FR2618776B1 - Procede et intermediaires de preparation de prolines 4-substituees, a action therapeutique - Google Patents
Procede et intermediaires de preparation de prolines 4-substituees, a action therapeutiqueInfo
- Publication number
- FR2618776B1 FR2618776B1 FR888805772A FR8805772A FR2618776B1 FR 2618776 B1 FR2618776 B1 FR 2618776B1 FR 888805772 A FR888805772 A FR 888805772A FR 8805772 A FR8805772 A FR 8805772A FR 2618776 B1 FR2618776 B1 FR 2618776B1
- Authority
- FR
- France
- Prior art keywords
- intermediates
- preparation
- therapeutic action
- substituted prolines
- prolines
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
- C07D207/277—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/044,691 US4734508A (en) | 1987-05-01 | 1987-05-01 | Process and intermediates for preparing 4-substituted proline derivatives |
US07/092,360 US4851514A (en) | 1987-05-01 | 1987-09-02 | Process for preparing a compound useful in preparing ace inhibitors and intermediate produced thereby |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2618776A1 FR2618776A1 (fr) | 1989-02-03 |
FR2618776B1 true FR2618776B1 (fr) | 1994-08-12 |
Family
ID=26721884
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR888805772A Expired - Lifetime FR2618776B1 (fr) | 1987-05-01 | 1988-04-29 | Procede et intermediaires de preparation de prolines 4-substituees, a action therapeutique |
FR898900664A Expired - Lifetime FR2626574B1 (fr) | 1987-05-01 | 1989-01-20 | Triphenylcerium |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR898900664A Expired - Lifetime FR2626574B1 (fr) | 1987-05-01 | 1989-01-20 | Triphenylcerium |
Country Status (6)
Country | Link |
---|---|
US (1) | US4851514A (fr) |
CA (1) | CA1328272C (fr) |
FR (2) | FR2618776B1 (fr) |
GB (3) | GB2204585B (fr) |
IE (1) | IE61532B1 (fr) |
IT (1) | IT1217443B (fr) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1268418B1 (fr) * | 2000-03-27 | 2006-06-14 | Applied Research Systems ARS Holding N.V. | Derives de la pyrrolidine pharmaceutiquement actifs comme inhibiteurs de bax |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4291040A (en) * | 1979-10-22 | 1981-09-22 | E. R. Squibb & Sons, Inc. | Mercaptoacyl derivatives of 4-disubstituted prolines and 4-substituted dehydroprolines |
US4316905A (en) * | 1980-07-01 | 1982-02-23 | E. R. Squibb & Sons, Inc. | Mercaptoacyl derivatives of various 4-substituted prolines |
US4337201A (en) * | 1980-12-04 | 1982-06-29 | E. R. Squibb & Sons, Inc. | Phosphinylalkanoyl substituted prolines |
US4501901A (en) * | 1983-09-19 | 1985-02-26 | E. R. Squibb & Sons, Inc. | Method for making substituted prolines |
US4492655A (en) * | 1984-04-27 | 1985-01-08 | Rhone-Poulenc, Inc. | Tricyclopentadienyl cerium and process for preparing the same |
US4588819A (en) * | 1984-11-19 | 1986-05-13 | E. R. Squibb & Sons, Inc. | Process and intermediates for preparing trans-4-substituted-s-prolines |
-
1987
- 1987-09-02 US US07/092,360 patent/US4851514A/en not_active Expired - Lifetime
-
1988
- 1988-03-28 CA CA000562635A patent/CA1328272C/fr not_active Expired - Lifetime
- 1988-04-28 IT IT20361/88A patent/IT1217443B/it active
- 1988-04-29 GB GB8810182A patent/GB2204585B/en not_active Expired - Lifetime
- 1988-04-29 IE IE127788A patent/IE61532B1/en not_active IP Right Cessation
- 1988-04-29 FR FR888805772A patent/FR2618776B1/fr not_active Expired - Lifetime
-
1989
- 1989-01-20 FR FR898900664A patent/FR2626574B1/fr not_active Expired - Lifetime
-
1990
- 1990-09-21 GB GB9020681A patent/GB2235452A/en not_active Withdrawn
- 1990-09-21 GB GB9020682A patent/GB2235453B/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
GB2235453B (en) | 1991-09-04 |
FR2626574A1 (fr) | 1989-08-04 |
FR2618776A1 (fr) | 1989-02-03 |
GB2204585A (en) | 1988-11-16 |
IT1217443B (it) | 1990-03-22 |
GB2204585B (en) | 1991-09-04 |
GB9020682D0 (en) | 1990-11-07 |
IE61532B1 (en) | 1994-11-16 |
FR2626574B1 (fr) | 1990-12-14 |
IE881277L (en) | 1988-11-01 |
IT8820361A0 (it) | 1988-04-28 |
GB8810182D0 (en) | 1988-06-02 |
GB9020681D0 (en) | 1990-11-07 |
GB2235452A (en) | 1991-03-06 |
CA1328272C (fr) | 1994-04-05 |
US4851514A (en) | 1989-07-25 |
GB2235453A (en) | 1991-03-06 |
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