FR2618678A1 - Pharmaceutical composition for the treatment of inflammations of the buccal cavity - Google Patents

Abstract

Pharmaceutical composition for the treatment of inflammations of the buccal cavity, especially aphthous stomatitis, which contains a soluble extract of tea as active principle, as well as a pharmaceutically acceptable vehicle suitable for providing for prolonged contact between the active principle and the buccal cavity. The vehicle advantageously consists of a chewing gum.

Description

Thalacaceutical composition for the treatment of inflammation of the oral cavity.

The invention relates to a pharmaceutical composition for the treatment of inflammation of the oral cavity, in particular aphthous stomatitis.

The oral cavity can be the site of various inflammations, the most common of which are aphthous stomatitis, also called canker sores. These aphthous stomatitis, the etiology of which is not completely understood, consists of a superficial lesion of the oral mucosa which causes a particularly painful sensation in the subject who suffers from it.

Other inflammations are also likely to appear in the oral cavity, for example in the gums following dental procedures or the fitting of appliances and / or prostheses.

 At the present time there are various pharmaceutical compositions for the treatment of oral inflammations, in particular foot-and-mouth disease. These compositions are most often in the form of solutes, solutions or powder for mouthwashes, sublingual tablets, mouthwashes, etc. These pharmaceutical compositions do not always allow rapid relief of the patient.

The applicant has found that tea, that is to say the soluble part of the plant obtained by infusion, is particularly effective for the preventive and curative treatment of inflammations of the oral cavity, and in particular foot-and-mouth disease.

The applicant has also highlighted the healing properties of tea on wounds caused by tooth extractions and on lesions caused by the fitting of devices and / or prostheses.

Until now, tea has been known for various medicinal and hygienic properties, in particular as an exciting, digestive, tonic and even sudorific.

We also know, from French Patent No. 73-37765, that the tea used in the form of co-precipitation with acetylsalicylic acid makes it possible to reduce the side effects of this acid.

The applicant has highlighted other properties of the tea which make it particularly suitable for the treatment of inflammations of the oral cavity.

When tea is incorporated into suitable compositions, it has new hygienic, antiseptic and pharmaceutical properties which have not been recognized so far, in particular healing properties with regard to inflammation of the oral cavity.

The invention therefore relates to a new pharmaceutical composition for the treatment of inflammation of the oral cavity which contains a soluble extract of tea as an active principle, as well as a pharmaceutically acceptable vehicle capable of ensuring prolonged contact between the principle active and the oral cavity.

The term "tea" or "soluble tea extract" as used herein is intended to denote the soluble part of the plant which is obtained by infusion and which makes it possible to prepare the well-known drink, designated under this name.

The soluble tea extract used for the preparation of the pharmaceutical compositions according to the invention can be an aqueous solution, such as a simple infusion obtained by hot maceration of the tea leaves having undergone, after picking, the usual roasting treatment. or partial fermentation. The concentration of the dry extract of tea in the solution is advantageously of the same order of magnitude as that of the tea infusions used as a drink, although higher concentrations can be envisaged in the context of the invention.

The soluble tea extract used for the preparation of the pharmaceutical compositions according to the invention can also consist of a soluble powder obtained by lyophilization or atomization of a tea infusion. Such soluble powders are well known and sold commercially for the preparation of so-called "instant" drinks, and this by simple solubilization of the powder in hot water.

The soluble tea extract used for the preparation of the compositions according to the invention is preferably obtained from green teas or black teas, in particular from teas belonging to the family of Ternstroemiaceae, from the Camellie tribe, because of their remarkable healing properties. Among the varieties of teas preferred for the implementation of the invention, there may be mentioned in particular: teas from China, teas from Ceylon, peko, peko from Assam, orange peko, black peko, congo, souchong, pouchong, ning -yong, houlong, campoy, caper, bohea, hyson, hjyson junior, hyswen, choulan, nysenskin, gunpowder, imperial or pearl tea, tun-ki, this list is not exhaustive.

On the other hand, certain varieties of teas are less suitable for the preparation of compositions according to the invention. Among these varieties we can cite: American tea, Bogota tea,
Bourbon tea, Chili tea, European tea, French tea,
Labrador tea, Mexican tea, Norwegian tea, Paraguay tea, mate, Pennsylvania or Oswego tea and Swiss tea, which do not belong to the family of Ternstroemaciés already mentioned.

The pharmaceutical compositions of the invention can be in different forms suitable for ensuring intimate and prolonged contact between the active principle, that is to say the tea extract, and the oral cavity.

In a preferred embodiment of the invention, the paraceutically acceptable vehicle is a chewing gum or "chewing gum" in which is incorporated a soluble extract of tea and, where appropriate, other additional ingredients.

The water used in the preparation of a classic chewing gum is then replaced, in whole or in part, by an infusion of tea.

The use of a chewing gum constitutes a particularly effective mode of treatment since the active principle is in intimate and prolonged contact with the mucous membranes during the whole time of the chewing of the gum, this chewing being able to be interrupted, the gum being then applied to the part of the oral cavity to be treated.

As a variant, the pharmaceutical composition of the invention may be in the form of an aqueous or hydro-alcoholic solution making it possible to obtain directly, or after dilution, solutions for mouthwashes or also for compresses or whitewashes.

The pharmaceutical composition can also be in the form of a powder to be dissolved in water, in which case a soluble powder based on tea is advantageously used as active ingredient. This powder to dissolve allows, after solubilization in water, to obtain a solution for mouthwashes, whitewashes or compresses.

Among other embodiments of the pharmaceutical composition of the invention, there may be mentioned sublingual tablets, mouthwashes or even toothpastes.

The pharmaceutical compositions of the invention have advantageous pharmacological properties, in particular healing properties, which make them remarkable medicaments for the treatment of oral inflammations, for example stomatitis in general and aphthous stomatitis in particular, as well as inflammations. gums following dental procedures, these healing properties can also be applied to wounds and bodily injuries.

These compositions are not toxic, being essentially constituted by a soluble extract of non-toxic tea in itself.

Usually, the treatment must include at least two intakes or administrations per day depending on the severity of the inflammation observed and must continue over a few days, the increase in these intakes or administrations accelerating the recovery from aphthous stomatitis and / or the scarring of the other above-mentioned harmless lesions.

From the first treatment, the feeling of appeasement is almost immediate due to the healing properties exerted by the tea extract on the inflamed areas of the oral mucosa.

Of course, the pharmaceutical composites of the invention may include additional ingredients, usually usable in pharmacy, for example perfumes, stabilizers, preservatives, etc.

 It is also within the scope of the invention to add, if necessary, to the pharmaceutical compositions one or more additional active principles capable of complementing or reinforcing the action of the soluble tea extract.

Among these additional active principles, there may be mentioned in particular antibiotic agents, anti-inflammatory agents, etc.

The examples which follow illustrate the invention, without however limiting it.

EXAMPLE 1 Chewing Gum
Chewing gums are prepared, according to a conventional production process. The only difference is that the water conventionally used in the preparation of chewing gum is replaced, in whole or in part, by a classic tea infusion. All other chewing gum ingredients remain the same: sugar, vinyl acetate or the like, perfume, plasticizer, etc.

Example 2: Antiseptic solution
An antiseptic solution is prepared from the following ingredients - hexamedine (DC1) -di-isothionate 100 mg - polysorbitol monostreearate 50 mg - citric acid 90 mg - mint essence 60 mg - anise essence 60 mg - ethyl alcohol 4000 mg - tea qs 100 ml
The tea used for the preparation of this antiseptic solution is preferably a tea infusion.

This solution can be used directly for mouthwashes, compresses or whitewashes.

Example 3: Powder to dissolve
A powder to be dissolved is prepared comprising the following ingredients - lyophilized tea 95 g - lysozyme hydrochloride 1 g - acid p. 2,2-trichoro-2-hydroxy-1-ethyl-salicylic 4 g
In this composition, lysozyme hydrochloride plays the role of antibiotic, while p.tricloro-2,2-hydroxy-1-ethyl-salicylic acid plays the role of anti-inflammatory.

The powder thus obtained must be dissolved C-xtra-temporarily at a rate of 2 g in 100 ml of water to obtain a solution to be used for mouthwashes, compressec or whitewashes.

Example 4: Mouthwash solution.

A solution is prepared comprising the following ingredients - hydrated chloral 1 g - menthol 0 g 25 - veratrol 0 g 25 - resorcin 0 g 02 - salicylic acid 0 g 02 - ethyl alcohol 35 g - tea qs 100 ml
The solution thus obtained will be diluted to 50 'to obtain a solution for mouthwashes, compresses, whitewashes.

Claims (10)

Claims. 1. Pharmaceutical composition for the treatment of inflammations and lesions of the oral cavity, in particular of aphthous stomatitis, characterized in that it contains a soluble extract of tea as an active principle, as well as a pharmaceutically acceptable vehicle suitable for ensuring prolonged contact between the active ingredient and the oral cavity. 2. Pharmaceutical composition, for the treatment, by scarring of wounds and bodily injuries, characterized in that it contains a soluble extract of tea as an active principle, as well as a pharmaceutically acceptable vehicle capable of ensuring prolonged contact between the active ingredient and the oral cavity. 3. Composition according to claim 1 and 2, characterized in that the soluble tea extract is an aqueous solution, for example an infusion of tea. 4. Composition according to claim 1 and 2, characterized in that the soluble tea extract is a soluble powder obtained by lyophilization or atomization of a tea infusion. 5. Composition according to one of claims 1 to 4, characterized in that the tea extract is obtained from green teas or black teas. 6. Composition according to claim 5, characterized in that the tea extract is obtained from a tea from the family of Ternstroemiaceae, tribe of Camellia. 7. Composition according to one of claims 1 to 6, characterized in that the pharmaceutically acceptable vehicle is a chewing gum and in that the water used for the preparation of this gum is replaced, in whole or in part, by an aqueous solution of tea, for example a tea infusion. 8. Composition according to one of claims 1 to 6, characterized in that the vehicle is an aqueous or hydro-alcoholic solution. 9. Composition according to one of claims 1 to 6, characterized in that it is in the form of a powder to be dissolved in water and in that the soluble tea extract is in the form of a soluble powder. 10. Composition according to one of claims 1 to 9, characterized in that it contains at least one additional active principle, for example an antibiotic agent or an anti-inflammatory agent.