FR2872158B1 - NOVEL DIAZENIUMDIOLATE COMPOUNDS, PROCESS FOR THEIR PREPARATION AND THEIR THERAPEUTIC USE - Google Patents

NOVEL DIAZENIUMDIOLATE COMPOUNDS, PROCESS FOR THEIR PREPARATION AND THEIR THERAPEUTIC USE

Info

Publication number
FR2872158B1
FR2872158B1 FR0407075A FR0407075A FR2872158B1 FR 2872158 B1 FR2872158 B1 FR 2872158B1 FR 0407075 A FR0407075 A FR 0407075A FR 0407075 A FR0407075 A FR 0407075A FR 2872158 B1 FR2872158 B1 FR 2872158B1
Authority
FR
France
Prior art keywords
preparation
therapeutic use
diazeniumdiolate compounds
novel
novel diazeniumdiolate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0407075A
Other languages
French (fr)
Other versions
FR2872158A1 (en
Inventor
Philippe Guedat
Claude Lardy
Jean Yves Nioche
Dangremont Valerie Guyard
Stephane Yvon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sante SAS
Original Assignee
Merck Sante SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sante SAS filed Critical Merck Sante SAS
Priority to FR0407075A priority Critical patent/FR2872158B1/en
Priority to PCT/EP2005/006080 priority patent/WO2006000294A1/en
Priority to ARP050102599A priority patent/AR049451A1/en
Publication of FR2872158A1 publication Critical patent/FR2872158A1/en
Application granted granted Critical
Publication of FR2872158B1 publication Critical patent/FR2872158B1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C291/00—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00
    • C07C291/02—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00 containing nitrogen-oxide bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C239/00—Compounds containing nitrogen-to-halogen bonds; Hydroxylamino compounds or ethers or esters thereof
    • C07C239/08—Hydroxylamino compounds or their ethers or esters
    • C07C239/12—Hydroxylamino compounds or their ethers or esters having nitrogen atoms of hydroxylamino groups further bound to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C239/00—Compounds containing nitrogen-to-halogen bonds; Hydroxylamino compounds or ethers or esters thereof
    • C07C239/08—Hydroxylamino compounds or their ethers or esters
    • C07C239/16—Hydroxylamino compounds or their ethers or esters having nitrogen atoms of hydroxylamino groups further bound to carbon atoms of hydrocarbon radicals substituted by nitrogen atoms not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/46—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having at least one of the nitrogen atoms, not being part of nitro or nitroso groups, further bound to other hetero atoms
    • C07C323/48—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having at least one of the nitrogen atoms, not being part of nitro or nitroso groups, further bound to other hetero atoms to nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/58—Radicals substituted by nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Vascular Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FR0407075A 2004-06-28 2004-06-28 NOVEL DIAZENIUMDIOLATE COMPOUNDS, PROCESS FOR THEIR PREPARATION AND THEIR THERAPEUTIC USE Expired - Fee Related FR2872158B1 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
FR0407075A FR2872158B1 (en) 2004-06-28 2004-06-28 NOVEL DIAZENIUMDIOLATE COMPOUNDS, PROCESS FOR THEIR PREPARATION AND THEIR THERAPEUTIC USE
PCT/EP2005/006080 WO2006000294A1 (en) 2004-06-28 2005-06-07 Novel diazeniumdiolate compounds, process for the preparation thereof, and therapeutic use thereof
ARP050102599A AR049451A1 (en) 2004-06-28 2005-06-24 DIAZENIO DIOLATE COMPOUNDS, PROCEDURE FOR PREPARATION AND THERAPEUTIC USE.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0407075A FR2872158B1 (en) 2004-06-28 2004-06-28 NOVEL DIAZENIUMDIOLATE COMPOUNDS, PROCESS FOR THEIR PREPARATION AND THEIR THERAPEUTIC USE

Publications (2)

Publication Number Publication Date
FR2872158A1 FR2872158A1 (en) 2005-12-30
FR2872158B1 true FR2872158B1 (en) 2006-11-03

Family

ID=34948711

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0407075A Expired - Fee Related FR2872158B1 (en) 2004-06-28 2004-06-28 NOVEL DIAZENIUMDIOLATE COMPOUNDS, PROCESS FOR THEIR PREPARATION AND THEIR THERAPEUTIC USE

Country Status (3)

Country Link
AR (1) AR049451A1 (en)
FR (1) FR2872158B1 (en)
WO (1) WO2006000294A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011511079A (en) * 2008-02-08 2011-04-07 メルク・シャープ・エンド・ドーム・コーポレイション Angiotensin II receptor antagonist
EP2725029A1 (en) 2012-10-29 2014-04-30 Laboratoire Biodim New antibacterial compounds and biological applications thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1024743B (en) * 1956-08-25 1958-02-20 Basf Ag Fungicides
US5212204A (en) * 1989-10-18 1993-05-18 The United States Of America As Represented By The Department Of Health And Human Services Antihypertensive compositions and use thereof
AU3969793A (en) * 1992-04-13 1993-11-18 United States Of America, Represented By The Secretary, Department Of Health And Human Services, The Use of nitric oxide/nucleophile complexes for the treatment of cancer
US5698738A (en) * 1995-05-15 1997-12-16 Board Of Regents, The University Of Texas System N-nitroso-N-substituted hydroxylamines as nitric oxide donors

Also Published As

Publication number Publication date
WO2006000294A1 (en) 2006-01-05
FR2872158A1 (en) 2005-12-30
AR049451A1 (en) 2006-08-02

Similar Documents

Publication Publication Date Title
MA28575B1 (en) 1-AMINO-PHTHALAZINE DERIVATIVES, THEIR PREPARATION, AND THERAPEUTIC USE THEREOF
MA28734B1 (en) 2-CARBAMID-4-PHENYLTHIAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USE
FR2910473B1 (en) N- (AMINO-HETEROARYL) -1H-PYRROLOPYRIDINE-2-CARBOXAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USE.
MA28343A1 (en) ARYLOXYALKYLCARBAMATE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE THEREOF
FR2882054B1 (en) 1,5-DIARYLPYRROLE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
FR2911604B1 (en) N- (HETEROARYL-1H-INDOLE-2-CARBOXAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USE
FR2888847B1 (en) N- (HETERIARYL) -1-HETEORARYLALKYL-1H-INDOLE-2-CARBOXAMIDE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC APPLICATION
MA29017B1 (en) 2-AMIDO-4-PHENYLTHIAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USE
MA28720B1 (en) TETRAHYDROISOQUINOLILSULFONAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USE
FR2891828B1 (en) DERIVATIVES OF SUBSTITUTED 1-AMINO-PHTALAZINE, THEIR PREPARATION AND THEIR THERAPEUTIC USE
FR2866888B1 (en) ALKYLPIPERAZINE- AND ALKYLHOMOPIPERAZINE-CARBOXYLATE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USE
FR2873691B1 (en) AMINO-PIPERIDINE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
FR2888848B1 (en) N- (ARYLALKYL) -1H-PYRRROLOPYRIDINE-2-CARBOXAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USE
FR2856684B1 (en) DIPHENYLPYRIDINE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
FR2891825B1 (en) 1-AMINO-ISOQUINOLINE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
FR2904557B1 (en) NOVEL EUCALYPTUS EXTRACT, PREPARATION METHOD THEREOF AND THERAPEUTIC USES THEREOF
FR2902428B1 (en) NOVEL DIAZENIUMDIOLATE DERIVATIVES, PROCESS FOR PREPARING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME
FR2924713B1 (en) NOVEL DIAZENIUMDIOLATE DERIVATIVES, PROCESS FOR PREPARING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME
FR2873690B1 (en) OXOPIPERIDINE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
FR2930249B1 (en) NOVEL 3-AMINOALKYL-1,3-DIHYDRO-2H-INDOL-2-ONE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE THEREOF
DK1940840T3 (en) 6-heteroarylpyridoindolone derivatives, their preparation and therapeutic use thereof
FR2887548B1 (en) 4,5-DIARYLPYRROLE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE THEREOF
FR2866245B1 (en) NOVEL THICKENING AGENTS AND PROCESS FOR THEIR PREPARATION
FR2916757B1 (en) NOVEL DIAZENIUMDIOLATE DERIVATIVES, PROCESS FOR PREPARING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
FR2873693B1 (en) AMINO-TROPANE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION

Legal Events

Date Code Title Description
ST Notification of lapse

Effective date: 20140228