FR2578542B2 - NOVEL HETEROCYCLIC DERIVATIVES, PROCESSES FOR THEIR PREPARATION, MEDICAMENTS CONTAINING THEM, USEFUL IN PARTICULAR AS INHIBITORS OF ALDOSE REDUCTASE - Google Patents

NOVEL HETEROCYCLIC DERIVATIVES, PROCESSES FOR THEIR PREPARATION, MEDICAMENTS CONTAINING THEM, USEFUL IN PARTICULAR AS INHIBITORS OF ALDOSE REDUCTASE

Info

Publication number
FR2578542B2
FR2578542B2 FR8503236A FR8503236A FR2578542B2 FR 2578542 B2 FR2578542 B2 FR 2578542B2 FR 8503236 A FR8503236 A FR 8503236A FR 8503236 A FR8503236 A FR 8503236A FR 2578542 B2 FR2578542 B2 FR 2578542B2
Authority
FR
France
Prior art keywords
inhibitors
useful
processes
preparation
aldose reductase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR8503236A
Other languages
French (fr)
Other versions
FR2578542A2 (en
Inventor
Jean-Marie Teulon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Carpibem SA
Original Assignee
Carpibem SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Carpibem SA filed Critical Carpibem SA
Priority to FR8503236A priority Critical patent/FR2578542B2/en
Priority to IE112685A priority patent/IE58312B1/en
Priority to PH32246A priority patent/PH21118A/en
Priority to AT85400927T priority patent/ATE42297T1/en
Priority to EP85400927A priority patent/EP0162776B1/en
Priority to NZ212060A priority patent/NZ212060A/en
Priority to DE8585400927T priority patent/DE3569529D1/en
Priority to GR851159A priority patent/GR851159B/el
Priority to CA000481503A priority patent/CA1306747C/en
Priority to US06/733,685 priority patent/US4755509A/en
Priority to AU42518/85A priority patent/AU586972B2/en
Priority to KR1019850003306A priority patent/KR900004320B1/en
Priority to JP60102788A priority patent/JPH0692371B2/en
Priority to PT80489A priority patent/PT80489B/en
Priority to DK219685A priority patent/DK219685A/en
Priority to ES543266A priority patent/ES8607263A1/en
Publication of FR2578542A2 publication Critical patent/FR2578542A2/en
Application granted granted Critical
Publication of FR2578542B2 publication Critical patent/FR2578542B2/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/70—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/36—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
    • C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
    • C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
    • C07D279/16—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FR8503236A 1984-05-18 1985-03-05 NOVEL HETEROCYCLIC DERIVATIVES, PROCESSES FOR THEIR PREPARATION, MEDICAMENTS CONTAINING THEM, USEFUL IN PARTICULAR AS INHIBITORS OF ALDOSE REDUCTASE Expired FR2578542B2 (en)

Priority Applications (16)

Application Number Priority Date Filing Date Title
FR8503236A FR2578542B2 (en) 1985-03-05 1985-03-05 NOVEL HETEROCYCLIC DERIVATIVES, PROCESSES FOR THEIR PREPARATION, MEDICAMENTS CONTAINING THEM, USEFUL IN PARTICULAR AS INHIBITORS OF ALDOSE REDUCTASE
IE112685A IE58312B1 (en) 1984-05-18 1985-05-06 Heterocyclic derivatives, processes for their preparation and drugs in which they are present, which are useful especially as aldose reductase inhibitors
PH32246A PH21118A (en) 1984-05-18 1985-05-09 Heterocyclic derivatives, a process for their preparation the pharmaceutical composition containing them
EP85400927A EP0162776B1 (en) 1984-05-18 1985-05-13 Heterocyclic derivatives, process for their preparation and medicaments useful as aldose reductase inhibitors containing them
NZ212060A NZ212060A (en) 1984-05-18 1985-05-13 Bicyclic hetrocycles and pharmaceutical derivatives
DE8585400927T DE3569529D1 (en) 1984-05-18 1985-05-13 Heterocyclic derivatives, process for their preparation and medicaments useful as aldose reductase inhibitors containing them
GR851159A GR851159B (en) 1984-05-18 1985-05-13
AT85400927T ATE42297T1 (en) 1984-05-18 1985-05-13 HETEROCYCLIC DERIVATIVES, PROCESSES FOR THEIR MANUFACTURE, PHARMACEUTICALS CONTAINING THEM USEFUL AS ALDOSE REDUCTAE INHIBITORS.
CA000481503A CA1306747C (en) 1984-05-18 1985-05-14 Process for the preparation of new heterocyclic derivatives which can be used especially as aldose reductase inhibitors
US06/733,685 US4755509A (en) 1984-05-18 1985-05-14 Heterocyclic aldose reductase inhibitors and methods of using them
AU42518/85A AU586972B2 (en) 1984-05-18 1985-05-15 New heterocyclic derivatives, the processes for their preparation and drugs in which they are present, which are useful especially as aldose reductase inhibitors
KR1019850003306A KR900004320B1 (en) 1984-05-18 1985-05-15 Process for preparation of new heterocyclic derivatives
JP60102788A JPH0692371B2 (en) 1984-05-18 1985-05-16 Novel heterocyclic derivative, method for producing the same, and method for producing a medicine containing these and particularly useful as an aldose reductase inhibitor
PT80489A PT80489B (en) 1984-05-18 1985-05-17 PROCESS FOR THE PREPARATION OF NOVEL HETEROCYCLIC DERIVATIVES USEFULLY AS INNIBITORS OF ALDOSE REDUCTASE
DK219685A DK219685A (en) 1984-05-18 1985-05-17 HETEROCYCLIC COMPOUNDS, THEIR PREPARATION AND USE AS MEDICINAL PRODUCTS
ES543266A ES8607263A1 (en) 1984-05-18 1985-05-17 Heterocyclic derivatives, process for their preparation and medicaments useful as aldose reductase inhibitors containing them.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8503236A FR2578542B2 (en) 1985-03-05 1985-03-05 NOVEL HETEROCYCLIC DERIVATIVES, PROCESSES FOR THEIR PREPARATION, MEDICAMENTS CONTAINING THEM, USEFUL IN PARTICULAR AS INHIBITORS OF ALDOSE REDUCTASE

Publications (2)

Publication Number Publication Date
FR2578542A2 FR2578542A2 (en) 1986-09-12
FR2578542B2 true FR2578542B2 (en) 1987-08-28

Family

ID=9316883

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8503236A Expired FR2578542B2 (en) 1984-05-18 1985-03-05 NOVEL HETEROCYCLIC DERIVATIVES, PROCESSES FOR THEIR PREPARATION, MEDICAMENTS CONTAINING THEM, USEFUL IN PARTICULAR AS INHIBITORS OF ALDOSE REDUCTASE

Country Status (1)

Country Link
FR (1) FR2578542B2 (en)

Also Published As

Publication number Publication date
FR2578542A2 (en) 1986-09-12

Similar Documents

Publication Publication Date Title
FR2493320B1 (en) NOVEL CARBOSTYRILE DERIVATIVES USEFUL IN PARTICULAR AS CARDIOTONICS, PROCESSES FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM
FR2607493B1 (en) NOVEL PHARMACOLOGICALLY ACTIVE COMPOUNDS, PROCESSES FOR THEIR PREPARATION AND COMPOSITIONS CONTAINING THEM
PT78340B (en) PROCESS FOR THE PREPARATION OF NOVEL 3', 4 ', 5,7-FLAVONE TETRAHYDROXY DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME
FR2602974B1 (en) PHARMACEUTICAL COMPOSITION CONTAINING NICOTINE OR DERIVATIVES THEREOF
PT87552A (en) PROCESS FOR THE PREPARATION OF NOVEL TETRAZOLE INTERMEDIATES TOANTIHYPERTENSIVE COMPOUNDS
KR870700602A (en) Heterocyclic analogs of mevaronolactone and its derivatives and methods for their production and pharmaceutical uses thereof
FR2595356B1 (en) DERIVATIVES OF NITRO OR AMINOBENZYLTETRAHYDROISOQUINOLEINS, PROCESSES FOR OBTAINING SAME, PHARMACEUTICAL COMPOSITIONS CONTAINING SAME, PHARMACOLOGICAL PROPERTIES AND APPLICATIONS
PT80921A (en) PROCESS FOR THE PREPARATION OF ACYLAMINOMETHYL-3-IMIDAZO <1,2-A> PYRIDINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME
FR2569689B1 (en) NOVEL BENZONORBORNENE DERIVATIVES, PREPARATION METHODS THEREOF, AND MEDICINAL AND COSMETIC COMPOSITIONS CONTAINING THEM
PT83896A (en) PROCESS FOR THE PREPARATION OF NEW CONJUGATES OF VINBLAS-TINE AND ITS DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME
BE895168A (en) NOVEL AMINOSULFONYLIDE DERIVATIVES USEFUL IN PARTICULAR AS HERBICIDES, METHODS OF MAKING SAME AND HERBICIDES CONTAINING THEM
FR2596050B1 (en) NOVEL BENZOFURAN DERIVATIVES, PREPARATION METHODS THEREOF, AND MEDICINAL AND COSMETIC COMPOSITIONS CONTAINING THEM
FR2549832B1 (en) NOVEL COUMARIN DERIVATIVES, PROCESSES FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
PT80489A (en) PROCESS FOR THE PREPARATION OF NOVEL HETEROCYCLIC DERIVATIVES USEFULLY AS INNIBITORS OF ALDOSE REDUCTASE
PT83593A (en) PROCESS FOR THE PREPARATION OF 7-ACYL-BENZOXAZINONES AND THEIR DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME
MC2050A1 (en) BENZOPYRANNOL DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND METHOD OF MANUFACTURE
FR2564832B1 (en) NOVEL N-ACYL DERIVATIVES OF AMINO ACIDS AND THEIR ESTERS, PROCESS FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM
FR2515175B1 (en) NOVEL DERIVATIVES OF 4-PHENYL 4-OXO 2-BUTENOIC ACID, THEIR SALTS, THEIR PREPARATION, THEIR APPLICATION AS MEDICAMENTS AND THE COMPOSITIONS CONTAINING THEM
MC1693A1 (en) NOVEL COMPOUNDS, COMPOSITIONS CONTAINING THEM AND INTERMEDIATES FOR THEIR PREPARATION
PT82364A (en) PROCESS FOR THE PREPARATION OF NITROFURAN DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
IL75874A0 (en) Naphthyl analogs of mevalonolactone and derivatives thereof,their production and pharmaceutical compositions containing them
PT80111A (en) PROCESS FOR THE PREPARATION OF NOVEL ARYLTHIO-PYRIDINYL-ALKANOLE AND FUNGICIDE COMPOSITIONS CONTAINING SAME
FR2564463B1 (en) NOVEL HETEROCYCLIC DERIVATIVES, PROCESSES FOR THEIR PREPARATION, MEDICAMENTS CONTAINING THEM, USEFUL IN PARTICULAR AS INHIBITORS OF ALDOSE REDUCTASE
FR2578542B2 (en) NOVEL HETEROCYCLIC DERIVATIVES, PROCESSES FOR THEIR PREPARATION, MEDICAMENTS CONTAINING THEM, USEFUL IN PARTICULAR AS INHIBITORS OF ALDOSE REDUCTASE
FR2571374B1 (en) NOVEL 5-FLUORO-2'-DESOXYURIDINE DERIVATIVES AND SALTS THEREOF, PROCESS FOR THEIR PREPARATION, AND ANTI-TUMOR AGENTS CONTAINING THEM

Legal Events

Date Code Title Description
TP Transmission of property