in neutral to cold environment (environmental temperature below 25 ° C). This composition is suitable for both individual and collective sports practitioners. The quantity of drink ingested should be between 0.5 and 1.5 L / hour. This quantity depends on the duration and the intensity of the exercise but also on the environmental conditions. It is recommended to consume between 200 and 250 mL of this composition just before the test. Indeed, if one does not drink the drink of the effort to warm up but later, it is demonstrated an alteration of the efficiency of the ingested carbohydrates as well as a decrease of the performance on a long exercise .
15 L'exemple suivant est destiné à illustrer l'invention sans aucunement en limiter la portée. The following example is intended to illustrate the invention without in any way limiting its scope.
A l'état de boisson prête à l'emploi ou de préparation buvable reconstituée, ladite composition comprend, de préférence exprimés en g/L (gramme/Litre) : 20 glucides acides aminés curcumine pipérine caféine 25 vitamines + sels minéraux de 60 à 110 de 3,4 à 5 de 0,150 à 0,350 de 0,0005 - 0,003 de 0,03 à 0,085 de 0,5 à 0,95 De préférence encore, la composition (gramme/Litre) : glucides 30 acides aminés curcumine pipérine caféinecomprend, exprimés en g/L In the state of ready-to-use beverage or reconstituted oral preparation, said composition preferably comprises g / L (gram / liter): 20 amino acid carbohydrates curcumin caffeine piperine 25 vitamins + mineral salts from 60 to 110 from 3.4 to 5 from 0.150 to 0.350 from 0.0005 - 0.003 from 0.03 to 0.085 from 0.5 to 0.95 More preferably, the composition (gram / liter): carbohydrates 30 amino acids curcumin caffeine piperineincludes, expressed in g / L
de 60 à 80 de 3,4 à 4,5 de 0,200 à 0,350 de 0,0015 - 0,0030 de 0,06 à 0,085 vitamines + sels minéraux de 0,7 à 0,95 from 60 to 80 from 3.4 to 4.5 from 0.200 to 0.350 from 0.0015 - 0.0030 from 0.06 to 0.085 vitamins + mineral salts from 0.7 to 0.95
Dans le cas d'une composition sous forme de préparation à reconstituer, ladite préparation se présente sous forme d'une poudre comportant la formulation telle que mentionnée ci-dessus correspondant à 50 % des quantités annoncées car la reconstitution s'opérera de préférence par dilution de ladite préparation dans 500 mL d'eau. Dans cette composition, la curcumine a de préférence pour source un extrait de Curcuma titré à 95 % en curcumine. La pipérine est quant à elle issue d'extrait de poivre titré à 95 % en to pipérine. Le sodium est issu de NaCl, le magnésium est introduit sous forme de citrate de magnésium tandis que le zinc est introduit sous forme de lactate de zinc. 20 25 30 In the case of a composition in the form of a preparation to be reconstituted, said preparation is in the form of a powder comprising the formulation as mentioned above corresponding to 50% of the quantities announced because reconstitution will preferably take place by dilution. of said preparation in 500 ml of water. In this composition, curcumin preferably has as its source an extract of turmeric titrated at 95% curcumin. Piperine is derived from pepper extract titrated to 95% to piperine. Sodium is derived from NaCl, magnesium is introduced as magnesium citrate while zinc is introduced as zinc lactate. 20 25 30
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| EP3131636A4 (en) * | 2014-04-18 | 2018-01-10 | OmniActive Health Technologies Limited | Curcumin compositions and uses thereof |
| US10646489B2 (en) | 2012-11-13 | 2020-05-12 | Nusirt Sciences, Inc. | Compositions and methods for increasing energy metabolism |
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| EP2508082A1 (en) * | 2011-04-04 | 2012-10-10 | PM-International AG | Food supplement preparation with amino acids and spice extract |
| JP2017160258A (en) * | 2011-07-15 | 2017-09-14 | ニューサート サイエンシーズ， インコーポレイテッド | Compositions and methods for modulating metabolic pathways |
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| US10646489B2 (en) | 2012-11-13 | 2020-05-12 | Nusirt Sciences, Inc. | Compositions and methods for increasing energy metabolism |
| EP3131636A4 (en) * | 2014-04-18 | 2018-01-10 | OmniActive Health Technologies Limited | Curcumin compositions and uses thereof |
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