FR2682955A1 - Nouvelle endopeptidase, son activite de clivage et d'inactivation de substrats peptidiques. - Google Patents

Nouvelle endopeptidase, son activite de clivage et d'inactivation de substrats peptidiques. Download PDF

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Publication number
FR2682955A1
FR2682955A1 FR9113279A FR9113279A FR2682955A1 FR 2682955 A1 FR2682955 A1 FR 2682955A1 FR 9113279 A FR9113279 A FR 9113279A FR 9113279 A FR9113279 A FR 9113279A FR 2682955 A1 FR2682955 A1 FR 2682955A1
Authority
FR
France
Prior art keywords
enzyme
endopeptidase
peptide
activity
enzyme according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR9113279A
Other languages
English (en)
French (fr)
Other versions
FR2682955B1 (enExample
Inventor
Cohen Paul
De Morais Carvalh Krishnamurti
Joudiou Carine
Boussetta Hamadi
Leseney Anne-Marie
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centre National de la Recherche Scientifique CNRS
Original Assignee
Centre National de la Recherche Scientifique CNRS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre National de la Recherche Scientifique CNRS filed Critical Centre National de la Recherche Scientifique CNRS
Priority to FR9113279A priority Critical patent/FR2682955A1/fr
Priority to PCT/FR1992/001009 priority patent/WO1993009226A1/fr
Priority to MX9206217A priority patent/MX9206217A/es
Priority to PT10101792A priority patent/PT101017A/pt
Publication of FR2682955A1 publication Critical patent/FR2682955A1/fr
Application granted granted Critical
Publication of FR2682955B1 publication Critical patent/FR2682955B1/fr
Granted legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6402—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from non-mammals
    • C12N9/6405—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from non-mammals not being snakes
    • C12N9/6416—Metalloendopeptidases (3.4.24)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/58—Atrial natriuretic factor complex; Atriopeptin; Atrial natriuretic peptide [ANP]; Cardionatrin; Cardiodilatin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
FR9113279A 1991-10-28 1991-10-28 Nouvelle endopeptidase, son activite de clivage et d'inactivation de substrats peptidiques. Granted FR2682955A1 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
FR9113279A FR2682955A1 (fr) 1991-10-28 1991-10-28 Nouvelle endopeptidase, son activite de clivage et d'inactivation de substrats peptidiques.
PCT/FR1992/001009 WO1993009226A1 (fr) 1991-10-28 1992-10-28 Nouvelle endopeptidase, son activite de clivage et d'inactivation de substrats peptidiques
MX9206217A MX9206217A (es) 1991-10-28 1992-10-28 Endopeptidas novedosas, su actividad en la segmentacion y la inactividad de substractos peptidicos
PT10101792A PT101017A (pt) 1991-10-28 1992-10-28 Enzima de tipo com capacidade para cindir pares de aminoacidos no seio de peptidos, anticorpo policlonal ou monoclonal que a reconhece, medicamentos que a contem e processo para a sua deteccao ou o corte de moleculas susceptiveis de se comportarem como inibidor, activador ou modulador da referida enzima

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9113279A FR2682955A1 (fr) 1991-10-28 1991-10-28 Nouvelle endopeptidase, son activite de clivage et d'inactivation de substrats peptidiques.

Publications (2)

Publication Number Publication Date
FR2682955A1 true FR2682955A1 (fr) 1993-04-30
FR2682955B1 FR2682955B1 (enExample) 1995-05-12

Family

ID=9418372

Family Applications (1)

Application Number Title Priority Date Filing Date
FR9113279A Granted FR2682955A1 (fr) 1991-10-28 1991-10-28 Nouvelle endopeptidase, son activite de clivage et d'inactivation de substrats peptidiques.

Country Status (4)

Country Link
FR (1) FR2682955A1 (enExample)
MX (1) MX9206217A (enExample)
PT (1) PT101017A (enExample)
WO (1) WO1993009226A1 (enExample)

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. vol. 167, no. 1, 28 Février 1990, DULUTH, MINNESOTA US pages 110 - 116; G. JOHNSON AND C. FOSTER: 'Partial characterization of a metalloendopeptidase activity produced by cultured endothelial cells that removs the COOH-terminal tripeptide from 125I-atrial natriuretic factor' *
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. vol. 175, no. 3, 29 Mars 1991, DULUTH, MINNESOTA US pages 886 - 893; L. TOLL ET AL.: 'Isolation and characterization of a new atrial peptide-degrading enzyme from bovine kidney' *
BIOCHEMICAL JOURNAL vol. 209, 1983, pages 741 - 752; W. GALLOWAY ET AL: 'Purification and characterization of a rabbit bone metalloproteinase that degrades proteoglycan and other connective-tissue components' *

Also Published As

Publication number Publication date
WO1993009226A1 (fr) 1993-05-13
MX9206217A (es) 1993-12-01
FR2682955B1 (enExample) 1995-05-12
PT101017A (pt) 1994-03-31

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