FR2934500A1 - INJECTION DEVICE WITH AUTOMATIC TRIPPING. - Google Patents

Abstract

A miniaturized injection device for medical use comprising an enclosure (2) in which is disposed a reservoir (3) for a medicinal substance to be injected with a needle (7) movable in the enclosure (2) in a certain axial direction ( A), a pump (8) adapted to circulate the drug substance from the reservoir (3) to the needle (7) and displacement means (9) adapted to move said needle in the axial direction (A) in a protruding position outside the enclosure, characterized in that it further comprises in the enclosure (2) a wireless signal receiver (14,15) which in response to the receipt of a control signal actuates the means displacement (9) and the pump (8).

Description

The invention relates to a miniaturized injection and / or sampling device for medical use comprising an enclosure in which is disposed a reservoir for a medicinal substance to be injected or a substance to be taken with a needle movable in the enclosure in a certain direction axial, a pump adapted to circulate the substance between the reservoir and the needle and displacement means adapted to move said needle in the axial direction in a projecting position out of the enclosure. In general, such drug injection devices are known which are in the form of syringes or patches which are held on an individual by a fixing means, which may be for example an adhesive, and which are operated by the individual without medical help. US Pat. No. 4,886,499 discloses a portable injection device comprising in a chamber a reservoir for a medicinal substance connected to a needle, the reservoir and the needle being movable in the chamber, a pump for circulating the drug substance from the reservoir to the needle and means for moving the needle operable by an individual to perform self-injection. The means for moving the needle comprises springs initially compressed by a cover that the individual returns to release the springs. This injection device implies that, during the injection, the individual has easy access to the device and is in physical condition to perform this gesture - which can be excluded in case of emergency. Moreover, at the end of injection, the needle remains out of the enclosure, which can present a danger for the individual.

The object of the present invention is to provide a fully automatic injection device and safe for the individual. For this purpose, the subject of the invention is a miniaturized injection or sampling device for medical use comprising an enclosure in which a reservoir for a medicinal substance to be injected or a substance to be sampled with a moving needle in the enclosure is placed. in a certain axial direction, a pump adapted to circulate the substance between the reservoir and the needle and displacement means adapted to move said needle in the axial direction in a projecting position outside the enclosure, characterized in that it further comprises in the enclosure a wireless signal receiver which in response to the receipt of a control signal actuates the moving means and the pump. With such an injection device (or sampling) according to the invention, the connection of the reservoir to the needle, and the movement of the needle to pierce the skin of the individual, then to retract into the enclosure of the device, are made fully automatically by the displacement means actuated by an external control signal received by the wireless signal receiver. In addition, the displacement means allow for the needle two positions: a projecting position only during injection (or sampling), and a withdrawal position before injection (or before sampling) and automatically after injection (or after sampling) , so that the individual is not likely to get hurt.

The device according to the invention may comprise a plurality of reservoirs respectively connected to a plurality of movable needles in the enclosure in a certain axial direction, and a plurality of pumps respectively adapted to circulate the substance between each reservoir and each needle and displacement means adapted to move simultaneously or selectively said needles in the axial direction in a protruding position outside the enclosure. The invention also extends to a garment comprising a housing intended to come into contact with a body part of an individual wearing the garment and a device according to the invention disposed in said garment housing in such a way that protruding position, the needle of the device enters the body of the individual. An injection device according to the invention is particularly well suited for use for one or more emergency treatment injections (drug, vaccine or other) since the device equipped with radio-identification module can receive a signal controlling an injection from a sensor external to the device, is located within the body of the individual to detect a crisis, identified for example by a change in concentration of a substance (insulin for example), is arranged remotely to detect pollution for example. An example of a particular embodiment of an injection device according to the invention is described in more detail below and illustrated by the drawings. This description is given as an indicative and non-limiting example of the invention. Figure 1 is a schematic longitudinal sectional view of an injection device according to the invention.

Figure 2 is a schematic view of the injection device according to the invention. Figure 3 is a very schematic view showing the injection device according to the invention embedded in a garment worn by an individual. Figure 4 is a schematic longitudinal sectional view of the injection device according to the invention in a projecting position of the needles. Figure 5 is a schematic longitudinal sectional view of the injection device according to the invention in an intermediate position of the needles. Figure 6 is a schematic longitudinal sectional view of the injection device according to the invention in a locked needles withdrawal position in the device. Figure 7 is a schematic longitudinal sectional view of another embodiment of the injection device according to the invention having four tanks operable at the same time. FIG. 8 is a diagrammatic cross-sectional view of the injection device of FIG. 7. FIG. 9 is a diagrammatic longitudinal sectional view of still another embodiment of the injection device according to the invention having four reservoirs that can be actuated separately.

FIG. 10 is a diagrammatic cross-sectional view of the injection device of FIG. 9. FIG. 1 shows an exemplary embodiment of the injection device 1 according to the invention which comprises an elongate external enclosure 2 according to FIG. a certain axial direction indicated by the arrow A, here essentially tubular in shape, and a reservoir 3 pre-filled with a drug substance housed in a lower support 4, movable in translation along the axial direction A inside the enclosure 2. The enclosure 2 is formed of a base provided with a bottom wall 5 intended to be placed on the skin of an individual (see FIG. 3) and a lid 6 which fits snugly on pedestal. The reservoir 3 may be chosen from vials of various volumes, here tubular, glass or rigid plastic material and advantageously from commercial vials. As can be seen in Figure 1, the lower support 4, here cylindrical, carries one or more needles 7 aligned in the axial direction A and a pump 8 for circulating the drug substance from the reservoir 3 to the needles 7. The pump 8, the needles 7 and the reservoir 3 on the support 4 are thus integral in translation in the chamber 2 in the axial direction A. Before any use of the injection device 1 according to the invention, the needles 7 are in the position of withdrawal in the enclosure 2, so invisible and safe for the individual. As can be seen in FIG. 1, the injection device 1 comprises disposed in the chamber 2 displacement means 9 composed of two substantially identical upper helical return springs 11 intended to move the reservoir 3 and the needles 7 in the axial direction. A in a first direction downwards, so as to reach a protruding position of the needles 7 in which they are out of the chamber 2 through one or more openings 12 of the respective bottom wall 5 of the enclosure 2, and two substantially identical lower helical return springs 13 intended to move the reservoir 3 and the needles 7 in the axial direction A in a second direction upwards, so as to reach a position of withdrawal of the needles 7 in which these They are retracted into the enclosure 2. As will be seen in more detail below, the stiffness constant K1 of the upper springs 11 is greater than the con The injection device 1 also comprises, as shown in FIG. 1, two wireless signal-emitter receivers 14, 15 disposed in the enclosure 2, preferably on an intermediate support 16 respectively. integral in motion with the reservoir 3 and an upper support 17 movable in the enclosure 2. The transmitter-receivers 14, 15 are able to actuate the displacement means 9, and in particular the respective electrical modules or batteries 18, 19 respectively of the moving means 9, in response to a control signal from a wireless signal transmitter 43,44 external to the device (see Figure 3 below). The control signal transmitted by the wireless signal transmitter 43, 44 may be encrypted according to the application of the device 1. Here, the term wireless signal receiver-transmitter, also called RFID module (Radio-Frequency Identification, identification by radio-frequency), an electronic module which generally comprises an antenna associated with an electronic chip which enables it to receive and respond to radio frequency signals transmitted from a radio transceiver.

The injection device 1 further comprises in the enclosure 2, preferably on the lower support 4, another wireless signal receiver-transmitter 20 adapted to receive a signal from the pump 8 and to transmit a signal of end of injection to the radio identification module 15, as will be detailed later. The device 1 may also comprise a delay means 21 connected to the pump 8 which defines a predetermined injection duration as a function of the volume of drug to be injected. Advantageously, the displacement means 9 comprise on the intermediate support 16 two lower diametrically symmetrical pads 22 and pointing upwards in the direction A, on the upper support 17 two diametrically symmetrical lower hollow tubes 23 pointing downwards in the direction A and intended respectively to receive the lower studs 22 and two upper studs 24 diametrically symmetrical and pointing upwards in the direction A, finally on the lid 6 of the enclosure 2 two diametrically symmetrical upper hollow tubes 25 pointing downwards in the direction A and intended to receive respectively the upper pads 24. As shown in Figure 1, the two lower springs 13 are attached to an end portion thereof on the bottom wall 5 of the chamber 2 and to the other portion of the end of these on the lower support 4. The two upper springs 11 are attached to an end portion of e on the intermediate support 16 so as to encircle the lower pads 22 and the other end portion thereof on the upper support 17 so as to encircle the lower hollow tubes 23. Before using the device 1 , the upper support 17 is mounted on the intermediate support 16 so that the lower pads 22 are fully engaged in the lower hollow tubes 23 and the lower hollow tubes 23 are fully engaged in the upper springs 11 and the cover 6 is mounted on the upper support 17 so that the upper pads 24 are barely engaged in the upper hollow tubes 25. The upper springs 11 are then compressed and the lower springs 13 relaxed, the lower springs 13 opposing the axial displacement of the lower support 4 in the direction of the bottom wall 5 and thus keeping the needles 7 set back inside the chamber 2. This gives a device Injection molding 1 compact volume reduced once mounted, and also easily removable.

As can be seen in FIG. 1, the lower pads 22 and upper 24 are respectively equipped with a first element of locking means 10 of displacement means 9 in the form of a pin 26, 27 with shape memory, and the tubes lower recesses 23 and upper 25 are respectively equipped with a second element of locking means 10 displacement means 9 in the form of first and second respective housing 28,29,30,31 respectively provided at the lower and upper ends of the hollow tubes 23.25, preferably diametrically opposed. Shape-memory pins are pins capable of successively presenting an elongate or retracted shape in response to a control signal transmitted by the emitter-receivers 14, 15 via the respective electrical modules 18, 19 arranged in the enclosure 2 , preferably respectively on the intermediate support 16 and the upper support 17. The locking means 10 may also be in the form of electromagnets or movable hooks operable by the electrical modules 18,19. More precisely, in its retracted form, the pin 26 (respectively 27) does not protrude laterally from the pad 22 (respectively 24) so as to allow axial displacement of the pad 22 (respectively 24) in the corresponding hollow tube 23 (respectively 25) . In its elongate form, the pin 26 (respectively 27) protrudes laterally out of the stud 22 (respectively 24) and engages in the housings 28 or 29 (respectively 30 or 31) so as to lock the stud 22 (respectively 24) with the corresponding hollow tube 23 (respectively 25): the stud will be locked in a position of the stud completely engaged in the corresponding hollow tube when the pin 26 (respectively 27) elongated is inserted into the housing 28 (respectively 30), or in a protruding position of the stud out of the corresponding hollow tube when the elongated pin 26 (respectively 27) is inserted into the housing 29 (respectively 31).

One or more percussion cones 32 disposed on the pump 8 point towards one or more complementary lids 33 located on the reservoir 3 so as to pass through the respective lids 33 to create a passage between the reservoir 3 and the needles 7 via the pump 8 when the reservoir 3 is moved in the chamber 2 in the axial direction A to the lower support 4 by a distance noted y in Figure 1. An elastic element 31 is disposed between the pump 8 and the reservoir 3 so initially maintain the reservoir 3 at a distance from the pump 8 such that the covers 33 are not crossed by the cones 32. Preferably, the percussion cones 32 are surrounded by a seal (not shown) sealing the the connection between the cones 32 and the covers 33. On the lower support 4 is also arranged a switch 35 adapted to switch when it comes into contact with a stop 36 disposed on the bottom wall 5 and whose function is to actuate the pump 8 in response to a certain axial displacement of the needles 7 in the chamber 2 in the direction A over a distance marked x in FIG. 1. The pump 8 can be an electric motor pump powered by a battery 34 through the switch 35. In the embodiment of the invention, the pump 8 can be made from micro mechanical or electromechanical microfluidic systems called MEMS or MOEMS powered by means battery 34 which may be a battery, a bio battery, an internal fuel or an inert gas. As an alternative to the use of timing means 21, the injection time of the drug substance can be conditioned by the autonomy of the supply. The pump 8 of the injection device 1 may for example be a peristaltic pump, rotary or centrifugal, or a diaphragm pump or vane, or more generally any suitable technology for pumping and injection.

Advantageously, a visual or audible alarm 38 provided in the chamber 2 may be actuated by one of the wireless signal receivers 14, 15 in response to the reception of the control signal to indicate to the individual the beginning of an injection. Alternatively, the alarm may be transmitted by a wireless transmitter 38 disposed in the chamber 2 adapted to communicate information on the injection to another wireless signal receiver (not shown) disposed outside the enclosure 2, and for example alerting help. The stroke x of the lower support 4 in the chamber 2 is designed so that the needles 7 penetrate to a pre-determined depth in the dermis or muscle tissue of the individual adapted to the medical treatment, depending on the type of injection hypodermic, intradermal, intramuscular or intravenous. For example, in the case of a subcutaneous injection, the needles 7 penetrate the dermis to a distance of 0.2 millimeters (mm) to 0.8 mm. In the case of an intramuscular injection, the needles 7 penetrate the muscle tissue to a distance of 2 mm to 3 mm. The needles 7 have a diameter of about 0.05 mm to 0.2 mm for a length of about 0.5 mm to 3 mm, depending on the medical applications. They are made of materials suitable for medical use, such as medical stainless steel, polymers or ceramics for example. The needles may be made so as to hold on the surface disinfectants or anesthetic or healing, for example by having a surface having micro-scratches, vents or a certain porosity.

The size of the injection device 1 varies between 2 to 5 cm in diameter and between 2 to 5 cm in height depending on the product to be injected. The size of the pump 8 varies between 2 to 5 cm in width and length and between 0.5 to 2 cm in height depending on the product to be injected.

Initially, the injection device 1 according to the invention (and in particular the needles 7) is sterile and packaged so as to remain sterile until use of the injection device 1. In particular, the bottom wall 5 of the enclosure 2 intended to be in contact with the skin of the individual is covered by a protective film 37 through which the needles 7 during an injection.

In FIG. 2, it is possible to see a transparent window 39 on the cover 6 of the enclosure 2 which possibly allows the individual to check the level of filling of the tank 3. In this case, it will be understood that the tank 3 and a part of the enclosure 2 are made of a transparent material. FIG. 3 shows a garment 40 comprising a housing 41, possibly made of transparent material, intended to come into contact with a body part of an individual wearing garment 40, here for example the top of arm 42, the injection device 1 according to the invention being disposed in said housing 41 so that in the projecting position of the needles 7, the needles 7 penetrate into the body of the individual to the predetermined depth.

The injection device 1 comprises for this purpose a fixing means 46, such as for example elastics, which plate the bottom wall 5 of the device 1 on the arm 42 of the individual.

As shown in FIG. 3, the wireless signal transmitter 43, 44 external to the device and adapted to transmit the control signal intended for the wireless signal receivers 14, 15 may be disposed either in an intradermal implant 43 integrated in the body of the individual, either in an external device 44 such as a computer for example. The wireless signal transmitter 43, 44 may comprise a chemical sensor capable of detecting, for example, a change in environmental pollution or a change in the concentration of an individual body substance such as insulin or an abnormal change in physiological data of the individual, so as to emit the control signal of an injection. We will now detail the sequence of operating steps of the injection device 1 according to the invention based on Figures 1, 4, 5 and 6 which show the injection device at different stages. In Figure 1, there is shown schematically the device 1 before use, that is to say that the needles 7 are recessed in the chamber 2, the upper springs 11 being compressed and the lower springs 13 being expanded. The locking of the displacement means is then carried out as follows: the pins 26, here in elongate position in the respective housings 28, lock the pads 22 completely engaged in the corresponding hollow tubes 23 and the pins 27, here in the extended position in the respective housings 31, lock the studs 24 in the released position out of the corresponding hollow tubes 25.

When the receiver 14 of the device 1 receives a control signal from a subcutaneous 43 or external transmitter 44, it actuates the moving means 9 via the electric battery 18, which unlock the upper springs 11 which are then free of relax. The expansion of the upper springs 11 first causes the displacement of the reservoir 3 in the direction of the support 4 in the axial direction A downwards on the distance y, which drives the percussion cones 32 into the covers 33 and creates a passage between the reservoir 3 and the needles 7. Then, the stiffness constant K1 of the upper springs 11 being greater than the stiffness constant K2 of the lower springs 13, the lower springs 13 are compressed under the pressure of the expansion of the upper springs 11. relaxation of the upper springs 11 then causes the displacement in the axial direction A down the distance x of the assembly formed by the reservoir 3 and the support 4 with the needles 7 and the pump 8, and the output of the needles 7 out of the enclosure 2 through the openings 12 and the film 37 and finally the penetration of the needles 7 in the individual to the predetermined depth. When the support 4 comes against the bottom wall 5, the switch 35 in contact with the stop 36 actuates the pump 8 to inject the drug product. The delay means 21 then begins to count down the duration of the injection, that is to say the duration of the power supply of the pump 8 by the battery 34. The alarm 38 is simultaneously triggered by the receiver- transmitter 14. Thus, the injection is performed automatically, simply and safely upon receipt of the control signal, without any action of the individual carrying the injection device 1. In Figure 4, there is shown schematically the device 1 during the injection, that is to say that the needles 7 are out of the chamber 2, the upper springs 11 being expanded and the lower springs 13 being compressed. The locking of the displacement means 9 is then carried out as follows: the pins 26, here in elongate position in the respective housings 29, lock the studs 22 in the disengaged position out of the corresponding hollow tubes 23 and the pins 27, here in the extended position in the respective housings 31, lock the studs 24 in the released position out of the corresponding hollow tubes 25. Once the predetermined injection time has elapsed, the timing means 21 controls the stopping of the pump 8 which sends an end of injection signal to the receiver 20. The receiver-transmitter 20 then transmits a signal to the receiver 15 which actuates the moving means 9 via the battery 19 to unlock the lower springs 13 which are then free to relax. The expansion of the lower springs 13 causes the needles 7 to be withdrawn into the chamber 2 in the axial direction A upwards over the distance x. FIG. 5 diagrammatically shows the device 1 just after the injection, that is to say that the needles 7 are being withdrawn in the enclosure 2, the upper springs 11 being always relaxed and the springs lower 13 beginning to relax. The displacement means 9 are locked at the pins 26 which are here engaged in the extended position in the respective housings 29 and free at the pins 27 which, here in retracted position, allow the pads 24 to engage in the hollow tubes When the lower springs 13 are completely relaxed, the moving means 9 are actuated by the receiver 15 which transmits a signal to the electric battery 19, to lock the lower springs 13, to block the needles 7 in the withdrawn position in the chamber 2. In Figure 6, there is shown schematically the device 1 locked in the safety position after the injection when the needles 7 are fully retracted into the chamber 2, the upper springs 11 and the lower springs 13 being completely relaxed. The displacement means 9 are now locked at the level of the pins 26 which, here engaged in elongate position in the respective housings 29, block the pads 22 in the disengaged position out of the corresponding hollow tubes 23, and at the pins 27 which , engaged in the extended position in the respective housings 30, block the pads 24 in the fully engaged position in the corresponding hollow tubes 25. Thus, the injection device 1 is blocked, the pump 8 can not be reused and the needles can not leave the enclosure. The device 1 according to the invention could also be made with a different number of springs 11,13, pads 22,24 and corresponding hollow tubes 23,25 without departing from the scope of the invention. The materials used to produce the various components of the injection device may advantageously be made of recyclable materials.

FIGS. 7 and 8 show diagrammatically another embodiment of the injection device 101 according to the invention having a plurality of substantially identical reservoirs 103A, 103B, 103C, 103D, each containing a different medicinal substance and operable simultaneously. The device 101 allows a simultaneous injection of several substances, for example immiscible or not compatible with each other. It is obvious that the injection device 101 could be designed with a different number of tanks without departing from the scope of the present invention.

In FIGS. 7 and 8, identical reference numerals correspond to the same elements as those bearing these references in FIGS. 1 to 6, and these elements respectively fulfill the same functions. For the sake of clarity and brevity, we will describe below only the elements of the injection device 101 which differ from the injection device 1 previously described and only as regards the two reservoirs 103A and 103B shown in FIG. The reservoirs 103A, 103B are arranged on the support 4, being separated by a wall 107 and each in correspondence with one or more respective needles 107A, 107B. As can be seen in FIG. 7, a respective pump 108A, 108B is intended to circulate the drug substance from each reservoir 103A, 103B to the corresponding needles 107A, 107B. One or more percussion cones 132A, 132B are disposed on each pump 108A, 108B and point towards respective complementary lids 133A, 133B disposed on each tank 103A, 103B. Before any use of the injection device 101 according to the invention, the needles 107A, 107B are in the retracted position in the chamber 2, so invisible and safe for the individual. The use of the device 101 is then analogous to the use of the device 1 described above: when a control signal is received by the receiver 14, the displacement device 9 causes the output of all the needles 107A, 107B of the enclosure 2 and a simultaneous injection of the substances contained in all the reservoirs 103A, 103B occurs as described above in correspondence with the injection device 1.

FIGS. 9 and 10 show diagrammatically another embodiment of the injection device 201 according to the invention having a plurality of substantially identical reservoirs 203, 303, 403, 503, each containing a different drug substance, operable from individual and selective manner, the tanks being movable in translation along an axis 245. The injection device 201 and allows to inject each substance selectively at a chosen time. It is obvious that the injection device 201 could also be designed with a different number of tanks without departing from the scope of the present invention. In Figures 9 and 10, the same reference numerals correspond to the same elements as those bearing the same references in Figures 1 to 6, and these elements fulfill respectively the same functions. For the sake of clarity and conciseness, we will describe below only the elements of the injection device 201 which differ from the injection device 1 previously described only with regard to the reservoir 203, the other reservoirs 303, 403, 503 being similar to the reservoir 203. The reservoir 203 is disposed on a support 204 in correspondence with one or more needles 207. As can be seen in Figure 9, a pump 208 for circulating the drug substance from the reservoir 203 to the needles 207 is housed on the support 204. One or more percussion cones 232 disposed on the pump 208 point towards one or more complementary lids 233 disposed on the reservoir 203. Before any use of the injection device 201 according to the invention, the needles 207 are in the retracted position in the chamber 2, and therefore invisible and safe for the individual carrying the injection device 201. As shown in FIG. 9, displacement means 209 disposed in enclosure 2 and associated with reservoir 203 comprise one or more substantially identical upper coil springs 211 intended to move reservoir 203 and needles 207 in the axial direction A in a first embodiment. downward direction, so as to reach a projecting position of the needles 207, and one or more lower helical springs 213 fixed between the support 204 and the bottom wall 5 of the enclosure 2, substantially identical for moving the reservoir 203 and the needles 207 in the axial direction A in a second direction upwards, so as to reach a needle retraction position 207. The stiffness constant of the upper springs 211 is greater than the stiffness constant of the lower springs 213.

The injection device 201 furthermore comprises, associated with each reservoir 203, two wireless signal-emitter receivers 214, 215 disposed respectively in the enclosure 2 on an intermediate support 216 and an upper support 217. The transmitter-receivers 214, 225 play here a role similar to the transceivers 14,15 of the device 1 described above, and in particular they actuate electric batteries 218,219 displacement means 209 in response to a control signal from a wireless signal transmitter 43,44 external to the device (shown in Figure 3). The injection device 201 further comprises, in the enclosure 2, preferably on the lower support 204, a timing means 221 which defines a predetermined injection duration as a function of the volume of drug to be injected into the reservoir 203, as well as a wireless signal receiver-transmitter 220 adapted to receive a signal from the delay means 221 and to transmit an end-of-injection signal to the radio identification modules 214,215.

Similarly to the displacement means 9 at the device 1, the displacement means 209 comprise a set of pads 222,224 and corresponding hollow tubes 223,225 respectively disposed on the intermediate support 216, the upper support 217 and the cover 6 of the enclosure 2 , the upper springs 211 being fixed between the supports 216 and 217 so as to encircle the lower pads 222 and the lower hollow tubes 223. The use of the device 201 is then similar to the use of the device 1 described above. A control signal is sent by a transmitter 43, 44 selectively to one of the transmitter receivers 214, 314, 414 (not shown), 514 (not shown) respectively corresponding to one of the tanks 203, 303, 403, 503, for example the receiver 214 associated with the reservoir 203. The associated displacement device 209 then causes the exit of the needles 207 from the chamber 2 and an injection of the substance contained in the reservoir 203 occurs as described above in correspondence with the injection device 1. It is obviously also possible with the injection device 201 simultaneous selective injection of two or more substances contained in two or more tanks by sending a control signal to two or more receivers-transmitters corresponding.

The miniaturized device according to the invention can also serve as a blood sampling device for example for subsequent analyzes.

Claims (1)

CLAIMS1 / Miniaturized injection or sampling device for medical use comprising an enclosure (2) in which is disposed a reservoir (3,103A, 203) for a medicinal substance to be injected or a substance to be taken with a needle (7,107A, 207 ) movable in the enclosure (2) in a certain axial direction (A), a pump (8,108A, 208) adapted to circulate the substance between the reservoir (3,103A, 203) and the needle (7,107A, 207). ) and displacement means (9,209) adapted to move said needle in the axial direction (A) in a projecting position outside the enclosure, characterized in that it further comprises in the enclosure (2) a receiver of wireless signal (14,15,214,215) which in response to receiving a control signal actuates the moving means (9,209) and the pump (8,108A, 208). 2 / Apparatus according to claim 1, wherein said displacement means (9,209) are arranged to move said needle (7,107A, 207) in one direction or the other in said axial direction (A), and in which it is provided a delay means (21,221) which actuates said moving means (9,209) to move the needle (7,107A, 207) from said projecting position to a retracted position in the enclosure (2). 3 / Apparatus according to claim 1 or 2, wherein said displacement means (9,209) comprise return springs (11,13,211,213). 4 / Apparatus according to claim 2 and 3, wherein said return springs comprise a first spring (11,211) having a first stiffness constant (K1) which expands to move said needle (7,107A, 207) to its position protruding at the same time as compressing a second spring (13,213) having a second stiffness constant (K2) less than said first stiffness constant (K1), which second spring (13,213) is expanded to move said needle (7,107). A, 207) of said projecting position to said retracted position. 5 / Apparatus according to one of the preceding claims, comprising a first wireless signal transmitter (43,44) disposed outside the enclosure (2) and adapted to transmit said control signal for the wireless signal receiver ( 14,15,214,215). 6 / Apparatus according to claim 5, wherein the transmitter is disposed in an intradermal implant (43). 7 / Apparatus according to one of claims 5 and 6, wherein the transmitter (43,44) comprises a chemical sensor. 8 / Apparatus according to one of the preceding claims, wherein said displacement means (9,209) further comprises a locking means (10) of the position of the needle (7,107A, 207) in said axial direction (A) , said locking means being based on a shape memory material excited by an electric battery (18,19,218,219). 9 / Apparatus according to one of claims 1 to 8, wherein said receiver (14,15,214,215) is an RFID receiver.10 / Device according to one of the preceding claims, comprising an alarm (38) which is actuated by said receiver (14,15,214,215) in response to receiving said control signal. 11 / Apparatus according to claim 10, wherein the alarm is transmitted by a second wireless signal transmitter (38) disposed in the enclosure. 12 / Garment comprising a housing (41) intended to come into contact with a body part of an individual wearing the garment (40) and a device (1,101,201) according to one of claims 1 to 11 disposed in said housing (41) garment such that in projecting position, the needle (7,107A, 207) of the device (1,101,201) enters the body of the individual (42).