FR2870356A1 - METHOD FOR ANALYZING MATERIAL, BY DETECTING BETA RADIATION EMITTED BY THIS MATERIAL AND DEVICE FOR IMPLEMENTING SAID METHOD - Google Patents

METHOD FOR ANALYZING MATERIAL, BY DETECTING BETA RADIATION EMITTED BY THIS MATERIAL AND DEVICE FOR IMPLEMENTING SAID METHOD

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Publication number
FR2870356A1
FR2870356A1 FR0405292A FR0405292A FR2870356A1 FR 2870356 A1 FR2870356 A1 FR 2870356A1 FR 0405292 A FR0405292 A FR 0405292A FR 0405292 A FR0405292 A FR 0405292A FR 2870356 A1 FR2870356 A1 FR 2870356A1
Authority
FR
France
Prior art keywords
detection
analyzed
electron
mass
emitted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR0405292A
Other languages
French (fr)
Other versions
FR2870356B1 (en
Inventor
Dominique Michel Elias
Stefano Buono
Fabrizio Murtas
Marcel Ricard
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Advanced Accelerator Applications SA
Original Assignee
Advanced Accelerator Applications SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Advanced Accelerator Applications SA filed Critical Advanced Accelerator Applications SA
Priority to FR0405292A priority Critical patent/FR2870356B1/en
Priority to PCT/FR2005/050330 priority patent/WO2005114254A1/en
Publication of FR2870356A1 publication Critical patent/FR2870356A1/en
Application granted granted Critical
Publication of FR2870356B1 publication Critical patent/FR2870356B1/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01T—MEASUREMENT OF NUCLEAR OR X-RADIATION
    • G01T1/00—Measuring X-radiation, gamma radiation, corpuscular radiation, or cosmic radiation
    • G01T1/16—Measuring radiation intensity
    • G01T1/161—Applications in the field of nuclear medicine, e.g. in vivo counting
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
    • A61B6/40—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment with arrangements for generating radiation specially adapted for radiation diagnosis
    • A61B6/4057—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment with arrangements for generating radiation specially adapted for radiation diagnosis by using radiation sources located in the interior of the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
    • A61B6/42—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment with arrangements for detecting radiation specially adapted for radiation diagnosis
    • A61B6/4208—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment with arrangements for detecting radiation specially adapted for radiation diagnosis characterised by using a particular type of detector
    • A61B6/4258—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment with arrangements for detecting radiation specially adapted for radiation diagnosis characterised by using a particular type of detector for detecting non x-ray radiation, e.g. gamma radiation

Abstract

L'invention concerne l'analyse de matériaux, en particulier de tissus biologiques, par détection de rayonnements β, en particulier de positons, émis par un matériau, en particulier un tissu biologique, radioactif, mais de préférence radiomarqué par des composés radio pharmaceutiques dès lors qu'il s'agit de tissu biologique.Un objectif essentiel de la présente invention est d'améliorer encore les performances des sondes peropératoires à positons, en termes de miniaturisation et d'augmentation de la sensibilité et de la sélectivité vis-à-vis des positons de détection utiles. Le procédé selon l'invention consiste à placer, de part et d'autre d'une masse de matériau à analyser, au moins deux détecteurs en opposition; à détecter en coïncidence dans chaque détecteur un électron Compton issu, selon le mécanisme de diffusion Compton, de l'interaction avec l'un des deux photons incidents résultant de l'annihilation entre un positon émis par la masse de matériau à analyser et un électron; à sélectionner les signaux de détection coïncidente, à savoir les signaux pour chacun desquels une détection d'un électron Compton dans un détecteur coïncide temporellement avec une détection d'un électron Compton dans l'autre détecteur en opposition; à compter les signaux sélectionnés de manière à recueillir des informations représentatives de la quantité de positons émis par la masse de matériau à analyser; et éventuellement à communiquer ces informations à l'utilisateur.Le dispositif [sonde (pince) peropératoire] pour la mise en oeuvre de ce procédé est un autre objet de l'invention.Application : Repérage et excision des tumeurs.The invention relates to the analysis of materials, in particular biological tissues, by detecting β radiation, in particular positrons, emitted by a material, in particular a biological tissue, radioactive, but preferably radiolabeled by radio-pharmaceutical compounds from when it comes to biological tissue.An essential objective of the present invention is to further improve the performance of intraoperative positron probes, in terms of miniaturization and of increasing the sensitivity and selectivity towards. screw useful detection positions. The method according to the invention consists in placing, on either side of a mass of material to be analyzed, at least two detectors in opposition; in detecting in coincidence in each detector a Compton electron resulting, according to the Compton scattering mechanism, from the interaction with one of the two incident photons resulting from the annihilation between a positron emitted by the mass of material to be analyzed and an electron ; in selecting the coincident detection signals, namely the signals for each of which a detection of a Compton electron in one detector temporally coincides with a detection of a Compton electron in the other detector in opposition; in counting the signals selected so as to collect information representative of the quantity of positrons emitted by the mass of material to be analyzed; and possibly communicating this information to the user. The device [intraoperative probe (clamp)] for implementing this method is another subject of the invention. Application: Locating and excising tumors.

FR0405292A 2004-05-14 2004-05-14 METHOD FOR ANALYZING MATERIAL, BY DETECTING BETA RADIATION EMITTED BY THIS MATERIAL AND DEVICE FOR IMPLEMENTING SAID METHOD Expired - Fee Related FR2870356B1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
FR0405292A FR2870356B1 (en) 2004-05-14 2004-05-14 METHOD FOR ANALYZING MATERIAL, BY DETECTING BETA RADIATION EMITTED BY THIS MATERIAL AND DEVICE FOR IMPLEMENTING SAID METHOD
PCT/FR2005/050330 WO2005114254A1 (en) 2004-05-14 2005-05-16 Method of analysing a material, comprising the detection of beta radiation emitted by said material, and device for implementing same

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0405292A FR2870356B1 (en) 2004-05-14 2004-05-14 METHOD FOR ANALYZING MATERIAL, BY DETECTING BETA RADIATION EMITTED BY THIS MATERIAL AND DEVICE FOR IMPLEMENTING SAID METHOD

Publications (2)

Publication Number Publication Date
FR2870356A1 true FR2870356A1 (en) 2005-11-18
FR2870356B1 FR2870356B1 (en) 2007-01-26

Family

ID=34949072

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0405292A Expired - Fee Related FR2870356B1 (en) 2004-05-14 2004-05-14 METHOD FOR ANALYZING MATERIAL, BY DETECTING BETA RADIATION EMITTED BY THIS MATERIAL AND DEVICE FOR IMPLEMENTING SAID METHOD

Country Status (2)

Country Link
FR (1) FR2870356B1 (en)
WO (1) WO2005114254A1 (en)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5014708A (en) * 1988-09-14 1991-05-14 Olympus Optical Co. Radioactive ray detecting therapeutic apparatus
WO1997042524A1 (en) * 1996-05-07 1997-11-13 The Regents Of The University Of Michigan Solid state beta-sensitive surgical probe
EP0535160B1 (en) * 1990-06-18 1998-07-08 The Regents Of The University Of California Intraoperative beta probe and method of using the same
US5965891A (en) * 1992-01-22 1999-10-12 Frederick M. Mako Dedicated apparatus and method for emission mammography
WO2003058275A1 (en) * 2002-01-08 2003-07-17 Pem Technologies, Inc. Open-access emission tomography scanner

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5014708A (en) * 1988-09-14 1991-05-14 Olympus Optical Co. Radioactive ray detecting therapeutic apparatus
EP0535160B1 (en) * 1990-06-18 1998-07-08 The Regents Of The University Of California Intraoperative beta probe and method of using the same
US5965891A (en) * 1992-01-22 1999-10-12 Frederick M. Mako Dedicated apparatus and method for emission mammography
WO1997042524A1 (en) * 1996-05-07 1997-11-13 The Regents Of The University Of Michigan Solid state beta-sensitive surgical probe
WO2003058275A1 (en) * 2002-01-08 2003-07-17 Pem Technologies, Inc. Open-access emission tomography scanner

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
RAYLMAN R R ET AL: "FLUORINE-18-FLUORODEOXYGLUCOSE-GUIDED BREAST CANCER SURGERY WITH A POSITRON-SENSITIVE PROBE: VALIDATION IN PRECLINICAL STUDIES", JOURNAL OF NUCLEAR MEDICINE, SOCIETY OF NUCLEAR MEDICINE. NEW YORK, US, vol. 36, 1995, pages 1869 - 1874, XP008044949, ISSN: 0161-5505 *

Also Published As

Publication number Publication date
WO2005114254A1 (en) 2005-12-01
FR2870356B1 (en) 2007-01-26

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Effective date: 20100129