FR2909383B1 - Nouveaux oligonucleotides et utilisation d'oligonucleotides interagissant avec le gene codant pour la tyrosinase related protein-1 (trp-1) pour en moduler son expression comme agents depigmentants. - Google Patents

Nouveaux oligonucleotides et utilisation d'oligonucleotides interagissant avec le gene codant pour la tyrosinase related protein-1 (trp-1) pour en moduler son expression comme agents depigmentants.

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Publication number
FR2909383B1
FR2909383B1 FR0610590A FR0610590A FR2909383B1 FR 2909383 B1 FR2909383 B1 FR 2909383B1 FR 0610590 A FR0610590 A FR 0610590A FR 0610590 A FR0610590 A FR 0610590A FR 2909383 B1 FR2909383 B1 FR 2909383B1
Authority
FR
France
Prior art keywords
oligonucleotides
trp
modulate
expression
gene encoding
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
FR0610590A
Other languages
English (en)
Other versions
FR2909383A1 (fr
Inventor
Robin Kurfust
Duquennoy Mathilde Bonnet
Kristell Lazou
Carine Giovannangeli
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
L V M H RECH GROUPEMENT D INTE
Centre National de la Recherche Scientifique CNRS
Museum National dHistoire Naturelle
Original Assignee
L V M H RECH GROUPEMENT D INTE
Centre National de la Recherche Scientifique CNRS
Museum National dHistoire Naturelle
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by L V M H RECH GROUPEMENT D INTE, Centre National de la Recherche Scientifique CNRS, Museum National dHistoire Naturelle filed Critical L V M H RECH GROUPEMENT D INTE
Priority to FR0610590A priority Critical patent/FR2909383B1/fr
Priority to JP2009539747A priority patent/JP5599615B2/ja
Priority to PCT/EP2007/063355 priority patent/WO2008068284A1/fr
Priority to KR1020097013196A priority patent/KR20090102764A/ko
Publication of FR2909383A1 publication Critical patent/FR2909383A1/fr
Application granted granted Critical
Publication of FR2909383B1 publication Critical patent/FR2909383B1/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof
    • A61K8/606—Nucleosides; Nucleotides; Nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/16—Emollients or protectives, e.g. against radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q1/00—Make-up preparations; Body powders; Preparations for removing make-up
    • A61Q1/02—Preparations containing skin colorants, e.g. pigments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q1/00—Make-up preparations; Body powders; Preparations for removing make-up
    • A61Q1/12—Face or body powders for grooming, adorning or absorbing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/15—Nucleic acids forming more than 2 strands, e.g. TFOs
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/323—Chemical structure of the sugar modified ring structure
    • C12N2310/3231—Chemical structure of the sugar modified ring structure having an additional ring, e.g. LNA, ENA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/33—Chemical structure of the base
    • C12N2310/334—Modified C
    • C12N2310/3341—5-Methylcytosine

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Dermatology (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Birds (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Toxicology (AREA)
  • Virology (AREA)
  • Cosmetics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
FR0610590A 2006-12-05 2006-12-05 Nouveaux oligonucleotides et utilisation d'oligonucleotides interagissant avec le gene codant pour la tyrosinase related protein-1 (trp-1) pour en moduler son expression comme agents depigmentants. Active FR2909383B1 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
FR0610590A FR2909383B1 (fr) 2006-12-05 2006-12-05 Nouveaux oligonucleotides et utilisation d'oligonucleotides interagissant avec le gene codant pour la tyrosinase related protein-1 (trp-1) pour en moduler son expression comme agents depigmentants.
JP2009539747A JP5599615B2 (ja) 2006-12-05 2007-12-05 チロシナーゼ関連タンパク質−１（ｔｒｐ−１）をコードする遺伝子と相互作用してその発現を調節する新規オリゴヌクレオチド、および該オリゴヌクレオチドの脱色素剤としての使用
PCT/EP2007/063355 WO2008068284A1 (fr) 2006-12-05 2007-12-05 Nouveaux oligonucléotides et utilisation d'oligonucléotides interagissant avec le gène codant pour la tyrosinase related protein-1 (trp-1) pour en moduler son expression comme agents dépigmentants
KR1020097013196A KR20090102764A (ko) 2006-12-05 2007-12-05 티로시나아제-관련 단백질-1(ｔｒｐ-1)을 코딩하는 유전자와 상호작용하는 신규한 올리고뉴클레오타이드 및 이 유전자의 탈색제로서 이의 발현을 조절하기 위한 용도

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0610590A FR2909383B1 (fr) 2006-12-05 2006-12-05 Nouveaux oligonucleotides et utilisation d'oligonucleotides interagissant avec le gene codant pour la tyrosinase related protein-1 (trp-1) pour en moduler son expression comme agents depigmentants.

Publications (2)

Publication Number Publication Date
FR2909383A1 FR2909383A1 (fr) 2008-06-06
FR2909383B1 true FR2909383B1 (fr) 2009-04-17

Family

ID=38198194

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0610590A Active FR2909383B1 (fr) 2006-12-05 2006-12-05 Nouveaux oligonucleotides et utilisation d'oligonucleotides interagissant avec le gene codant pour la tyrosinase related protein-1 (trp-1) pour en moduler son expression comme agents depigmentants.

Country Status (4)

Country Link
JP (1) JP5599615B2 (fr)
KR (1) KR20090102764A (fr)
FR (1) FR2909383B1 (fr)
WO (1) WO2008068284A1 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2274423A2 (fr) 2008-04-04 2011-01-19 Isis Pharmaceuticals, Inc. Composés oligomères comprenant des nucléosides bicycliques et ayant une toxicité réduite
FR2962902B1 (fr) * 2010-07-21 2013-03-29 Lvmh Rech Utilisation cosmetique d'une eau de source et compositions cosmetiques ou dermatologiques la contenant
KR20190011181A (ko) * 2017-07-24 2019-02-01 올리패스 주식회사 티로시나아제 안티센스 올리고뉴클레오티드

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2804960B1 (fr) * 2000-02-11 2005-06-24 Lvmh Rech Nouveaux oligonucleotides et utilisation d'oligonucleotides modulant l'expression de la tyrosinase et de la tyrosinase- related-protein 1 comme agents depigmentants
FR2864540B1 (fr) * 2005-02-22 2010-10-22 Lvmh Rech Nouveaux oligonucleotides et utilisation d'oligonucleotides modulant l'expression de la tyrosinase et de la tyrosinase-related-protein 1 comme agents depigmentants

Also Published As

Publication number Publication date
WO2008068284A1 (fr) 2008-06-12
FR2909383A1 (fr) 2008-06-06
JP2010511398A (ja) 2010-04-15
KR20090102764A (ko) 2009-09-30
JP5599615B2 (ja) 2014-10-01

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