FR2698367B1 - Fragments of the p53 protein and their uses in the detection and monitoring of disease states. - Google Patents

Fragments of the p53 protein and their uses in the detection and monitoring of disease states.

Info

Publication number
FR2698367B1
FR2698367B1 FR9213110A FR9213110A FR2698367B1 FR 2698367 B1 FR2698367 B1 FR 2698367B1 FR 9213110 A FR9213110 A FR 9213110A FR 9213110 A FR9213110 A FR 9213110A FR 2698367 B1 FR2698367 B1 FR 2698367B1
Authority
FR
France
Prior art keywords
fragments
protein
monitoring
detection
disease states
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR9213110A
Other languages
French (fr)
Other versions
FR2698367A1 (en
Inventor
Thierry Soussi
Richard Lubin
Yann Legros
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
EUROBIO LAB
Original Assignee
EUROBIO LAB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by EUROBIO LAB filed Critical EUROBIO LAB
Priority to FR9213110A priority Critical patent/FR2698367B1/en
Priority to AU54246/94A priority patent/AU5424694A/en
Priority to EP93924668A priority patent/EP0666913A1/en
Priority to JP6510784A priority patent/JPH08502414A/en
Priority to CA 2148274 priority patent/CA2148274A1/en
Priority to PCT/FR1993/001082 priority patent/WO1994010306A1/en
Publication of FR2698367A1 publication Critical patent/FR2698367A1/en
Application granted granted Critical
Publication of FR2698367B1 publication Critical patent/FR2698367B1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4746—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used p53
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/82—Translation products from oncogenes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Peptides Or Proteins (AREA)
FR9213110A 1992-11-02 1992-11-02 Fragments of the p53 protein and their uses in the detection and monitoring of disease states. Expired - Fee Related FR2698367B1 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
FR9213110A FR2698367B1 (en) 1992-11-02 1992-11-02 Fragments of the p53 protein and their uses in the detection and monitoring of disease states.
AU54246/94A AU5424694A (en) 1992-11-02 1993-11-02 P53 protein fragments and use thereof for detecting and monitoring diseased conditions
EP93924668A EP0666913A1 (en) 1992-11-02 1993-11-02 P53 protein fragments and use thereof for detecting and monitoring diseased conditions
JP6510784A JPH08502414A (en) 1992-11-02 1993-11-02 Use of p53 protein fragment and its detection and monitoring of disease
CA 2148274 CA2148274A1 (en) 1992-11-02 1993-11-02 Protein p53 fragments and their uses in detecting and following-up pathological conditions
PCT/FR1993/001082 WO1994010306A1 (en) 1992-11-02 1993-11-02 P53 protein fragments and use thereof for detecting and monitoring diseased conditions

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9213110A FR2698367B1 (en) 1992-11-02 1992-11-02 Fragments of the p53 protein and their uses in the detection and monitoring of disease states.

Publications (2)

Publication Number Publication Date
FR2698367A1 FR2698367A1 (en) 1994-05-27
FR2698367B1 true FR2698367B1 (en) 1995-02-17

Family

ID=9435099

Family Applications (1)

Application Number Title Priority Date Filing Date
FR9213110A Expired - Fee Related FR2698367B1 (en) 1992-11-02 1992-11-02 Fragments of the p53 protein and their uses in the detection and monitoring of disease states.

Country Status (6)

Country Link
EP (1) EP0666913A1 (en)
JP (1) JPH08502414A (en)
AU (1) AU5424694A (en)
CA (1) CA2148274A1 (en)
FR (1) FR2698367B1 (en)
WO (1) WO1994010306A1 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5770377A (en) * 1994-07-20 1998-06-23 University Of Dundee Interruption of binding of MDM2 and P53 protein and therapeutic application thereof
US5721340A (en) * 1994-11-28 1998-02-24 The Wistar Institute Of Anatomy & Biology p53 proteins with altered tetramerization domains
US5573925A (en) * 1994-11-28 1996-11-12 The Wistar Institute Of Anatomy And Biology P53 proteins with altered tetramerization domains
JPH10510988A (en) * 1994-12-14 1998-10-27 ザ スクリップス リサーチ インスティテュート In vivo activation of tumor-specific cytotoxic T cells
US5985829A (en) * 1994-12-19 1999-11-16 The United States Of America As Represented By The Department Of Health And Human Services Screening assays for compounds that cause apoptosis and related compounds
US6169073B1 (en) 1995-02-16 2001-01-02 Bayer Corporation Peptides and peptidomimetics with structural similarity to human p53 that activate p53 function
US5847083A (en) * 1996-08-21 1998-12-08 The Wistar Institute Of Anatomy And Biology Modified p53 constructs which enhance DNA binding
NZ334809A (en) * 1996-10-07 2000-12-22 Schering Corp Assay for the detection of antibodies against p53
EP0989136A4 (en) * 1997-05-15 2002-10-09 Kyowa Hakko Kogyo Kk Peptides having cyclic structures and exerting p53 protein activty-restoring effect on p53 protein mutants
WO2017153336A1 (en) * 2016-03-07 2017-09-14 F. Hoffmann-La Roche Ag Detection of anti-p53 antibodies

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61259337A (en) * 1985-05-13 1986-11-17 Matsushita Electric Ind Co Ltd Electronic memo device
EP0204922A3 (en) * 1985-05-28 1987-09-30 Abbott Laboratories Immunohistochemical assay for detection of a tumor-associated marker (p53)
JPS62271122A (en) * 1986-05-20 1987-11-25 Ricoh Co Ltd Portable information recorder
JPH02219131A (en) * 1989-02-20 1990-08-31 Toshiba Corp Display device
DE69032864T3 (en) * 1989-03-29 2013-01-31 The Johns Hopkins University Evidence of failure of the wild-type p53 gene
JPH02300918A (en) * 1989-05-16 1990-12-13 Seiko Epson Corp Small electronic equipment
JP3155562B2 (en) * 1991-06-10 2001-04-09 株式会社ニチレイ Body
US5411860A (en) * 1992-04-07 1995-05-02 The Johns Hopkins University Amplification of human MDM2 gene in human tumors
DE69326064T2 (en) * 1992-05-26 2000-05-25 Rijksuniversiteit Te Leiden Le Human protein P53 peptides for use in human cytotoxic T cell response inducing compositions and human P53 protein specific T lymphocytes

Also Published As

Publication number Publication date
AU5424694A (en) 1994-05-24
CA2148274A1 (en) 1994-05-11
EP0666913A1 (en) 1995-08-16
JPH08502414A (en) 1996-03-19
FR2698367A1 (en) 1994-05-27
WO1994010306A1 (en) 1994-05-11

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