FR2577223B1 - INDOLE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION - Google Patents

INDOLE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION

Info

Publication number
FR2577223B1
FR2577223B1 FR8501774A FR8501774A FR2577223B1 FR 2577223 B1 FR2577223 B1 FR 2577223B1 FR 8501774 A FR8501774 A FR 8501774A FR 8501774 A FR8501774 A FR 8501774A FR 2577223 B1 FR2577223 B1 FR 2577223B1
Authority
FR
France
Prior art keywords
preparation
therapeutic application
indole derivatives
indole
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR8501774A
Other languages
French (fr)
Other versions
FR2577223A1 (en
Inventor
Dennis Bigg
Jacques Menin
Christian Maloizel
Jean-Pierre Merly
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synthelabo SA
Original Assignee
Synthelabo SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthelabo SA filed Critical Synthelabo SA
Priority to FR8501774A priority Critical patent/FR2577223B1/en
Priority to DE8686400200T priority patent/DE3677277D1/en
Priority to AT86400200T priority patent/ATE60601T1/en
Priority to EP86400200A priority patent/EP0211698B1/en
Priority to US06/826,500 priority patent/US4659731A/en
Priority to AU53303/86A priority patent/AU575711B2/en
Priority to KR1019860000860A priority patent/KR860006456A/en
Priority to NO860429A priority patent/NO164899C/en
Priority to NZ215070A priority patent/NZ215070A/en
Priority to ZA86932A priority patent/ZA86932B/en
Priority to FI860561A priority patent/FI80690C/en
Priority to PT81992A priority patent/PT81992B/en
Priority to GR860363A priority patent/GR860363B/en
Priority to CA000501356A priority patent/CA1273939A/en
Priority to JP61026646A priority patent/JPS61183284A/en
Priority to ES551733A priority patent/ES8707226A1/en
Priority to DK60486A priority patent/DK60486A/en
Priority to HU86523A priority patent/HU195212B/en
Publication of FR2577223A1 publication Critical patent/FR2577223A1/en
Priority to ES557370A priority patent/ES8802515A1/en
Application granted granted Critical
Publication of FR2577223B1 publication Critical patent/FR2577223B1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
FR8501774A 1985-02-08 1985-02-08 INDOLE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION Expired FR2577223B1 (en)

Priority Applications (19)

Application Number Priority Date Filing Date Title
FR8501774A FR2577223B1 (en) 1985-02-08 1985-02-08 INDOLE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
DE8686400200T DE3677277D1 (en) 1985-02-08 1986-01-31 (DIHYDRO-4,5-1H-IMIDAZOLYL-2) -2-DIHYDRO-2,3-INDOLDE DERIVATIVES, THEIR PRODUCTION AND USE AS A MEDICINE.
AT86400200T ATE60601T1 (en) 1985-02-08 1986-01-31 (DIHYDRO-4,5-1H-IMIDAZOLYL-2)-2-DIHYDRO-2,3INDOLDERIVATE, THEIR PRODUCTION AND APPLICATION AS MEDICINES.
EP86400200A EP0211698B1 (en) 1985-02-08 1986-01-31 (dihydro-4,5-1h-imidazolyl-2)-2-dihydro-2,3-indole derivatives, their preparation and their use as medicaments
US06/826,500 US4659731A (en) 1985-02-08 1986-02-05 2-(4,5-Dihydro-1H-imidazol-2-yl)-2,3-dihydroindole derivatives and their application as α2 receptor antagonist or α1 receptor agonists
JP61026646A JPS61183284A (en) 1985-02-08 1986-02-07 Dihydroindoles and manufacture
NO860429A NO164899C (en) 1985-02-08 1986-02-07 ANALOGUE PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE IMIDAZOLYLINDOL COMPOUNDS.
NZ215070A NZ215070A (en) 1985-02-08 1986-02-07 Imidazole-indoles and pharmaceutical compositions
ZA86932A ZA86932B (en) 1985-02-08 1986-02-07 2-(4,5-dihydro-1h-imidazol-2-yl)-2,3-dihydroindole derivatives,the preparation thereof and their application in therapy
FI860561A FI80690C (en) 1985-02-08 1986-02-07 Process for the preparation of therapeutically useful 2- (4,5-dihydro-1H-imidazol-2-yl) -2,3-dihydro-indole derivatives
AU53303/86A AU575711B2 (en) 1985-02-08 1986-02-07 2-(4,5-dihydro-1h-imidazol-2-yl)-2,3-dihydroindole derivatives the preparation therof and their application in therapy
GR860363A GR860363B (en) 1985-02-08 1986-02-07 Method for the preparation of ( imidazolyl-2)-2 indole derivatives
CA000501356A CA1273939A (en) 1985-02-08 1986-02-07 2-(4,5-dihydro-1h-imidazol-2-yl)-2,3-dihydroindole derivatives, the preparation thereof and their application in therapy
KR1019860000860A KR860006456A (en) 1985-02-08 1986-02-07 2- (4,5-dihydro-1H-imidazol-2-yl-2,3-dihydro indole derivatives, their preparation and application in therapy
ES551733A ES8707226A1 (en) 1985-02-08 1986-02-07 (Dihydro-4,5-1H-imidazolyl-2)-2-dihydro-2,3-indole derivatives, their preparation and their use as medicaments.
DK60486A DK60486A (en) 1985-02-08 1986-02-07 DERIVATIVES OF 2- (4,5-DIHYDRO-2-1H-IMIDAZOLYL) -2,3-DIHYDROINDOL, PROCEDURES FOR THE PREPARATION OF MEDICINAL PRODUCTS CONTAINING SUCH DERIVATIVES
HU86523A HU195212B (en) 1985-02-08 1986-02-07 Process for production of derivatives of 2-/4,5-dihydro-1/1-imidasole-2-il/-2,3-dihydro-indol and medical preparatives containing them
PT81992A PT81992B (en) 1985-02-08 1986-02-07 2- (4,5-DIHYDRO-1H-IMIDAZOLYL-2) -2,3-DIHYDRO-INDOLE DERIVATIVES AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
ES557370A ES8802515A1 (en) 1985-02-08 1987-02-06 (Dihydro-4,5-1H-imidazolyl-2)-2-dihydro-2,3-indole derivatives, their preparation and their use as medicaments.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8501774A FR2577223B1 (en) 1985-02-08 1985-02-08 INDOLE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION

Publications (2)

Publication Number Publication Date
FR2577223A1 FR2577223A1 (en) 1986-08-14
FR2577223B1 true FR2577223B1 (en) 1987-02-27

Family

ID=9316063

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8501774A Expired FR2577223B1 (en) 1985-02-08 1985-02-08 INDOLE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION

Country Status (4)

Country Link
JP (1) JPS61183284A (en)
KR (1) KR860006456A (en)
FR (1) FR2577223B1 (en)
ZA (1) ZA86932B (en)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3047388A1 (en) * 1980-12-16 1982-07-15 Basf Ag, 6700 Ludwigshafen ISATOGEN DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS FUNGICIDES
DE3141063A1 (en) * 1981-10-13 1983-04-28 Schering Ag, 1000 Berlin Und 4619 Bergkamen NEW IMIDAZOLE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM

Also Published As

Publication number Publication date
ZA86932B (en) 1986-12-30
KR860006456A (en) 1986-09-11
JPS61183284A (en) 1986-08-15
FR2577223A1 (en) 1986-08-14

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Legal Events

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ST Notification of lapse