FR2659967B1 - N-SUBSTITUTED IMIDAZOLINONE DERIVATIVES, THEIR PREPARATION, THE PHARMACEUTICAL COMPOSITIONS CONTAINING SAME. - Google Patents

N-SUBSTITUTED IMIDAZOLINONE DERIVATIVES, THEIR PREPARATION, THE PHARMACEUTICAL COMPOSITIONS CONTAINING SAME.

Info

Publication number
FR2659967B1
FR2659967B1 FR9003563A FR9003563A FR2659967B1 FR 2659967 B1 FR2659967 B1 FR 2659967B1 FR 9003563 A FR9003563 A FR 9003563A FR 9003563 A FR9003563 A FR 9003563A FR 2659967 B1 FR2659967 B1 FR 2659967B1
Authority
FR
France
Prior art keywords
preparation
pharmaceutical compositions
compositions containing
containing same
imidazolinone derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
FR9003563A
Other languages
French (fr)
Other versions
FR2659967A1 (en
Inventor
Bernhart Claude
Breliere Jean-Claudecl Jacques
Nisato Dino
Perreaut Pierre
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi SA
Original Assignee
Sanofi SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi SA filed Critical Sanofi SA
Priority to FR9003563A priority Critical patent/FR2659967B1/en
Priority to IE091391A priority patent/IE910913A1/en
Priority to PT97078A priority patent/PT97078B/en
Priority to NZ237476A priority patent/NZ237476A/en
Priority to TW080102155A priority patent/TW201738B/zh
Priority to CA002057913A priority patent/CA2057913C/en
Priority to PL91304152A priority patent/PL166581B1/en
Priority to SG1996005558A priority patent/SG49053A1/en
Priority to UA5010343A priority patent/UA42669A/en
Priority to SK1256-98A priority patent/SK283197B6/en
Priority to ZA912072A priority patent/ZA912072B/en
Priority to AU75610/91A priority patent/AU641005B2/en
Priority to PL91304153A priority patent/PL166403B1/en
Priority to HU603/91A priority patent/HU221188B1/en
Priority to HU9302497A priority patent/HUT67648A/en
Priority to DE69129606T priority patent/DE69129606T2/en
Priority to IL9761291A priority patent/IL97612A/en
Priority to MYPI91000464A priority patent/MY115638A/en
Priority to PCT/FR1991/000224 priority patent/WO1991014679A1/en
Priority to AT91400745T priority patent/ATE167475T1/en
Priority to KR1019910701647A priority patent/KR0175310B1/en
Priority to SU5010343/04A priority patent/RU2099331C1/en
Priority to JP3506471A priority patent/JP2868313B2/en
Priority to EP91400745A priority patent/EP0454511B1/en
Priority to HU9302497A priority patent/HU223141B1/en
Priority to PL91293015A priority patent/PL165945B1/en
Priority to ES91400745T priority patent/ES2119764T3/en
Priority to IL11082091A priority patent/IL110820A/en
Priority to DK91400745T priority patent/DK0454511T3/en
Priority to DE1999175029 priority patent/DE19975029I2/en
Priority to CS1991745A priority patent/CZ287064B6/en
Priority to SK745-91A priority patent/SK280096B6/en
Publication of FR2659967A1 publication Critical patent/FR2659967A1/en
Priority to NO914528A priority patent/NO301977B1/en
Priority to FI915458A priority patent/FI103407B1/en
Priority to US07/794,497 priority patent/US5270317A/en
Priority to MX9203586A priority patent/MX9203586A/en
Application granted granted Critical
Publication of FR2659967B1 publication Critical patent/FR2659967B1/en
Priority to LVP-93-147A priority patent/LV10439B/en
Priority to LTIP586A priority patent/LT3376B/en
Priority to US08/079,866 priority patent/US5352788A/en
Priority to US08/269,101 priority patent/US5559233A/en
Priority to IL11082094A priority patent/IL110820A0/en
Priority to HU95P/P00555P priority patent/HU211839A9/en
Priority to CZ1996120A priority patent/CZ287225B6/en
Priority to JP9339895A priority patent/JPH10279566A/en
Priority to HK98109660A priority patent/HK1008918A1/en
Priority to LU90279C priority patent/LU90279I2/en
Priority to NO1998021C priority patent/NO1998021I1/en
Priority to NL980039C priority patent/NL980039I2/en
Priority to NL990006C priority patent/NL990006I2/en
Priority to LU90371C priority patent/LU90371I2/en
Priority to NO1999025C priority patent/NO1999025I1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/70—One oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
FR9003563A 1990-03-20 1990-03-20 N-SUBSTITUTED IMIDAZOLINONE DERIVATIVES, THEIR PREPARATION, THE PHARMACEUTICAL COMPOSITIONS CONTAINING SAME. Expired - Lifetime FR2659967B1 (en)

Priority Applications (51)

Application Number Priority Date Filing Date Title
FR9003563A FR2659967B1 (en) 1990-03-20 1990-03-20 N-SUBSTITUTED IMIDAZOLINONE DERIVATIVES, THEIR PREPARATION, THE PHARMACEUTICAL COMPOSITIONS CONTAINING SAME.
IE091391A IE910913A1 (en) 1990-03-20 1991-03-19 N-substituted heterocyclic derivates, their preparation¹and pharmaceutical compositions containing them
PT97078A PT97078B (en) 1990-03-20 1991-03-19 PROCESS FOR THE PREPARATION OF N-SUBSTITUTED HETEROCYCLIC DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
NZ237476A NZ237476A (en) 1990-03-20 1991-03-19 N-substituted heterocyclic compounds and pharmaceutical compositions.
TW080102155A TW201738B (en) 1990-03-20 1991-03-19
CA002057913A CA2057913C (en) 1990-03-20 1991-03-20 N-substituted heterocyclic derivatives, their preparation and the pharmaceutical compositions in which they are present
PL91304152A PL166581B1 (en) 1990-03-20 1991-03-20 Method of obtaining imidazole or pirymidyne derivatives
SG1996005558A SG49053A1 (en) 1990-03-20 1991-03-20 Arylalkylamines process for preparing them and pharmaceutical compositions containing them
UA5010343A UA42669A (en) 1990-03-20 1991-03-20 Angiotensin-ii antagonists, process for preparation thereof (variants), intermediate (variants), process for preparation thereof and pharmaceutical composition
SK1256-98A SK283197B6 (en) 1990-03-20 1991-03-20 N-substituted heterocycle derivatives, their preparation, compositions containing them
ZA912072A ZA912072B (en) 1990-03-20 1991-03-20 N-substituted heterocyclic derivatives,their preparation and pharmaceutical compositions containing them
AU75610/91A AU641005B2 (en) 1990-03-20 1991-03-20 Heterocyclic N-substituted derivatives, their preparation and thepharmaceutical compositions containing them
PL91304153A PL166403B1 (en) 1990-03-20 1991-03-20 Method of obtaining n-substituted derivatives of imidazole or pyrimidine
HU603/91A HU221188B1 (en) 1990-03-20 1991-03-20 N-substituted imidazole and pyrimidine derivatives, pharmaceutical compositions comprising such compounds as active ingredients and process for producing them
HU9302497A HUT67648A (en) 1990-03-20 1991-03-20 Process for producing novel imidazole and pyrimidine derivatives and pharmaceutical copositions containing them
DE69129606T DE69129606T2 (en) 1990-03-20 1991-03-20 N-substituted heterocyclic derivatives, processes for their preparation, compositions containing them
IL9761291A IL97612A (en) 1990-03-20 1991-03-20 N-substituted heterocyclic derivatives their preparation and pharmaceutical compositions containing them
MYPI91000464A MY115638A (en) 1990-03-20 1991-03-20 N-substituted heterocyclic derivatives, their preparation and pharmaceutical compositions containing them
PCT/FR1991/000224 WO1991014679A1 (en) 1990-03-20 1991-03-20 Heterocyclic n-substituted derivatives, their preparation and thepharmaceutical compositions containing them
AT91400745T ATE167475T1 (en) 1990-03-20 1991-03-20 N-SUBSTITUTED HETEROCYCLIC DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, COMPOSITIONS CONTAINING SAME
KR1019910701647A KR0175310B1 (en) 1990-03-20 1991-03-20 Heterocyclic n-substituted derivatives, their preparation and pharmaceutical compositions containing them
SU5010343/04A RU2099331C1 (en) 1990-03-20 1991-03-20 N-substituted heterocyclic derivatives or their salts, intermediate derivatives of pyrimidine and imidazoline and a pharmaceutical composition based on the substituted heterocyclic derivatives
JP3506471A JP2868313B2 (en) 1990-03-20 1991-03-20 N-substituted heterocyclic derivative and method for producing the same
EP91400745A EP0454511B1 (en) 1990-03-20 1991-03-20 N-substituted heterocycle derivatives, their preparation, compositions containing them
HU9302497A HU223141B1 (en) 1990-03-20 1991-03-20 Novel imidazole and pyrimidine derivatives and process for producing them
PL91293015A PL165945B1 (en) 1990-03-20 1991-03-20 Method of obtaining n-substituted heterocyclic derivatives
ES91400745T ES2119764T3 (en) 1990-03-20 1991-03-20 HETERO CYCLIC DERIVATIVES N-SUBSTITUTED FOR THEIR PREPARATION, THE PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM.
IL11082091A IL110820A (en) 1990-03-20 1991-03-20 Imidazolin-5-one and 5,6-dihydropyrimidin-4-one derivatives and their preparation
DK91400745T DK0454511T3 (en) 1990-03-20 1991-03-20 N-substituted heterocyclic derivatives, their preparation and pharmaceutical compositions containing them
DE1999175029 DE19975029I2 (en) 1990-03-20 1991-03-20 N-substituted heterocyclic derivatives Process for their preparation compositions containing them
CS1991745A CZ287064B6 (en) 1990-03-20 1991-03-20 N-substituted heterocyclic derivatives, process of their preparation and pharmaceutical compositions containing such derivatives
SK745-91A SK280096B6 (en) 1990-03-20 1991-03-20 Heterocyclic n-substituted derivatives, their preparation and pharmaceutical compositions containing them
NO914528A NO301977B1 (en) 1990-03-20 1991-11-19 Analogous Process for Preparation of N-Substituted Heterocyclic Derivatives, and Intermediates for Their Preparation
FI915458A FI103407B1 (en) 1990-03-20 1991-11-19 A process for the preparation of therapeutically active N-substituted pyrimidine and imidazoline derivatives and pyrimidine and imidazoline derivatives useful as intermediates
US07/794,497 US5270317A (en) 1990-03-20 1991-11-20 N-substituted heterocyclic derivatives, their preparation and the pharmaceutical compositions in which they are present
MX9203586A MX9203586A (en) 1990-03-20 1992-06-26 N-SUBSTITUTED HETERO CYCLIC DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
LVP-93-147A LV10439B (en) 1990-03-20 1993-02-25 N-substituted heterocyclic derivatives, their preparation and the pharmaceutical compositions containing them
LTIP586A LT3376B (en) 1990-03-20 1993-05-31 N-substituted heterocyclic derivatives, process fof their preparation, intermediates, process for their preparation and pharmaceutical composition
US08/079,866 US5352788A (en) 1990-03-20 1993-06-23 N-substituted heterocyclic derivatives
US08/269,101 US5559233A (en) 1990-03-20 1994-06-30 Methods for preparing n-substituted heterocyclic derivatives
IL11082094A IL110820A0 (en) 1990-03-20 1994-08-30 N-substituted heterocyclic derivatives and their preparation
HU95P/P00555P HU211839A9 (en) 1990-03-20 1995-06-29 N-substituted heterocyclic derivatives, their preparation and the pharmaceutical compositions in which they are present
CZ1996120A CZ287225B6 (en) 1990-03-20 1996-01-15 Nitrogen heterocyclic derivative and process for preparing thereof
JP9339895A JPH10279566A (en) 1990-03-20 1997-12-10 Pharmaceutical composition containing n-substituted heterocyclic derivative
HK98109660A HK1008918A1 (en) 1990-03-20 1998-08-04 N-substituted heterocycle derivatives their preparation compositions containing them
LU90279C LU90279I2 (en) 1990-03-20 1998-08-21 Aprovel
NO1998021C NO1998021I1 (en) 1990-03-20 1998-09-16 Irbesartan
NL980039C NL980039I2 (en) 1990-03-20 1998-12-02 N-substituted heterocyclic derivatives, their preparation, pharmaceutical preparations containing them.
NL990006C NL990006I2 (en) 1990-03-20 1999-03-05 N-substituted heterocyclic derivatives, their preparation, pharmaceutical preparations containing them.
LU90371C LU90371I2 (en) 1990-03-20 1999-03-12 Coaprovel-Irbesartan / hydrochlorothiazide
NO1999025C NO1999025I1 (en) 1990-03-20 1999-12-09 Irbesartan + hydrochlorothiazide

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9003563A FR2659967B1 (en) 1990-03-20 1990-03-20 N-SUBSTITUTED IMIDAZOLINONE DERIVATIVES, THEIR PREPARATION, THE PHARMACEUTICAL COMPOSITIONS CONTAINING SAME.

Publications (2)

Publication Number Publication Date
FR2659967A1 FR2659967A1 (en) 1991-09-27
FR2659967B1 true FR2659967B1 (en) 1992-07-24

Family

ID=9394923

Family Applications (1)

Application Number Title Priority Date Filing Date
FR9003563A Expired - Lifetime FR2659967B1 (en) 1990-03-20 1990-03-20 N-SUBSTITUTED IMIDAZOLINONE DERIVATIVES, THEIR PREPARATION, THE PHARMACEUTICAL COMPOSITIONS CONTAINING SAME.

Country Status (3)

Country Link
FR (1) FR2659967B1 (en)
LT (1) LT3376B (en)
ZA (1) ZA912072B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5087634A (en) * 1990-10-31 1992-02-11 G. D. Searle & Co. N-substituted imidazol-2-one compounds for treatment of circulatory disorders
EP1750862B1 (en) 2004-06-04 2011-01-05 Teva Pharmaceutical Industries Ltd. Pharmaceutical composition containing irbesartan

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1334092C (en) * 1986-07-11 1995-01-24 David John Carini Angiotensin ii receptor blocking imidazoles
US4820843A (en) * 1987-05-22 1989-04-11 E. I. Du Pont De Nemours And Company Tetrazole intermediates to antihypertensive compounds
US5015651A (en) * 1988-01-07 1991-05-14 E. I. Du Pont De Nemours And Company Treatment of hypertension with 1,2,4-angiotensin II antagonists
CA1338238C (en) * 1988-01-07 1996-04-09 David John Carini Angiotensin ii receptor blocking imidazoles and combinations thereof with diuretics and nsaids

Also Published As

Publication number Publication date
LT3376B (en) 1995-08-25
FR2659967A1 (en) 1991-09-27
LTIP586A (en) 1994-12-27
ZA912072B (en) 1992-03-25

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