FR2586192A1 - Device for drawing, keeping or injecting liquid substances of the organic type - Google Patents

Abstract

The invention relates to a device for drawing and injecting liquid substances, carrier liquid mixtures, cells or tissues, used in particular for drawing or injecting doses of blood, spermatozoa or ovocytes, the device also being usable for artificial insemination or embryo transfer by transcervical or transperitoneal means, this device consisting of a syringe formed by an external sheath 4 in which a suction and delivery plunger 3 slides, with the absence of leaks. This device is characterised in that it comprises a control handle 1, ensuring the control of the piston 3, formed by a handle which is passed through axially by a pipe 2 in which the rear end of the said plunger is moved, a rotary driving member 7 being mounted tangentially to this plunger 3 in order for the latter to be movable with one hand, by simple pressure and movement of the thumb.

Description

"Device for the collection, conservation or injection of liquid substances, of organic type".

 The invention relates to a device for the collection, conservation and restitution, in particular by injection, of liquid substances related to genetics such as spermatooids, or alternatively carrier liquid media such as those used during sampling or embryo transfer, this device can also be used for taking doses of serum from cells or tissues, for example pancreatic.

 We already contact the syringes intended for the withdrawal and injection of liquid substances formed, in the manner of a piston, a cylinder or outer sheath in which slides with sealing, a piston whose translation is carried out manually.

These usual syringes can be extended on their front face before a sampling tip (in particular if it is a question of aspirating a substance in a container3 or of a needle if the sampling is done on a living organism. drawback of these syringes lies, on the one hand, in the random nature of the displacement of the piston, (and consequently, the difficulty of obtaining precise doses), on the other hand, in the obligation to transfer the substance withdrawn into sterile packaging when you want to keep it, especially by freezing.

However, precisely, the transfer of the substance from the syringe in a package goes against the desired aseptic since the material is brought into contact with air, that is to say the microbial environment. .

 The subject of the invention is therefore an original device enabling the plunger of the syringe to be controlled with precision, which can receive a sterile straw which will be used for packaging the substance withdrawn.

 The invention therefore relates to a device for withdrawing and injecting liquid substances, carrier liquid media, cells or even tissues, used in particular for withdrawing doses of sperm serum or also for transferring embryos or artificial insemination by transcervical or transperitoneal route, this device being formed by a syringe and being characterized in that it comprises a control handle for piloting the piston, this being formed by a handle axially crossed by a conduit in which the rear end of said piston moves, a rotary drive member being mounted tangentially to this piston, so that it can be moved with one hand, by simple pressure and animation of the thumb.

 According to a preferred embodiment of the invention, the rotary drive member is formed by a notched wheel, accessible from the outside, the axis of which is mounted floating in two openings in the control handle.

 According to one characteristic of the invention, the syringe contains a sterile freezing straw for the collection and storage of the substance, the tip of the syringe comprising a frustoconical axial cavity for the tight coupling of the straw, the front end of which is force-fitted into this end piece. In this hypothesis, that is to say when the syringe contains a sterile freezing straw, the filling of the straw is carried out through a permeable plug closing its rear end, by the simple suction caused by the piston of the syringe, controlled by the control handle.

Other characteristics and advantages will emerge from the description below and the attached drawings in which
- Fig. 1 is an axial sectional view of the entire syringe and its control handle;
- Fig. 2 is an enlarged view in axial section of the handle used to control the piston rod.

 The essential object of the invention is to make available to practitioners, a new instrument for withdrawing and injecting liquid substances which is on the one hand, easy to use and which, on the other hand, allows manipulation of the substance in the best possible aseptic conditions, This instrument can be used, in fact, for the collection of doses of serum but also, for the collection of spermatozoa, oocytes, tissues, carrier media, etc. for serotecs and virutecs.

 This instrument can also be used, mbn only for the removal but also for the conservation of the substances collected and, also and especially for 1R restitution, that is to say, the injection of these substances, for example in the case artificial insemination or embryo transfer by the transcervical route, (without needle), i.e. by the natural route of the cervix or by the transperitoneal route (with needle), if the insimfination or embryo transfer operation requires surgery.

 The device for controlling the piston of the syringe is formed, as can be seen clearly in FIG. 2, from a control handle 1 of elongated shape, for example cylindrical, which can be easily held in the hand, this being crossed by a axial conduit 2, which extends over its entire length, and in which the piston 3 can move, movable in alternating translation in the sheath 4 of the syringe 5 visible in FIG. 1. This handle comprises a blind cavity 6 in which is rotatably mounted a notched wheel 7, accessible from the outside, that is to say slightly protruding from the periphery of the handle 1 so that it can be easily operated by the thumb, this wheel being mounted floating by its movable axis 8 in two slots 9 made in the two flanges laterally bordering the cavity 6. Thus, the simple pressure of the thumb on the thumbwheel 7 tends to apply it downwards which then tangentially comes into contact with the rod of p iston 3. A rotation of the wheel in one direction or another, when it is applied with pressure on the piston has the effect of causing the displacement of the latter inside the sheath 4.

 To obtain a relative displacement of the piston relative to the sheath 4, it is obviously essential that the latter be immobilized and there is provided for this purpose, in the body of the control handle 1, a locking member which, in l 'occurrence, is a needle screw 10 housed in an orifice opening into the conduit 2 ot passes the piston 3. At this level, the orifice 2 is slightly larger in diameter than that passing through the rear part of the handle so so that the sheath 4 can be brought into force in this conduit 2 oh it will be locked by simply notching the needle screw lO. The sheath being thus immobilized, the piston 3 can freely move therein. 'introduçtaon of the sheath in the control handle and to ensure its the handle is extended on its front end face, with a nozzle 12 formed of a tube section whose rear part comprises a threaded connection coming to be screwed in a housing tapped 14 of the handle, after interposition of an O-ring 15.

This nozzle will preferably be made of transparent rigid plastic, so that the operator can monitor and control the movements of the piston 3 in the sheath 4.

 This handle has the essential advantage, on the one hand, of freeing one of the practitioner's hands, on the other hand, of precisely controlling the piston 3 by controlling its movements and, consequently, of allowing a metering of the substance withdrawn or injected. To further improve the dosing precision, you can calibrate the piston or the sheath and in particular mark it with marks intended to check its linear stroke.

 This control handle can be used with a conventional syringe simply formed by a sheath and a plunger extended or not by a needle, or even be coupled to a syringe of a more improved version, the sheath 4 of which contains a glitter. 16 intended in particular for packaging the substance collected. This straw is conventionally in the form of a coating of small diameter, the rear part of which is closed by a plug 17, formed of two cotton pads between which a dose of powder is sandwiched, polymerizable in contact with the substance. liquid. This fine straw is placed inside the sheath 4 and is made integral with the needle 18 so that the substance removed passes through the needle and comes to lodge directly in the packaging straw.

In this spirit, the needle 18 has a tip 19 on which is crimped or glued the front end of the sheath 4 so that a perfect seal is obtained. This endpiece f9 internally comprises a channel 20 communicating with the needle 18 and opening into a frustoconical chamber 21 into which will be fixed, by force fitting or crimping,
the packaging straw 16.

 The sampling of the substance (when using syringes with glitter?) Is carried out by simple suction through the plug 17 (permeable to air) this depression being created by the recoil of the piston 3, controlled by the notched wheel 7. In fact, the withdrawal of the piston 3 creates a suction inside the syringe since its prominent head 31 closely follows the inner channel of the sheath 4. This depression is expressed through the plug of the glitter and thus, the liquid is sucked through the needle or the sheath into the storage straw 16. When the sample is finished, we can either extract the straw 16 and then close it at both ends by heat sealing, or leave inside the syringe and use the assembly as packaging. In this case, it will suffice to weld the rear part of the sheath 4, then crimp, crush or weld the needle 18 for the packaging to be completely safe from contaminations. This double coaxial conditioning (sheath + glitter) will thus make it possible to obtain high protection of the substance against thermal shock or against any other harmful external effect, while guaranteeing the personnel of possible contamination.

 The syringe assembly containing its straw will be sterilized and sold in an equally sterile packaging so that the samples are taken in the best possible aseptic conditions. Taking into account the hygienic precautions which are used here, it is consequently of the greatest interest, to avoid the transfer of the semen from the syringe in a container of conditioning, from where the double interest of the straw which is used for the both receiving and storing the substance.

 As indicated above, the syringe can be extended by a needle 18 but the latter can be rigid or flexible. In fact, when it comes to taking serum, for example, we will use a rigid needle; on the other hand, when it is a question for example of making artificial insemination or the transfer of embryos one can use, if one uses the transcervical way, a flexible conduit in order not to perforate the mucous membranes while crossing the cervix.

 The restitution, that is to say the injection of the aubs tance from the straw will be very stmplement, since at the time of use, it will be enough to cut the ends of the straw or sheath , then use the piston 3 as an expelling member, having taken care beforehand, to remove the removable plate 31 from the piston so that its front end can penetrate inside the straw 16 <immobilized in the cone 21) to push forward the plug 17 which will then serve as the piston head.

 Ultimately, the control handle according to the invention can be used with a conventional syringe formed of a simple sheath and a plunger with or without a needle or, with a more sophisticated syringe, containing a glitter. This can be either extracted from the syringe, or stored inside the syringe, the syringe then becoming itself, sterile packaging.

We can use this set to collect serum, follicular fluids, oocytes, viruses, or even perform procedures such as artificial insemination by intrauterine route or embryo transfers, or even, finally, serve for 'inoculation of culture media for the seeding of kneaders,
According to an alternative embodiment, it is possible as indicated above, to use the sheath as a packaging for the substance removed, In this eventuality, it is possible, if the sheath contains a fine preservation straw, to be housed in the sheath (behind the straw) an identification ring which can be read through the transparent sheath. This ring will serve as a synoptic benchmark and means of identification since it may include all references as to the breed of the animal, date of collection, the dose collected, etc. In this eventuality it will be enough, after removal, to cut the needle (if needle there is} please take out the glitter slightly to weld it on its front part, after which we will turn the sheath of 180 ~ to bring out the rear part of the empty straw in order to weld it. Then we will enclose the identification rod in the sheath behind the welded end of the straw then we will weld the sheath itself. We will thus obtain a double packaging of coaxial type perfectly hermetic and allowing the substance taken to be conditioned under the best possible conditions of aseptic and protective conditions both for the substance and for those who handle it.

Claims (2)

CLAIMS 19) Device for the removal and injection of liquid substances, carrier liquid media, cells or even tissues, used in particular to withdraw or inject doses of serum, spermatozoa or oocytes, the device also being able to be used during artificial insemination or embryo transfer by transcervical or transperitoneal route, this device consisting of a syringe formed of an outer sheath (4> in which slides, with a tightness, a piston (3) of suction and discharge, device characterized in that it comprises a control handle (13 ensuring the piloting of the piston (3), formed of a handle traversed axially by a conduit (2) in which the rear end of said movement moves piston, a rotary drive member (7) being mounted tangentially to this piston (3) so that it can be moved with one hand, by the simple pressure and animation of the thumb. 2 ~) Device according to claim 1, characterized in that the handle 1 comprises axial immobilization means (10) of the outer sheath (4) of the syringe. 3) Device according to claim 2, characterized in that the means for immobilizing the sheath (4) consist of a needle screw (lo) opening into the axial duct (2) of the control handle.  40) Device according to any one of claims 1 to 3, characterized in that the handle (1) is extended towards the syringe with a rigid tubular tip (12) coupled to said handle by screwing.  50) Device according to claim 4, characterized in that the rigid tubular end piece (12) is transparent to display the movements of the piston (12).  6-) Device according to claim 1, caqctérisé in that the rotary drive member (7) is formed by a notched wheel, accessible from the outside, whose axis (8) is mounted floating in two lights (9) practiced in the control handle (1).  7 ~) Device according to claim 1, characterized in that the syringe is formed of a single sheath (4) associated with an expulsion piston (3), the front end of this sheath (4) being crimped or welded on a tip extended or not by a needle (18> which, depending on the nature of the intervention, may be flexible or rigid.