FR2618776B1 - Procede et intermediaires de preparation de prolines 4-substituees, a action therapeutique - Google Patents

Procede et intermediaires de preparation de prolines 4-substituees, a action therapeutique

Info

Publication number
FR2618776B1
FR2618776B1 FR888805772A FR8805772A FR2618776B1 FR 2618776 B1 FR2618776 B1 FR 2618776B1 FR 888805772 A FR888805772 A FR 888805772A FR 8805772 A FR8805772 A FR 8805772A FR 2618776 B1 FR2618776 B1 FR 2618776B1
Authority
FR
France
Prior art keywords
intermediates
preparation
therapeutic action
substituted prolines
prolines
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
FR888805772A
Other languages
English (en)
Other versions
FR2618776A1 (fr
Inventor
John Kurian Thottathil
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ER Squibb and Sons LLC
Original Assignee
ER Squibb and Sons LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/044,691 external-priority patent/US4734508A/en
Application filed by ER Squibb and Sons LLC filed Critical ER Squibb and Sons LLC
Publication of FR2618776A1 publication Critical patent/FR2618776A1/fr
Application granted granted Critical
Publication of FR2618776B1 publication Critical patent/FR2618776B1/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • C07D207/277—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
FR888805772A 1987-05-01 1988-04-29 Procede et intermediaires de preparation de prolines 4-substituees, a action therapeutique Expired - Lifetime FR2618776B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/044,691 US4734508A (en) 1987-05-01 1987-05-01 Process and intermediates for preparing 4-substituted proline derivatives
US07/092,360 US4851514A (en) 1987-05-01 1987-09-02 Process for preparing a compound useful in preparing ace inhibitors and intermediate produced thereby

Publications (2)

Publication Number Publication Date
FR2618776A1 FR2618776A1 (fr) 1989-02-03
FR2618776B1 true FR2618776B1 (fr) 1994-08-12

Family

ID=26721884

Family Applications (2)

Application Number Title Priority Date Filing Date
FR888805772A Expired - Lifetime FR2618776B1 (fr) 1987-05-01 1988-04-29 Procede et intermediaires de preparation de prolines 4-substituees, a action therapeutique
FR898900664A Expired - Lifetime FR2626574B1 (fr) 1987-05-01 1989-01-20 Triphenylcerium

Family Applications After (1)

Application Number Title Priority Date Filing Date
FR898900664A Expired - Lifetime FR2626574B1 (fr) 1987-05-01 1989-01-20 Triphenylcerium

Country Status (6)

Country Link
US (1) US4851514A (fr)
CA (1) CA1328272C (fr)
FR (2) FR2618776B1 (fr)
GB (3) GB2204585B (fr)
IE (1) IE61532B1 (fr)
IT (1) IT1217443B (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1268418B1 (fr) * 2000-03-27 2006-06-14 Applied Research Systems ARS Holding N.V. Derives de la pyrrolidine pharmaceutiquement actifs comme inhibiteurs de bax

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4291040A (en) * 1979-10-22 1981-09-22 E. R. Squibb & Sons, Inc. Mercaptoacyl derivatives of 4-disubstituted prolines and 4-substituted dehydroprolines
US4316905A (en) * 1980-07-01 1982-02-23 E. R. Squibb & Sons, Inc. Mercaptoacyl derivatives of various 4-substituted prolines
US4337201A (en) * 1980-12-04 1982-06-29 E. R. Squibb & Sons, Inc. Phosphinylalkanoyl substituted prolines
US4501901A (en) * 1983-09-19 1985-02-26 E. R. Squibb & Sons, Inc. Method for making substituted prolines
US4492655A (en) * 1984-04-27 1985-01-08 Rhone-Poulenc, Inc. Tricyclopentadienyl cerium and process for preparing the same
US4588819A (en) * 1984-11-19 1986-05-13 E. R. Squibb & Sons, Inc. Process and intermediates for preparing trans-4-substituted-s-prolines

Also Published As

Publication number Publication date
GB2235453B (en) 1991-09-04
FR2626574A1 (fr) 1989-08-04
FR2618776A1 (fr) 1989-02-03
GB2204585A (en) 1988-11-16
IT1217443B (it) 1990-03-22
GB2204585B (en) 1991-09-04
GB9020682D0 (en) 1990-11-07
IE61532B1 (en) 1994-11-16
FR2626574B1 (fr) 1990-12-14
IE881277L (en) 1988-11-01
IT8820361A0 (it) 1988-04-28
GB8810182D0 (en) 1988-06-02
GB9020681D0 (en) 1990-11-07
GB2235452A (en) 1991-03-06
CA1328272C (fr) 1994-04-05
US4851514A (en) 1989-07-25
GB2235453A (en) 1991-03-06

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