FR2611908A1 - Chromatography column assembly - Google Patents

Chromatography column assembly Download PDF

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Publication number
FR2611908A1
FR2611908A1 FR8702413A FR8702413A FR2611908A1 FR 2611908 A1 FR2611908 A1 FR 2611908A1 FR 8702413 A FR8702413 A FR 8702413A FR 8702413 A FR8702413 A FR 8702413A FR 2611908 A1 FR2611908 A1 FR 2611908A1
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France
Prior art keywords
columns
group
filter
holding block
assembly according
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Granted
Application number
FR8702413A
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French (fr)
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FR2611908B1 (en
Inventor
Jean-Louis Rocca
Georges Ferraris
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TOUZART MATIGNON FOURNITURES L
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TOUZART MATIGNON FOURNITURES L
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Priority to FR8702413A priority Critical patent/FR2611908B1/en
Publication of FR2611908A1 publication Critical patent/FR2611908A1/en
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02Column chromatography
    • G01N30/26Conditioning of the fluid carrier; Flow patterns
    • G01N30/38Flow patterns
    • G01N30/46Flow patterns using more than one column
    • G01N30/461Flow patterns using more than one column with serial coupling of separation columns
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02Column chromatography
    • G01N30/60Construction of the column
    • G01N30/6004Construction of the column end pieces
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02Column chromatography
    • G01N30/60Construction of the column
    • G01N30/6004Construction of the column end pieces
    • G01N30/603Construction of the column end pieces retaining the stationary phase, e.g. Frits
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02Column chromatography
    • G01N30/88Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G01N2030/8881Modular construction, specially adapted therefor
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02Column chromatography
    • G01N30/60Construction of the column
    • G01N30/6034Construction of the column joining multiple columns
    • G01N30/6039Construction of the column joining multiple columns in series
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02Column chromatography
    • G01N30/60Construction of the column
    • G01N30/6047Construction of the column with supporting means; Holders

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  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)

Abstract

The invention relates to an assembly of chromatography columns connected in series, comprising two columns which each have two ends, and a filter made of a sintered material located at one of the ends of each column. According to the invention, a) the two columns 13 have equal lengths L and are arranged parallel and side by side; b) two adjacent ends of the columns are held in position by means of a holding unit 15 fitted with a connection face 18, with which the extreme segments of the columns are flush; and, c) a filter holder 19, fitted with a bearing face 19a, whose shape is complementary with that of the connection face 18 of the holding unit 15, is fixed removably 20; 29 to each holding unit, the connection and bearing faces bearing on each other, and the filter holder 19 having two through-holes 21, inside each of which a filter 23, made of a sintered material, is located. One application is the production of high-performance and inexpensive chromatography columns.

Description

EnsembLe de coLonnes de chromatographie.Set of chromatography columns.

La chromatographie utiLise des colonnes emplies au préalable du matériau permettant la séparation d'un mélange en ses divers constituants et fait traverser ces colonnes par ledit mélange. Chromatography uses columns filled beforehand with the material allowing the separation of a mixture into its various constituents and makes these columns pass through said mixture.

A ce jour, le coût des colonnes utilisées est élevé, car les colonnes les plus performantes doivent être longues et de faibles diamètres intérieurs, donc fragiles, et doivent en outre être bien remplies du matériau de séparation, ce qui est évidemment difficile à réaliser avec des colonnes longues et de faibles diamètres. To date, the cost of the columns used is high, because the most efficient columns must be long and of small internal diameters, therefore fragile, and must also be well filled with the separating material, which is obviously difficult to achieve with long columns and small diameters.

L'invention procede de L'idée de s'affranchir de La contrainte de longueur des colonnes de chromatographie connues, en limitant a priori La longueur de chaque tronçon individuel de colonnes, mais, bien entendu, en réalisant la Longueur totale désirée en reliant en série autant de tronçons individuels que celà est nécessaire. Pour réaliser ces branchements en série, il a fallu concevoir des dispositions particulières, qui sont précisément
L'objet de l'invention.
The invention proceeds from the idea of overcoming the length constraint of known chromatography columns, by limiting a priori the length of each individual section of columns, but, of course, by achieving the desired total length by connecting in series as many individual sections as necessary. To make these series connections, special arrangements had to be devised, which are precisely
The object of the invention.

Celle-ci est donc relative à un ensemble de colonnes de chromatographie reliées en série, ensemble comprenant au moins un groupe de deux colonnes, chaque colonne présentant deux extrémités et un filtre en matériau fritté étant disposé à au moins L'une des deux extrémités de chaque colonne. This therefore relates to a set of chromatography columns connected in series, a set comprising at least one group of two columns, each column having two ends and a sintered material filter being disposed at at least one of the two ends of each column.

Selon L'invention, a) les deux colonnes de chaque groupe de deux colonnes ont des longueurs égales et sont disposées parallelement, côte à côte, leurs extrémités étant voisines deux à deux ; b) deux extrémités voisines de colonnes d'un groupe de deux colonnes sont maintenues en position relative au moyen d'un bloc de maintien, qui est muni d'une face de communication que les tranches extrêmes desdites deux colonnes affleurent ; et, c) un support de filtres, muni d'une face d'appui de forme complémentaire de celle de la face de communication du bloc de maintien, est fixé de manière amovible à chaque bloc de maintien,
Lesdites faces de communication et d'appui étant en appui L'une sur L'autre, et le support de filtres présentant, au droit des emplacements où affleurent Les tranches extrêmes des deux colonnes, deux trous traversants à L'intérieur de chacun desquels un filtre en matériau fritté est susceptible d'être disposé.
According to the invention, a) the two columns of each group of two columns have equal lengths and are arranged parallel, side by side, their ends being close in pairs; b) two neighboring ends of columns of a group of two columns are held in relative position by means of a holding block, which is provided with a communication face that the end edges of said two columns are flush; and, c) a filter support, provided with a support face of a shape complementary to that of the communication face of the holding block, is removably fixed to each holding block,
Said communication and support faces being supported One on the other, and the filter support having, in line with the locations where the extreme edges of the two columns are flush, two through holes inside each of which a sintered material filter is likely to be disposed.

Les avantageuses dispositions suivantes sont en outre, de preférence, adoptées
- la liaison entre les deux colonnes d'un groupe de deux colonnes est realisée au moyen d'un conduit en U scellé dans un contre-bloc, qui est fixé au bloc de maintien de deux extrémités voisines desdites deux colonnes, L'écartement ces extrémités du conduit en U étant égal à celui des tranches extrêmes desdites extrémités de colonnes et les extrémités du corduit en U étant disposées en regard desdites tranches extrêmes ;
- le support de filtres est disposé entre le bloc de maintien et Le contre-bloc, ces trois pièces étant maintenues assemblées par des moyens de fixation communs ;
- l'ensemble comprend des pions de- centrage du support de filtres par rapport au bloc de maintien, qui assurent la mise en place relative précise de ces deux pieces ;;
- l'ensemble comprend plusieurs groupes de deux colonnes, ainsi qu'un soc le commun auxdits groupes et muni d'une plaque superieure commune d'intercommunication, chaque groupe de deux colonnes étant fixé au socle, en regard de la plaque d'intercommunication ;
- chaque groupe de deux colonnes est fixé sur le soc le par un moyen de fixation rapide, tel qu'un dispositif à grenouillères.
The following advantageous arrangements are also preferably adopted
- The connection between the two columns of a group of two columns is carried out by means of a U-shaped conduit sealed in a counter-block, which is fixed to the holding block of two adjacent ends of said two columns, The spacing these ends of the U-shaped duct being equal to that of the end sections of said column ends and the ends of the U-shaped duct being arranged opposite said end sections;
- The filter support is arranged between the holding block and the counter-block, these three parts being held together by common fixing means;
- The assembly includes pins centering the filter support relative to the holding block, which ensure the precise relative positioning of these two parts;
- The assembly includes several groups of two columns, as well as a plowshare common to said groups and provided with a common upper intercommunication plate, each group of two columns being fixed to the base, opposite the intercommunication plate ;
- Each group of two columns is fixed to the base by a quick fixing means, such as a latches device.

L'invention sera mieux comprise, et des caractéristiques secondaires et leurs avantages apparaîtront au cours de la description d'une realisation donnée ci-dessous à titre d'exemple. The invention will be better understood, and secondary characteristics and their advantages will appear during the description of an embodiment given below by way of example.

Il est entendu que la description et les dessins ne sont donnés qu'à titre indicatif et non limitatif. It is understood that the description and the drawings are given for information only and are not limiting.

Il sera fait référence aux dessins annexes, dans lesquels
- la figure 1 est une vue en élévation d'un ensemble de colonnes de chromatographie conforme à l'invention ;
- la figure 2 est une coupe suivant II-II de la figure 1;
- la figure 3 est une coupe suivant III-III de la figure 1
- La figure 4 est une vue suivant fleche F de la figure 1 et,
- la figure 5 est une coupe partielle suivant V-V de la figure 2.
Reference will be made to the accompanying drawings, in which
- Figure 1 is an elevational view of a set of chromatography columns according to the invention;
- Figure 2 is a section along II-II of Figure 1;
- Figure 3 is a section along III-III of Figure 1
FIG. 4 is a view along arrow F of FIG. 1 and,
- Figure 5 is a partial section along VV of Figure 2.

L'appareil de colonnes de chromatographie représente comprend :
- un socle inférieur 1, qui comporte deux parois longitudinales 2, un fond 3 et deux parois extrêmes 4 ;
- une plaque 5 d'intercommunication, qui est appliquée sur les faces supérieures planes 6 des parois longitudinales 2 et des parois extrêmes 4, et qui coopère avec ces parois et le fond 3 à délimiter une chambre inférieure 7 ;
- une vanne d'admission 8, qui est fixée (9) sur la face supérieure 10 de La plaque d'intercommunication 5, à une extrémité de cette plaque, et à laquelle le conduit d'admission 11 des mélanges devant être séparés est raccordé ;
- quatre ensembles 12 de chacun deux colonnes de chromatographie 13 ;
- un ensemble 14 d'échappement du mélange ayant traverse tes diverses colonnes de chromatographie.
The apparatus for chromatography columns represents comprises:
- A lower base 1, which has two longitudinal walls 2, a bottom 3 and two end walls 4;
- An intercommunication plate 5, which is applied to the flat upper faces 6 of the longitudinal walls 2 and the end walls 4, and which cooperates with these walls and the bottom 3 to define a lower chamber 7;
- an intake valve 8, which is fixed (9) on the upper face 10 of the intercommunication plate 5, at one end of this plate, and to which the intake duct 11 of the mixtures to be separated is connected ;
- Four sets 12 of each two chromatography columns 13;
- A set 14 of mixture exhaust having passed through your various chromatography columns.

Un ensemble 12 de deux colonnes 13 est constitué par ces deux colonnes, qui sont parallèles, de longueurs égales L, et dont les extrémités sont deux à deux voisines et maintenues dans cette position par un bloc de maintien 15, dans lequel elles sont scellées (16). Les tranches d'extremité 17 des colonnes 13 affleurent une face de communication 18, dont est muni te bloc de maintien 15. A set 12 of two columns 13 is formed by these two columns, which are parallel, of equal length L, and the ends of which are two by two neighbors and held in this position by a holding block 15, in which they are sealed ( 16). The end edges 17 of the columns 13 are flush with a communication face 18, which is provided with the holding block 15.

Une plaque mince, formant support 19 de filtres, est fixée par des vis amovibles 20 sur le bloc de maintien 15, sur la face de communication 18 duquel elle est en appui par sa face d'appui 19a. Ce support de filtres 19 comporte deux trous 21, ayant même écartement E, que les colonnes de chromatographie 13. A
L'intérieur de chaque trou 21 sont disposés un gicleur calibré 22, qui, en ce qui concerne les extrémités, inférieures des colonnes de chromatographie 13, est en appui sur la face supérieure 10 de la plaque d'intercommunication 6, et un filtre 23, en matériau fritté, qui repose sur Le gicleur 22.
A thin plate, forming a support 19 for filters, is fixed by removable screws 20 to the holding block 15, on the communication face 18 from which it is supported by its support face 19a. This filter support 19 has two holes 21, having the same spacing E, as the chromatography columns 13. A
Inside each hole 21 are arranged a calibrated nozzle 22, which, as regards the lower ends of the chromatography columns 13, is supported on the upper face 10 of the intercommunication plate 6, and a filter 23 , of sintered material, which rests on the nozzle 22.

Des pions de centrage 24 sont introduits concomitamment dans des orifices de centrage 25 dont sont munis le bloc de maintien 15, le support de filtres 19 et la plaque d'intercommunication 5. L'ensemble de ces trois éléments est fixé de manière amovible sur le soc le 1 au moyen d'un dispositif à grenouillères 26. Centering pins 24 are introduced concomitantly into centering orifices 25 which are fitted with the retaining block 15, the filter support 19 and the intercommunication plate 5. All of these three elements are removably attached to the plowshare 1 by means of a latches device 26.

Les extrémités supérieures de deux colonnes de chromatographie 13 sont également maintenues dans un bloc de maintien 15. Une plaque mince, support 19 de filtres, est prévue, dans laquelle deux trous 21 reçoivent, chacun, un gicleur calibré 22 et un filtre 23 en matériau fritté, le gicleur 22 reposant sur
La tranche d'extrémité d'une colonne 13, et le filtre 23 reposant sur le gicleur 22. Un contre-bloc 27 supporte un tube en U, 28, de faible Longueur, et, en étant appliqué sur la face supérieure du support de filtres 19, réalise la liaison entre les deux colonnes de chromatographie 13. L'ensemble d'un bloc de rraintien supérieur 15, du support de filtres 19 associé et du contre-bloc 27 est centré par des pions de centrage 24 et maintenu assemblé par des vis 29, communes aux trois éléments.
The upper ends of two chromatography columns 13 are also held in a holding block 15. A thin plate, support 19 for filters, is provided, in which two holes 21 each receive a calibrated nozzle 22 and a filter 23 made of material sintered, the nozzle 22 resting on
The end edge of a column 13, and the filter 23 resting on the nozzle 22. A counterblock 27 supports a U-shaped tube, 28, of short length, and, being applied to the upper face of the support filters 19, provides the connection between the two chromatography columns 13. The assembly of an upper rail block 15, the associated filter support 19 and the counter-block 27 is centered by centering pins 24 and kept assembled by screws 29, common to the three elements.

D'autres tubes en U 30, contenus dans la chambre inférieure 7, relient la vanne d'admission 8 à La première colonne de chromatographie 13 du premier ensemble 12 de deux colonnes, puis la deuxieme colonne de chromatographie 13 d'un ensemble à la première colonne de chromatographie 13 de l'ensemble suivant, enfin la deuxième colonne de chromatographie du dernier ensemble 12 de deux colonnes de chromatographie au tube de sortie 31 (figure 5). Other U-shaped tubes 30, contained in the lower chamber 7, connect the inlet valve 8 to the first chromatography column 13 of the first set 12 of two columns, then the second chromatography column 13 of a set to the first chromatography column 13 of the following set, finally the second chromatography column of the last set 12 of two chromatography columns at the outlet tube 31 (FIG. 5).

L'ensemble d'échappement 14, de manière analogue aux ensembles inférieurs des blocs de maintien 15, supports de filtres 19 et plaque d'intercommunication 5 des ensembles de deux colonnes de chromatographie 13, est fixé au soc le 1 par des grenouilléres 26. Il comprend Le bloc de maintien 15 du tube externe de sortie 31, ainsi qu'un support de filtre 19, la plaque d'intercommunication 5, Les pions de centrage 24, les vis 20 , un gicleur 22, un filtre 23 en matériau fritté. Le tube externe de sortie 31 est en communication, avec interposition des gicleur 22 et filtre 23, avec le dernier tube en U inférieur 30. The exhaust assembly 14, analogously to the lower assemblies of the retaining blocks 15, filter supports 19 and intercommunication plate 5 of the sets of two chromatography columns 13, is fixed to the ploughshare 1 by latches 26. It includes the holding block 15 of the external outlet tube 31, as well as a filter support 19, the intercommunication plate 5, the centering pins 24, the screws 20, a nozzle 22, a filter 23 made of sintered material. . The external outlet tube 31 is in communication, with the interposition of the nozzle 22 and filter 23, with the last lower U-shaped tube 30.

Le fonctionnement observé est simple : le mélange qui doit être separé en ses différents constituants traverse, entre la vanne d'admission 8 et le tube de sortie 31, autant de fois deux colonnes de chromatograpie 13, qu'il y a d'ensembles de telles deux colonnes, soit, dans la réalisation représentée, huit colonnes de chromatographie 13, ce qui, même-si chaque colonne de chromatographie 13 a une longueur relativement petite (12 cm dans une réalisation réelle), constitue une longueur totale efficace considérable (12 cm x 8 = 96 cm). The observed operation is simple: the mixture which must be separated into its different constituents passes through two inlet chromatography columns 13 between the inlet valve 8 and the outlet tube 31 as many sets of such two columns, that is, in the embodiment shown, eight chromatography columns 13, which, even if each chromatography column 13 has a relatively small length (12 cm in an actual embodiment), constitutes a considerable effective total length (12 cm x 8 = 96 cm).

Une telle longueur totale efficace n'aurait pu être réalisée que très difficilement auparavant au moyen d'une colonne unique de chromatographie, monobloc, ou éventuellement de deux colonnes de chromatographie mises bout à bout. Such an effective total length could only have been achieved very difficult before by means of a single chromatography column, monobloc, or possibly of two chromatography columns placed end to end.

On connait la difficulté de fabrication de colonnes de chromatographie de bonne qualité, qui réside dans la difficulté de remplir correctement et complètement Les colonnes de chromatographie avec le matériau actif de séparation. We know the difficulty of manufacturing good quality chromatography columns, which lies in the difficulty of correctly and completely filling the chromatography columns with the active separation material.

La possibilité offerte par L'invention de fractionner la longueur totale nécessaire en plusieurs tronçons plus petits réduit considérablement cette difficuLté antérieure, compte tenu de la facilité relative d'emplir correctement un tronçon de faible longueur, et permet la réalisation d'appareils de séparation à un prix de revient très inférieur à ce lui des appareils connus antérieurement. The possibility offered by the invention to split the total length required into several smaller sections considerably reduces this prior difficulty, taking into account the relative ease of correctly filling a short section, and allows the production of separation apparatuses with a cost price much lower than that of previously known devices.

A ce premier avantage, l'invention en ajoute un deuxieme principal : la mise en place de deux colonnes de chromatographie adjacentes, reliées par un tube en U, voire de plusieurs ensembles de telles deux colonnes de chromatographie, réduit L'encombrement total de l'appareil, ce qui est intéressant, et réduit également
Les risques de bris d'un matériel coûteux, ce qui est aussi très intéressant.
To this first advantage, the invention adds a second main one: the installation of two adjacent chromatography columns, connected by a U-shaped tube, or even of several sets of such two chromatography columns, reduces the total size of the device, which is interesting, and also reduces
The risk of breakage of expensive equipment, which is also very interesting.

IL convient également d'observer La facilité de choisir la Longueur de colonne de chromatographie en fonction de la separation désirée, ceci avec un matériel "standard". Il suffit en effet de fixer, pratiquement instantanément au moyen des dispositifs à grenouillères 26, autant d'ensembles de deux colonnes de chromatographie 12 que cela est nécessaire, sans qu'il soit besoin de réaliser des colonnes individuelles de chromatographie 13 de longueurs différentes. Ceci constitue un avantage supplémentaire significatif. The ease of choosing the length of the chromatography column as a function of the desired separation should also be observed, using "standard" equipment. It suffices to fix, almost instantaneously by means of latches 26, as many sets of two chromatography columns 12 as necessary, without the need to produce individual chromatography columns 13 of different lengths. This constitutes a significant additional advantage.

Enfin, il peut être noté que Le montage simple, amovible, des filtres en matériau fritté 23 rend aisé Le remplacement de ces éléments, contrairement aux montages antérieurement connus, dans
Lesquels ces filtres étaient encastrés à force dans les extrémités des colonnes de chromatographie, leur remplacement impliquant alors le bris d'un certain nombre desdites couteuses colonnes de chromatographie.
Finally, it can be noted that the simple, removable mounting of filters made of sintered material 23 makes it easy to replace these elements, unlike previously known mounting, in
Which these filters were forcibly embedded in the ends of the chromatography columns, their replacement then involving the breakage of a number of said expensive chromatography columns.

L'invention n'est pas limitée à La réalisation décrite, mais en couvre au contraire toutes les variantes qui pourraient
Lui être apportées sans sortir de son cadre, ni de son esprit.
The invention is not limited to the embodiment described, but on the contrary covers all the variants which could
To be brought to it without leaving its framework, nor of its spirit.

Claims (6)

REVENDICATIONS 1. Ensemble de colonnes de chromatographie reliées en série, ensemble comprenant au moins un groupe de deux colonnes, chaque colonne présentant deux extrémités et un filtre en matériau fritté étant disposé à au moins L'une des deux extrémités de chaque colonne, caractérisé en ce que1. Set of chromatography columns connected in series, assembly comprising at least one group of two columns, each column having two ends and a sintered material filter being arranged at at least one of the two ends of each column, characterized in that than a) les deux colonnes (13) de chaque groupe (12) de deux colonnes ont des Longueurs égales (L) et sont disposées parallelement, côte à côte, Leurs extrémités étant voisines deux à deux ; a) the two columns (13) of each group (12) of two columns have equal lengths (L) and are arranged parallel, side by side, their ends being close in pairs; b) deux extrémités voisines de colonnes d'un groupe de deux colonnes sont maintenues en position relative au moyen d'un bloc de maintien (15), qui est muni d'une face de communication (18) que les tranches extrêmes desdites deux cotonnes affleurent ; et, b) two neighboring ends of columns of a group of two columns are held in relative position by means of a holding block (15), which is provided with a communication face (18) that the extreme edges of said two cotton fabrics outcrop; and, c) un support de filtres (19), muni d'une face d'appui (19a) de forme complémentaire de celle de la face de communication (18) du bloc de maintien (15), est fixé de manière amovible (20 ; 29) à chaque bloc de maintien, Lesdites faces de communication et d'appui étant en appui L'une sur L'autre , et le support de filtres (19) présentant, au droit des emplacements où affleurent les tranches extrêmes des deux colonnes, deux trous traversants (21) à L'intérieur de chacun desquels un filtre (23) en matériau fritté est susceptible d'être disposé. c) a filter support (19), provided with a support face (19a) of shape complementary to that of the communication face (18) of the retaining block (15), is removably fixed (20; 29) at each holding block, said communication and support faces being supported one on the other, and the filter support (19) having, in line with the locations where the extreme edges of the two columns are flush, two through holes (21) inside each of which a filter (23) made of sintered material can be arranged. 2. Ensemble selon la revendication 1, caractérisé en ce que la liaison entre les deux colonnes d'un groupe de deux colonnes est réalisée au moyen d'un conduit en U (28) scellé dans un contre-bloc (27), qui est fixé (29) au bloc de maintien (15) de deux extrémités voisines desdites deux colonnes, L'écartement (E) des extrémités du conduit en U etant égal à celui des tranches extrêmes desdites xtrémités de colonnes et les extrémités du conduit en U étant disposées en regard desdites tranches extrêmes.2. Assembly according to claim 1, characterized in that the connection between the two columns of a group of two columns is carried out by means of a U-shaped duct (28) sealed in a counter-block (27), which is fixed (29) to the holding block (15) of two adjacent ends of said two columns, the spacing (E) of the ends of the U-shaped conduit being equal to that of the end sections of said x ends of columns and the ends of the U-shaped conduit being arranged opposite said extreme edges. 3. Ensemble selon La revendication 2, caractérisé en ce que le support de filtres (19) est disposé entre le bloc de maintien (15) et Le contre-bloc (27), ces trois pieces etant maintenues assemblées par des moyens de fixation communs (29).3. An assembly according to claim 2, characterized in that the filter support (19) is disposed between the holding block (15) and the counter-block (27), these three parts being held together by common fixing means (29). 4. Ensemble selon L'une quelconque des revendications 1 à 3, caractérisé en ce qu'il comprend des pions de centrage (24) du support de filtres (19) par rapport au bloc de maintien (15), qui assurent la mise en place relative précise de ces deux pièces.4. Assembly according to any one of claims 1 to 3, characterized in that it comprises centering pins (24) of the filter support (19) relative to the holding block (15), which ensure the setting in precise relative place of these two parts. 5. Ensemble selon L'une quelconque des revendications 1 à 4, caractérisé en ce qu'il comprend plusieurs groupes (12) de deux colonnes, ainsi qu'un soc le (1) commun auxdits groupes et muni d'une plaque supérieure commune d'intercommunication (5), chaque groupe (12) de deux colonnes etant fixe (*6) au soc Le (1), en regard de la plaque d'intercommunication.5. Assembly according to any one of claims 1 to 4, characterized in that it comprises several groups (12) of two columns, as well as a ploughshare (1) common to said groups and provided with a common upper plate intercommunication (5), each group (12) of two columns being fixed (* 6) to the share Le (1), opposite the intercommunication plate. 6. Ensemble selon La revendication 5, caractérisé en ce que chaque groupe (12) de deux colonnes est fixé sur le soc le (1) par un moyen de fixation rapide (26), tel qu'un dispositif à grenouilleres. 6. An assembly according to claim 5, characterized in that each group (12) of two columns is fixed on the ploughshare (1) by a quick fixing means (26), such as a frog device.
FR8702413A 1987-02-24 1987-02-24 SET OF COLUMNS OF CHROMATOGRAPHY Expired FR2611908B1 (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0724722A4 (en) * 1991-12-23 1994-12-01 Agilent Technologies Inc Detachable column cartridge for gas chromatograph
US5578157A (en) * 1991-12-23 1996-11-26 Microsensor Technology, Inc. Method of fabricating connector

Citations (5)

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Publication number Priority date Publication date Assignee Title
US3225521A (en) * 1962-06-04 1965-12-28 Gulf Research Development Co Serially connected thermochromatographic columns
US3922223A (en) * 1974-03-25 1975-11-25 Us Navy Multiple chromatographic column system
US3926809A (en) * 1973-10-10 1975-12-16 Roosevelt J Jones Multi-column fractionator
DE2545997A1 (en) * 1975-10-14 1977-04-21 Max Planck Gesellschaft DEVICE FOR MULTIPLE COLUMN CHROMATOGRAPHY
US4604198A (en) * 1984-05-18 1986-08-05 Amf Inc. Multicartridge chromatography cartridge housing

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3225521A (en) * 1962-06-04 1965-12-28 Gulf Research Development Co Serially connected thermochromatographic columns
US3926809A (en) * 1973-10-10 1975-12-16 Roosevelt J Jones Multi-column fractionator
US3922223A (en) * 1974-03-25 1975-11-25 Us Navy Multiple chromatographic column system
DE2545997A1 (en) * 1975-10-14 1977-04-21 Max Planck Gesellschaft DEVICE FOR MULTIPLE COLUMN CHROMATOGRAPHY
US4604198A (en) * 1984-05-18 1986-08-05 Amf Inc. Multicartridge chromatography cartridge housing

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0724722A4 (en) * 1991-12-23 1994-12-01 Agilent Technologies Inc Detachable column cartridge for gas chromatograph
EP0724722A1 (en) * 1991-12-23 1996-08-07 Inc. Microsensor Technology Detachable column cartridge for gas chromatograph
US5578157A (en) * 1991-12-23 1996-11-26 Microsensor Technology, Inc. Method of fabricating connector
US5601785A (en) * 1991-12-23 1997-02-11 Microsensor Technology, Inc. Connector for detachable column cartridge for gas chromatograph

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