FR2912740A1 - Porous macroscopic or microscopic composite, for biomedical use, is obtained by molecular dissolution of substrate contained in polymer matrix - Google Patents

Porous macroscopic or microscopic composite, for biomedical use, is obtained by molecular dissolution of substrate contained in polymer matrix Download PDF

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Publication number
FR2912740A1
FR2912740A1 FR0701214A FR0701214A FR2912740A1 FR 2912740 A1 FR2912740 A1 FR 2912740A1 FR 0701214 A FR0701214 A FR 0701214A FR 0701214 A FR0701214 A FR 0701214A FR 2912740 A1 FR2912740 A1 FR 2912740A1
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polymer matrix
pores
porous
biomedical use
biological
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FR0701214A
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French (fr)
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FR2912740B1 (en
Inventor
Cougoulic Catherine Cadorel
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ETHICAL MEDICAL IMPLANTS, FR
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Cougoulic Catherine Cadorel
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix

Abstract

A new porous macroscopic or microscopic composite (I) for biomedical use is obtained by molecular dissolution of a substrate contained in a synthetic or natural polymer matrix.

Description

- MATERIAU COMPOSITE POREUX A USAGE BIOMEDICAL La présente invention- POROUS COMPOSITE MATERIAL FOR BIOMEDICAL USE The present invention

concerne le dispositif de réalisation d'un composite poreux macroscopique ou microscopique à usage biomédical. Les pores ou porosités peuvent être interconnectés, transversaux ou limités à la surface de contact avec les fluides biologiques. Le matériau poreux est obtenu par dissolution moléculaire d'un substrat biologique de type chlorure de sodium ou autre, contenu dans une matrice polymère synthétique, par exemple du polyetherethercetone ou naturelle comme la cellulose. Les méthodologies de l'obtention d'un tel matériau poreux sont indépendantes, uniques ou concomitants en fonction de la taille des pièces réalisées. La réalisation du mélange composé, précurseur de ce principe d'invention, appelé composite , s'effectue par adjonction à la matrice polymère naturelle ou synthétique ou déjà mélangée d'un soluté ou d'un substrat biologique déshydraté ou cristallisé par exemple du chlorure de sodium , ou tous autres cristaux ou zéolithes mélangés. Les cristaux ou agglomérats de matériau peuvent être de tailles multiples et même poreux. Les proportions de mélange varient entre 0% et 50% afin d'obtenir des pièces suffisamment solides. Ce mélange subit alors un procédé d'injection, de moulage ou d'extrusion pour configurer une forme volumétrique. Cet objet réalisé subit à tout instant de la fabrication un décapage surfacique, chimique ou mécanique ou physique par exemple, un bain de solvant soumis à la vibration ultrasonore. Des trous ou puits peuvent être réalisées par exemple à l'eau sous hyperpression dans les différents axes volumétriques de la pièce afin de favoriser le passage du solvant.  relates to the device for producing a porous macroscopic or microscopic composite for biomedical use. The pores or porosities can be interconnected, transverse or limited to the contact surface with the biological fluids. The porous material is obtained by molecular dissolution of a biological substrate of sodium chloride or other type, contained in a synthetic polymer matrix, for example polyetheretherketone or natural such as cellulose. The methodologies for obtaining such a porous material are independent, unique or concomitant depending on the size of the parts produced. The production of the compound mixture, a precursor of this principle of invention, called composite, is carried out by adding to the natural or synthetic polymer matrix or already mixed a solute or a dehydrated or crystallized biological substrate, for example sodium, or any other crystals or zeolites mixed. The crystals or agglomerates of material can be of multiple sizes and even porous. Mixing proportions vary between 0% and 50% in order to obtain sufficiently solid pieces. This mixture is then subjected to an injection, molding or extrusion process for configuring a volumetric shape. This object produced is subjected at all times to the manufacture of a surface etching, chemical or mechanical or physical for example, a solvent bath subjected to ultrasonic vibration. Holes or wells may be made for example with water under high pressure in the different volumetric axes of the part to promote the passage of the solvent.

L'assemblage de pièces moulées par clipsage, rivetage ou vissage permet de configurer tout type de pièce. Ce type de pièce subit alors une atteinte de dissolution par un fluide solvant ou tout autre soluté biologique ou de traitement permettant de créer les pores dans le matériau par élimination de la charge du mélange ou d'une partie de cette charge. Des solutés biologiques ou de traitement peuvent alors être injectés, absorbés ou adsorbés par ces pores nouvellement formés.  The assembly of molded parts by clipping, riveting or screwing makes it possible to configure any type of part. This type of part is then dissolving by a solvent fluid or other biological solute or treatment to create the pores in the material by removing the load of the mixture or part of this load. Biological solutes or treatment can then be injected, absorbed or adsorbed by these newly formed pores.

Claims (9)

REVENDICATIONS 1- Composite poreux macroscopique ou microscopique à usage biomédical caractérisé en ce que le matériau poreux est obtenu par dissolution moléculaire d'un substrat contenu dans la matrice polymère synthétique ou naturelle.  A porous macroscopic or microscopic composite for biomedical use, characterized in that the porous material is obtained by molecular dissolution of a substrate contained in the synthetic or natural polymer matrix. 2- Dispositif selon revendication 1, caractérisé en ce que les pores ou porosités peuvent être interconnectés, transversaux ou limités à la surface de contacts avec les fluides biologiques.  2- Device according to claim 1, characterized in that the pores or pores may be interconnected, transverse or limited to the surface of contacts with biological fluids. 3- Dispositif selon la revendication 2, caractérisé en ce que les méthodologies pour obtenir un tel matériau poreux sont indépendantes, uniques ou concomitantes en fonction de la taille des pièces à réaliser.  3- Device according to claim 2, characterized in that the methodologies for obtaining such a porous material are independent, unique or concomitant depending on the size of the parts to be produced. 4- Dispositif selon revendication 3, caractérisé en ce que le matériau est réalisé par adjonction à la matrice polymère, naturelle ou synthétique d'un soluté ou substrat biologique déshydraté ou cristallisé ou zéolithique.  4- Device according to claim 3, characterized in that the material is produced by adding to the polymer matrix, natural or synthetic dehydrated or crystallized solute or biological substrate or zeolite. 5- Dispositif selon revendication 4, caractérisé en ce que les cristaux ou aggloméras de matériau peuvent être de taille multiples et même poreux.  5. Device according to claim 4, characterized in that the crystals or material agglomerates can be of multiple size and even porous. 6- Dispositif selon revendication 5, caractérisé en ce que les objets réalisés subissent un décapage surfacique chimique mécanique ou physique.  6. Device according to claim 5, characterized in that the objects produced undergo a mechanical or physical chemical surface etching. 7- Dispositif selon revendication 6, caractérisé en ce que les trous, puits ou pores peuvent être réalisés par un soluté sous hyperpression dans les différents axes volumétriques.  7- Device according to claim 6, characterized in that the holes, wells or pores can be made by a solute under high pressure in the various volumetric axes. 8- Dispositif selon revendication 7, caractérisé en ce que l'ensemble des pièces moulées ou extrudées peuvent être assemblées par clipsage, rivetage ou vissage afin de former des porosités.  8- Device according to claim 7, characterized in that all the molded or extruded parts can be assembled by clipping, riveting or screwing to form porosities. 9-Dispositif selon revendication 8, caractérisé en ce que des solutés biologiques ou de traitement peuvent être injectés ou adsorbés ou absorbés dans les pores.  9-Device according to claim 8, characterized in that biological solutes or treatment may be injected or adsorbed or absorbed in the pores.
FR0701214A 2007-02-21 2007-02-21 POROUS COMPOSITE MATERIAL FOR BIOMEDICAL USE Expired - Fee Related FR2912740B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR0701214A FR2912740B1 (en) 2007-02-21 2007-02-21 POROUS COMPOSITE MATERIAL FOR BIOMEDICAL USE

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0701214A FR2912740B1 (en) 2007-02-21 2007-02-21 POROUS COMPOSITE MATERIAL FOR BIOMEDICAL USE

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FR2912740A1 true FR2912740A1 (en) 2008-08-22
FR2912740B1 FR2912740B1 (en) 2012-02-17

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2504041B1 (en) 2009-11-25 2017-04-12 Difusion Technologies Inc. Post-charging of zeolite doped plastics with antimicrobial metal ions

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20010004713A1 (en) * 1996-01-15 2001-06-21 Anita Lucas Macro-porous composite support for medicinal substance(s) that can be used as a bone reconstitution material and a method of producing it
WO2002008320A1 (en) * 2000-07-21 2002-01-31 Vivoxid Oy Biologically active material
WO2003020191A1 (en) * 2001-09-04 2003-03-13 University Of Iowa Research Foundation Cellulose membranes for biodegradable scaffolds
EP1666129A1 (en) * 2003-08-07 2006-06-07 Asahi Kasei Kabushiki Kaisha Composite porous membrane and process for producing the same

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20010004713A1 (en) * 1996-01-15 2001-06-21 Anita Lucas Macro-porous composite support for medicinal substance(s) that can be used as a bone reconstitution material and a method of producing it
WO2002008320A1 (en) * 2000-07-21 2002-01-31 Vivoxid Oy Biologically active material
WO2003020191A1 (en) * 2001-09-04 2003-03-13 University Of Iowa Research Foundation Cellulose membranes for biodegradable scaffolds
EP1666129A1 (en) * 2003-08-07 2006-06-07 Asahi Kasei Kabushiki Kaisha Composite porous membrane and process for producing the same

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2504041B1 (en) 2009-11-25 2017-04-12 Difusion Technologies Inc. Post-charging of zeolite doped plastics with antimicrobial metal ions

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FR2912740B1 (en) 2012-02-17

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