FR2932386A1 - Composition, comprises at least three original natural bioactive compounds e.g. Aloe vera, apricot kernel, rosehip and manuka, with additional ingredients e.g. zinc, iron and phosphorus - Google Patents
Composition, comprises at least three original natural bioactive compounds e.g. Aloe vera, apricot kernel, rosehip and manuka, with additional ingredients e.g. zinc, iron and phosphorus Download PDFInfo
- Publication number
- FR2932386A1 FR2932386A1 FR0803365A FR0803365A FR2932386A1 FR 2932386 A1 FR2932386 A1 FR 2932386A1 FR 0803365 A FR0803365 A FR 0803365A FR 0803365 A FR0803365 A FR 0803365A FR 2932386 A1 FR2932386 A1 FR 2932386A1
- Authority
- FR
- France
- Prior art keywords
- vitamin
- composition
- gel
- oral
- zinc
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000004615 ingredient Substances 0.000 title claims abstract description 13
- 239000000203 mixture Substances 0.000 title claims abstract description 11
- 230000000975 bioactive effect Effects 0.000 title claims abstract description 8
- 150000001875 compounds Chemical class 0.000 title claims abstract description 8
- 235000002961 Aloe barbadensis Nutrition 0.000 title claims description 8
- 235000011399 aloe vera Nutrition 0.000 title claims description 8
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 title claims description 6
- 240000003553 Leptospermum scoparium Species 0.000 title claims description 5
- 235000016887 Leptospermum scoparium Nutrition 0.000 title claims description 3
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 title claims description 3
- 244000018633 Prunus armeniaca Species 0.000 title claims description 3
- 235000009827 Prunus armeniaca Nutrition 0.000 title claims description 3
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 title claims description 3
- 229910052742 iron Inorganic materials 0.000 title claims description 3
- 239000011574 phosphorus Substances 0.000 title claims description 3
- 229910052698 phosphorus Inorganic materials 0.000 title claims description 3
- 239000011701 zinc Substances 0.000 title claims description 3
- 229910052725 zinc Inorganic materials 0.000 title claims description 3
- -1 Aloe vera Chemical class 0.000 title description 2
- 241000049213 Aloe gariepensis Species 0.000 title 1
- 239000000284 extract Substances 0.000 claims abstract description 20
- 210000001519 tissue Anatomy 0.000 claims abstract description 13
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- 239000006071 cream Substances 0.000 claims abstract description 7
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- 239000002324 mouth wash Substances 0.000 claims abstract description 6
- 229910052500 inorganic mineral Inorganic materials 0.000 claims abstract description 5
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- 229940051866 mouthwash Drugs 0.000 claims abstract description 5
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- 241000241413 Propolis Species 0.000 claims description 8
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- LXNHXLLTXMVWPM-UHFFFAOYSA-N pyridoxine Chemical compound CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 claims description 8
- 244000144927 Aloe barbadensis Species 0.000 claims description 7
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 6
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 claims description 6
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 claims description 6
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 claims description 6
- 150000003839 salts Chemical class 0.000 claims description 6
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims description 4
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 claims description 4
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- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 claims description 4
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 claims description 4
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- FDJOLVPMNUYSCM-WZHZPDAFSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+3].N#[C-].N([C@@H]([C@]1(C)[N-]\C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C(\C)/C1=N/C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C\C1=N\C([C@H](C1(C)C)CCC(N)=O)=C/1C)[C@@H]2CC(N)=O)=C\1[C@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]1[C@@H](O)[C@@H](N2C3=CC(C)=C(C)C=C3N=C2)O[C@@H]1CO FDJOLVPMNUYSCM-WZHZPDAFSA-L 0.000 claims description 4
- 229920002770 condensed tannin Polymers 0.000 claims description 4
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- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 claims description 4
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- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 2
- 244000025254 Cannabis sativa Species 0.000 claims description 2
- 235000012766 Cannabis sativa ssp. sativa var. sativa Nutrition 0.000 claims description 2
- 235000012765 Cannabis sativa ssp. sativa var. spontanea Nutrition 0.000 claims description 2
- 235000009024 Ceanothus sanguineus Nutrition 0.000 claims description 2
- ACTIUHUUMQJHFO-UHFFFAOYSA-N Coenzym Q10 Natural products COC1=C(OC)C(=O)C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UHFFFAOYSA-N 0.000 claims description 2
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- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims description 2
- 102000010445 Lactoferrin Human genes 0.000 claims description 2
- 108010063045 Lactoferrin Proteins 0.000 claims description 2
- 235000015459 Lycium barbarum Nutrition 0.000 claims description 2
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims description 2
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 claims description 2
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 claims description 2
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- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 claims description 2
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- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 claims description 2
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- UDMBCSSLTHHNCD-KQYNXXCUSA-N adenosine 5'-monophosphate Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O UDMBCSSLTHHNCD-KQYNXXCUSA-N 0.000 claims description 2
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Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
- A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
- A23G3/36—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds
- A23G3/48—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds containing plants or parts thereof, e.g. fruits, seeds, extracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9733—Lichens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
- A61K8/988—Honey; Royal jelly, Propolis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Mycology (AREA)
- Botany (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Chemical & Material Sciences (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Inorganic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dermatology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Cosmetics (AREA)
Abstract
Description
L'invention est une composition constituée d'au moins 3 extraits naturels bioactifs originaux (d'origine végétale, animale ou minérale), - en application buccale sur les gencives et les muqueuses, chez l'Humain ou l'Animal, par le moyen d'une solution d'irrigation pour instrumentation ultrasonore, d'une solution de rinçage (bain de bouche), d'un gel, d'un dentifrice ou d'une pastille à sucer ou croquer ; - ou en application sur les tissus de revêtement (peau, muqueuses), chez l'Humain ou l'Animal, par le moyen d'une crème, d'un gel, d'un bâton applicateur (stick) ou d'une solution de rinçage. The invention is a composition consisting of at least 3 original bioactive natural extracts (of vegetable, animal or mineral origin), - in oral application on the gums and mucous membranes, in humans or animals, by the medium an ultrasonic instrumentation irrigation solution, a rinse solution (mouthwash), a gel, a toothpaste or a lozenge to be sucked or chewed; - or in application on the coating tissues (skin, mucous membranes), in humans or animals, by means of a cream, a gel, an applicator stick (stick) or a solution rinsing.
Les extraits naturels, d'origine végétale, animale ou minérale, sont fréquemment utilisés dans les préparations en application orale ou cutanée. Les bains de bouche, gels et dentifrices, utilisés pour éliminer la plaque dentaire et les résidus alimentaires, peuvent être à base d'extraits naturels, afin de nettoyer tout en respectant les équilibres de l'écosystème oral. De même, de nombreux extraits naturels ayant des effets bénéfiques sur ces tissus, ils sont parfois utilisés dans des crèmes, gel ou solution cosmétiques ou dermatologiques, pour nettoyer la peau et les muqueuses. Enfin, des pastilles à sucer ou croquer aux extraits naturels (en particulier la propolis) sont utilisées pour rafraîchir l'haleine et améliorer la santé bucco-dentaire. Dans l'Art antérieur, on décrit donc de nombreuses préparations à base d'extraits naturels pour des applications orales ou cutanéo-muqueuses. Les effets bénéfiques de toutes ces préparations sont reconnus, mais demeurent faibles en raison des propriétés limitées de ces extraits naturels utilisés seuls. La spécificité de cette invention est qu'elle utilise en synergie des composés naturels originaux, dont l'association pour des applications orales et cutanéo-muqueuses n'a jamais été envisagée. Certains ingrédients de cette invention n'ont jamais été proposés pour des applications orales ou cutanéo-muqueuses (extraits de chrysantelum americanum, de leptospermum morrisonii ; sels de Schussler, mégamine). Les autres ingrédients de cette invention sont déjà connus de l'homme du métier et même parfois du grand public pour ces applications. Tous les ingrédients de l'invention présentent seuls des effets bénéfiques pour les tissus oropharyngés et cutanéo-muqueux. Mais l'association d'au moins 3 de ces ingrédients naturels, afin d'obtenir des effets synergiques et plus étendus, n'a jamais été décrite, quelle que soit le support (dentifrice, crème, gel, solution, pastille, stick, etc...) ou le type d'application orale ou cutanéo-muqueuse. Natural extracts, of vegetable, animal or mineral origin, are frequently used in preparations for oral or dermal application. Mouthwashes, gels and toothpastes, used to remove plaque and food residues, can be based on natural extracts, to clean while respecting the balance of the oral ecosystem. Similarly, many natural extracts having beneficial effects on these tissues, they are sometimes used in creams, gel or cosmetic or dermatological solution, to clean the skin and mucous membranes. Finally, lozenges to chew or chew with natural extracts (especially propolis) are used to refresh the breath and improve oral health. In the prior art, numerous preparations based on natural extracts for oral or mucocutaneous applications are thus described. The beneficial effects of all these preparations are recognized, but remain low because of the limited properties of these natural extracts used alone. The specificity of this invention is that it uses in synergy original natural compounds, whose association for oral and mucocutaneous applications has never been considered. Certain ingredients of this invention have never been proposed for oral or mucocutaneous applications (extracts of chrysantelum americanum, leptospermum morrisonii, Schussler salts, megamine). The other ingredients of this invention are already known to those skilled in the art and sometimes even the general public for these applications. All the ingredients of the invention alone have beneficial effects for the oropharyngeal and cutaneo-mucous tissues. But the combination of at least 3 of these natural ingredients, in order to obtain synergistic and more extensive effects, has never been described, whatever the medium (toothpaste, cream, gel, solution, lozenge, stick, etc ...) or the type of oral or mucocutaneous application.
Enfin, il faut noter que la solution bioactive pour instrumentation ultrasonore (en particulier les détartreurs dentaires) est totalement méconnue de l'homme du métier. En chirurgie dentaire, les détartreurs ultrasonores sont couplés à l'eau courante pour l'irrigation et le drainage des débris. L'eau courante est parfois remplacée par une solution antiseptique à base de chlorhexidine. Ce type de solution présente l'inconvénient d'abîmer les canalisations du matériel ultrasonore. L'invention est une solution d'irrigation bioactive à base d'extraits naturels originaux, non brutale pour les tissus parodontaux et les canalisations du matériel. Elle se présente en flacons déjà préparés, ou sous la forme d'un concentré à diluer dans la bouteille d'eau d'irrigation. Finally, it should be noted that the bioactive solution for ultrasonic instrumentation (in particular dental scalers) is totally unknown to those skilled in the art. In dental surgery, ultrasound scalers are coupled with running water for irrigation and drainage of debris. The running water is sometimes replaced by an antiseptic solution based on chlorhexidine. This type of solution has the disadvantage of damaging the pipes of the ultrasonic material. The invention is a bioactive irrigation solution based on original natural extracts, not brutal for periodontal tissues and material ducts. It comes in vials already prepared, or in the form of a concentrate to be diluted in the bottle of irrigation water.
L'objet de l'invention peut être appliqué, de manière ponctuelle ou au long cours, chez l'Homme ou l'Animal : - sur les tissus de la cavité orale (en particulier les gencives, les muqueuses des joues et du dos de la langue), quel que soit leur état : tissu sain, plaies gingivales ou muqueuses, ulcérations, irritations, troubles immunitaires (lichen, aphtes,...) ou déséquilibre de l'écosystème oral (candida albicans, halitose, etc...), gingivites, maladie parodontale ; - sur les tissus de revêtement (peau, muqueuses), quel que soit leur état : tissu sain, plaies ouvertes, irritations, ulcérations, troubles microvasculaires (hémorroïdes, couperose...), troubles des tissus matriciels (vieillissement cutané dû à la dégradation du réseau élastique ou collagénique,...), lésions bactérienne, mycotique ou virale. Les composés originaux sélectionnés n'ont que des effets bénéfiques, et leur association offre une synergie d'effets très large. Les effets de chaque préparation dépendent des extraits naturels qui la constituent et de leur dosage. Chaque formule est sélectionnée en fonction de l'application et du résultat recherché. Les principaux effets rencontrés, seuls ou associés, sont : activité antioxydante (contre le stress oxydatif des cellules), propriétés antiseptiques (contre les bactéries, champignons, et même certains virus), activité anti-inflammatoire, décongestionnante et astringeante, propriétés analgésiques naturelles, pouvoir tampon (pour réguler le pH local), action cicatrisante. Le mode de réalisation de l'invention rassemble au moins 3 composés naturels bioactifs originaux principaux, associés éventuellement à des ingrédients accessoires en fonction de la combinaison d'effets recherchée. Les ingrédients originaux principaux sont choisis parmi les composés suivants, sans excéder les proportions maximum indiquées pour chaque composé par rapport à la composition du produit fini : extrait de pépin de pamplemousse (70%), d'aloe vera ou barbadensis (12%), de noyau d'abricot (10%), de rose musquée (5%), de manuka (20%), de spilanthes (30%), de thé vert (30%), de melaleuca (arbre à thé) (20%), d'usnea barbata (10%), de chrysantelum americanum (10%), de leptospermum morrisonii (10%), d'echinacea (7%) ; huile d'amande douce (10%), d'argan (10%), de chanvre (10%), d'avocat (15%) ; pycnogénol (5%), propolis (10%), chitosan (20%), lactoferrine (5%), sels de Schussler (8%), mégamine (5%). Les ingrédients accessoires sont choisis parmi les éléments suivants : zinc, fer, iode, phosphore, magnésium, calcium, sélénium, fluor, argile, vitamine A (rétinol), bêta- carotène (provitamine A), vitamine B1, vitamine B2 (riboflavine), vitamine PP (acide nicotinique), vitamine B5 (acide pantothénique), vitamine B6 (pyridoxine), vitamine B8 (biotine), vitamine B9 (acide folique), vitamine B12 (cobalamine), vitamine C (acide ascorbique), vitamine D, vitamine E (tocophérol), vitamine K, coenzyme Q10. Chaque ingrédient accessoire ne peut dépasser 1% de la formule finale. The object of the invention can be applied, in a specific or long-term manner, in humans or animals: - on the tissues of the oral cavity (in particular the gums, the mucous membranes of the cheeks and back of the the tongue), whatever their condition: healthy tissue, gingival wounds or mucous membranes, ulcerations, irritations, immune disorders (lichen, canker sores, ...) or imbalance of the oral ecosystem (candida albicans, halitosis, etc ...) ), gingivitis, periodontal disease; - on the covering tissues (skin, mucous membranes), whatever their state: healthy tissue, open wounds, irritations, ulcerations, microvascular disorders (hemorrhoids, rosacea ...), matrix tissue disorders (skin aging due to degradation elastic or collagenous network, ...), bacterial, mycotic or viral lesions. The original compounds selected have only beneficial effects, and their combination offers a very broad synergy of effects. The effects of each preparation depend on the natural extracts that constitute it and their dosage. Each formula is selected according to the application and the desired result. The main effects encountered, alone or in combination, are: antioxidant activity (against the oxidative stress of cells), antiseptic properties (against bacteria, fungi, and even certain viruses), anti-inflammatory, decongestant and astringent activity, natural analgesic properties, buffering capacity (to regulate the local pH), healing action. The embodiment of the invention brings together at least 3 main original bioactive natural compounds, possibly associated with accessory ingredients depending on the desired effect combination. The main original ingredients are chosen from the following compounds, without exceeding the maximum proportions indicated for each compound in relation to the composition of the finished product: extract of grapefruit seed (70%), aloe vera or barbadensis (12%), of apricot kernel (10%), rose hip (5%), manuka (20%), spilanthes (30%), green tea (30%), tea tree tea (20%) ), usnea barbata (10%), chrysantelum americanum (10%), leptospermum morrisonii (10%), echinacea (7%); sweet almond oil (10%), argan (10%), hemp (10%), avocado (15%); pycnogenol (5%), propolis (10%), chitosan (20%), lactoferrin (5%), Schussler salts (8%), megamine (5%). The accessory ingredients are selected from the following elements: zinc, iron, iodine, phosphorus, magnesium, calcium, selenium, fluorine, clay, vitamin A (retinol), beta-carotene (provitamin A), vitamin B1, vitamin B2 (riboflavin) , vitamin PP (nicotinic acid), vitamin B5 (pantothenic acid), vitamin B6 (pyridoxine), vitamin B8 (biotin), vitamin B9 (folic acid), vitamin B12 (cobalamin), vitamin C (ascorbic acid), vitamin D, vitamin E (tocopherol), vitamin K, coenzyme Q10. Each accessory ingredient can not exceed 1% of the final formula.
Pour chaque type de préparation (gel, dentifrice, bain de bouche,...), l'invention est mise en oeuvre dans un excipient de formulation classique et connue par l'homme du métier, adapté au moyen de l'application. Ainsi que cela ressort de ce qui précède, l'invention ne se limite nullement à ceux de ses modes de réalisation et d'application qui viennent d'être décrits de façon plus explicite ; elle en embrasse, au contraire, toutes les variantes qui peuvent venir à l'esprit du technicien en la matière sans s'écarter du cadre, ni de la portée, de la présente invention. On trouvera ci-après quelques exemples de mise en oeuvre de l'invention : les proportions des extraits naturels et autres ingrédients cités dans les exemples ci-dessous sont données par rapport à la composition du produit fini (bain de bouche, gel, crème, pastille, solution concentrée pour instruments ultrasonores,...). EXEMPLE 1 : un dentifrice à base de propolis (0,5%), de pycnogénol (1%), de chitosan (8%) et de mégamine (1%). Le reste de la préparation est composé de manière classique avec de la silice (23%), du glycérol (10%), du sorbitol (16%), de l'eau (34,5%) et des arômes (6%). L'huile de propolis rassemble un grand nombre de principes actifs, dont beaucoup de minéraux et de vitamines, ce qui explique une gamme assez large de propriétés antiseptiques, analgésiques, anti-inflammatoires et cicatrisantes. La propolis est déjà bien connue en odonto-stomatologie, en particulier pour ses effets sur l'halitose et les aphtes. Le pycnogénol est un extrait de pin maritime et contient avant tout des composés flavonoïdes et des acides phénoliques, à l'origine d'importantes activités antioxydantes et anti-inflammatoires. Le chitosan est une fibre extraite de la carapace des crustacés, et constituée de polysaccharides hydrosolubles. Les propriétés bioadhésives d'un tel polymère lui confèrent des effets protecteurs sur les tissus. De plus, il présente un pouvoir tampon capable de normaliser localement le pH et la capacité d'inhiber l'adhésion bactérienne aux surfaces traitées. La mégamine est un complément alimentaire dont la substance active fondamentale est une zéolite micronisée et activée, dont les effets de régulateur du système immunitaire et d'antioxydant puissant ont été mis en évidence. EXEMPLE 2 : une solution concentrée pour détartreur ultrasonore à base d'extrait de spilanthes (20%), d'extrait de pépin de pamplemousse (66%), de mégamine (2%), d'arôme citron-pamplemousse (12%). Cette formule est un concentré, à utiliser sous la forme de quelques gouttes, diluées dans la bouteille d'eau d'irrigation du détartreur. L'extrait de spilanthes présente une activité antiseptique (due entre autres à des phytostérols bactéricides et fongicides) et analgésique. L'extrait de pépin de pamplemousse est riche en vitamines, il concentre surtout une grande quantité de polyphénols ayant de fortes activités antioxydantes et antibiotiques naturelles. En alcalinisant les fluides, cet extrait joue un rôle tampon sur le pH. Il présente également des effets anti-inflammatoires. EXEMPLE 3 : un dentifrice à base de propolis (1%), d'aloe vera (2%), de gluconate de calcium (moins de 0,5%), de gluconate de zinc (moins de 0,5%) et de mégamine (0,5%). Le reste de la préparation est composé de manière classique avec de la silice (22%), du glycérol (10%), du sorbitol (20%), de l'eau (38%) et des arômes (6%). L'aloe vera est recommandé en phytothérapie en application sur les ulcérations et aphtes. Cet extrait est connu pour ses effets antiseptiques, analgésiques et anti-inflammatoires. Le gluconate de calcium permet un apport local d'ions calcium potentiellement reminéralisants sur les surfaces dentaires. Le gluconate de zinc offre un apport significatif d'ion zinc, indispensable au bon fonctionnement du métabolisme cellulaire et du système immunitaire. On lui reconnaît ainsi des propriétés antioxydantes et anti-inflammatoires. EXEMPLE 4 : pastilles à sucer constituées de sucre cuit non cariogène (88%), d'extraits de thé vert (5%), de pépin de pamplemousse (5%) et de propolis (2%). Les extraits de thé vert apportent une grande quantité de polyphénols, particulièrement l'épigallocatéchine gallate (EGCG), avec de puissants effets antioxydants et anti-inflammatoires. Ces pastilles peuvent être associées au dentifrice de l'exemple 3 pour réaliser une cure de la sphère oropharyngée, en particulier pour rééquilibrer le terrain gingivo-muqueux. EXEMPLE 5 : crème cutanée pour application sur les irritations et les hémorroïdes à base d'extraits de thé vert (5%), de sels de Schussler (2%), d'aloe vera (4%), d'huile d'argan (3%) et d'huile de chanvre (3%). Le reste de la crème sert de support et est composé classiquement d'acide stéarique, de palmitate de cetyl, de paraffine, de propylene glycol, d'alginate de sodium, de sorbate de potassium et d'eau purifiée. Les sels de Schussler sont un ensemble de 12 sels anorganiques mis en évidence par le Dr Schussler (1821-1898) dans le sang et les cellules humaines, et dont la présence est nécessaire au bon fonctionnement cellulaire. Les huiles d'argan et de chanvre sont des huiles naturelles bien connues en dermatologie pour leurs propriétés nourrissantes et apaisantes. Les compositions présentées en exemples sont seulement illustratives, et ne limitent pas la portée plus générale de l'invention. For each type of preparation (gel, toothpaste, mouthwash, ...), the invention is implemented in a conventional formulation of excipient and known to those skilled in the art, adapted by means of the application. As is apparent from the above, the invention is not limited to those of its embodiments and applications which have just been described more explicitly; it embraces, on the contrary, all the variants that may come to the mind of the technician in the field without departing from the scope or scope of the present invention. Some examples of implementation of the invention are given below: the proportions of the natural extracts and other ingredients mentioned in the examples below are given with respect to the composition of the finished product (mouthwash, gel, cream, pastille, concentrated solution for ultrasonic instruments, etc.). EXAMPLE 1: a toothpaste containing propolis (0.5%), pycnogenol (1%), chitosan (8%) and megamine (1%). The rest of the preparation is conventionally compounded with silica (23%), glycerol (10%), sorbitol (16%), water (34.5%) and flavorings (6%). . Propolis oil contains a large number of active ingredients, including many minerals and vitamins, which explains a fairly wide range of antiseptic, analgesic, anti-inflammatory and healing properties. Propolis is already well known in odonto-stomatology, especially for its effects on halitosis and canker sores. Pycnogenol is an extract of maritime pine and contains, above all, flavonoid compounds and phenolic acids, which have important antioxidant and anti-inflammatory activities. Chitosan is a fiber extracted from the shell of crustaceans, and consists of water-soluble polysaccharides. The bioadhesive properties of such a polymer give it protective effects on the tissues. In addition, it has a buffering capacity capable of locally normalizing the pH and the ability to inhibit bacterial adhesion to treated surfaces. Megamine is a dietary supplement whose active substance is a micronized and activated zeolite, whose effects of regulator of the immune system and powerful antioxidant have been highlighted. EXAMPLE 2: Concentrated solution for ultrasonic scaler based on spilanthes extract (20%), grapefruit seed extract (66%), megamine (2%), lemon-grapefruit flavor (12%) . This formula is a concentrate, to be used in the form of a few drops, diluted in the bottle of scaler irrigation water. The extract of spilanthes has antiseptic activity (due among others to bactericidal and fungicidal phytosterols) and analgesic. Grapefruit seed extract is rich in vitamins, it concentrates a large amount of polyphenols with strong antioxidant activities and natural antibiotics. By alkalinizing the fluids, this extract plays a buffer role on the pH. It also has anti-inflammatory effects. EXAMPLE 3: a toothpaste containing propolis (1%), aloe vera (2%), calcium gluconate (less than 0.5%), zinc gluconate (less than 0.5%) and megamine (0.5%). The rest of the preparation is conventionally compounded with silica (22%), glycerol (10%), sorbitol (20%), water (38%) and flavorings (6%). Aloe vera is recommended in herbal medicine in application on ulcers and canker sores. This extract is known for its antiseptic, analgesic and anti-inflammatory effects. Calcium gluconate allows a local supply of potentially remineralising calcium ions on dental surfaces. Zinc gluconate offers a significant contribution of zinc ion, essential for the proper functioning of cellular metabolism and the immune system. It is thus recognized antioxidant and anti-inflammatory properties. EXAMPLE 4: lozenges consisting of non-cariogenic cooked sugar (88%), green tea extract (5%), grapefruit seed (5%) and propolis (2%). Green tea extracts provide a large amount of polyphenols, particularly epigallocatechin gallate (EGCG), with potent antioxidant and anti-inflammatory effects. These pellets may be combined with the toothpaste of Example 3 to effect a cure of the oropharyngeal sphere, in particular to rebalance the gingivo-mucous terrain. EXAMPLE 5: skin cream for application on irritations and hemorrhoids made from extracts of green tea (5%), Schussler salts (2%), aloe vera (4%), argan oil (3%) and hemp oil (3%). The rest of the cream serves as a carrier and is conventionally composed of stearic acid, cetyl palmitate, paraffin, propylene glycol, sodium alginate, potassium sorbate and purified water. Schussler salts are a set of 12 inorganic salts demonstrated by Dr. Schussler (1821-1898) in blood and human cells, and whose presence is necessary for proper cell function. Argan and hemp oils are natural oils well known in dermatology for their nourishing and soothing properties. The compositions presented as examples are illustrative only, and do not limit the more general scope of the invention.
Claims (3)
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| FR0803365A FR2932386B1 (en) | 2008-06-17 | 2008-06-17 | COMPOSITION COMPRISING ORIGINAL NATURAL EXTRACTS FOR ORAL OR MUCOSAL APPLICATION |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2808009A1 (en) * | 2013-05-28 | 2014-12-03 | Vitalgaia SAS | Toothpaste comprising propolis extract |
| WO2015158555A1 (en) | 2014-04-17 | 2015-10-22 | Unilever N.V. | Aloe vera extract for personal care compositions |
| ES2578057R1 (en) * | 2013-05-28 | 2016-09-27 | Vitalgaia España, S.L. | TOOTHPASTE THAT INCLUDES PROPOLIS EXTRACT |
| US10456353B2 (en) | 2014-04-17 | 2019-10-29 | Conopco, Inc. | Personal care compositions |
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| FR2618670A1 (en) * | 1987-07-28 | 1989-02-03 | Philip Gerard | Medicinal preparation based on essential oils, as well as toothpaste and chewing gum containing it |
| EP0870507A1 (en) * | 1997-04-02 | 1998-10-14 | Farmo-Nat Ltd. | Synergistic herbal extracts |
| JP2003095905A (en) * | 2001-09-27 | 2003-04-03 | Nagase & Co Ltd | Deodorant for oral cavity |
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| FR2618670A1 (en) * | 1987-07-28 | 1989-02-03 | Philip Gerard | Medicinal preparation based on essential oils, as well as toothpaste and chewing gum containing it |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2808009A1 (en) * | 2013-05-28 | 2014-12-03 | Vitalgaia SAS | Toothpaste comprising propolis extract |
| ES2578057R1 (en) * | 2013-05-28 | 2016-09-27 | Vitalgaia España, S.L. | TOOTHPASTE THAT INCLUDES PROPOLIS EXTRACT |
| WO2015158555A1 (en) | 2014-04-17 | 2015-10-22 | Unilever N.V. | Aloe vera extract for personal care compositions |
| US10449143B2 (en) | 2014-04-17 | 2019-10-22 | Conopco, Inc. | Aloe vera extract for personal care compositions |
| US10456353B2 (en) | 2014-04-17 | 2019-10-29 | Conopco, Inc. | Personal care compositions |
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| FR2932386B1 (en) | 2016-02-19 |
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