FR2897688B1 - METHOD FOR IMMOBILIZATION OF HYDROGELS ON NON-MODIFIED POLYMERIC MATERIALS, BIOPUCE BASED ON NON-MODIFIED POLYMERIC MATERIALS AND METHOD OF MANUFACTURING THE SAME - Google Patents

METHOD FOR IMMOBILIZATION OF HYDROGELS ON NON-MODIFIED POLYMERIC MATERIALS, BIOPUCE BASED ON NON-MODIFIED POLYMERIC MATERIALS AND METHOD OF MANUFACTURING THE SAME

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Publication number
FR2897688B1
FR2897688B1 FR0753405A FR0753405A FR2897688B1 FR 2897688 B1 FR2897688 B1 FR 2897688B1 FR 0753405 A FR0753405 A FR 0753405A FR 0753405 A FR0753405 A FR 0753405A FR 2897688 B1 FR2897688 B1 FR 2897688B1
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FR
France
Prior art keywords
polymeric materials
modified polymeric
biopuce
hydrogels
immobilization
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0753405A
Other languages
French (fr)
Other versions
FR2897688A1 (en
Inventor
Alexandr Sergeevich Zasedatelev
Sergei Vasilievich Pankov
Eduard Yakovlevich Kreindlin
Olga Georgievna Somova
Olga Vladimirovna Moiseeva
Viktor Evenievich Barsky
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
INST MOLEKULYARNOI BIOLOG IM V A ENGELGARDTA ROSSIISKOI AKADEMII NAUK
Original Assignee
INST MOLEKULYARNOI BIOLOG IM V A ENGELGARDTA ROSSIISKOI AKADEMII NAUK
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Priority to FR0755783A priority Critical patent/FR2903120B1/en
Publication of FR2897688A1 publication Critical patent/FR2897688A1/en
Application granted granted Critical
Publication of FR2897688B1 publication Critical patent/FR2897688B1/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54353Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals with ligand attached to the carrier via a chemical coupling agent
    • GPHYSICS
    • G01MEASURING; TESTING
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    • B01J19/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B82NANOTECHNOLOGY
    • B82YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00Nanotechnology for materials or surface science, e.g. nanocomposites
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K17/00Carrier-bound or immobilised peptides; Preparation thereof
    • C07K17/02Peptides being immobilised on, or in, an organic carrier
    • C07K17/08Peptides being immobilised on, or in, an organic carrier the carrier being a synthetic polymer
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/02Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
    • C08G63/12Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from polycarboxylic acids and polyhydroxy compounds
    • C08G63/40Polyesters derived from ester-forming derivatives of polycarboxylic acids or of polyhydroxy compounds, other than from esters thereof
    • C08G63/44Polyamides; Polynitriles
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    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
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FR0753405A 2006-02-22 2007-02-21 METHOD FOR IMMOBILIZATION OF HYDROGELS ON NON-MODIFIED POLYMERIC MATERIALS, BIOPUCE BASED ON NON-MODIFIED POLYMERIC MATERIALS AND METHOD OF MANUFACTURING THE SAME Expired - Fee Related FR2897688B1 (en)

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Application Number Priority Date Filing Date Title
FR0755783A FR2903120B1 (en) 2006-02-22 2007-06-15 METHOD FOR IMMOBILIZATION OF HYDROGELS ON NON-MODIFIED POLYMERIC MATERIALS, BIOPUCE BASED ON NON-MODIFIED POLYMERIC MATERIALS AND METHOD OF MANUFACTURING THE SAME

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RU2006105491/04A RU2309959C1 (en) 2006-02-22 2006-02-22 Using unmodified polymeric materials for preparing biochip backing, biochip based on thereof and method for its preparing, method for immobilization of hydrogels on unmodified polymeric materials

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FR2897688A1 FR2897688A1 (en) 2007-08-24
FR2897688B1 true FR2897688B1 (en) 2014-02-07

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FR0755783A Expired - Fee Related FR2903120B1 (en) 2006-02-22 2007-06-15 METHOD FOR IMMOBILIZATION OF HYDROGELS ON NON-MODIFIED POLYMERIC MATERIALS, BIOPUCE BASED ON NON-MODIFIED POLYMERIC MATERIALS AND METHOD OF MANUFACTURING THE SAME

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DE (1) DE102007008499B4 (en)
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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101286149B1 (en) * 2010-10-20 2013-07-15 제일모직주식회사 Glass Fiber Reinforced Polyester Resin Composition With Color Stability at High Temperature
CN106883334B (en) 2012-02-09 2019-06-18 生命技术公司 Hydrophilic polymer particle and preparation method thereof
CN102993741B (en) * 2012-08-23 2015-06-10 广东威林工程塑料有限公司 Cold resistant and high thermal resistance PPA (Phenyl-Propanolamine)/PETG (Polyethylene Terephthalate Glycol) alloy as well as preparation method and application of alloy
CN102993700A (en) * 2012-10-19 2013-03-27 芜湖市鑫海橡塑制品有限责任公司 Polyvinyl chloride modified nylon polyamide 6 (PA6) material for automobile oil pipe and preparation method of polyvinyl chloride modified nylon PA6 material
RU2545334C2 (en) * 2013-06-25 2015-03-27 Международная коммерческая компания "МИРАТОН Интернешнл Корп." Structural sheet from polycarbonate and polyether-based composition
RU2552483C1 (en) * 2014-08-11 2015-06-10 Федеральное Государственное Бюджетное Учреждение Науки Институт Молекулярной Биологии Им. В.А. Энгельгардта Российской Академии Наук (Имб Ран) Method of analysis of somatic mutations in genes egfr, kras and braf using lna-blocking multiplex pcr and subsequent hybridisation with oligonucleotide biological microchip (biochip)
US9868826B2 (en) 2015-07-02 2018-01-16 Life Technologies Corporation Polymer substrates formed from carboxy functional acrylamide
KR102055043B1 (en) * 2017-12-01 2019-12-11 전남대학교산학협력단 A hydrogel film capable of selectively detecting aluminum ions and method of manufacturing the same
RU2749465C1 (en) * 2020-09-28 2021-06-11 Федеральное Государственное Бюджетное Учреждение Науки Институт Молекулярной Биологии Им. В.А. Энгельгардта Российской Академии Наук (Имб Ран) Method for determining genetic markers for assessing polygenic risk of breast cancer (hormone-negative and hormone-positive subtypes)
RU2753002C1 (en) * 2020-09-28 2021-08-11 Федеральное Государственное Бюджетное Учреждение Науки Институт Молекулярной Биологии Им. В.А. Энгельгардта Российской Академии Наук (Имб Ран) Method for determining genetic markers for assessing polygenic risk of developing hormone-positive subtype of breast cancer
CN113980410B (en) * 2021-07-22 2022-10-04 广东金发科技有限公司 Thermoplastic polyolefin material and preparation method and application thereof

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0001223A3 (en) * 1977-09-19 1979-12-12 F.Hoffmann-La Roche & Co. Aktiengesellschaft Latex coated with a polyhydroxy compound, process for the preparation of this latex, immunological reagent containing this latex, process for the preparation of this reagent, application of this reagent, testing procedure utilising this reagent and reagent kit containing this reagent
DE4009186A1 (en) * 1990-03-22 1991-09-26 Miles Inc USE OF POLYMER BLEND FILMS AS A TRAIGER FOR DIAGNOSTIC TEST STRIPS
CA2365780C (en) * 1999-03-05 2012-01-31 Mitsubishi Rayon Co., Ltd. Carriers having biological substance
DE60030978T2 (en) * 1999-07-05 2007-06-14 Novartis Ag METHOD FOR USING A SENSOR UNIT
JP3883539B2 (en) * 2001-09-01 2007-02-21 サムスン エレクトロニクス カンパニー リミテッド Method for producing hydrogel biochip using radial polyethylene glycol derivative having epoxy group
US7368296B2 (en) * 2002-01-17 2008-05-06 Applied Biosystems Solid phases optimized for chemiluminescent detection
CN100412203C (en) * 2002-09-13 2008-08-20 株式会社Lg生命科学 Bio-chip prepared by gelation on a chip substrate
EP2789383B1 (en) * 2004-01-07 2023-05-03 Illumina Cambridge Limited Molecular arrays
DE102004021351A1 (en) * 2004-04-23 2005-11-17 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Functionalized porous carrier for microarrays

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