FR2796863B1 - PROCESS AND DEVICE FOR CONDUCTING A HEAT TREATMENT PROTOCOL ON A SUBSTANCE IN CONTINUOUS FLOW - Google Patents

PROCESS AND DEVICE FOR CONDUCTING A HEAT TREATMENT PROTOCOL ON A SUBSTANCE IN CONTINUOUS FLOW

Info

Publication number
FR2796863B1
FR2796863B1 FR9909806A FR9909806A FR2796863B1 FR 2796863 B1 FR2796863 B1 FR 2796863B1 FR 9909806 A FR9909806 A FR 9909806A FR 9909806 A FR9909806 A FR 9909806A FR 2796863 B1 FR2796863 B1 FR 2796863B1
Authority
FR
France
Prior art keywords
conducting
substance
heat treatment
continuous flow
treatment protocol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR9909806A
Other languages
French (fr)
Other versions
FR2796863A1 (en
Inventor
Yves Fouillet
Claude Vauchier
Jean Frederic Clerc
Christine Peponnet
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Commissariat a lEnergie Atomique et aux Energies Alternatives CEA
Original Assignee
Commissariat a lEnergie Atomique CEA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR9909806A priority Critical patent/FR2796863B1/en
Application filed by Commissariat a lEnergie Atomique CEA filed Critical Commissariat a lEnergie Atomique CEA
Priority to US09/627,647 priority patent/US7015030B1/en
Priority to EP00949852A priority patent/EP1203096B1/en
Priority to DE60041264T priority patent/DE60041264D1/en
Priority to AT00949852T priority patent/ATE419384T1/en
Priority to AU63109/00A priority patent/AU782726B2/en
Priority to PCT/IB2000/001137 priority patent/WO2001007159A2/en
Priority to JP2001512031A priority patent/JP2003505059A/en
Priority to CA002379927A priority patent/CA2379927A1/en
Priority to US09/772,280 priority patent/US6977145B2/en
Publication of FR2796863A1 publication Critical patent/FR2796863A1/en
Application granted granted Critical
Publication of FR2796863B1 publication Critical patent/FR2796863B1/en
Priority to US11/197,040 priority patent/US20050282224A1/en
Priority to US11/196,989 priority patent/US20060011478A1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • B01L7/525—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples with physical movement of samples between temperature zones
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/08—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a stream of discrete samples flowing along a tube system, e.g. flow injection analysis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/087—Multiple sequential chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
    • B01L2300/1822—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using Peltier elements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
    • B01L2300/1827—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using resistive heater
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1838—Means for temperature control using fluid heat transfer medium
    • B01L2300/185—Means for temperature control using fluid heat transfer medium using a liquid as fluid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1861—Means for temperature control using radiation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1883—Means for temperature control using thermal insulation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5025—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures for parallel transport of multiple samples

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Dispersion Chemistry (AREA)
  • Hematology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
FR9909806A 1999-07-28 1999-07-28 PROCESS AND DEVICE FOR CONDUCTING A HEAT TREATMENT PROTOCOL ON A SUBSTANCE IN CONTINUOUS FLOW Expired - Fee Related FR2796863B1 (en)

Priority Applications (12)

Application Number Priority Date Filing Date Title
FR9909806A FR2796863B1 (en) 1999-07-28 1999-07-28 PROCESS AND DEVICE FOR CONDUCTING A HEAT TREATMENT PROTOCOL ON A SUBSTANCE IN CONTINUOUS FLOW
CA002379927A CA2379927A1 (en) 1999-07-28 2000-07-28 Integration of biochemical protocols in a continuous flow microfluidic device
DE60041264T DE60041264D1 (en) 1999-07-28 2000-07-28 Flow microreactor act in the local temperature cycles on a flowing sample
AT00949852T ATE419384T1 (en) 1999-07-28 2000-07-28 FLOW MICROREACTOR IN WHICH LOCAL TEMPERATURE CYCLES ACTION ON A FLOWING SAMPLE
AU63109/00A AU782726B2 (en) 1999-07-28 2000-07-28 Integration of biochemical protocols in a continuous flow microfluidic device
PCT/IB2000/001137 WO2001007159A2 (en) 1999-07-28 2000-07-28 Integration of biochemical protocols in a continuous flow microfluidic device
US09/627,647 US7015030B1 (en) 1999-07-28 2000-07-28 Microfluidic devices and uses thereof in biochemical processes
EP00949852A EP1203096B1 (en) 1999-07-28 2000-07-28 Continuous flow micro device in which local temperature cycles act on a flowing sample
JP2001512031A JP2003505059A (en) 1999-07-28 2000-07-28 Integration of biochemical protocols in continuous flow microfluidic devices
US09/772,280 US6977145B2 (en) 1999-07-28 2001-01-29 Method for carrying out a biochemical protocol in continuous flow in a microreactor
US11/197,040 US20050282224A1 (en) 1999-07-28 2005-08-04 Method for carrying out a biochemical protocol in continuous flow in a microreactor
US11/196,989 US20060011478A1 (en) 1999-07-28 2005-08-04 Integration of biochemical protocols in a continuous flow microfluidic device

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9909806A FR2796863B1 (en) 1999-07-28 1999-07-28 PROCESS AND DEVICE FOR CONDUCTING A HEAT TREATMENT PROTOCOL ON A SUBSTANCE IN CONTINUOUS FLOW

Publications (2)

Publication Number Publication Date
FR2796863A1 FR2796863A1 (en) 2001-02-02
FR2796863B1 true FR2796863B1 (en) 2001-09-07

Family

ID=9548627

Family Applications (1)

Application Number Title Priority Date Filing Date
FR9909806A Expired - Fee Related FR2796863B1 (en) 1999-07-28 1999-07-28 PROCESS AND DEVICE FOR CONDUCTING A HEAT TREATMENT PROTOCOL ON A SUBSTANCE IN CONTINUOUS FLOW

Country Status (1)

Country Link
FR (1) FR2796863B1 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004502926A (en) * 2000-05-24 2004-01-29 マイクロニックス、インコーポレーテッド Microfluidic device that produces a concentration gradient
US6586233B2 (en) * 2001-03-09 2003-07-01 The Regents Of The University Of California Convectively driven PCR thermal-cycling
JP3877572B2 (en) * 2001-08-09 2007-02-07 オリンパス株式会社 Fine channel device and method of using the same
FR2930457B1 (en) 2008-04-24 2010-06-25 Commissariat Energie Atomique PROCESS FOR MANUFACTURING RECONFIGURABLE MICROCHANNELS
CN109557330A (en) * 2018-12-14 2019-04-02 贵州大学 A kind of three axis mobile platforms for high-throughput droplet array microfluid point sample
CN113877485A (en) * 2021-10-18 2022-01-04 江苏汉邦科技有限公司 Nucleic acid synthesizer
CN113817577B (en) * 2021-10-20 2023-08-08 郑州大学 Liquid drop micro-fluidic chip with automatic nucleic acid extraction and purification functions

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5270183A (en) * 1991-02-08 1993-12-14 Beckman Research Institute Of The City Of Hope Device and method for the automated cycling of solutions between two or more temperatures
DE4435107C1 (en) * 1994-09-30 1996-04-04 Biometra Biomedizinische Analy Miniaturized flow thermal cycler
DE19717085C2 (en) * 1997-04-23 1999-06-17 Bruker Daltonik Gmbh Processes and devices for extremely fast DNA multiplication using polymerase chain reactions (PCR)

Also Published As

Publication number Publication date
FR2796863A1 (en) 2001-02-02

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Legal Events

Date Code Title Description
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Effective date: 20160331