FR2919870B1 - NOVEL 6-TRIAZOLOPYRIDAZINE-SULFANYL BENZOTHIAZOLE AND BENZOTHIAZOLE AND BENZIMIDAZOLE DERIVATIVES, PROCESS, PHARMACEUTICAL COMPOSITIONS, AND NOVEL USE AS CMET INHIBITORS - Google Patents

NOVEL 6-TRIAZOLOPYRIDAZINE-SULFANYL BENZOTHIAZOLE AND BENZOTHIAZOLE AND BENZIMIDAZOLE DERIVATIVES, PROCESS, PHARMACEUTICAL COMPOSITIONS, AND NOVEL USE AS CMET INHIBITORS

Info

Publication number
FR2919870B1
FR2919870B1 FR0705789A FR0705789A FR2919870B1 FR 2919870 B1 FR2919870 B1 FR 2919870B1 FR 0705789 A FR0705789 A FR 0705789A FR 0705789 A FR0705789 A FR 0705789A FR 2919870 B1 FR2919870 B1 FR 2919870B1
Authority
FR
France
Prior art keywords
benzothiazole
novel
triazolopyridazine
pharmaceutical compositions
sulfanyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0705789A
Other languages
French (fr)
Other versions
FR2919870A1 (en
Inventor
Eva Albert
Eric Bacque
Conception Nemecek
Antonio Ugolini
Sylvie Wentzler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Sanofi Aventis France
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis France filed Critical Sanofi Aventis France
Priority to FR0705789A priority Critical patent/FR2919870B1/en
Priority to PA8792501A priority patent/PA8792501A1/en
Priority to MEP-2010-7A priority patent/ME00972B/en
Priority to PL08845285T priority patent/PL2178881T3/en
Priority to AU2008320791A priority patent/AU2008320791B2/en
Priority to NZ583177A priority patent/NZ583177A/en
Priority to EP08845285.9A priority patent/EP2178881B1/en
Priority to CN200880106250.6A priority patent/CN101801973B/en
Priority to SG2012055091A priority patent/SG183077A1/en
Priority to SI200831106T priority patent/SI2178881T1/en
Priority to ES08845285T priority patent/ES2436657T3/en
Priority to CA2884102A priority patent/CA2884102A1/en
Priority to PT08845285T priority patent/PT2178881E/en
Priority to MX2010001593A priority patent/MX2010001593A/en
Priority to KR1020107005087A priority patent/KR101654376B1/en
Priority to DK08845285T priority patent/DK2178881T3/en
Priority to BRPI0815606 priority patent/BRPI0815606A2/en
Priority to EA201070235A priority patent/EA023465B1/en
Priority to JP2010519489A priority patent/JP5694767B2/en
Priority to RSP20130542 priority patent/RS53078B/en
Priority to MX2014000226A priority patent/MX340060B/en
Priority to CA2695628A priority patent/CA2695628C/en
Priority to MYPI2010000582A priority patent/MY152535A/en
Priority to PCT/FR2008/001172 priority patent/WO2009056692A2/en
Priority to UAA201002523A priority patent/UA101328C2/en
Priority to JO2008361A priority patent/JO2935B1/en
Priority to TW97130120A priority patent/TWI429649B/en
Priority to ARP080103452 priority patent/AR068055A1/en
Priority to PE2008001322A priority patent/PE20090900A1/en
Priority to CL2008002351A priority patent/CL2008002351A1/en
Priority to UY31277A priority patent/UY31277A1/en
Publication of FR2919870A1 publication Critical patent/FR2919870A1/en
Priority to TNP2010000026A priority patent/TN2010000026A1/en
Priority to US12/693,736 priority patent/US8546393B2/en
Priority to GT201000023A priority patent/GT201000023A/en
Priority to DO2010000040A priority patent/DOP2010000040A/en
Priority to CO10009506A priority patent/CO6251270A2/en
Priority to CR11252A priority patent/CR11252A/en
Priority to NI201000022A priority patent/NI201000022A/en
Priority to IL20373410A priority patent/IL203734A/en
Priority to ZA2010/00912A priority patent/ZA201000912B/en
Priority to ECSP109944 priority patent/ECSP109944A/en
Priority to HN2010000295A priority patent/HN2010000295A/en
Priority to MA32659A priority patent/MA31685B1/en
Priority to US14/011,110 priority patent/US9115134B2/en
Priority to HRP20131182AT priority patent/HRP20131182T1/en
Priority to CY20131101130T priority patent/CY1114906T1/en
Application granted granted Critical
Publication of FR2919870B1 publication Critical patent/FR2919870B1/en
Priority to PH12014501625A priority patent/PH12014501625A1/en
Priority to US14/731,246 priority patent/US9321777B2/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
FR0705789A 2007-08-09 2007-08-09 NOVEL 6-TRIAZOLOPYRIDAZINE-SULFANYL BENZOTHIAZOLE AND BENZOTHIAZOLE AND BENZIMIDAZOLE DERIVATIVES, PROCESS, PHARMACEUTICAL COMPOSITIONS, AND NOVEL USE AS CMET INHIBITORS Expired - Fee Related FR2919870B1 (en)

Priority Applications (48)

Application Number Priority Date Filing Date Title
FR0705789A FR2919870B1 (en) 2007-08-09 2007-08-09 NOVEL 6-TRIAZOLOPYRIDAZINE-SULFANYL BENZOTHIAZOLE AND BENZOTHIAZOLE AND BENZIMIDAZOLE DERIVATIVES, PROCESS, PHARMACEUTICAL COMPOSITIONS, AND NOVEL USE AS CMET INHIBITORS
PA8792501A PA8792501A1 (en) 2007-08-09 2008-08-05 NEW DERIVATIVES OF 6-TRIAZOLOPIRIDACINA-SULFANIL BENZOTIAZOL AND BENCIMIDAZOL, ITS PREPARATION PROCEDURE, ITS APPLICATION AS MEDICATIONS, PHARMACEUTICAL COMPOSITIONS AND NEW MAIN USE AS MET INHIBITORS.
MEP-2010-7A ME00972B (en) 2007-08-09 2008-08-06 Novel 6-triazolopyridazinesulfanyl benzothiazole and benzimidazole derivatives, method for production thereof and application as medicaments and pharmaceutical compositions and novel use as met inhibitors
PL08845285T PL2178881T3 (en) 2007-08-09 2008-08-06 Novel 6-triazolopyridazinesulfanyl benzothiazole and benzimidazole derivatives, method for production thereof and application as medicaments and pharmaceutical compositions and novel use as met inhibitors
AU2008320791A AU2008320791B2 (en) 2007-08-09 2008-08-06 Novel 6-triazolopyridazinesulfanyl benzothiazole and benzimidazole derivatives, method for production thereof and application as medicaments and pharmaceutical compositions and novel use as MET inhibitors
NZ583177A NZ583177A (en) 2007-08-09 2008-08-06 Novel 6-triazolopyridazinesulfanyl benzothiazole and benzimidazole derivatives, method for production thereof and application as medicaments and pharmaceutical compositions and novel use as met inhibitors
EP08845285.9A EP2178881B1 (en) 2007-08-09 2008-08-06 Novel 6-triazolopyridazinesulfanyl benzothiazole and benzimidazole derivatives, method for production thereof and application as medicaments and pharmaceutical compositions and novel use as met inhibitors
CN200880106250.6A CN101801973B (en) 2007-08-09 2008-08-06 6-triazolopyridazinesulfanyl benzothiazole and benzimidazole derivatives, method for production thereof and application as medicaments and pharmaceutical compositions and use as met inhibitors
SG2012055091A SG183077A1 (en) 2007-08-09 2008-08-06 Novel 6-triazolopyridazinesulfanyl benzothiazole and benzimidazole derivatives, method for production thereof and application as medicaments and pharmaceutical compositions and novel use as met inhibitors
SI200831106T SI2178881T1 (en) 2007-08-09 2008-08-06 Novel 6-triazolopyridazinesulfanyl benzothiazole and benzimidazole derivatives, method for production thereof and application as medicaments and pharmaceutical compositions and novel use as met inhibitors
ES08845285T ES2436657T3 (en) 2007-08-09 2008-08-06 New derivatives of 6-triazolopyridazin-sulfanyl benzothiazole and benzimidazole, its preparation procedure, its application as medicines, pharmaceutical compositions and new use as Met inhibitors
CA2884102A CA2884102A1 (en) 2007-08-09 2008-08-06 Novel 6-triazolopyridazinesulfanyl benzothiazole and benzimidazole derivatives, method for production thereof and application as medicaments and pharmaceutical compositions and novel use as met inhibitors
PT08845285T PT2178881E (en) 2007-08-09 2008-08-06 Novel 6-triazolopyridazinesulfanyl benzothiazole and benzimidazole derivatives, method for production thereof and application as medicaments and pharmaceutical compositions and novel use as met inhibitors
MX2010001593A MX2010001593A (en) 2007-08-09 2008-08-06 Novel 6-triazolopyridazinesulfanyl benzothiazole and benzimidazole derivatives, method for production thereof and application as medicaments and pharmaceutical compositions and novel use as met inhibitors.
KR1020107005087A KR101654376B1 (en) 2007-08-09 2008-08-06 Novel 6-triazolopyridazinesulfanyl benzothiazole and benzimidazole derivatives, method for production thereof and application as medicaments and pharmaceutical compositions and novel use as met inhibitors
DK08845285T DK2178881T3 (en) 2007-08-09 2008-08-06 HIS UNKNOWN 6-TRIAZOLOPYRIDAZINE-SULFANYL-BENZOTHIAZOL AND -BENZIMIDAZOLD DERIVATIVES, PROCEDURES FOR PREPARING THEREOF, USING ITS LIKE PHARMACEUTICALS AND PHARMACEUTICALS AND SAME MEDICINES AND SAME MEDICINALS
BRPI0815606 BRPI0815606A2 (en) 2007-08-09 2008-08-06 6-Triazole PYRIDAZINE - SULFANIL BENZOTIAZOL AND BENZIMIDAZOL DERIVATIVES, THEIR PREPARATION PROCESS, THEIR APPLICATION FOR DRUGS, PHARMACEUTICAL COMPOSITIONS AND USE, IN PARTICULAR AS METHODS OF INHIBITORS.
EA201070235A EA023465B1 (en) 2007-08-09 2008-08-06 Novel 6-triazolopyridazinesulfanyl benzothiazole and benzimidazole derivatives, method for production thereof, application thereof as medicaments, pharmaceutical compositions and novel use as met inhibitors
JP2010519489A JP5694767B2 (en) 2007-08-09 2008-08-06 Novel 6-triazolopyridazine sulfanylbenzothiazole and benzimidazole derivatives, processes for their preparation, application as pharmaceuticals and pharmaceutical compositions and novel use as MET inhibitors
RSP20130542 RS53078B (en) 2007-08-09 2008-08-06 Novel 6-triazolopyridazinesulfanyl benzothiazole and benzimidazole derivatives, method for production thereof and application as medicaments and pharmaceutical compositions and novel use as met inhibitors
MX2014000226A MX340060B (en) 2007-08-09 2008-08-06 Novel 6-triazolopyridazinesulfanyl benzothiazole and benzimidazole derivatives, method for production thereof and application as medicaments and pharmaceutical compositions and novel use as met inhibitors.
CA2695628A CA2695628C (en) 2007-08-09 2008-08-06 Novel 6-triazolopyridazinesulfanyl benzothiazole and benzimidazole derivatives, method for production thereof and application as medicaments and pharmaceutical compositions and novel use as met inhibitors
MYPI2010000582A MY152535A (en) 2007-08-09 2008-08-06 Novel 6-triazolopyridazinesulfanyl benzothiazole and benzimidazole derivatives, method for production thereof and application as medicaments and pharmaceutical compositions and novel use as met inhibitors
PCT/FR2008/001172 WO2009056692A2 (en) 2007-08-09 2008-08-06 Novel 6-triazolopyridazinesulfanyl benzothiazole and benzimidazole derivatives, method for production thereof and application as medicaments and pharmaceutical compositions and novel use as met inhibitors
UAA201002523A UA101328C2 (en) 2007-08-09 2008-08-06 Normal;heading 1;heading 2;heading 3;NOVEL 6-TRIAZOLOPYRIDAZINESULFANYL BENZOTHIAZOLE AND BENZIMIDAZOLE DERIVATIVES, METHOD FOR PRODUCTION THEREOF AND APPLICATION AS MEDICAMENTS AND PHARMACEUTICAL COMPOSITIONS AND NOVEL USE AS MET INHIBITORS
JO2008361A JO2935B1 (en) 2007-08-09 2008-08-07 Novel 6-triazolopyridazine sulphanyl benzothiazole and benzimidazole derivatives, process for preparing same, use thereof as medicaments, pharmaceutical compositions and novel use especially as met inhibitors
TW97130120A TWI429649B (en) 2007-08-09 2008-08-07 Novel 6-triazolopyridazine sulphanyl benzothiazole and benzimidazole derivatives, process for preparing same, use thereof as medicaments, pharmaceutical compositions and novel use especially as met inhibitors
ARP080103452 AR068055A1 (en) 2007-08-09 2008-08-07 DERIVATIVES OF 6-TRIAZOLOPIRIDACINA-SULFANIL BENZOTIAZOL AND BENCIMIDAZOL ITS PREPARATION PROCEDURE ITS APPLICATION AS MEDICINES PHARMACEUTICAL COMPOSITIONS AND ITS MAIN USE AS MET INHIBITORS
PE2008001322A PE20090900A1 (en) 2007-08-09 2008-08-07 6-TRIAZOLOPYRIDACINE-SULFANIL BENZOTIAZOLE AND BENZOTHIAZOLE DERIVATIVES AS INHIBITORS OF THE HEPATOcyte GROWTH FACTOR RECEPTOR (MET), THEIR PREPARATION PROCEDURE AND A PHARMACEUTICAL COMPOSITION CONTAINING THEM
CL2008002351A CL2008002351A1 (en) 2007-08-09 2008-08-08 Compounds derived from 6-triazolopyridazine-sulfanyl benzothiazole and benzimidazole; preparation procedure; intermediate compounds; pharmaceutical composition comprising said compounds; and its use in the treatment of cancer.
UY31277A UY31277A1 (en) 2007-08-09 2008-08-08 NEW DERIVATIVES OF 6-TRIAZOLOPIRIDACINA -SULFANIL BENZOTIAZOL AND BENCIMIDAZOL, ITS PREPARATION PROCEDURE, ITS APPLICATION AS MEDICATIONS, PHARMACEUTICAL COMPOSITIONS AND NEW MAIN USE AS MET INHIBITORS
TNP2010000026A TN2010000026A1 (en) 2007-08-09 2010-01-13 NOVEL 6-TRIAZOLOPYRIDAZINE-SULFANYL BENZOTHIAZOLE AND BENZIMIDAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION, THEIR USE AS MEDICAMENTS, PHARMACEUTICAL COMPOSITIONS AND NOVEL USE, IN PARTICULAR AS MET INHIBITORS
US12/693,736 US8546393B2 (en) 2007-08-09 2010-01-26 6-triazolopyridazine sulfanyl benzothiazole derivatives as MET inhibitors
GT201000023A GT201000023A (en) 2007-08-09 2010-01-28 NEW DERIVATIVES OF 6-TRIALZOLOPIRIDACINA-SULFANIL BENZOTIAZOL AND BENCIMIDAZOL, ITS PREPARATION PROCEDURE, ITS APPLICATION AS MEDICATIONS, PHARMACEUTICAL COMPOSITIONS AND NEW MAIN USE AS MET INHIBITORS.
DO2010000040A DOP2010000040A (en) 2007-08-09 2010-01-28 NEW DERIVATIVES OF 6-TRIAZOLOPIRIDACINA-SULFANIL BENZOTIAZOL AND BENCIMIDAZOL, ITS PREPARATION PROCEDURE, ITS APPLICATION AS MEDICATIONS, PHARMACEUTICAL COMPOSITIONS AND NEW MAIN USE AS MET INHIBITORS
CO10009506A CO6251270A2 (en) 2007-08-09 2010-01-29 NEW DERIVATIVES OF 6-TRIAZOLOPIRIDACINA-SULFANIL BENZOTIAZOL AND BENCIMIDAZOL ITS PREPARATION PROCEDURE ITS APPLICATION AS MEDICINES PHARMACEUTICAL COMPOSITIONS AND NEW USE MAINLY AS MET INHIBITORS
CR11252A CR11252A (en) 2007-08-09 2010-02-03 NEW DERIVATIVES OF 6-TRIAZOLOPIRIDACINA-SULFANIL BENZOTIAZOL AND BENCIMIDAZOL, ITS PREPARATION PROCEDURE, ITS APPLICATION AS MEDICATIONS, PHARMACEUTICAL COMPOSITIONS AND NEW MAIN USE AS MET INHIBITORS
NI201000022A NI201000022A (en) 2007-08-09 2010-02-03 NEW 6-TRIAZOLOPYRIDACINE-SULFANIL BENZOTHIAZOLE AND BENZHIMIDAZOLE DERIVATIVES, THEIR PREPARATION PROCEDURE, THEIR APPLICATION AS MEDICINES, PHARMACEUTICAL COMPOSITIONS AND NEW USE MAINLY AS MET INHIBITORS.
IL20373410A IL203734A (en) 2007-08-09 2010-02-04 6-triazolopyridazinesulfanyl benzothiazole and benzimidazole derivatives, method for production thereof and application as medicaments and pharmaceutical compositions and use as met inhibitors
ZA2010/00912A ZA201000912B (en) 2007-08-09 2010-02-08 Novel 6-triazolopyridazinesulfanyl benzothiazole and benzimidazole derivatives,method for production thereof and application as medicaments and pharmaceutical compositions and novel use as met inhibitors
ECSP109944 ECSP109944A (en) 2007-08-09 2010-02-08 NEW DERIVATIVES OF 6-TRIAZOLOPIRIDACINA-SULFANIL BENZOTIAZOL AND BENCIMIDAZOL, ITS PREPARATION PROCEDURE, ITS APPLICATION AS MEDICATIONS, PHARMACEUTICAL COMPOSITIONS AND NEW MAIN USE AS MET INHIBITORS
HN2010000295A HN2010000295A (en) 2007-08-09 2010-02-08 NEW DERIVATIVES OF 6- TRIAZOLOPIRIDACINA-SULFANIL BENZOTIAZOL AND BENCIMIDAZOL ITS PREPARATION PROCEDURE, ITS APPLICATION AS MEDICATIONS, PHARMACEUTICAL COMPOSITIONS AND NEW MAIN USE AS MET INHIBITORS
MA32659A MA31685B1 (en) 2007-08-09 2010-03-01 NOVEL 6-TRIAZOLOPYRIDAZINE-SULFANYL BENZOTHIAZOLE AND BENZIMIDAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION, THEIR USE AS MEDICAMENTS, PHARMACEUTICAL COMPOSITIONS AND NOVEL USE, IN PARTICULAR AS MET INHIBITORS
US14/011,110 US9115134B2 (en) 2007-08-09 2013-08-27 6-triazolopyridazine sulfanyl benzothiazole derivatives as MET inhibitors
HRP20131182AT HRP20131182T1 (en) 2007-08-09 2013-12-12 Novel 6-triazolopyridazinesulfanyl benzothiazole and benzimidazole derivatives, method for production thereof and application as medicaments and pharmaceutical compositions and novel use as met inhibitors
CY20131101130T CY1114906T1 (en) 2007-08-09 2013-12-13 Novel 6-triazolopyridazine-sulfanyl VENZOTHEIAZOLIS VENZIMIDAZOLIS AND, OR THEIR PREPARATION PROCESS, THE APPLICATION THEREOF AS MEDICAMENTS, PHARMACEUTICAL COMPOSITIONS AND NEW USE AS INHIBITORS OF MAIN MET
PH12014501625A PH12014501625A1 (en) 2007-08-09 2014-07-15 Novel 6-triazolopyridazinesulfanyl benzothiazole and benzimidazole derivatives, method for production thereof and application as medicaments and pharmaceutical compositions and novel use as met inhibitors
US14/731,246 US9321777B2 (en) 2007-08-09 2015-06-04 6-triazolopyridazine sulfanyl benzothiazole derivatives as MET inhibitors

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0705789A FR2919870B1 (en) 2007-08-09 2007-08-09 NOVEL 6-TRIAZOLOPYRIDAZINE-SULFANYL BENZOTHIAZOLE AND BENZOTHIAZOLE AND BENZIMIDAZOLE DERIVATIVES, PROCESS, PHARMACEUTICAL COMPOSITIONS, AND NOVEL USE AS CMET INHIBITORS

Publications (2)

Publication Number Publication Date
FR2919870A1 FR2919870A1 (en) 2009-02-13
FR2919870B1 true FR2919870B1 (en) 2014-05-16

Family

ID=39304792

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0705789A Expired - Fee Related FR2919870B1 (en) 2007-08-09 2007-08-09 NOVEL 6-TRIAZOLOPYRIDAZINE-SULFANYL BENZOTHIAZOLE AND BENZOTHIAZOLE AND BENZIMIDAZOLE DERIVATIVES, PROCESS, PHARMACEUTICAL COMPOSITIONS, AND NOVEL USE AS CMET INHIBITORS

Country Status (3)

Country Link
FR (1) FR2919870B1 (en)
HN (1) HN2010000295A (en)
PH (1) PH12014501625A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010092371A1 (en) 2009-02-10 2010-08-19 Astrazeneca Ab Triazolo [4,3-b] pyridazine derivatives and their uses for prostate cancer

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007064797A2 (en) * 2005-11-30 2007-06-07 Vertex Pharmaceuticals Incorporated Inhibitors of c-met and uses thereof
KR101412675B1 (en) * 2005-12-21 2014-07-03 얀센 파마슈티카 엔.브이. Triazolopyridazines as tyrosine kinase modulators
CA2651979A1 (en) * 2006-05-30 2007-12-06 Pfizer Products Inc. Triazolopyridazine derivatives
PE20080403A1 (en) * 2006-07-14 2008-04-25 Amgen Inc FUSED HETEROCYCLIC DERIVATIVES AND METHODS OF USE

Also Published As

Publication number Publication date
HN2010000295A (en) 2013-04-22
PH12014501625A1 (en) 2016-01-18
FR2919870A1 (en) 2009-02-13

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