FR2593814B1 - P-CYANOPHENYLALANINAMIDES, THEIR PREPARATION PROCESS AND THEIR APPLICATION AS SYNTHESIS INTERMEDIATES - Google Patents

P-CYANOPHENYLALANINAMIDES, THEIR PREPARATION PROCESS AND THEIR APPLICATION AS SYNTHESIS INTERMEDIATES

Info

Publication number
FR2593814B1
FR2593814B1 FR8601400A FR8601400A FR2593814B1 FR 2593814 B1 FR2593814 B1 FR 2593814B1 FR 8601400 A FR8601400 A FR 8601400A FR 8601400 A FR8601400 A FR 8601400A FR 2593814 B1 FR2593814 B1 FR 2593814B1
Authority
FR
France
Prior art keywords
cyanophenylalaninamides
application
preparation process
synthesis intermediates
intermediates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR8601400A
Other languages
French (fr)
Other versions
FR2593814A1 (en
Inventor
Daniel Frehel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi SA
Original Assignee
Sanofi SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi SA filed Critical Sanofi SA
Priority to FR8601400A priority Critical patent/FR2593814B1/en
Priority to PT84171A priority patent/PT84171B/en
Priority to PT84170A priority patent/PT84170B/en
Priority to DE8787400150T priority patent/DE3764828D1/en
Priority to EP87400150A priority patent/EP0236164B1/en
Priority to EP87400149A priority patent/EP0236163B1/en
Priority to CA000527938A priority patent/CA1307076C/en
Priority to DE8787400149T priority patent/DE3765270D1/en
Priority to CA000527936A priority patent/CA1312703C/en
Priority to AT87400149T priority patent/ATE57179T1/en
Priority to AT87400150T priority patent/ATE56429T1/en
Priority to US07/006,152 priority patent/US4977168A/en
Priority to US07/006,421 priority patent/US4791102A/en
Publication of FR2593814A1 publication Critical patent/FR2593814A1/en
Application granted granted Critical
Publication of FR2593814B1 publication Critical patent/FR2593814B1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/0606—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing heteroatoms not provided for by C07K5/06086 - C07K5/06139, e.g. Ser, Met, Cys, Thr
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FR8601400A 1986-01-24 1986-01-24 P-CYANOPHENYLALANINAMIDES, THEIR PREPARATION PROCESS AND THEIR APPLICATION AS SYNTHESIS INTERMEDIATES Expired FR2593814B1 (en)

Priority Applications (13)

Application Number Priority Date Filing Date Title
FR8601400A FR2593814B1 (en) 1986-01-24 1986-01-24 P-CYANOPHENYLALANINAMIDES, THEIR PREPARATION PROCESS AND THEIR APPLICATION AS SYNTHESIS INTERMEDIATES
PT84170A PT84170B (en) 1986-01-24 1987-01-21 N-ALPHA-ARIL-SULFONYLAMINOACYL D-AMIDINEFENYL-ALANINAMID D NON-SUBSTITUTED DERIVATIVES PROCESS FOR THE PREPARATION OF N ALPHA-SUBSTITUTED DERIVATIVES
PT84171A PT84171B (en) 1986-01-24 1987-01-21 A process for the preparation of derivatives of alpha-arylsulfonylamininoacyl-β-aminophenylalanineamides, as well as their synergistic derivatives and pharmaceutical compositions containing them
DE8787400149T DE3765270D1 (en) 1986-01-24 1987-01-22 N-ALPHA-SUBSTITUTED DERIVATIVES OF N-ALPHA-ARYLSULFONYLAMINOACYL-P-AMIDINOPHENYLALANINAMIDES, THEIR PRODUCTION, THEIR USE AS A MEDICINAL PRODUCT AND THEIR INTERMEDIATE COMPOUNDS.
EP87400149A EP0236163B1 (en) 1986-01-24 1987-01-22 Derivatives of n-alpha-substituted n-alpha-arylsulfonylaminoacyl p-amidinophenylalaninamides, their preparation, their use as medicaments and their intermediates
CA000527938A CA1307076C (en) 1986-01-24 1987-01-22 DERIVATIVES OF THE N.alpha.-ARYLSULPHONYLAMINOACYL-P- AMIDINOPHENYLALANINAMIDES, THEIR PREPARATION PROCESS, THEIR USE AS MEDICAMENTS AND THE INTERMEDIATES FOR THEIR SYNTHESIS
DE8787400150T DE3764828D1 (en) 1986-01-24 1987-01-22 DERIVATIVES OF N-ALPHA-ARYLSULFONYLAMINOACYL-P-AMIDINO-PHENYLALANINAMIDES, METHOD FOR THE PRODUCTION THEREOF, THEIR USE AS A MEDICINAL PRODUCT AND THEIR INTERMEDIATE COMPOUNDS.
CA000527936A CA1312703C (en) 1986-01-24 1987-01-22 Derivatives of the n–-arylsulphonylaminoacyl-p- amidinophenylalaninamides, their preparation process, their use as medicaments and the pharmaceutical compositions containing them
AT87400149T ATE57179T1 (en) 1986-01-24 1987-01-22 N-ALPHA-SUBSTITUTED DERIVATIVES OF N-ALPHAARYLSULFONYLAMINOACYL-PAMIDINOPHENYLALANINAMIDES, THEIR PRODUCTION, THEIR USE AS MEDICINES AND THEIR INTERMEDIATE COMPOUNDS.
AT87400150T ATE56429T1 (en) 1986-01-24 1987-01-22 DERIVATIVES OF N-ALPHA-ARYLSULFONYLAMINOACYL-PAMIDINO-PHENYLALANINAMIDES, PROCESSES FOR THEIR PRODUCTION, THEIR USE AS MEDICINES AND THEIR INTERMEDIATE COMPOUNDS.
EP87400150A EP0236164B1 (en) 1986-01-24 1987-01-22 Derivatives of n-alpha-arylsolfonylaminoacyl p-amidino-phenylalaninamides, process for their preparation, their use as medicaments and their intermediates
US07/006,421 US4791102A (en) 1986-01-24 1987-01-23 Derivatives of the N α-arylsulphonylaminoacyl-p-amidinophenylalaninamides, their preparation process, their use as medicaments and the pharmaceutical compositions containing them
US07/006,152 US4977168A (en) 1986-01-24 1987-01-23 Derivatives of the N α-arylsulphonylaminoacyl-p-amidinophenyl-alaninamides, and their use as medicaments

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8601400A FR2593814B1 (en) 1986-01-24 1986-01-24 P-CYANOPHENYLALANINAMIDES, THEIR PREPARATION PROCESS AND THEIR APPLICATION AS SYNTHESIS INTERMEDIATES

Publications (2)

Publication Number Publication Date
FR2593814A1 FR2593814A1 (en) 1987-08-07
FR2593814B1 true FR2593814B1 (en) 1988-12-30

Family

ID=9331703

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8601400A Expired FR2593814B1 (en) 1986-01-24 1986-01-24 P-CYANOPHENYLALANINAMIDES, THEIR PREPARATION PROCESS AND THEIR APPLICATION AS SYNTHESIS INTERMEDIATES

Country Status (1)

Country Link
FR (1) FR2593814B1 (en)

Also Published As

Publication number Publication date
FR2593814A1 (en) 1987-08-07

Similar Documents

Publication Publication Date Title
FR2645533B1 (en) PROCESS FOR THE SYNTHESIS OF SULFONYLIMIDURES
MA22668A1 (en) PROCESS FOR THE PREPARATION OF OXAMIDES.
MA20739A1 (en) PROCESS FOR THE PREPARATION OF TERTIARY HYDROXYALKYLXANTHINES
FR2611366B1 (en) NOVEL TRICYCLIC KETONES USEFUL AS MEDICAMENTS, PROCESS AND INTERMEDIATES FOR THEIR PREPARATION
AR242187A1 (en) 1-hydroxy-2-pyridinones, process for their preparation and medicines containing them, as well as intermediates formed by the preparation of 1- hydroxy-2-pyridinones
MA21148A1 (en) PROCESS FOR THE PREPARATION OF B-LACTAMIC COMPOUND AND INTERMEDIATES FOR ITS SYNTHESIS.
FR2595352B1 (en) INDOLE DERIVATIVES USEFUL AS MEDICAMENTS AND PROCESS AND INTERMEDIATES FOR THEIR PREPARATION
FR2644787B1 (en) NOVEL AMINOSUBSTITUTED STEROIDS 21, THEIR PREPARATION PROCESS AND THE INTERMEDIATES THEREOF, THEIR APPLICATION AS MEDICAMENTS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
FR2662178B1 (en) PROCESS FOR THE PREPARATION OF INTERMEDIATES USEFUL IN THE SYNTHESIS OF BENZOTHIAZEPINES.
FR2612189B1 (en) NOVEL PYRIDINE DERIVATIVES, THEIR PREPARATION PROCESS AND THE NEW INTERMEDIATES OBTAINED, THEIR APPLICATION AS MEDICAMENTS AND THE COMPOSITIONS CONTAINING THEM
FR2630735B1 (en) PROCESS FOR THE PREPARATION OF HALOGENOPHENOLS
FR2556721B1 (en) NOVEL AMINO-ACID O-MERCAPTOPROPANAMIDE DERIVATIVES, THEIR PREPARATION PROCESS, THEIR USE AS MEDICAMENTS AND THE COMPOSITIONS CONTAINING THEM
FR2558471B1 (en) PROCESS FOR THE PREPARATION OF ASPARTYL PEPTIDES, AND NOVEL SYNTHESIS INTERMEDIATES
MA21130A1 (en) PROCESS FOR THE PREPARATION OF NEW AMINOPROPIONAMIDES.
FR2593814B1 (en) P-CYANOPHENYLALANINAMIDES, THEIR PREPARATION PROCESS AND THEIR APPLICATION AS SYNTHESIS INTERMEDIATES
FR2652079B1 (en) PROCESS FOR THE PREPARATION OF BRIDGE CLAYS AND BRIDGE CLAYS OBTAINED ACCORDING TO THIS PROCESS.
FR2612186B1 (en) CARBONYL 2,2 'BIS (ALKYL-4 OXADIAZOLIDINES-1,2,4-DIONES-3,5), THEIR PREPARATION PROCESS AND THEIR USE AS SYNTHESIS INTERMEDIATES IN THE PREPARATION OF CARBAMATES
FR2576596B1 (en) PROCESS FOR THE PREPARATION OF 4,4-DIALKYL-2-AZETIDINONES, AND NOVEL COMPOUNDS THUS PREPARED
FR2603886B1 (en) PROCESS FOR THE PREPARATION OF ALKENYL-1 CARBONATES
FR2579206B1 (en) NOVEL 5-H PYRIDO (3 ', 4': 4,5) (PYRROLO 3,2-C) PYRIDONES, THEIR PREPARATION PROCESS AND THEIR APPLICATION AS SYNTHESIS INTERMEDIATES
FR2610924B1 (en) PROCESS FOR THE PREPARATION OF HYDROXYBIPHENYLES
FR2617481B1 (en) NOVEL TETRAHYDROPYRIDINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PREPARATION INTERMEDIATES, THEIR APPLICATION AS MEDICAMENTS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
FR2605318B1 (en) PROCESS FOR THE PREPARATION OF AZETIDINONES.
FR2614891B1 (en) NOVEL FORSKOLINE DERIVATIVES, THEIR PREPARATION PROCESS, THEIR APPLICATION AS MEDICAMENTS, THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AS WELL AS INTERMEDIATES OF THEIR PREPARATION PROCESS
FR2579207B1 (en) NOVEL 5-H PYRIDO (3 ', 4': 4.5) PYRROLO (3,2-C) PYRIDINES, THEIR PREPARATION PROCESS AND THEIR APPLICATION AS SYNTHESIS INTERMEDIATES

Legal Events

Date Code Title Description
ST Notification of lapse