FR2930890B1 - NOVEL TARGETED RADIOTHERAPY AGENTS OR CURIETHERAPY AGENTS BASED ON RARE EARTH OXIDES OR OXO HYDROXIDES - Google Patents

NOVEL TARGETED RADIOTHERAPY AGENTS OR CURIETHERAPY AGENTS BASED ON RARE EARTH OXIDES OR OXO HYDROXIDES

Info

Publication number
FR2930890B1
FR2930890B1 FR0853001A FR0853001A FR2930890B1 FR 2930890 B1 FR2930890 B1 FR 2930890B1 FR 0853001 A FR0853001 A FR 0853001A FR 0853001 A FR0853001 A FR 0853001A FR 2930890 B1 FR2930890 B1 FR 2930890B1
Authority
FR
France
Prior art keywords
agents
curietherapy
rare earth
earth oxides
novel targeted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
FR0853001A
Other languages
French (fr)
Other versions
FR2930890A1 (en
Inventor
Claire Billotey
Olivier Tillement
Pascal Perriat
Stephane Roux
Marc Janier
Brice Mutelet
Jacqueline Taleb
Cedric Louis
Luca Maciocco
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ADVANCED ACCELERATOR APPLICATIONS
Centre National de la Recherche Scientifique CNRS
Universite Claude Bernard Lyon 1 UCBL
Hospices Civils de Lyon HCL
NANOH
Advanced Accelerator Applications SA
Original Assignee
ADVANCED ACCELERATOR APPLICATIONS
Centre National de la Recherche Scientifique CNRS
Universite Claude Bernard Lyon 1 UCBL
Hospices Civils de Lyon HCL
NANOH
Advanced Accelerator Applications SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ADVANCED ACCELERATOR APPLICATIONS, Centre National de la Recherche Scientifique CNRS, Universite Claude Bernard Lyon 1 UCBL, Hospices Civils de Lyon HCL, NANOH, Advanced Accelerator Applications SA filed Critical ADVANCED ACCELERATOR APPLICATIONS
Priority to FR0853001A priority Critical patent/FR2930890B1/en
Publication of FR2930890A1 publication Critical patent/FR2930890A1/en
Application granted granted Critical
Publication of FR2930890B1 publication Critical patent/FR2930890B1/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/103—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being acyclic, e.g. DTPA
    • A61K49/105—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being acyclic, e.g. DTPA the metal complex being Gd-DTPA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1818—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
    • A61K49/1821—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles
    • A61K49/1824—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles
    • A61K49/1827—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle
    • A61K49/183—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle having a (super)(para)magnetic core coated or functionalised with an inorganic material or being composed of an inorganic material entrapping the MRI-active nucleus, e.g. silica core doped with a MRI-active nucleus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A61K51/1217—Dispersions, suspensions, colloids, emulsions, e.g. perfluorinated emulsion, sols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A61K51/1241—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules particles, powders, lyophilizates, adsorbates, e.g. polymers or resins for adsorption or ion-exchange resins
    • A61K51/1255—Granulates, agglomerates, microspheres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01F—COMPOUNDS OF THE METALS BERYLLIUM, MAGNESIUM, ALUMINIUM, CALCIUM, STRONTIUM, BARIUM, RADIUM, THORIUM, OR OF THE RARE-EARTH METALS
    • C01F17/00—Compounds of rare earth metals
    • C01F17/20—Compounds containing only rare earth metals as the metal element
    • C01F17/206—Compounds containing only rare earth metals as the metal element oxide or hydroxide being the only anion
    • C01F17/224—Oxides or hydroxides of lanthanides
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01F—COMPOUNDS OF THE METALS BERYLLIUM, MAGNESIUM, ALUMINIUM, CALCIUM, STRONTIUM, BARIUM, RADIUM, THORIUM, OR OF THE RARE-EARTH METALS
    • C01F17/00—Compounds of rare earth metals
    • C01F17/20—Compounds containing only rare earth metals as the metal element
    • C01F17/206—Compounds containing only rare earth metals as the metal element oxide or hydroxide being the only anion
    • C01F17/241—Compounds containing only rare earth metals as the metal element oxide or hydroxide being the only anion containing two or more rare earth metals, e.g. NdPrO3 or LaNdPrO3
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
    • C01P2004/00—Particle morphology
    • C01P2004/01—Particle morphology depicted by an image
    • C01P2004/03—Particle morphology depicted by an image obtained by SEM
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
    • C01P2004/00—Particle morphology
    • C01P2004/60—Particles characterised by their size
    • C01P2004/62—Submicrometer sized, i.e. from 0.1-1 micrometer
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
    • C01P2004/00—Particle morphology
    • C01P2004/60—Particles characterised by their size
    • C01P2004/64—Nanometer sized, i.e. from 1-100 nanometer
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
    • C01P2006/00—Physical properties of inorganic compounds
    • C01P2006/44—Alpha, beta or gamma radiation related properties

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nanotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Geology (AREA)
  • Inorganic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Radiology & Medical Imaging (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Rheumatology (AREA)
  • Composite Materials (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • General Physics & Mathematics (AREA)
  • Materials Engineering (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
FR0853001A 2008-05-06 2008-05-06 NOVEL TARGETED RADIOTHERAPY AGENTS OR CURIETHERAPY AGENTS BASED ON RARE EARTH OXIDES OR OXO HYDROXIDES Active FR2930890B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR0853001A FR2930890B1 (en) 2008-05-06 2008-05-06 NOVEL TARGETED RADIOTHERAPY AGENTS OR CURIETHERAPY AGENTS BASED ON RARE EARTH OXIDES OR OXO HYDROXIDES

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0853001A FR2930890B1 (en) 2008-05-06 2008-05-06 NOVEL TARGETED RADIOTHERAPY AGENTS OR CURIETHERAPY AGENTS BASED ON RARE EARTH OXIDES OR OXO HYDROXIDES

Publications (2)

Publication Number Publication Date
FR2930890A1 FR2930890A1 (en) 2009-11-13
FR2930890B1 true FR2930890B1 (en) 2010-12-10

Family

ID=39800660

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0853001A Active FR2930890B1 (en) 2008-05-06 2008-05-06 NOVEL TARGETED RADIOTHERAPY AGENTS OR CURIETHERAPY AGENTS BASED ON RARE EARTH OXIDES OR OXO HYDROXIDES

Country Status (1)

Country Link
FR (1) FR2930890B1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2959502B1 (en) 2010-04-30 2012-09-07 Nanoh ULTRAFINE NANOPARTICLES WITH FUNCTIONALIZED POLYORGANOSILOXANE MATRIX AND INCLUDING METAL COMPLEXES; PROCESS FOR OBTAINING THEM AND THEIR APPLICATIONS IN MEDICAL IMAGING AND / OR THERAPY
JP2022536748A (en) 2019-06-14 2022-08-18 アドヴァンスド・アクセラレーター・アプリケーションズ Method for treating cancer by intratumoral deposition of radioactive fine particles

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR0170811B1 (en) * 1995-03-07 1999-03-20 신재인 Radioactive patch/film and the manufacturing process thereof
WO2001034196A2 (en) * 1999-11-09 2001-05-17 Forschungszentrum Karlsruhe Gmbh Mixture containing rare earths and use thereof
FR2867180B1 (en) * 2004-03-02 2006-06-16 Univ Claude Bernard Lyon HYBRID NANOPARTICLES COMPRISING A HEART OF LN203 CARRIERS OF BIOLOGICAL LIGANDS AND PROCESS FOR THEIR PREPARATION
US20060014938A1 (en) * 2004-07-14 2006-01-19 Groman Ernest V Stable aqueous colloidal lanthanide oxides
US20070009436A1 (en) * 2005-07-08 2007-01-11 Rondinone Adam J Radionuclide nanoparticles encased by inorganic shell having vector biomolecules attached thereto

Also Published As

Publication number Publication date
FR2930890A1 (en) 2009-11-13

Similar Documents

Publication Publication Date Title
IT1392499B1 (en) IMPACT DETECTION DEVICE.
SE0400425L (en) Authorization procedure
BR112012004414A2 (en) "belt drive system"
DK1755713T3 (en) injecting
BRPI0820512A2 (en) "improved plastic platform"
DE602005024904D1 (en) Permanent magnet motor
BRPI0911743A2 (en) "peptide"
CR10409A (en) SPIROCYCLIC NITRILES AS PROTEASE INHIBITORS
DE602005003882D1 (en) Aspartic ester functional compounds
DE602006006605D1 (en) Injection line
FR2933861B3 (en) IMPROVED MANDIBULATED ADVANCE DEVICE
FR2937555B1 (en) INJECTION NEEDLE
BRPI0909895A2 (en) "initiator system and hardening composition"
DE602004005127D1 (en) Common rail injection device
FR2930890B1 (en) NOVEL TARGETED RADIOTHERAPY AGENTS OR CURIETHERAPY AGENTS BASED ON RARE EARTH OXIDES OR OXO HYDROXIDES
BRPI0923161A2 (en) "implantable device"
FR2934328B1 (en) INJECTION VALVE
DE502005007830D1 (en) Common rail injector
DE502005007483D1 (en) injection
FR2936764B1 (en) INTERCIRCULATION HALL
DE502005000548D1 (en) Common rail injector
ES2365717T5 (en) CONJUGATED MENINGOCOCIC VACCINATION.
ITVA20050036A1 (en) MAGNETIC DEVICE FOR FUEL TREATMENT
DE502006000154D1 (en) injection
ITMI20061864A1 (en) MOLECULAR BIORISONANCE DEVICE

Legal Events

Date Code Title Description
CA Change of address
TQ Partial transmission of property
PLFP Fee payment

Year of fee payment: 9

PLFP Fee payment

Year of fee payment: 10

PLFP Fee payment

Year of fee payment: 11

PLFP Fee payment

Year of fee payment: 12

PLFP Fee payment

Year of fee payment: 13

PLFP Fee payment

Year of fee payment: 14

PLFP Fee payment

Year of fee payment: 15

PLFP Fee payment

Year of fee payment: 16