FR2876250A1 - Dietetic composition, useful to restore the natural cycles of the hormones, comprises phytotherapy products, fatty acids, amino acids, vitamins, oligo-elements and vegetable 5-hydroxytryptophan - Google Patents

Dietetic composition, useful to restore the natural cycles of the hormones, comprises phytotherapy products, fatty acids, amino acids, vitamins, oligo-elements and vegetable 5-hydroxytryptophan Download PDF

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Publication number
FR2876250A1
FR2876250A1 FR0410730A FR0410730A FR2876250A1 FR 2876250 A1 FR2876250 A1 FR 2876250A1 FR 0410730 A FR0410730 A FR 0410730A FR 0410730 A FR0410730 A FR 0410730A FR 2876250 A1 FR2876250 A1 FR 2876250A1
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vitamins
restore
hydroxytryptophan
oligo
vegetable
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FR0410730A
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French (fr)
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FR2876250B1 (en
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Veronique Marie-Pier Peyrusson
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International Nutrition Research Co SRL
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Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/175—Amino acids
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/115—Fatty acids or derivatives thereof; Fats or oils
    • A23L33/12—Fatty acids or derivatives thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15—Vitamins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/16—Inorganic salts, minerals or trace elements
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Abstract

Dietetic composition (I) comprises phytotherapy products, fatty acids, amino acids, vitamins, oligo-elements and/or vegetable 5-hydroxytryptophan to the daily dose of 150-600mg.

Description

3 28762503 2876250

La présente invention concerne un composé diététique qui agit pour restaurer les cycles naturels des hormones contrôlant les fluctuations du poids Le contrôle de la satiété dans l'organisme est réalisé au niveau cérébral par une hormone appelée sérotonine; la synthèse de la sérotonine se réalise à partir du TRYPTOPHANE en passant par le 5HTP. Le tryptophane est un acide aminé qui se trouve en petite quantité dans la nourriture et dont l'utilisation pose des problèmes: au niveau de la pénétration de la barrière intestinale car il se lie à de grosses molécules et dès qu'il existe un problème intestinal ce produit n'est plus absorbé ; il existe en très petite quantité sous forme circulante qui ne soit pas lié à l'albumine, or le seule forme libre pénètre la barrière encéphalique si le rapport du tryptophane sur acides aminés neutres (leucine, isoleucine, valine, tyrosine, phénylalanine) est supérieur à 6, de plus pour réaliser la synthèse il est nécessaire la 20 présence de magnésium et de vitamine B6.  The present invention relates to a dietary compound that acts to restore the natural cycles of hormones controlling weight fluctuations. Control of satiety in the body is achieved at the brain level by a hormone called serotonin; the synthesis of serotonin is carried out from TRYPTOPHANE via 5HTP. Tryptophan is an amino acid that is found in small amounts in food and whose use causes problems: at the level of the penetration of the intestinal barrier because it binds to large molecules and as soon as there is a problem intestinal this product is no longer absorbed; it exists in a very small quantity in circulating form which is not bound to albumin, and the only free form penetrates the brain barrier if the ratio of tryptophan to neutral amino acids (leucine, isoleucine, valine, tyrosine, phenylalanine) is higher at 6, moreover to carry out synthesis it is necessary the presence of magnesium and vitamin B6.

l'utilisation de tryptophane synthétique ou de 5HTP se heurte à une activité fugace et demandant de fortes doses qui deviennent sérotoninonergiques avec des effets secondaires qui vont jusqu'à la confusion mentale.  the use of synthetic tryptophan or 5HTP encounters a fugitive activity and requiring high doses that become serotoninergic with side effects that go as far as mental confusion.

Le contrôle de l'appétit se réalise par la sécrétion de l'adiponectine, hormone secrétée par les tissus adipeux et par les secrétions d'insuline.  Appetite control is achieved by the secretion of adiponectin, a hormone secreted by adipose tissue and insulin secretions.

Le contrôle du poids sur le long terme se fait par la leptine qui répartit aussi les localisations des graisses et en particulier le gras viscéral-abdominal qui est le sécréteur des adipokines inflammatoires IL6 et TNF alpha. Ces adipokines inflammatoires contrarient par divers mécanismes les actions des hormones régulatrices en particulier insuline, adiponectine et sérotonine.  Long-term weight control is achieved by leptin, which also distributes fat deposits, particularly visceral-abdominal fat, which secretes IL6 and TNF alpha inflammatory adipokines. These inflammatory adipokines antagonize by various mechanisms the actions of regulatory hormones, in particular insulin, adiponectin and serotonin.

Depuis peu de temps, il a été constaté dans des études épidémiologiques que les obèses manquaient de tryptophane circulant et que la perte de poids ne rétablissait pas les taux à la normale; les auteurs n'ont pas donné d'explication à ce phénomène D'autre part les obèses souffrent d'inflammation 40 chronique due à la sécrétion des adipokines par les tissus adipeux viscéraux En particulier cette inflammation empêche le passage du tryptophane à travers la barrière intestinale et consomme le tryptophane circulant.  Recently, it has been found in epidemiological studies that obese patients lack circulating tryptophan and that weight loss does not restore normal levels; the authors have not given an explanation for this phenomenon On the other hand obese suffer chronic inflammation 40 due to the secretion of adipokines by visceral adipose tissue In particular this inflammation prevents the passage of tryptophan through the intestinal barrier and consume the circulating tryptophan.

L'invention est la mise au point d'un produit diététique qui résout plusieurs problèmes simultanés pour rétablir les cycles naturels de régulation du poids en apportant: - De la sérotonine qui soit utilisable immédiatement par du 5HTP végétal dans des proportions de 150 à 600 mg par jour et du tryptophane de lactosérum ou d'alphalactabumine qui soit mieux assimilé dès que l'inflammation régresse dans des proportions de 2 à 3 g/ jour, - Du magnésium de 300 à 900 mg/jour et de la vitamine B6 de 3 à 15 mg/jour pour la synthèse de la sérotonine - De l'histidine pour combattre la production de cytokines avec un apport de 2 à 3g/jour et de l'omega3 de 150 à 300 mg /jour, - Des principes actifs de phytothérapie pour combattre l'inflammation centrale comme l'extrait de saule ou de curcumine de 150 à 600 mg/jour; ils agissent aux niveau de l'inhibition des prostaglandines inflammatoires et les extraits de curcumine spécifiquement sur les TNFalpha - Des principes actifs de phytothérapie dont le principal composant est l'anéthol ( anis, fenouil, badiane) de 300 à 600mg/jour pour agir au niveau des inflammation en particulier intestinales,  The invention is the development of a dietary product that solves several simultaneous problems to restore natural cycles of weight regulation by providing: - Serotonin that is immediately usable by plant 5HTP in proportions of 150 to 600 mg per day and tryptophan of whey or alphalactabumin that is better assimilated as soon as the inflammation regresses in proportions of 2 to 3 g / day, - Magnesium of 300 to 900 mg / day and vitamin B6 of 3 to 15 mg / day for the synthesis of serotonin - Histidine to fight the production of cytokines with an intake of 2 to 3g / day and omega3 of 150 to 300 mg / day, - Active principles of herbal medicine for fight central inflammation such as willow extract or curcumin from 150 to 600 mg / day; they act at the level of inhibition of inflammatory prostaglandins and extracts of curcumin specifically on TNFalpha - Active principles of herbal medicine whose main component is anethole (anise, fennel, star anise) from 300 to 600mg / day to act on level of inflammation especially intestinal,

Claims (1)

2876250 REVENDICATIONS2876250 Claims 1 Composé diététique comprenant un mélange de produits de phytothérapie, d'acides gras, d'acides aminés, de vitamines, d'oligo-éléments et caractérisé en ce qu'il comprend du 5 HTP végétal à la dose journalière de 150 à 600mg, 2 Composé diététique dans la revendication caractérisé en ce qu'il comprend en plus de l'oméga3 à la dose journalière de 150 à 300 mg, des extraits de curcumine et /ou des extraits de saule à la dose journalière de 150 à 600 mg, 3 Composé diététique dans la revendication 2 caractérisé en ce qu'il comprend en plus du tryptophane et de l'histidine à la dose journalière respective de 2 à 3 g 4 Composé diététique dans la revendication 3 caractérisé en ce qu'il comprend des extraits d'anéthol sous forme d'extrait de fenouil, anis ou badiane à la dose journalière de 300 à 600 mg, Composé diététique dans la revendication 4 caractérisé en ce qu'il comprend du magnésium et de la vitamine B6 à la dose journalière respective de 300 à 900 mg et de 3 à 15 mg.  A dietetic compound comprising a mixture of phytotherapy products, fatty acids, amino acids, vitamins, trace elements and characterized in that it comprises 5 plant HTP at the daily dose of 150 to 600 mg, 2 dietary compound in the claim characterized in that it comprises in addition to omega3 at the daily dose of 150 to 300 mg, extracts of curcumin and / or willow extracts at the daily dose of 150 to 600 mg, 3 dietary compound in claim 2 characterized in that it comprises in addition to tryptophan and histidine at the daily dose of 2 to 3 g respectively 4 dietary compound in claim 3 characterized in that it comprises extracts of anethole in the form of an extract of fennel, anise or star anise at a daily dose of 300 to 600 mg, dietary compound in claim 4 characterized in that it comprises magnesium and vitamin B6 at the daily dose of 300 to 900 mg and 3 to 15 mg.
FR0410730A 2004-10-12 2004-10-12 DIETETIC COMPOUND TO PROVIDE WEATHER SATETE AND REGULATION Active FR2876250B1 (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3009013A1 (en) * 2014-09-16 2016-04-20 ALFA WASSERMANN S.p.A. Therapeutic and nutritional compositions for functional gastrointestinal disorders

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999042094A1 (en) * 1995-08-24 1999-08-26 Heng Madalene C Y Use of curcumin in treatment of psoriasis, inflammation, skin wounds, burns, and eczemas
WO2002011562A2 (en) * 2000-08-08 2002-02-14 Advanced Functional Foods International, Inc. Nutritional supplement for the management of weight

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999042094A1 (en) * 1995-08-24 1999-08-26 Heng Madalene C Y Use of curcumin in treatment of psoriasis, inflammation, skin wounds, burns, and eczemas
WO2002011562A2 (en) * 2000-08-08 2002-02-14 Advanced Functional Foods International, Inc. Nutritional supplement for the management of weight

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
ALBERT-PULEO M: "FENNEL AND ANISE AS ESTROGENIC AGENTS", JOURNAL OF ETHNOPHARMACOLOGY, vol. 2, no. 4, 1980, pages 337 - 344, XP009087407, ISSN: 0378-8741 *
ANONYMOUS: "Fennel", INTERNET ARTICLE, XP002444664, Retrieved from the Internet <URL:http://www.ienica.net/crops/fennel.pdf> [retrieved on 20070726] *
ANONYMOUS: "Prairie Willow", PLANT GUIDE, XP002444662, Retrieved from the Internet <URL:http://plants.usda.gov/plantguide/pdf/cs_sahu2.pdf> [retrieved on 20070726] *
BLOK, W.. ET AL.: "Modulation of inflammation and cytokine production by dietary (n-3) fatty acids", JOURNAL OF NUTRITION, vol. 126, no. 6, 1996, pages 1515 - 1533, XP002444661 *
CANGIANO, C. ET AL.: "Eating behaviour and adherence to dietary prescriptions in obese adult subjects treated with 5-hydroxytryptophan", AMERICAN JOURNAL OF CLINICAL NUTRITION, vol. 56, 1992, pages 863 - 867, XP002444660 *
ORTHEN-GAMBILL, N.: "Antihistaminic drugs increase feeding, while histidine suppresses feeding in rats", PHARMACOLOGY BIOCHEMISTRY BEHAVIOR, vol. 31, 1988, pages 81 - 86, XP002444663 *
SHILS, M.E., OLSON, J.A. ET AL.: "Nutrition in health and disease. Vitamin B6, by Leklem, J.E., pp. 413-421", 1999, WILLIAMS AND WILKINS, BALTIMORE, XP001536620 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3009013A1 (en) * 2014-09-16 2016-04-20 ALFA WASSERMANN S.p.A. Therapeutic and nutritional compositions for functional gastrointestinal disorders

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