FR2651231B1 - CHEMICAL COMPOUNDS BASED ON A NETROPSIN MOLECULE COUPLED WITH AN INTERCALATING AGENT, PROCESS FOR THE PREPARATION OF SAID COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME. - Google Patents

CHEMICAL COMPOUNDS BASED ON A NETROPSIN MOLECULE COUPLED WITH AN INTERCALATING AGENT, PROCESS FOR THE PREPARATION OF SAID COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME.

Info

Publication number
FR2651231B1
FR2651231B1 FR8911177A FR8911177A FR2651231B1 FR 2651231 B1 FR2651231 B1 FR 2651231B1 FR 8911177 A FR8911177 A FR 8911177A FR 8911177 A FR8911177 A FR 8911177A FR 2651231 B1 FR2651231 B1 FR 2651231B1
Authority
FR
France
Prior art keywords
netropsin
preparation
pharmaceutical compositions
compositions containing
same
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR8911177A
Other languages
French (fr)
Other versions
FR2651231A1 (en
Inventor
Auclair Christian
Gosselin Gilles
Imbach Jean-Louis
Paoletti Claude
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centre National de la Recherche Scientifique CNRS
Institut Gustave Roussy (IGR)
Original Assignee
Centre National de la Recherche Scientifique CNRS
Institut Gustave Roussy (IGR)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre National de la Recherche Scientifique CNRS, Institut Gustave Roussy (IGR) filed Critical Centre National de la Recherche Scientifique CNRS
Priority to FR8911177A priority Critical patent/FR2651231B1/en
Priority to PCT/FR1990/000625 priority patent/WO1991002735A1/en
Publication of FR2651231A1 publication Critical patent/FR2651231A1/en
Application granted granted Critical
Publication of FR2651231B1 publication Critical patent/FR2651231B1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/525—Tumour necrosis factor [TNF]
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B57/00—Other synthetic dyes of known constitution
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B57/00—Other synthetic dyes of known constitution
    • C09B57/02—Coumarine dyes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1136—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/321—2'-O-R Modification

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FR8911177A 1989-08-23 1989-08-23 CHEMICAL COMPOUNDS BASED ON A NETROPSIN MOLECULE COUPLED WITH AN INTERCALATING AGENT, PROCESS FOR THE PREPARATION OF SAID COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME. Expired - Fee Related FR2651231B1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
FR8911177A FR2651231B1 (en) 1989-08-23 1989-08-23 CHEMICAL COMPOUNDS BASED ON A NETROPSIN MOLECULE COUPLED WITH AN INTERCALATING AGENT, PROCESS FOR THE PREPARATION OF SAID COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME.
PCT/FR1990/000625 WO1991002735A1 (en) 1989-08-23 1990-08-23 Chemical compounds based on a netropsin or distamycin molecule coupled with an intercalating agent, method for preparing said compounds and pharmaceutical compositions containing same

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8911177A FR2651231B1 (en) 1989-08-23 1989-08-23 CHEMICAL COMPOUNDS BASED ON A NETROPSIN MOLECULE COUPLED WITH AN INTERCALATING AGENT, PROCESS FOR THE PREPARATION OF SAID COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME.

Publications (2)

Publication Number Publication Date
FR2651231A1 FR2651231A1 (en) 1991-03-01
FR2651231B1 true FR2651231B1 (en) 1992-01-10

Family

ID=9384883

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8911177A Expired - Fee Related FR2651231B1 (en) 1989-08-23 1989-08-23 CHEMICAL COMPOUNDS BASED ON A NETROPSIN MOLECULE COUPLED WITH AN INTERCALATING AGENT, PROCESS FOR THE PREPARATION OF SAID COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME.

Country Status (2)

Country Link
FR (1) FR2651231B1 (en)
WO (1) WO1991002735A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6187566B1 (en) * 1999-03-09 2001-02-13 Applied Gene Technologies, Inc. Method of labeling a nucleic acid amplicon with simultaneous contamination prevention
US6620586B2 (en) 2001-02-20 2003-09-16 Applied Gene Technologies, Inc. Methods and compositions for analyzing nucleic acids

Also Published As

Publication number Publication date
WO1991002735A1 (en) 1991-03-07
FR2651231A1 (en) 1991-03-01

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