FR2733500B1 - Nouveaux antisens diriges contre ras, preparation et utilisations - Google Patents

Nouveaux antisens diriges contre ras, preparation et utilisations

Info

Publication number
FR2733500B1
FR2733500B1 FR9505165A FR9505165A FR2733500B1 FR 2733500 B1 FR2733500 B1 FR 2733500B1 FR 9505165 A FR9505165 A FR 9505165A FR 9505165 A FR9505165 A FR 9505165A FR 2733500 B1 FR2733500 B1 FR 2733500B1
Authority
FR
France
Prior art keywords
antisens
novel
preparation
directed against
against ras
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
FR9505165A
Other languages
English (en)
Other versions
FR2733500A1 (fr
Inventor
Claude Helene
Piet Herdewijn
Behmoaras Ester Saison
Aerschot Arthur Van
Thanh Thuong Nguyen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centre National de la Recherche Scientifique CNRS
Original Assignee
Centre National de la Recherche Scientifique CNRS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre National de la Recherche Scientifique CNRS filed Critical Centre National de la Recherche Scientifique CNRS
Priority to FR9505165A priority Critical patent/FR2733500B1/fr
Priority to PCT/FR1996/000652 priority patent/WO1996034008A1/fr
Publication of FR2733500A1 publication Critical patent/FR2733500A1/fr
Application granted granted Critical
Publication of FR2733500B1 publication Critical patent/FR2733500B1/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate
    • C12N2310/3511—Conjugate intercalating or cleaving agent
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/352—Nature of the modification linked to the nucleic acid via a carbon atom
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/352—Nature of the modification linked to the nucleic acid via a carbon atom
    • C12N2310/3527—Other alkyl chain
FR9505165A 1995-04-28 1995-04-28 Nouveaux antisens diriges contre ras, preparation et utilisations Expired - Lifetime FR2733500B1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
FR9505165A FR2733500B1 (fr) 1995-04-28 1995-04-28 Nouveaux antisens diriges contre ras, preparation et utilisations
PCT/FR1996/000652 WO1996034008A1 (fr) 1995-04-28 1996-04-29 Nouveaux antisens diriges contre ras, preparation et utilisations

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9505165A FR2733500B1 (fr) 1995-04-28 1995-04-28 Nouveaux antisens diriges contre ras, preparation et utilisations

Publications (2)

Publication Number Publication Date
FR2733500A1 FR2733500A1 (fr) 1996-10-31
FR2733500B1 true FR2733500B1 (fr) 1997-07-25

Family

ID=9478568

Family Applications (1)

Application Number Title Priority Date Filing Date
FR9505165A Expired - Lifetime FR2733500B1 (fr) 1995-04-28 1995-04-28 Nouveaux antisens diriges contre ras, preparation et utilisations

Country Status (2)

Country Link
FR (1) FR2733500B1 (fr)
WO (1) WO1996034008A1 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6339066B1 (en) 1990-01-11 2002-01-15 Isis Pharmaceuticals, Inc. Antisense oligonucleotides which have phosphorothioate linkages of high chiral purity and which modulate βI, βII, γ, δ, Ε, ζ and η isoforms of human protein kinase C
US6537973B1 (en) 1992-03-16 2003-03-25 Isis Pharmaceuticals, Inc. Oligonucleotide inhibition of protein kinase C
US5985558A (en) 1997-04-14 1999-11-16 Isis Pharmaceuticals Inc. Antisense oligonucleotide compositions and methods for the inibition of c-Jun and c-Fos
WO1999001579A1 (fr) 1997-07-01 1999-01-14 Isis Pharmaceuticals, Inc. Compositions et procedes d'apport d'oligonucleotides par le tube digestif
US6809193B2 (en) 1997-08-13 2004-10-26 Isis Pharmaceuticals, Inc. Antisense oligonucleotide compositions and methods for the modulation of JNK proteins
US6133246A (en) * 1997-08-13 2000-10-17 Isis Pharmaceuticals Inc. Antisense oligonucleotide compositions and methods for the modulation of JNK proteins
US5877309A (en) * 1997-08-13 1999-03-02 Isis Pharmaceuticals, Inc. Antisense oligonucleotides against JNK
EP2057284A4 (fr) 2006-08-04 2011-06-29 Isis Pharmaceuticals Inc Compositions et procédés de modulation de protéines jnk

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992002534A2 (fr) * 1990-08-03 1992-02-20 Sterling Drug, Inc. Composes et procedes d'inhibition de l'expression de genes
WO1994008003A1 (fr) * 1991-06-14 1994-04-14 Isis Pharmaceuticals, Inc. INHIBITION DU GENE ras A L'AIDE D'OLIGONUCLEOTIDES NON CODANTS
AU6633694A (en) * 1993-04-09 1994-11-08 Board Of Regents Of The University Of Nebraska, The Novel methods and compositions for the treatment of (ras)-activated cancer with heterotypic anti-(raf) antisense oligonucleotides
CA2129565A1 (fr) * 1993-08-06 1995-02-07 Hiroshi Tanimura Composes oligonucleotides, leur production et leur utilisation

Also Published As

Publication number Publication date
WO1996034008A1 (fr) 1996-10-31
FR2733500A1 (fr) 1996-10-31

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