FR2645748A1 - Method for production of a material intended for a bone prosthesis, and the device for carrying out the method - Google Patents

Method for production of a material intended for a bone prosthesis, and the device for carrying out the method Download PDF

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Publication number
FR2645748A1
FR2645748A1 FR8905161A FR8905161A FR2645748A1 FR 2645748 A1 FR2645748 A1 FR 2645748A1 FR 8905161 A FR8905161 A FR 8905161A FR 8905161 A FR8905161 A FR 8905161A FR 2645748 A1 FR2645748 A1 FR 2645748A1
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piston
cavity
cylinder
rack
intended
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FR2645748B1 (en
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Christian Boutmy
Charles Guedom
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Boutmy SA Ets
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Boutmy SA Ets
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A61L27/3608—Bone, e.g. demineralised bone matrix [DBM], bone powder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/32—Bones; Osteocytes; Osteoblasts; Tendons; Tenocytes; Teeth; Odontoblasts; Cartilage; Chondrocytes; Synovial membrane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3641—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the site of application in the body
    • A61L27/3645—Connective tissue
    • A61L27/365—Bones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/3094—Designing or manufacturing processes

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Botany (AREA)
  • Vascular Medicine (AREA)
  • Zoology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Prostheses (AREA)

Abstract

The present invention is in the field of surgical techniques. It relates to a method for production of a material intended for a bone prosthesis, characterised in that a spongy bone tissue taken from a living organism is compacted in a mould at a pressure of the order of 500 to 1000 hPa, and the device for carrying out the method comprises a cylindrical cavity 1, forming a mould 1', provided with a removable base 2, the cavity and the base being provided with openings 11, a plunger 3 intended to slide in the said cavity, and means 5 for applying to the plunger a controlled force tending to drive it into the cylinder.

Description

La présente invention est du domaine des techniques chirurgicales, et elle a plus précisément pour objet un matériau destiné à la prothèse osseuse, son procédé de fabrication et les moyens de mise en oeuvre de ce dernier. The present invention is in the field of surgical techniques, and more specifically it relates to a material intended for bone prosthesis, its manufacturing process and the means of implementing the latter.

On rappelle qu'il est quelquefois nécéssaire, à la suite de certaines affections ou de certains traumatismes de procéder au} remplacement de parties du squelette, l'élément de remplacement pouvant être soit artificiel, dans ce cas on parlera plus spécialement de prothèse, soit naturel, et dans ce dernier cas, s'il y effet de symbiose, on parlera plus spécialement de greffe. La greffe est une solution souhaitée dans de nombreux cas, mais une difficulté réside dans le fait que l'on ne dispose pas toujours d'un élément endogène de remplacement ayant la forme et/ou la com pacité requise. aussi dans de nombreux cas doit-on se satisfaire de matériaux exogènes, naturels ou synthéthiques.Dans ces dernières éventualités la prothèse fait généralement appel à des moyens de fixation mécaniques; en outre de telles prothèses sont souvent sujettes à des réaction de rejet de l'organisme implanté. It is recalled that it is sometimes necessary, following certain affections or certain traumas to proceed to the replacement of parts of the skeleton, the replacement element being either artificial, in this case we will speak more specifically of prosthesis, or natural, and in the latter case, if there is a symbiosis effect, we will speak more specifically of grafting. Grafting is a desired solution in many cases, but a difficulty lies in the fact that one does not always have an endogenous replacement element having the required shape and / or compactness. so in many cases we have to be satisfied with exogenous, natural or synthetic materials. In the latter eventualities the prosthesis generally uses mechanical fixing means; furthermore, such prostheses are often subject to rejection reactions from the implanted organism.

La présente invention s'est fixé pour but de proposer un matériau destiné à la prothése osseuse, matériau de nature endogène, qui présente l'avantage des greffons osseux tout en autorisant le choix de la forme et de la compacité. Un autre but de l'invention est de proposer un procédé d'obtention d'un tel matériau, ainsi que des moyens de mise en oeuvre, le procédé pouvant être mis en oeuvre sur le lieu même, et dans le temps, de l'opération. The aim of the present invention is to propose a material intended for bone prosthesis, a material of endogenous nature, which has the advantage of bone grafts while allowing the choice of shape and compactness. Another object of the invention is to propose a method for obtaining such a material, as well as means of implementation, the method being able to be implemented on the very place, and in time, of the surgery.

Selon la présente invention, un procédé de fabrication de matériau destiné à la prothèse osseuse, est caractérisé d'une manière générale en ce qu'il consiste à mouler par compactage dans un moule sous une pression de l'ordre de 500 à 1.000 HPa un tissu osseux spongieux prélevé sur un organisme vivant; de préférence le prélèvement, le compactage et la réimplantation sont effectués de façon extemporanée; il résulte de cette façon de procéder que l'on peut réaliser des prothèses dont les qualités sont voisines de celles des greffes, et cela sur des parties du squelette réputées délicates, telles par exemple que les os de la tête. According to the present invention, a method of manufacturing material intended for bone prosthesis, is generally characterized in that it consists in molding by compacting in a mold under a pressure of the order of 500 to 1,000 HPa a cancellous bone tissue taken from a living organism; preferably the removal, compaction and reimplantation are carried out extemporaneously; It follows from this way of proceeding that it is possible to produce prostheses whose qualities are similar to those of grafts, and this on parts of the skeleton known to be delicate, such as for example the bones of the head.

Un dispositif de compactage pour la mise en oeuvre d'un procédé tel que sus-défini, est caractérisé de manière générale en ce qu'il comprend une cavité cylindrique formant moule pourvue d'un fond amovible, la cavité et le fond étant pourvus d'orifices, un piston destiné à coulisser dans la dite cavité, et des moyens pour appliquer au piston ure force controlée tendant à l'enfoncer dans le cylindre. Avantageusement un tel dispositif comprend en outre des moyens pour controler, simultanément à l'application de la force, le déplacement du piston. A compacting device for implementing a method as defined above, is generally characterized in that it comprises a cylindrical cavity forming a mold provided with a removable bottom, the cavity and the bottom being provided with orifices, a piston intended to slide in said cavity, and means for applying to the piston a controlled force tending to push it into the cylinder. Advantageously, such a device further comprises means for controlling, simultaneously with the application of force, the movement of the piston.

Selon une forme particulière de réalisation, le diamètre de la cavité cylindrique est compris entre 0,5 et 2 cm, le diamètre du piston étant inférieur à celui de la. cavité de quelques micromètres, les orifices ont un diamètre compris entre 0,5 et 2 mm, et la longueur du piston, sensiblement égale à celle du cylindre, est comprise entre 5 et 10 cm 6. According to a particular embodiment, the diameter of the cylindrical cavity is between 0.5 and 2 cm, the diameter of the piston being less than that of the. cavity of a few micrometers, the orifices have a diameter between 0.5 and 2 mm, and the length of the piston, substantially equal to that of the cylinder, is between 5 and 10 cm 6.

Suivant une disposition avantageuse par sa simplicité de réalisation, les moyens de production de force comprennent une crémaillère et un pignon engrenant dans la crémaillère et pourvu d'un levier, la crémallière étant en relation avec le piston. According to an advantageous arrangement by its simplicity of embodiment, the force generation means comprise a rack and a pinion meshing in the rack and provided with a lever, the rack being in relation to the piston.

La présente invention sera mieux comprise et des détails en relevant apparaîtront, dans la description qui va en etre faite, en relation avec les figures de la planche annexée, dans laquelle:
-la fig.l est une coupe longitudinale schématique du dispositif de compactage de l'invention,
-la fig.2 est une illustration en perspective d'une phase du procédé.The present invention will be better understood and details will be apparent from the description which will be given thereof, in relation to the figures in the appended plate, in which:
FIG. 1 is a schematic longitudinal section of the compacting device of the invention,
FIG 2 is a perspective illustration of a phase of the process.

Sur la fig.1, un dispositif de compactage se compose essentiellement d'un cylindre 1 pourvu à son extremité d'un fond, ou bouchon, vissé 2, un piston cylindrique 3, un moyen de poduction de force 5 constitué d'une crémallière 7 et d'un pignon denté 8 pourvu d'un levier 9; la crémallière est en prise directe sur le piston; cependant des moyens 10 de mesure de la force, ou effort de compression, à laquelle sont sont soumis la crémallière et le piston sont intégrés à la crémallière, ces moyens 10 pouvant être par exemple un anneau cylindrique sur les parois duquel ont été rapportées des jauges extensométriques, ou encore une jauge de contrainte comprimmée entre deux parties de la crémallière, etc... In fig.1, a compacting device essentially consists of a cylinder 1 provided at its end with a bottom, or plug, screwed 2, a cylindrical piston 3, a force-producing means 5 consisting of a rack 7 and a toothed pinion 8 provided with a lever 9; the rack is in direct engagement with the piston; however means 10 for measuring the force, or compressive force, to which the rack and the piston are subjected are integrated into the rack, these means 10 may for example be a cylindrical ring on the walls of which gauges have been added strain gauges, or a strain gauge compressed between two parts of the rack, etc ...

On remarque que le cylindre comporte des orifices 11 mettant son volume intérieur en relation avec l'extérieur; ces orifices sont destinés à permettre l'écoulement des liquides et du sang contenus dans le tissu osseux spongieux soumis à compression; des orifices 11' sont également prévus dans le bouchon. Note that the cylinder has orifices 11 putting its internal volume in relation to the outside; these orifices are intended to allow the flow of liquids and blood contained in the cancellous bone tissue subjected to compression; orifices 11 ′ are also provided in the plug.

L'ensemble des moyens sus-décrits est supporté par un bâti massif 12 offrant des points d'appui aux moyens de production de force, d'une part, et au cylindre d'autre part. All of the above-described means are supported by a solid frame 12 providing support points for the means for producing force, on the one hand, and for the cylinder on the other hand.

Le procédé de l'invention va consister, ayant prélever sur le patient une certaine quantité de matière osseuse spongieuse, par exemple dans la région des crêtes illiaques, - à remplir de matière osseuse spongieuse le cylindre, préalablement obturé à son extrémité à l'aide du bouchon vissable, - à introduire le piston dans le cylindre et lui appliquer à l'aide du levier, la force nécessaire pour créer dans le cylindre une pression comprise entre 500 et 1.000 HPa, - à, lorsque le volume initial de matière a été suffisament réduit, à cesser d'exercer l'effort, et - à déboucher l'extrèmité du cylindre en dévissant le bouchon, puis enfin - à expulser le matériau ainsi moulé, au moyen du piston, et retirer le piston.  The method of the invention will consist, having taken from the patient a certain amount of cancellous bone material, for example in the region of the iliac ridges, - filling the cylinder with cancellous bone material, previously closed at its end using of the screw cap, - insert the piston into the cylinder and apply to it using the lever, the force necessary to create in the cylinder a pressure between 500 and 1,000 HPa, - to, when the initial volume of material has been sufficiently reduced, to cease exerting the effort, and - to unclog the end of the cylinder by unscrewing the cap, then finally - to expel the material thus molded, by means of the piston, and withdraw the piston.

Sur la fig.2, l'étape du procédé de fabrication du matériau de l'invention, est celle dans laquelle, après que le compactage ait été réalisé par application d'un effort de compression, à une certaine quantité de tissu osseux spongieux, et après que ce dernier ait exsudé une certaine quantité de liquides intersticiels et/ou de sang, le matériau a été expulsé sous la forme d'un cylindre moulé 14, et le piston 8 retiré du cylindre. In FIG. 2, the step of the process for manufacturing the material of the invention is that in which, after the compaction has been carried out by application of a compressive force, to a certain amount of spongy bone tissue, and after the latter has exuded a certain amount of interstitial liquids and / or blood, the material has been expelled in the form of a molded cylinder 14, and the piston 8 withdrawn from the cylinder.

Dans les expériences réalisées à ce jour, il est apparu que le cylindre moulé de matériau osseux compacté était d'un part suffisament friable pour pouvoir être sculpté au scalpel, et suffisament malléable pour pouvoir être déformé légèrement de façon manuelle; un élément de prothèse ainsi travaillé est représenté en 15.  In the experiments carried out to date, it has appeared that the molded cylinder of compacted bone material was on the one hand sufficiently brittle to be able to be sculpted with a scalpel, and sufficiently malleable so as to be able to be slightly deformed manually; a prosthesis element thus worked is shown in 15.

Claims (1)

R E V E N D I C A T ï O N S 1.- Procédé de fabrication d'un matériau destiné à la pro thèse osseuse, caractérisé : en ce que l'on compacte dans un moule sous une pression ae l'ordre de 500 à 1.000 hpa un tissu osseux spongieux prélevé sur un organisme vivant ; 2.- Procédé selon la revendication 1, caractérisé : en ce que le prélèvement, le compac tage-moulage et la -réimplantation sont effectués de façon extemporanée 3.- Dispositif de compactage pour la mise en oeuvre d'un pro cédé conforme à la revendication l, caractérisé : en ce qu'il comprend :: - une cavité cylindrique(l),formant moule(l'), pourvue d'un fond amovible(2), la cavité et le fond étant pourvus d'orifices(ll), - un piston(3) destiné à coulisser dans la dite cavité, - des moyens(5) pour appliquer au piston une force contro lée tendant à l'enfoncer dans le cylindre ; 4.- Dispositif selon la revendication 3, caractérisé en ce qu'il comprend en outre des moyens(ll) pour controler, simultanément à l'application de la force, le déplacement au piston ;CLAIMS ï ONS 1.- Process for manufacturing a material intended for bone prosthesis, characterized: in that a spongy bone tissue taken from a a living organism; 2.- Method according to claim 1, characterized: in that the removal, compacting-molding and -reimplantation are carried out extemporaneously 3.- Compaction device for the implementation of a process in accordance with Claim 1, characterized: in that it comprises: - a cylindrical cavity (l), forming a mold (l '), provided with a removable bottom (2), the cavity and the bottom being provided with orifices (ll ), - a piston (3) intended to slide in said cavity, - means (5) for applying to the piston a controlled force tending to push it into the cylinder; 4.- Device according to claim 3, characterized in that it further comprises means (ll) for controlling, simultaneously with the application of force, the movement of the piston; 5.- Dispositif selon la revendication 3, caractérisé : 5.- Device according to claim 3, characterized: en ce que le diamètre de la cavité in that the diameter of the cavity cylindrique est compris entre 0,5 et 2 cm, le diamètre cylindrical is between 0.5 and 2 cm, the diameter du piston étant inférieur à celui de la cavité de quelques of the piston being less than that of the cavity of a few micromètres, micrometers, en ce que les orifices ont un dia in that the orifices have a dia mètre compris entre 0,5 et 2 mm, et  meter between 0.5 and 2 mm, and en ce que la longueur du piston, in that the length of the piston, sensiblement égale à celle du cylindre, est comprise entre substantially equal to that of the cylinder, is between 5 et l0 cm ; 6.- Dispositif selon la revendication 3, caractérisé 5 and 10 cm; 6.- Device according to claim 3, characterized en ce que les moyens de production in that the means of production de force comprennent une crémaillère(7) et un pignon(8) forcibly include a rack (7) and a pinion (8) engrenant dans la crémaillère et pourvu d'un levier(9).  meshing in the rack and provided with a lever (9).
FR898905161A 1989-04-12 1989-04-12 METHOD FOR MANUFACTURING A MATERIAL FOR BONE PROSTHESIS, AND ITS IMPLEMENTING DEVICE Expired - Fee Related FR2645748B1 (en)

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6632247B2 (en) 2000-03-22 2003-10-14 Synthes (Usa) Implants formed of coupled bone
US6776800B2 (en) 2001-02-28 2004-08-17 Synthes (U.S.A.) Implants formed with demineralized bone
CN1316947C (en) * 2004-10-23 2007-05-23 温中一 Replacement equipment for artificial ilium
CN105496610A (en) * 2016-01-25 2016-04-20 中国人民解放军第二军医大学 Hip dislocation preventive adjustable artificial hemipelvic prosthesis

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8043377B2 (en) 2006-09-02 2011-10-25 Osprey Biomedical, Inc. Implantable intervertebral fusion device

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Publication number Priority date Publication date Assignee Title
FR1539182A (en) * 1967-08-03 1968-09-13 Inst Francais De La Fievre Aph New bone prosthesis and its preparation process
DE2917135A1 (en) * 1978-09-28 1980-04-03 Katagiri Masataka ARTIFICIAL BONELY TRANSPLANT AND METHOD FOR THE PRODUCTION THEREOF
DE3127270A1 (en) * 1981-07-10 1983-03-24 Link, Gottlieb, 4950 Minden Bone substitute implant as base for implantation of an artificial tooth
EP0107476A2 (en) * 1982-10-25 1984-05-02 Calcitek, Inc. Bone graft substitute
US4717115A (en) * 1986-10-14 1988-01-05 The United States Of America As Represented By The Secretary Of The Army Adjustable mold for fabricating bone replacements
EP0303941A1 (en) * 1987-08-19 1989-02-22 MERCK PATENT GmbH Method for making a bone-substitute material

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1539182A (en) * 1967-08-03 1968-09-13 Inst Francais De La Fievre Aph New bone prosthesis and its preparation process
DE2917135A1 (en) * 1978-09-28 1980-04-03 Katagiri Masataka ARTIFICIAL BONELY TRANSPLANT AND METHOD FOR THE PRODUCTION THEREOF
DE3127270A1 (en) * 1981-07-10 1983-03-24 Link, Gottlieb, 4950 Minden Bone substitute implant as base for implantation of an artificial tooth
EP0107476A2 (en) * 1982-10-25 1984-05-02 Calcitek, Inc. Bone graft substitute
US4717115A (en) * 1986-10-14 1988-01-05 The United States Of America As Represented By The Secretary Of The Army Adjustable mold for fabricating bone replacements
EP0303941A1 (en) * 1987-08-19 1989-02-22 MERCK PATENT GmbH Method for making a bone-substitute material

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6632247B2 (en) 2000-03-22 2003-10-14 Synthes (Usa) Implants formed of coupled bone
US7087087B2 (en) 2000-03-22 2006-08-08 Boyer Ii Michael L Implants formed of coupled bone
US6776800B2 (en) 2001-02-28 2004-08-17 Synthes (U.S.A.) Implants formed with demineralized bone
CN1316947C (en) * 2004-10-23 2007-05-23 温中一 Replacement equipment for artificial ilium
CN105496610A (en) * 2016-01-25 2016-04-20 中国人民解放军第二军医大学 Hip dislocation preventive adjustable artificial hemipelvic prosthesis
CN105496610B (en) * 2016-01-25 2018-02-02 中国人民解放军第二军医大学 A kind of adjustable anti-hip dislocation artificial semi-pelvis prosthesis

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FR2645748B1 (en) 1994-10-21

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