FR2792832A1 - Preventing cellular aging of the skin using heat shock proteins or heat shock protein inducers isolated from algae - Google Patents
Preventing cellular aging of the skin using heat shock proteins or heat shock protein inducers isolated from algae Download PDFInfo
- Publication number
- FR2792832A1 FR2792832A1 FR9905580A FR9905580A FR2792832A1 FR 2792832 A1 FR2792832 A1 FR 2792832A1 FR 9905580 A FR9905580 A FR 9905580A FR 9905580 A FR9905580 A FR 9905580A FR 2792832 A1 FR2792832 A1 FR 2792832A1
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- FR
- France
- Prior art keywords
- heat shock
- skin
- algae
- shock proteins
- proteins
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9706—Algae
- A61K8/9722—Chlorophycota or Chlorophyta [green algae], e.g. Chlorella
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
Abstract
Description
La présente invention concerne un procédé de protection de la peau pour laThe present invention relates to a method of protecting the skin for the
prévenir de son vieillissement cellulaire. prevent cell aging.
Le but de la présente invention est de proposer un tel procédé qui soit nouveau. The object of the present invention is to propose such a process which is new.
Selon la présente invention, ce procédé consiste à utiliser des protéines de choc thermique isolées d'algues. La présente invention concerne également une composition pharmaceutique ou cosmétique destinée à prévenir le vieillissement cellulaire de la peau qui est caractérisée en ce qu'elle comporte à titre de principe actif des protéines de choc According to the present invention, this method consists in using heat shock proteins isolated from algae. The present invention also relates to a pharmaceutical or cosmetic composition intended to prevent cellular aging of the skin which is characterized in that it comprises, as active principle, shock proteins
thermique isolées d'algues.thermal isolated from algae.
Les protéines de choc thermique sont des protéines chaperonnes produites par Heat shock proteins are chaperone proteins produced by
les cellules pour lutter contre des oxydations liées à des dérivés réactifs de l'oxygène. cells to fight against oxidations linked to reactive oxygen derivatives.
Elles sont connues sous le nom de protéines de choc thermique (Heat Shock Proteins) They are known as Heat Shock Proteins
ou sous l'abréviation hsp.or under the abbreviation hsp.
Ces protéines sont exprimées dans les cellules cutanées humaines telles que les kératinocytes et les fibroblastes. La production de ces protéines hsp est stimulée par des stress telle qu'une augmentation de température (d'o leur nom), une exposition aux UVB, etc. On sait par ailleurs que les algues expriment des marqueurs biologiques de réponse à un stress. Ces marqueurs sont des protéines qui présentent une structure très proche de celle des protéines hsp de mammifères. Des homologies de séquence ont These proteins are expressed in human skin cells such as keratinocytes and fibroblasts. The production of these hsp proteins is stimulated by stresses such as an increase in temperature (hence their name), exposure to UVB, etc. We also know that algae express biological markers in response to stress. These markers are proteins which have a structure very close to that of mammalian hsp proteins. Sequence homologies have
montré la présence des gènes codant des protéines hsp dans des algues. demonstrated the presence of genes encoding hsp proteins in algae.
Il a par exemple été montré que des algues du genre Chlorella exposée à 40 C pendant 30 minutes augmentent la quantité de protéines hsp de 43, 60, 73 et 95 Kda et induisent l'expression d'une protéine hsp 27 Kda. Ces protéines protègent ces algues Chlorella contre une incubation ultérieure à 45 C. On a pu montrer qu'une composition pharmaceutique ou cosmétique dont le principe actif est constitué de protéines de choc thermique isolées d'algues a une For example, it has been shown that algae of the genus Chlorella exposed to 40 ° C. for 30 minutes increase the quantity of hsp proteins by 43, 60, 73 and 95 Kda and induce the expression of a hsp 27 Kda protein. These proteins protect these Chlorella algae against a subsequent incubation at 45 C. It has been shown that a pharmaceutical or cosmetic composition whose active principle consists of thermal shock proteins isolated from algae has a
influence sur le vieillissement des cellules cutanées. influence on the aging of skin cells.
Cette influence est corroborée par des études sur le vieillissement qui ont mis en évidence une relation entre l'âge des cellules cutanées humaines et le taux basal de protéines de choc thermique ou entre l'âge des cellules et l'aptitude à exprimer des This influence is corroborated by studies on aging which have shown a relationship between the age of human skin cells and the basal level of heat shock proteins or between the age of cells and the ability to express
protéines de choc thermique après un choc thermique. heat shock proteins after heat shock.
2 27928322 2792832
Le procédé de la présente invention consiste par exemple à utiliser en tant que principe actif des protéines de choc thermique constitutives afin d'augmenter le taux The process of the present invention consists, for example, in using, as active ingredient, constitutive heat shock proteins in order to increase the rate
desdites protéines dans lesdites cellules cutanées. said proteins in said skin cells.
Mais, il peut également consister à utiliser en tant que principe actif des protéines de choc thermique inductrices afin de stimuler la production desdites However, it can also consist in using as active principle inducing heat shock proteins in order to stimulate the production of said proteins.
protéines par lesdites cellules cutanées. proteins by said skin cells.
La présente invention consiste également à utiliser des substances isolées The present invention also consists in using isolated substances
d'algues et inductrices, dans les cellules de la peau, de protéines de choc thermique. algae and inducing heat shock proteins in skin cells.
Les protéines de choc thermique induites par lesdites molécules ont ainsi pour effet de protéger les cellules de la peau contre les agressions extérieures et de prévenir The heat shock proteins induced by said molecules thus have the effect of protecting the skin cells against external aggressions and of preventing
son vieillissement cellulaire.its cellular aging.
La présente invention concerne encore une composition pharmaceutique ou cosmétique pour prévenir le vieillissement cellulaire de la peau qui comporte à titre de principe actif des substances isolées d'algues et inductrices dans lesdites cellules de The present invention also relates to a pharmaceutical or cosmetic composition for preventing cellular aging of the skin which comprises, as active principle, substances isolated from algae and inducing in said cells.
protéines de choc thermique.heat shock proteins.
Enfin, la présente invention concerne également des procédés d'obtention d'une composition pharmaceutique ou cosmétique destinée à prévenir du vieillissement Finally, the present invention also relates to methods for obtaining a pharmaceutical or cosmetic composition intended to prevent aging.
cellulaire de la peau.skin cell.
L'un est caractérisé en ce qu'il consiste à utiliser un extrait d'algues contenant One is characterized in that it consists in using an algae extract containing
des protéines de choc thermique constitutives et/ou inductrices. constitutive and / or inducing heat shock proteins.
L'autre consiste à utiliser un extrait d'algues contenant des substances inductrices dans lesdites cellules de la peau de protéines de choc thermique The other is to use an algae extract containing inducing substances in said skin cells of heat shock proteins
constitutives et/ou inductrices.constitutive and / or inductive.
3 27928323 2792832
Claims (7)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9905580A FR2792832B1 (en) | 1999-04-28 | 1999-04-28 | METHOD FOR PROTECTING THE SKIN TO PREVENT ITS CELL AGING |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9905580A FR2792832B1 (en) | 1999-04-28 | 1999-04-28 | METHOD FOR PROTECTING THE SKIN TO PREVENT ITS CELL AGING |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2792832A1 true FR2792832A1 (en) | 2000-11-03 |
FR2792832B1 FR2792832B1 (en) | 2002-05-10 |
Family
ID=9545138
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR9905580A Expired - Fee Related FR2792832B1 (en) | 1999-04-28 | 1999-04-28 | METHOD FOR PROTECTING THE SKIN TO PREVENT ITS CELL AGING |
Country Status (1)
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FR (1) | FR2792832B1 (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2809308A1 (en) * | 2000-05-29 | 2001-11-30 | Seporga Lab | Cosmetic and dermo-pharmaceutical compositions for skin protection containing heat shock proteins and/or heat shock factors |
EP1433463A1 (en) * | 2002-12-26 | 2004-06-30 | Shirako Co., Ltd. | Cosmetics comprising algal proteins |
FR2898808A1 (en) * | 2006-03-27 | 2007-09-28 | Biotechmarine Soc Par Actions | Cosmetic active ingredient consisting of arginine ferrulate and a microalgal extract, useful for fighting against cutaneous aging |
WO2010102988A1 (en) * | 2009-03-10 | 2010-09-16 | Alfa Biogene International B.V. | Skin care product |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2202146A (en) * | 1987-03-18 | 1988-09-21 | Caola Kozmetikai | Skin-regenerating cosmetic composition |
WO1997016439A1 (en) * | 1995-11-02 | 1997-05-09 | Biorex Kutató és Fejlesztó Rt. | Hydroxylamine derivatives useful for enhancing the molecular chaperon production and the preparation thereof |
FR2757863A1 (en) * | 1996-12-27 | 1998-07-03 | Inovat Sarl | NEW SUBSTANCES WITH BIOLOGICAL ACTIVITY, PROCESS FOR OBTAINING THEM AND COMPOSITIONS COMPRISING THE SAME |
WO1998033475A1 (en) * | 1997-02-03 | 1998-08-06 | Laboratoires Serobiologiques | Active synergetic complex and cosmetic and/or pharmaceutical product containing this complex |
-
1999
- 1999-04-28 FR FR9905580A patent/FR2792832B1/en not_active Expired - Fee Related
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2202146A (en) * | 1987-03-18 | 1988-09-21 | Caola Kozmetikai | Skin-regenerating cosmetic composition |
WO1997016439A1 (en) * | 1995-11-02 | 1997-05-09 | Biorex Kutató és Fejlesztó Rt. | Hydroxylamine derivatives useful for enhancing the molecular chaperon production and the preparation thereof |
FR2757863A1 (en) * | 1996-12-27 | 1998-07-03 | Inovat Sarl | NEW SUBSTANCES WITH BIOLOGICAL ACTIVITY, PROCESS FOR OBTAINING THEM AND COMPOSITIONS COMPRISING THE SAME |
WO1998033475A1 (en) * | 1997-02-03 | 1998-08-06 | Laboratoires Serobiologiques | Active synergetic complex and cosmetic and/or pharmaceutical product containing this complex |
Non-Patent Citations (4)
Title |
---|
H. ARS: "Les Algues, sources d'actifs bio-naturels", PARFUMS, COSMTÉTIQUES, ACTUALITÉS, vol. 134, 1997, pages 55-58, XP002129144 * |
H. SHEN: "Thermotolerance induced by heat shock in Chlorella", JOURNAL OF APPLIED PHYCOLOY, vol. 9, no. 5, 1997, pages 471 - 475, XP000870265 * |
S. I. RATTAN: "Repeated Mild Heat Shock Delays Ageing in cultured Human Skin Fibroblasts.", BIOCHEMISTRY AND MOLECULAR BIOLOGY INTERNATIONAL, vol. 45, no. 4, July 1998 (1998-07-01), pages 753 - 759, XP002129142 * |
X. ZHOU ET AL.: "Heat Shock Transcription Factor-1 Regulates Heat Shock Protein-72 Expression in Human Keratinocytes Exposed to Ultraviolet B light.", JOURNAL OF INVESTIGATIVE DERMATOLOGY, vol. 111, no. 2, August 1998 (1998-08-01), pages 194 - 198, XP002129141 * |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2809308A1 (en) * | 2000-05-29 | 2001-11-30 | Seporga Lab | Cosmetic and dermo-pharmaceutical compositions for skin protection containing heat shock proteins and/or heat shock factors |
EP1433463A1 (en) * | 2002-12-26 | 2004-06-30 | Shirako Co., Ltd. | Cosmetics comprising algal proteins |
FR2898808A1 (en) * | 2006-03-27 | 2007-09-28 | Biotechmarine Soc Par Actions | Cosmetic active ingredient consisting of arginine ferrulate and a microalgal extract, useful for fighting against cutaneous aging |
WO2007110511A1 (en) * | 2006-03-27 | 2007-10-04 | Biotechmarine Societe Par Actions Simplifiee | Cosmetic active ingredient composed of arginine ferrulate and a microalgae extract and its uses |
AU2007231265B2 (en) * | 2006-03-27 | 2012-03-15 | Biotechmarine | Cosmetic active ingredient composed of arginine ferrulate and a microalgae extract and its uses |
KR101434839B1 (en) | 2006-03-27 | 2014-10-01 | 바이오테크마린 소시에테 파 액죵 심플리피에 | Cosmetic active ingredient composed of arginine ferrulate and a microalgae extract and its uses |
WO2010102988A1 (en) * | 2009-03-10 | 2010-09-16 | Alfa Biogene International B.V. | Skin care product |
Also Published As
Publication number | Publication date |
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FR2792832B1 (en) | 2002-05-10 |
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